Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review

Lung ischemia-reperfusion injury (LIRI) and primary graft dysfunction are leading causes of morbidity and mortality among lung transplant recipients. Although extensive research endeavors have been undertaken, few preventative and therapeutic treatments have emerged for clinical use. Novel strategies are still needed to improve outcomes after lung transplantation. In this review, we discuss the underlying mechanisms of transplanted LIRI, potential modifiable targets, current practices, and areas of ongoing investigation to reduce LIRI and primary graft dysfunction in lung transplant recipients.

• Publication year

  2021

• Venue

  Transplantation Direct

• Publication date

  2021-01-07

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/TXD.0000000000001104PMID 33437867PMCID 7793349
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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