The effect of collagen I mimetic peptides on mesenchymal stem cell adhesion and differentiation, and on bone formation at hydroxyapatite surfaces.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Biomaterials

• Publication date

  2009-04-01

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.1016/j.biomaterials.2008.12.053PMID 19157536PMCID PMC3679919
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The effect of RGD peptides on osseointegration of hydroxyapatite biomaterials.

  2008influential reference
• Treatment of Hydroxyapatite Scaffolds with Fibronectin and Fetal Calf Serum Increases Osteoblast Adhesion and Proliferation In Vitro

  2008cited by this paper
• Electrospun fibrous web of collagen–apatite precipitated nanocomposite for bone regeneration

  2008cited by this paper
• Development of specific collagen scaffolds to support the osteogenic and chondrogenic differentiation of human bone marrow stromal cells.

  2008cited by this paper
• Additive Effect of RGD Coating to Functionalized Titanium Surfaces on Human Osteoprogenitor Cell Adhesion and Spreading

  2008cited by this paper
• The effect of adsorbed serum proteins, RGD and proteoglycan-binding peptides on the adhesion of mesenchymal stem cells to hydroxyapatite.

  2007cited by this paper
• Hydroxyapatite grown on a native extracellular matrix: initial interactions with human fibroblasts.

  2007cited by this paper
• Suppression of apoptosis by enhanced protein adsorption on polymer/hydroxyapatite composite scaffolds.

  2007cited by this paper
• A comparative evaluation of the effectiveness of an anorganic bone matrix/cell binding peptide with an open flap debridement in human infrabony defects: a clinical and radiographic study.

  2007cited by this paper
• Biomolecular surface coating to enhance orthopaedic tissue healing and integration.

  2007cited by this paper
• Comparison of Bone Grafting Materials in Human Extraction Sockets: Clinical, Histologic, and Histomorphometric Evaluations

  2006cited by this paper
• A comparison of ProOsteon, DBX, and collagraft in a rabbit model.

  2006cited by this paper
• Quantitative kinetic analysis of gene expression during human osteoblastic adhesion on orthopaedic materials.

  2006cited by this paper
• Anorganic bovine matrix/p-15 "flow" in the treatment of periodontal defects: case series with 12 months of follow-up.

  2006cited by this paper
• Mediation of Biomaterial–Cell Interactions by Adsorbed Proteins: A Review

  2005cited by this paper
• Bio-adhesive Surfaces to Promote Osteoblast Differentiation and Bone Formation

  2005cited by this paper
• Maxillary Sinus Augmentation Using a Synthetic Cell-Binding Peptide: A Histologic and Transmission Electron Microscopy Case Study in Man

  2005cited by this paper
• Regulation of mesenchymal stem cell attachment and spreading on hydroxyapatite by RGD peptides and adsorbed serum proteins.

  2005influential reference
• Fibronectin Preadsorbed on Hydroxyapatite Together With Rough Surface Structure Increases Osteoblasts' Adhesion “In Vitro”: The Theoretical Usefulness of Fibronectin Preadsorption on Hydroxyapatite to Increase Permanent Stability and Longevity in Spine Implants

  2005cited by this paper
• Alpha2beta1 integrin-specific collagen-mimetic surfaces supporting osteoblastic differentiation.

  2004cited by this paper
• Structure of the integrin alpha2beta1-binding collagen peptide.

  2004cited by this paper
• Structure of the Integrin α2β1-binding Collagen Peptide

  2004cited by this paper
• α2β1 integrin‐specific collagen‐mimetic surfaces supporting osteoblastic differentiation

  2004cited by this paper
• Adhesion to Vitronectin and Collagen I Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells

  2004cited by this paper
• Comparative clinical evaluation of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) and open flap debridement (DEBR) in human periodontal osseous defects: a 6 month pilot study.

  2004cited by this paper
• Phenotypic expression of bone-related genes in osteoblasts grown on calcium phosphate ceramics with different phase compositions.

  2004cited by this paper
• Grafting RGD containing peptides onto hydroxyapatite to promote osteoblastic cells adhesion

  2004cited by this paper
• Evaluation of suitable biodegradable scaffolds for engineered bone tissue.

  2004influential reference
• Primary human marrow stromal cells and Saos-2 osteosarcoma cells use different mechanisms to adhere to hydroxylapatite.

  2004cited by this paper
• Biomimetic peptides that engage specific integrin-dependent signaling pathways and bind to calcium phosphate surfaces.

  2003cited by this paper
• Clinical, Radiographic, Histologic, and Histomorphometric Comparison of PepGen P-15 Particulate and PepGen P-15 Flow in Extraction Sockets: A Same-Mouth Case Study

  2003cited by this paper
• Selective adhesion of osteoblastic cells to different integrin ligands induces osteopontin gene expression.

  2003cited by this paper
• Hydroxyapatite accelerates differentiation and suppresses growth of MC3T3-E1 osteoblasts.

  2003cited by this paper
• Three-dimensional culture of differentiating marrow stromal osteoblasts in biomimetic poly(propylene fumarate-co-ethylene glycol)-based macroporous hydrogels.

  2003cited by this paper
• The RGD story: a personal account.

  2003cited by this paper
• Enhancement of osteogenesis on hydroxyapatite surface coated with synthetic peptide (EEEEEEEPRGDT) in vitro.

  2002cited by this paper
• Biomimetic surfaces for control of cell adhesion to facilitate bone formation.

  2002cited by this paper
• Periodontal regeneration following use of ABM/P-1 5: a case report.

  2002cited by this paper
• Hydroxylapatite binds more serum proteins, purified integrins, and osteoblast precursor cells than titanium or steel.

  2001cited by this paper
• Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen.

  2001cited by this paper
• Human osteoprogenitor growth and differentiation on synthetic biodegradable structures after surface modification.

  2001cited by this paper
• Blood coagulation.

  2000cited by this paper
• Multi-center clinical comparison of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) and ABM in human periodontal osseous defects. 6-month results.

  2000cited by this paper
• Surface Coating with Cyclic RGD Peptides Stimulates Osteoblast Adhesion and Proliferation as well as Bone Formation

  2000cited by this paper
• The Collagen-binding A-domains of Integrins α1β1 and α2β1Recognize the Same Specific Amino Acid Sequence, GFOGER, in Native (Triple-helical) Collagens*

  2000cited by this paper
• Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-alpha2beta1 integrin interaction.

  2000cited by this paper
• Diverse mechanisms of osteoblast spreading on hydroxyapatite and titanium.

  2000cited by this paper
• Type I collagen‐induced osteoblastic differentiation of bone‐marrow cells mediated by collagen‐α2β1 integrin interaction

  2000cited by this paper
• Design of Biomimetic Habitats for Tissue Engineering with P-15, a Synthetic Peptide Analogue of Collagen

  1999cited by this paper
• Identification in Collagen Type I of an Integrin α2β1-binding Site Containing an Essential GER Sequence*

  1998cited by this paper
• Specific activation of platelets by surface-adsorbed plasma proteins.

  1998cited by this paper
• Multi-center clinical evaluation of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) as a bone replacement graft material in human periodontal osseous defects. 6-month results.

  1998cited by this paper
• Role of the α2-Integrin in Osteoblast-specific Gene Expression and Activation of the Osf2 Transcription Factor*

  1998cited by this paper
• Differentiation and Transforming Growth Factor-β Receptor Down-regulation by Collagen-α2β1 Integrin Interaction Is Mediated by Focal Adhesion Kinase and Its Downstream Signals in Murine Osteoblastic Cells*

  1997cited by this paper
• Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells.

  1997cited by this paper
• The role in cell binding of a beta-bend within the triple helical region in collagen alpha 1 (I) chain: structural and biological evidence for conformational tautomerism on fiber surface.

  1997cited by this paper
• Osteogenic differentiation of purified, culture‐expanded human mesenchymal stem cells in vitro

  1997cited by this paper
• Structural Requirements for Biological Activity of the Ninth and Tenth FIII Domains of Human Fibronectin*

  1997cited by this paper
• The Role of Surface Characteristics in the Initial Adhesion of Human Bone-Derived Cells on Ceramics

  1996cited by this paper
• RGD and other recognition sequences for integrins.

  1996cited by this paper
• Role of the heparin binding domain of fibronectin in attachment and spreading of human bone-derived cells.

  1995cited by this paper
• A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formation.

  1993cited by this paper
• Characterization of regions of fibronectin besides the arginine-glycine-aspartic acid sequence required for adhesive function of the cell-binding domain using site-directed mutagenesis.

  1991cited by this paper
• Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen.

  1991cited by this paper
• Structure and biological role of vitronectin.

  1991cited by this paper
• Effects of modifications of the RGD sequence and its context on recognition by the fibronectin receptor.

  1989cited by this paper
• Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments.

  1986cited by this paper
• Physiology of fibronectin.

  1984cited by this paper
• Synthetic peptide with cell attachment activity of fibronectin.

  1983cited by this paper
• A new method for analysis of the adsorbed plasma protein layer on biomaterial surfaces.

  1976cited by this paper

• Synergistic Multi-Peptide Interfaces Enhance Early Osteogenic Differentiation of Mesenchymal Stem Cells.

  2025cites this paper
• Fully Defined 3D Hybrid System for Bone Tissue Engineering: Integration of MeHA–RGD/PCL–TCP Scaffolds With Human Stem Cells via 3D-Printed Vacuum-Assisted Cell Loading Device

  2025cites this paper
• Peptide-conjugated biodegradable polyester scaffolds for bone regeneration.

  2025cites this paper
• New updates on peptides and peptide-based biopolymeric materials: medical, pharmaceutical and sensors applications

  2025cites this paper
• Effects of adding poloxamer, collagen, and citric acid on mechanical strength, injectability, shape stability, and biocompatibility of mechanochemically modified beta-tricalcium phosphate cement using ball milling.

  2025cites this paper
• Enhanced Osteogenic Differentiation via Collagen and BMP-2 Mimetic Peptide Conjugation to β-TCP Scaffolds Using a Cold Atmospheric Plasma-Assisted Strategy.

  2025cites this paper
• Clinical efficacy and safety of P-15 peptide enhanced bone graft substitute in surgical bone regenerative procedures in adult maxillofacial, spine, and trauma patients

  2025cites this paper
• Enhanced surface of collagen-Zn-Ag-HA coated Ti-6Al-4V alloy for biocompatibility

  2025cites this paper
• Peptide-Based Biomaterials for Bone and Cartilage Regeneration

  2024cites this paper
• Collagen type I mimicking peptide additives to functionalize synthetic supramolecular hydrogels

  2024cites this paper
• Towards Stem Cell Therapy for Critical-Sized Segmental Bone Defects: Current Trends and Challenges on the Path to Clinical Translation

  2024cites this paper
• The Osteogenic Peptide P-15 for Bone Regeneration: A Narrative Review of the Evidence for a Mechanism of Action

  2024cites this paper
• Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix

  2024cites this paper
• Shape memory cycle conditions impact human bone marrow stromal cell binding to RGD- and YIGSR-conjugated poly (glycerol dodecanedioate).

  2024cites this paper
• Bioactive peptides for boosting stem cell culture platform: Methods and applications.

  2023cites this paper
• Aligned Skeletal Muscle Assembly on a Biofunctionalized Plant Leaf Scaffold.

  2023cites this paper
• In vitro strategies for mimicking dynamic cell–ECM reciprocity in 3D culture models

  2023cites this paper
• Hydrogels as Scaffolds in Bone Related Tissue Engineering and Regeneration.

  2023cites this paper
• Synthesis of Functionalized Triblock Copolyesters Derived from Lactic Acid and Macrolactones for Bone Tissue Regeneration.

  2023cites this paper
• Bone tissue engineering for treating osteonecrosis of the femoral head

  2023cites this paper
• Cell-binding peptides on the material surface guide stem cell fate of adhesion, proliferation and differentiation.

  2023cites this paper
• Active Peptides and Motifs within Collagen and Other ECM Proteins

  2023cites this paper
• Effectiveness of biomolecule-based bioactive surfaces, on os-seointegration of titanium dental implants: A systematic review and meta-analysis of in vivo studies

  2022cites this paper
• Preparation of mineralized pericardium by alternative soaking for soft-hard interregional tissue application.

  2022cites this paper
• Biomaterial functionalization with triple-helical peptides for tissue engineering.

  2022cites this paper
• Bovine collagen oligopeptides accelerate wound healing by promoting fibroblast migration via PI3K/Akt/mTOR signaling pathway

  2022cites this paper
• Supramolecular assembly of protein building blocks: from folding to function

  2022cites this paper
• Design of a custom-made device for real-time optical measurement of differential mineral concentrations in three-dimensional scaffolds for bone tissue engineering

  2022cites this paper
• Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes

  2021cites this paper
• Peptide Regulation of Gene Expression: A Systematic Review

  2021cites this paper
• Rat model of an autologous cancellous bone graft

  2021cites this paper
• Design of two natural deproteinized bovine bone scaffolds and evaluation of the effect of initial cell seeding density on repairing bone defects

  2021cites this paper
• Hydrogels for Large-Scale Expansion of Stem Cells.

  2021cites this paper
• Osteogenic potential of the growth factors and bioactive molecules in bone regeneration.

  2021cites this paper
• Quantification of iPSC-derived vascular networks in novel phototunable angiogenic hydrogels

  2020cites this paper
• Review on material parameters to enhance bone cell function in vitro and in vivo.

  2020cites this paper
• Chemical Functionalization of Calcium Phosphate Bioceramic Surfaces

  2020cites this paper
• Characterization of cell signaling, morphology, and differentiation potential of human mesenchymal stem cells based on cell adhesion mechanism

  2020cites this paper
• Phototunable interpenetrating polymer network hydrogels to stimulate the vasculogenesis of stem cell-derived endothelial progenitors.

  2020cites this paper
• Review of Integrin‐Targeting Biomaterials in Tissue Engineering

  2020cites this paper
• Peptide-mediated Bone Tissue Engineering

  2020cites this paper
• Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

  2020cites this paper
• Comprehensive Review on Full Bone Regeneration through 3D Printing Approaches

  2020cites this paper
• 3D Printing of Anisotropic Bone-Mimetic Structure with Controlled Fluid Flow Stimuli for Osteocytes: Flow Orientation Determines the Elongation of Dendrites

  2020cites this paper
• A modular programmed biphasic dual-delivery system on 3D ceramic scaffolds for osteogenesis in vitro and in vivo.

  2020cites this paper
• Peptide-modified bone repair materials: Factors influencing osteogenic activity.

  2019cites this paper
• Collagen Peptide Upregulates Osteoblastogenesis from Bone Marrow Mesenchymal Stem Cells through MAPK- Runx2

  2019cites this paper
• Combinatorial presentation of cartilage-inspired peptides on nanopatterned surfaces enables directed differentiation of human mesenchymal stem cells towards distinct articular chondrogenic phenotypes.

  2019cites this paper
• Self-Assembling Peptides as Extracellular Matrix Mimics to Influence Stem Cell's Fate

  2019cites this paper
• Mesenchymal Stem Cell Capping on ECM-Anchored Caspase Inhibitor-Loaded PLGA Microspheres for Intraperitoneal Injection in DSS-Induced Murine Colitis.

  2019cites this paper
• A crosslinked collagen membrane versus a non-crosslinked bilayer collagen membrane for supporting osteogenic functions of human bone marrow-multipotent stromal cells.

  2019cites this paper
• Folded Synthetic Peptides for Biomedical Applications

  2019cites this paper
• Addition of an oligoglutamate domain to bone morphogenic protein 2 confers binding to hydroxyapatite materials and induces osteoblastic signaling

  2019cites this paper
• Hierarchical micro/nanofibrous membranes of sustained releasing VEGF for periosteal regeneration.

  2019cites this paper
• Covalent Attachment of P15 Peptide to Ti Alloy Surface Modified with Polymer to Enhance Osseointegration of Implants.

  2019cites this paper
• Outer-inner dual reinforced micro/nano hierarchical scaffolds for promoting osteogenesis.

  2019cites this paper
• Dual effective core-shell electrospun scaffolds: Promoting osteoblast maturation and reducing bacteria activity.

  2019cites this paper
• Inflammatory Cytokines and Biodegradable Scaffolds in Dental Mesenchymal Stem Cells Priming.

  2019cites this paper
• Analysis of sequential dual immobilization of type I collagen and BMP-2 short peptides on hydrolyzed poly(buthylene succinate)/β-tricalcium phosphate composites for bone tissue engineering

  2019cites this paper
• Driving mesenchymal stem cell differentiation from self-assembled monolayers

  2018cites this paper
• Probing fibroblast activation in response to extracellular cues with whole protein- or peptide-functionalized step-growth hydrogels.

  2018cites this paper
• Hydroxyapatite/collagen coating on PLGA electrospun fibers for osteogenic differentiation of bone marrow mesenchymal stem cells.

  2018cites this paper
• Investigating fibroblast activation in response to extracellular cues using synthetic hydrogels

  2018cites this paper
• Evaluation of Differentiated Bone Cells Proliferation by Blue Shark Skin Collagen via Biochemical for Bone Tissue Engineering

  2018cites this paper
• Cross-talk between primary osteocytes and bone marrow macrophages for osteoclastogenesis upon collagen treatment

  2018cites this paper
• Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives.

  2018cites this paper
• A Biomimetic and Biodegradable Hydrogel and the Impact of Macrophages for Bone Tissue Engineering

  2017cites this paper
• The use of bioactive peptides to modify materials for bone tissue repair

  2017influential citation
• Exploring the in vitro and in vivo compatibility of PLA, PLA/GNP and PLA/CNT-COOH biodegradable nanocomposites: Prospects for tendon and ligament applications.

  2017cites this paper
• P15 peptide stimulates chondrogenic commitment and endochondral ossification

  2017cites this paper
• Osteogenic differentiation of 3D cultured mesenchymal stem cells induced by bioactive peptides

  2017cites this paper
• PEG-peptide hydrogels reveal differential effects of matrix microenvironmental cues on melanoma drug sensitivity.

  2017cites this paper
• Tailoring biomaterial scaffolds for osteochondral repair.

  2017cites this paper
• The development of polymeric biomaterials inspired by the extracellular matrix

  2017cites this paper
• Osteoinduction of stem cells by collagen peptide-immobilized hydrolyzed poly(butylene succinate)/β-tricalcium phosphate scaffold for bone tissue engineering

  2017cites this paper
• Matrix Chemistry Controlling Stem Cell Behavior

  2017cites this paper
• Biotechnological applications of a surfactant protein, ranaspumin-2

  2017cites this paper
• Bone Tissue Engineering: State of the Art, Challenges, and Prospects

  2017cites this paper
• Cationic osteogenic peptide P15-CSP coatings promote 3-D osteogenesis in poly(epsilon-caprolactone) scaffolds of distinct pore size.

  2017cites this paper
• Dual-functioning peptides discovered by phage display increase the magnitude and specificity of BMSC attachment to mineralized biomaterials.

  2017cites this paper
• Structural studies and macro-performances of hydroxyapatite-reinforced keratin thin films for biological applications

  2016cites this paper
• Test in canine extraction site preservations by using mineralized collagen plug with or without membrane

  2016cites this paper
• The role of peptides in bone healing and regeneration: a systematic review

  2016cites this paper
• Carbon Nanostructures in Bone Tissue Engineering

  2016cites this paper
• Peptides for bone tissue engineering.

  2016cites this paper
• Short Anabolic Peptides for Bone Growth

  2016cites this paper
• Improved Cell Adhesion and Osteogenesis of op-HA/PLGA Composite by Poly(dopamine)-Assisted Immobilization of Collagen Mimetic Peptide and Osteogenic Growth Peptide.

  2016cites this paper
• Role of cell–matrix interactions on VIC phenotype and tissue deposition in 3D PEG hydrogels

  2016cites this paper
• Modulation of human multipotent and pluripotent stem cells using surface nanotopographies and surface-immobilised bioactive signals: A review.

  2016cites this paper
• Nanomaterials for Bone Tissue Regeneration and Orthopedic Implants

  2016cites this paper
• Bio-inspired synthesis of hybrid tube-like structures based on CaCO3 and type I-collagen

  2016cites this paper
• Investigation of shielding parameters for smart polymers

  2016cites this paper
• The role of chemistry and strut porosity and the influence of serum proteins in modulating cellular response to bone graft substitutes

  2015cites this paper
• The collagen I mimetic peptide DGEA enhances an osteogenic phenotype in mesenchymal stem cells when presented from cell-encapsulating hydrogels.

  2015cites this paper
• Enhancement of the Regenerative Potential of Anorganic Bovine Bone Graft Utilizing a Polyglutamate-Modified BMP2 Peptide with Improved Binding to Calcium-Containing Materials

  2015cites this paper
• Influence de films de polycaprolactone fonctionnalisés par des peptides d'adhésion sur la signalisation intracellulaire de cellules souches : régulation de la réponse aux facteurs de croissance

  2015cites this paper
• Regulation of melanoma cell survival and function by matricellular signaling and microenvironmental factors

  2015cites this paper
• Fusion peptide P15-CSP shows antibiofilm activity and pro-osteogenic activity when deposited as a coating on hydrophilic but not hydrophobic surfaces.

  2015cites this paper
• Self-assembled peptide amphiphile nanofibers and peg composite hydrogels as tunable ECM mimetic microenvironment.

  2015cites this paper
• Structure and properties of hydroxyapatite for biomedical applications

  2015cites this paper