Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Nature Medicine

• Publication date

  2000-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/74672PMID 10742148
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Risk factors in the pathogenesis of invasive group A streptococcal infections: role of protective humoral immunity.

  1999cited by this paper
• Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity.

  1998cited by this paper
• A Mutational Analysis of the Binding of Staphylococcal Enterotoxins B and C3 to the T Cell Receptor β Chain and Major Histocompatibility Complex Class II

  1998cited by this paper
• Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors.

  1998cited by this paper
• Intranasal and intramuscular proteosome-staphylococcal enterotoxin B (SEB) toxoid vaccines: immunogenicity and efficacy against lethal SEB intoxication in mice

  1996cited by this paper
• 2-Aminopurine selectively inhibits splicing of tumor necrosis factor alpha mRNA

  1996cited by this paper
• Crystal structure of a T-cell receptor beta-chain complexed with a superantigen.

  1996cited by this paper
• Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells

  1996cited by this paper
• Toxic shock syndrome toxin-1-induced death is prevented by CTLA4Ig.

  1996cited by this paper
• Crystal structure of a T-cell receptor β-chain complexed with a superantigen

  1996cited by this paper
• Prediction of response to treatment in superficial bladder carcinoma through pattern of interleukin-2 gene expression.

  1996cited by this paper
• B7.2 provides co‐stimulatory functions in vivo in response to staphylococcal enterotoxin B

  1995cited by this paper
• Crystal structure of the superantigen staphylococcal enterotoxin type A.

  1995cited by this paper
• Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II

  1995cited by this paper
• Activation of murine T cells by bacterial superantigens requires B7-mediated costimulation.

  1995cited by this paper
• Transient expression of human interleukin-2 and interferon-gamma genes is regulated by interaction between distinct cell subsets.

  1995cited by this paper
• Post-transcriptional Regulation of Human Interleukin-2 Gene Expression at Processing of Precursor Transcripts (*)

  1995cited by this paper
• Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A.

  1995cited by this paper
• Localization of binding sites of staphylococcal enterotoxin B (SEB), a superantigen, for HLA-DR by inhibition with synthetic peptides of SEB

  1994cited by this paper
• Predictions of T-cell receptor- and major histocompatibility complex-binding sites on staphylococcal enterotoxin C1

  1994cited by this paper
• Identification of staphylococcal enterotoxin B sequences important for induction of lymphocyte proliferation by using synthetic peptide fragments of the toxin

  1994cited by this paper
• Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen

  1994cited by this paper
• Superantigens associated with staphylococcal and streptococcal toxic shock syndrome are potent inducers of tumor necrosis factor-beta synthesis.

  1993cited by this paper
• Role of superantigens in human disease.

  1993cited by this paper
• Localization of an immunologically functional region of the streptococcal superantigen pepsin-extracted fragment of type 5 M protein.

  1993cited by this paper
• Structure of toxic shock syndrome toxin 1.

  1993cited by this paper
• Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock

  1993cited by this paper
• Mutations defining functional regions of the superantigen staphylococcal enterotoxin B

  1992cited by this paper
• Crystal structure of staphylococcal enterotoxin B, a superantigen

  1992cited by this paper
• T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor

  1992cited by this paper
• Localization of the immunologic activity in the superantigen Staphylococcal enterotoxin B using truncated recombinant fusion proteins.

  1992cited by this paper
• Superantigens: mechanism of T-cell stimulation and role in immune responses.

  1991cited by this paper
• Aberrant regulation of interleukin-2 but not of interferon-gamma gene expression in Down syndrome (trisomy 21).

  1991cited by this paper
• IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

  1991cited by this paper
• Residues of the variable region of the T-cell-receptor β-chain that interact with S. aureus toxin superantigens

  1990cited by this paper
• The staphylococcal enterotoxins and their relatives.

  1990cited by this paper
• Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illnesses.

  1990cited by this paper
• The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells

  1990cited by this paper
• T‐Cell Responses to Mls and to Bacterial Proteins that Mimic its Behavior #

  1989cited by this paper
• Relative strength of the mitogenic and interleukin-2-production-inducing activities of staphylococcal exotoxins presumed to be causative exotoxins of toxic shock syndrome: toxic shock syndrome toxin-1 and enterotoxins A, B and C to murine and human T cells.

  1989cited by this paper
• Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.

  1989cited by this paper
• Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules.

  1989cited by this paper
• High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR

  1989cited by this paper
• V beta-specific stimulation of human T cells by staphylococcal toxins.

  1989cited by this paper
• Nucleotide sequence of the type A staphylococcal enterotoxin gene

  1988cited by this paper
• Galactosamine-induced sensitization to the lethal effects of endotoxin.

  1979cited by this paper

• The Therapeutic Efficacy of MS473, a Fully Human Single-Chain Variable Fragment Targeting Staphylococcus aureus Toxic Shock Syndrome Toxin-1, in a D-Galactosamine-Sensitized Mouse Model of Lethal Shock

  2025influential citation
• Blocking Superantigen-Mediated Diseases: Challenges and Future Trends

  2024cites this paper
• Subduing the Inflammatory Cytokine Storm

  2024influential citation
• RNA Activators of Stress Kinase PKR within Human Genes That Control Splicing or Translation Create Novel Targets for Hereditary Diseases

  2024cites this paper
• The homodimer interfaces of costimulatory receptors B7 and CD28 control their engagement and pro-inflammatory signaling

  2023influential citation
• De novo design of a protein binder against Staphylococcus enterotoxin B.

  2023cites this paper
• The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells

  2023cites this paper
• Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells

  2023cites this paper
• SARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity

  2022influential citation
• Role of Superantigens In Various Childhood Inflamatory Diseases.

  2022cites this paper
• Binding of Staphylococcal Enterotoxin B (SEB) to B7 Receptors Triggers TCR- and CD28-Mediated Inflammatory Signals in the Absence of MHC Class II Molecules

  2021influential citation
• Administration of Δ9‐Tetrahydrocannabinol (THC) Post‐Staphylococcal Enterotoxin B Exposure Protects Mice From Acute Respiratory Distress Syndrome and Toxicity

  2020cites this paper
• Potent Neutralization of Staphylococcal Enterotoxin B In Vivo by Antibodies that Block Binding to the T-Cell Receptor.

  2019cites this paper
• Uncovering the Mechanisms of Staphylococcus aureus Enterotoxin A-induced Systemic and Pulmonary Inflammation

  2019cites this paper
• Staphylococcal and Streptococcal Superantigens Trigger B7/CD28 Costimulatory Receptor Engagement to Hyperinduce Inflammatory Cytokines

  2019cites this paper
• Drugs in Development for Acute Kidney Injury

  2019cites this paper
• Comparison of two commonly used methods for stimulating T cells

  2019cites this paper
• Staphylococcal Superantigens Stimulate Epithelial Cells through CD40 To Produce Chemokines

  2019cites this paper
• A new therapeutic approach for type 1 diabetes: Rationale for GNbAC1, an anti‐HERV‐W‐Env monoclonal antibody

  2018cites this paper
• Bacterial Superantigen Toxins, CD28, and Drug Development

  2018cites this paper
• Validation of a clinical trial composite endpoint for patients with necrotizing soft tissue infections

  2017cites this paper
• Sepsis: A Review of Advances in Management

  2017cites this paper
• Bacterial superantigen toxins induce a lethal cytokine storm by enhancing B7-2/CD28 costimulatory receptor engagement, a critical immune checkpoint.

  2017cites this paper
• Neutrophil killing of Staphylococcus aureus In Sepsis

  2017cites this paper
• An Ancient Pseudoknot in TNF-α Pre-mRNA Activates PKR, Inducing eIF2α Phosphorylation that Potently Enhances Splicing.

  2017cites this paper
• MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: Relevance of GNbAC1 in multiple sclerosis treatment.

  2016cites this paper
• sCD48 is anti‐inflammatory in Staphylococcus aureus Enterotoxin B‐induced eosinophilic inflammation

  2016cites this paper
• Preliminary investigation of human serum albumin-Vβ inhibition on toxic shock syndrome induced by staphylococcus enterotoxin B in vitro and in vivo.

  2016cites this paper
• Innate Immune Signaling Activated by MDR Bacteria in the Airway.

  2016cites this paper
• TNF and CD28 Signaling Play Unique but Complementary Roles in the Systemic Recruitment of Innate Immune Cells after Staphylococcus aureus Enterotoxin A Inhalation

  2016cites this paper
• Superantigens hyperinduce inflammatory cytokines by enhancing the B7-2/CD28 costimulatory receptor interaction

  2016cites this paper
• CD28 homodimer interface mimetic peptide acts as a preventive and therapeutic agent in models of severe bacterial sepsis and gram-negative bacterial peritonitis.

  2015influential citation
• Bacterial superantigens and superantigen-like toxins

  2015cites this paper
• Neutralization of Staphylococcal enterotoxin B by aptamer 1 antagonist 2

  2015cites this paper
• Neutralization of Staphylococcal Enterotoxin B by an Aptamer Antagonist

  2015cites this paper
• Persistent infection by Yersinia pseudotuberculosis

  2015cites this paper
• Correction: Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock

  2015cites this paper
• Treatment Against Human Endogenous Retrovirus: A Possible Personalized Medicine Approach for Multiple Sclerosis

  2015cites this paper
• Streptococcal superantigens: categorization and clinical associations.

  2014cites this paper
• Single Administration of p2TA (AB103), a CD28 Antagonist Peptide, Prevents Inflammatory and Thrombotic Reactions and Protects against Gastrointestinal Injury in Total-Body Irradiated Mice

  2014cites this paper
• Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome

  2014cites this paper
• Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus

  2014cites this paper
• A Review on Superantigens Dr .

  2014cites this paper
• A Novel Drug for Treatment of Necrotizing Soft-Tissue Infections: A Randomized Clinical Trial.

  2014cites this paper
• A Review on Superantigens

  2014cites this paper
• Assessment of the Functional Regions of the Superantigen Staphylococcal Enterotoxin B

  2013cites this paper
• DETERMINATION OF C5a IN MURINE MODELS OF STAPHYLOCOCCAL ENTEROTOXIN B–INDUCED TOXIC SHOCK

  2013cites this paper
• Reemergence of Established Pathogens in the 21st Century

  2013cites this paper
• The staphylococcal enterotoxin (SE) family

  2013cites this paper
• Staphylococcal and Streptococcal Superantigen Exotoxins

  2013cites this paper
• Ubiquitin E3 Ligase A20 is Required in Degradation of Microbial Superantigens in Vascular Endothelial Cells

  2013cites this paper
• CD28: Direct and Critical Receptor for Superantigen Toxins

  2013influential citation
• A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes.

  2013cites this paper
• Gram-positive and gram-negative bacterial toxins in sepsis

  2013cites this paper
• Identification of bacterial antigens and super antigens in synovial fluid of patients with arthritis: a cross sectional study

  2013cites this paper
• Bacterial Toxins—Staphylococcal Enterotoxin B

  2013cites this paper
• Secreted virulence factors in lethal illness due to Staphylococcus aureus

  2013cites this paper
• Update on Staphylococcal Superantigen-Induced Signaling Pathways and Therapeutic Interventions

  2013cites this paper
• Intranasal Rapamycin Rescues Mice from Staphylococcal Enterotoxin B-Induced Shock

  2012cites this paper
• Staphylococcal and Streptococcal Superantigens: In Vitro and In Vivo Assays

  2012cites this paper
• Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections

  2012cites this paper
• Staphylococcal superantigens in synovial fluid of 62 patients with arthritis

  2012cites this paper
• PI3K/Akt/mTOR, a Pathway Less Recognized for Staphylococcal Superantigen-Induced Toxicity

  2012cites this paper
• A Disintegrin and Metalloproteinase 17 (ADAM17) and Epidermal Growth Factor Receptor (EGFR) Signaling Drive the Epithelial Response to Staphylococcus aureus Toxic Shock Syndrome Toxin-1 (TSST-1)*

  2012cites this paper
• Clarifying the Mechanism of Superantigen Toxicity

  2011influential citation
• Genome scale analysis of the role of superantigens in Staphylococcus aureus disease pathogenesis

  2011cites this paper
• Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock

  2011influential citation
• Gram‐positive bacterial superantigen outside‐in signaling causes toxic shock syndrome

  2011cites this paper
• Staphylococcal toxic shock syndrome toxin -1 interactions with human vaginal epithilial cells and novel theraputics

  2011cites this paper
• Chimeric Anti-Staphylococcal Enterotoxin B Antibodies and Lovastatin Act Synergistically to Provide In Vivo Protection against Lethal Doses of SEB

  2011cites this paper
• Staphylococcal Enterotoxins

  2010cites this paper
• Murine models of staphylococcal enterotoxin B-induced toxic shock.

  2010cites this paper
• Potent Neutralization of Staphylococcal Enterotoxin B by Synergistic Action of Chimeric Antibodies

  2010cites this paper
• Rapamycin Protects Mice from Staphylococcal Enterotoxin B-Induced Toxic Shock and Blocks Cytokine Release InVitro and In Vivo

  2010cites this paper
• Therapeutic Down-Modulators of Staphylococcal Superantigen-Induced Inflammation and Toxic Shock

  2010cites this paper
• Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B

  2010cites this paper
• Protein Toxins from Bacteria

  2010cites this paper
• Urodilatin and Pentoxifylline Prevent the Early Onset of Escherichia coli-Induced Acute Renal Failure in a Model of Isolated Perfused Rat Kidney

  2009cites this paper
• Dynamic refolding of IFN-gamma mRNA enables it to function as PKR activator and translation template.

  2009cites this paper
• Interactions of staphylococcal and streptococcal exotoxins with vaginal epithelium

  2009cites this paper
• Superantigen gene profile diversity among clinical group A streptococcal isolates.

  2008cites this paper
• Syndecan-1 Is an in Vivo Suppressor of Gram-positive Toxic Shock*

  2008cites this paper
• Novel toxic shock syndrome toxin-1 amino acids required for biological activity.

  2008cites this paper
• A broad-spectrum inhibitory peptide against staphylococcal enterotoxin superantigen SEA, SEB and SEC.

  2008cites this paper
• The bacterial superantigen and superantigen‐like proteins

  2008cites this paper
• Staphylococcal and Streptococcal Superantigens: an Update

  2007cites this paper
• Broad-Spectrum Peptide Antagonists of Superantigen Toxins

  2007cites this paper
• Small Nonpeptide Inhibitors of Staphylococcal Superantigen-Induced Cytokine Production and Toxic Shock

  2007cites this paper
• Pathogenetic Mechanisms and Therapeutic Approaches in Superantigen-Induced Experimental Autoimmune Diseases

  2007cites this paper
• Streptococcus pyogenes: Insight into the function of the streptococcal superantigens.

  2007cites this paper
• T cell signalling induced by bacterial superantigens.

  2007cites this paper
• Identification of small peptides and their antibodies in the prevention of toxic shock syndrome

  2006cites this paper
• The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1

  2006cites this paper
• Staphylococcus aureus enterotoxins induce IL-8 secretion by human nasal epithelial cells

  2006cites this paper
• Cytokine storm and an anti-CD28 monoclonal antibody.

  2006cites this paper
• The HIV-1 Vpr and glucocorticoid receptor complex is a gain of function interaction that prevents the nuclear localization of PARP-1

  2006cites this paper
• Dexamethasone Attenuates Staphylococcal Enterotoxin B-Induced Hypothermic Response and Protects Mice from Superantigen-Induced Toxic Shock

  2006cites this paper
• Group A Streptococcal Extra-Cellular Products

  2006cites this paper
• Interferon-gamma mRNA attenuates its own translation by activating PKR: a molecular basis for the therapeutic effect of interferon-beta in multiple sclerosis.

  2006cites this paper
• Cytokine storm and an anti-CD28 monoclonal antibody.

  2006cites this paper