Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Nature Cell Biology

• Publication date

  2010-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncb2028PMID 20118921
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Investigating the Genetic Circuitry of Mastermind in Drosophila, a Notch Signal Effector

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• Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos.

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• Hedgehog regulates smoothened activity by inducing a conformational switch

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• Notch signalling: a simple pathway becomes complex

  2006cited by this paper
• Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.

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• Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

  2006cited by this paper
• STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.

  2005cited by this paper
• Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an Unstructured Region

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• Role of the TAK1-NLK-STAT3 pathway in TGF-β-mediated mesoderm induction

  2004cited by this paper
• Identification of Two Binding Regions for the Suppressor of Hairless Protein within the Intracellular Domain of Drosophila Notch*

  2004cited by this paper
• Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction.

  2004cited by this paper
• nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development

  2004cited by this paper
• Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.

  2004cited by this paper
• Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos.

  2003cited by this paper
• Regulation of Lymphoid Enhancer Factor 1/T-Cell Factor by Mitogen-Activated Protein Kinase-Related Nemo-Like Kinase-Dependent Phosphorylation in Wnt/β-Catenin Signaling

  2003cited by this paper
• p300 and PCAF Act Cooperatively To Mediate Transcriptional Activation from Chromatin Templates by Notch Intracellular Domains In Vitro

  2002cited by this paper
• Functional diversity among Notch1, Notch2, and Notch3 receptors.

  2002cited by this paper
• Thymocyte development: Jacket and tie required

  2002cited by this paper
• Involvement of NLK and Sox11 in neural induction in Xenopus development

  2002cited by this paper
• Identification of New Human Mastermind Proteins Defines a Family That Consists of Positive Regulators for Notch Signaling*

  2002cited by this paper
• Phosphorylation of Ser2078 Modulates the Notch2 Function in 32D Cell Differentiation*

  2001cited by this paper
• A Human Protein with Sequence Similarity to DrosophilaMastermind Coordinates the Nuclear Form of Notch and a CSL Protein To Build a Transcriptional Activator Complex on Target Promoters

  2001cited by this paper
• Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

  2001cited by this paper
• Abnormal bone marrow stroma in mice deficient for nemo‐like kinase, Nlk

  2001cited by this paper
• MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors

  2000cited by this paper
• Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5*

  2000cited by this paper
• SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function

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• Notch signaling: cell fate control and signal integration in development.

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• Notch signalling controls pancreatic cell differentiation

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• MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans

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• The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

  1999cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling.

  1999cited by this paper
• Notch1 and Notch2 Inhibit Myeloid Differentiation in Response to Different Cytokines

  1998cited by this paper
• Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region.

  1998cited by this paper
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  1997cited by this paper
• Analysis of dominant enhancers and suppressors of activated Notch in Drosophila.

  1996cited by this paper
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  1996cited by this paper
• Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene.

  1994cited by this paper

• Evolutionary analysis through structural modeling of FAM222 proteins reveals a novel disordered conserved domain in vertebrates that interacts with NLK

  2025cites this paper
• Crosstalk of Nemo-Like Kinase (NLK) and Yes-Associated Protein (YAP) Phosphorylation in Endometrial Epithelial Cells

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• Notch4 but not Notch1 yin-yang dimerization correlates with condensate formation but not transcriptional activity.

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• Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS

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• Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS

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• Notch NICD domains form biomolecular condensates

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• Nemo‐like kinase blocks myeloid differentiation by targeting tumor suppressor C/EBPα in AML

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• The Immunomodulatory Role of Hypoxic Tumor-Derived Extracellular Vesicles

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• Asialoglycoprotein receptor 1 functions as a tumor suppressor in liver cancer via inhibition of STAT3.

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• Nemo-like kinase (NLK) gene regulates apoptosis via the p53 signaling pathway in Litopenaeus vannamei under low-temperature stress.

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• Grass carp (Ctenopharyngodon idella) NLK2 inhibits IFN I response through blocking MAVS-IRF3 axis.

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• The phosphorylation of the Smad2/3 linker region by nemo-like kinase regulates TGF-β signaling

  2021cites this paper
• A proteogenomic portrait of lung squamous cell carcinoma.

  2021cites this paper
• A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis.

  2021cites this paper
• NLK suppresses MAVS-mediated signaling in black carp antiviral innate immunity.

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• Pan-cancer analysis of nemo-like kinase (NLK) expression convergence to pancreatic adenocarcinoma that has diagnostic, prognostic and treatment value

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  2018cites this paper
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