Molecular Alterations in Hepatocyte Transport Mechanisms in Acquired Cholestatic Liver Disorders

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Seminars in liver disease (Print)

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1055/s-2000-9390PMID 11076403
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular pathogenesis of cholestasis.

  2012cited by this paper
• Cell membrane and transepithelial voltages and resistances in isolated rat hepatocyte couplets

  2005cited by this paper
• Expression and regulation of ABC transporter genes during liver regeneration

  2002cited by this paper
• Mutations of the cystic fibrosis gene in patients with chronic pancreatitis

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• Expression of the bile salt export pump is maintained after chronic cholestasis in the rat.

  2000cited by this paper
• Zonal down‐regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver

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• Interleukin-1β Suppresses Retinoid Transactivation of Two Hepatic Transporter Genes Involved in Bile Formation*

  2000cited by this paper
• Molecular cloning and characterization of the murine bile salt export pump.

  2000cited by this paper
• A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane.

  2000cited by this paper
• Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver.

  2000cited by this paper
• Characterization of inducible nature of MRP3 in rat liver.

  2000cited by this paper
• ATP-dependent Transport of Bile Salts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)*

  2000cited by this paper
• Identification of a nuclear receptor for bile acids.

  1999cited by this paper
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  1999cited by this paper
• Liver involvement in cystic fibrosis.

  1999cited by this paper
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  1999cited by this paper
• Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy.

  1999cited by this paper
• Molecular regulation of hepatocellular transport systems in cholestasis.

  1999cited by this paper
• Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)*

  1999cited by this paper
• Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver.

  1999cited by this paper
• Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1.

  1999cited by this paper
• Regulation of hepatic transport systems involved in bile secretion during liver regeneration in rats

  1999cited by this paper
• Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione.

  1999cited by this paper
• MRP3, an organic anion transporter able to transport anti-cancer drugs.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

  1999cited by this paper
• Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells.

  1999cited by this paper
• A Novel Human Hepatic Organic Anion Transporting Polypeptide (OATP2)

  1999cited by this paper
• Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver.

  1999cited by this paper
• Changes in the localization of the rat canalicular conjugate export pump mrp2 in phalloidin‐induced cholestasis

  1999cited by this paper
• Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis.

  1999cited by this paper
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  1999cited by this paper
• Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1*

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  1999cited by this paper
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  1998cited by this paper
• A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis

  1998cited by this paper
• Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets.

  1998cited by this paper
• Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors.

  1998cited by this paper
• Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.

  1998cited by this paper
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  1998cited by this paper
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• Molecular Characterization and Tissue Distribution of a New Organic Anion Transporter Subtype (oatp3) That Transports Thyroid Hormones and Taurocholate and Comparison with oatp2*

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• The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver*

  1998cited by this paper
• Upregulation of the multidrug resistance genes mrp1 and mdr1b and downregulation of the organic anion transporter mrp2 and bile salt transporter spgp in endotoxemic rat liver

  1998cited by this paper
• Changes in biliary excretory mechanisms in rats with ethinyloestradiol‐induced cholestasis

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• Mutations in the Canalicular Multispecific Organic Anion Transporter (cMOAT) Gene, a Novel ABC Transporter, in Patients with Hyperbilirubinemia II/Dubin-Johnson Syndrome

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• Vanishing Bile Duct Syndrome: Pathophysiology and Treatment

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• Up‐regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down‐regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver

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• Expression of the liver Na+-independent organic anion transporting polypeptide (oatp-1) in rats with bile duct ligation.

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• Inhibition of biliary bicarbonate secretion in ethinyl estradiol-induced cholestasis is not associated with impaired activity of the Cl-/HCO-3 exchanger in the rat.

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• Regulation of hepatocyte bile salt transporters during hepatic regeneration.

  1997cited by this paper
• Hepatic basolateral sodium‐dependent–bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia

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• Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes.

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• The role of mdr2 P‐glycoprotein in hepatobiliary lipid transport

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  1997cited by this paper
• Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion.

  1997cited by this paper
• Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis

  1997cited by this paper
• A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin‐Johnson syndrome

  1997cited by this paper
• The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis.

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• Liver Regeneration

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• Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter.

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• Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

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• Multiple Factors Regulate the Rat Liver Basolateral Sodium-dependent Bile Acid Cotransporter Gene Promoter*

  1996cited by this paper
• Absence of the canalicular isoform of the MRP gene–encoded conjugate export pump from the hepatocytes in Dubin‐Johnson syndrome

  1996cited by this paper
• Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents.

  1996cited by this paper
• cDNA Cloning of the Hepatocyte Canalicular Isoform of the Multidrug Resistance Protein, cMrp, Reveals a Novel Conjugate Export Pump Deficient in Hyperbilirubinemic Mutant Rats*

  1996cited by this paper
• Ion transporters that regulate intracellular pH and secretion in bile duct epithelial cells

  1996cited by this paper
• Sinusoidal (Basolateral) Bile Salt Uptake Systems of Hepatocytes

  1996cited by this paper
• Defect of multidrug‐resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis

  1996cited by this paper
• Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters.

  1996cited by this paper
• Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis.

  1996cited by this paper
• Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis.

  1996cited by this paper
• Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets.

  1995cited by this paper
• Tumor necrosis factor–alpha decreases hepatocyte bile salt uptake and mediates endotoxin‐induced cholestasis

  1995cited by this paper
• Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.

  1995cited by this paper
• Impaired hepatocanalicular organic anion transport in endotoxemic rats.

  1995cited by this paper
• Expression cloning of a rat liver Na(+)-independent organic anion transporter.

  1994cited by this paper
• Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter.

  1994cited by this paper
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  1994cited by this paper
• Hepatobiliary Disease in Cystic Fibrosis

  1994cited by this paper
• Decreased bilirubin transport in the perfused liver of endotoxemic rats.

  1994cited by this paper
• Bile acid transport by the rat liver canalicular bile acid transport/ecto-ATPase protein is dependent on ATP but not on its own ecto-ATPase activity.

  1994cited by this paper
• Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver

  1994cited by this paper
• Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells.

  1993cited by this paper
• Expression of multidrug resistance genes in rat liver during regeneration and after carbon tetrachloride intoxication

  1993cited by this paper
• Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver.

  1993cited by this paper

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