Physical exercise promotes brain remodeling by regulating epigenetics, neuroplasticity and neurotrophins

Abstract Exercise has been shown to have beneficial effects on brain functions in humans and animals. Exercise can improve memory and learning in age-related neurodegenerative diseases. In animal models, physical exercise regulates epigenetics, promotes synaptic plasticity and hippocampal neurogenesis, regulates the expression levels of neurotrophic factors, and improves cognitive function. Therefore, exercise is very important for brain rehabilitation and remodeling. The purpose of this review is to explore the mechanisms by which exercise exerts positive effects on brain function. This knowledge implies that physical exercise can be used as a non-drug therapy for neurological diseases.

• Publication year

  2021

• Venue

  Reviews in the Neurosciences

• Publication date

  2021-02-15

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1515/revneuro-2020-0099PMID 33583156
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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