Dysregulation of CXCR3 Signaling due to CXCL10 Deficiency Impairs the Antiviral Response to Herpes Simplex Virus 1 Infection1

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Immunology

• Publication date

  2008-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.181.11.7985PMID 19017990PMCID PMC2596651
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history.

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• The role of chemokines during herpes simplex virus-1 infection.

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• IFN-gamma and STAT1 are required for efficient induction of CXC chemokine receptor 3 (CXCR3) on CD4+ but not CD8+ T cells.

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• CXCR3‐mediated T‐cell chemotaxis involves ZAP‐70 and is regulated by signalling through the T‐cell receptor

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• Chemokine research trends

  2007cited by this paper
• Human primary immunodeficiencies of type I interferons.

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• A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

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• Neutrophil chemorepulsion in defined interleukin‐8 gradients in vitro and in vivo

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• NK cells contribute to the early clearance of HSV‐1 from the lung but cannot control replication in the central nervous system following intranasal infection

  2006cited by this paper
• Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11.

  2006cited by this paper
• Oligomerization of CXCL10 Is Necessary for Endothelial Cell Presentation and In Vivo Activity1

  2006cited by this paper
• In Vivo Ablation of CD11c-Positive Dendritic Cells Increases Susceptibility to Herpes Simplex Virus Type 1 Infection and Diminishes NK and T-Cell Responses

  2006cited by this paper
• Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS

  2006cited by this paper
• Herpes simplex virus and the chemokines that mediate the inflammation.

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• Herpes Simplex Virus Type 1 Induction of Chemokine Production Is Unrelated to Viral Load in the Cornea But Not in the Nervous System

  2006cited by this paper
• Viral encephalitis

  2005cited by this paper
• Neuronal CXCL10 Directs CD8+ T-Cell Recruitment and Control of West Nile Virus Encephalitis

  2005cited by this paper
• Herpesviruses and the Innate Immune Response

  2005cited by this paper
• Chemokine receptor deficiency is associated with increased chemokine expression in the peripheral and central nervous systems and increased resistance to herpetic encephalitis.

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• NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells.

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• Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs

  2005cited by this paper
• Chemokine Monokine Induced by IFN-γ/CXC Chemokine Ligand 9 Stimulates T Lymphocyte Proliferation and Effector Cytokine Production1

  2004cited by this paper
• NMR structure of CXCR3 binding chemokine CXCL11 (ITAC)

  2004cited by this paper
• Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection

  2004cited by this paper
• CXC Chemokine Ligand 10 Controls Viral Infection in the Central Nervous System: Evidence for a Role in Innate Immune Response through Recruitment and Activation of Natural Killer Cells

  2004cited by this paper
• Immune control of herpes simplex virus during latency.

  2004cited by this paper
• Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules.

  2004cited by this paper
• Intracellular Domains of CXCR3 That Mediate CXCL9, CXCL10, and CXCL11 Function*

  2004cited by this paper
• IL-8 responsiveness defines a subset of CD8 T cells poised to kill.

  2004cited by this paper
• Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi‐step model of ligand binding and receptor activation

  2003cited by this paper
• Activating and Inhibitory Ly49 Receptors Modulate NK Cell Chemotaxis to CXC Chemokine Ligand (CXCL) 10 and CXCL12 1

  2003cited by this paper
• Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase.

  2003cited by this paper
• The Inducible CXCR3 Ligands Control Plasmacytoid Dendritic Cell Responsiveness to the Constitutive Chemokine Stromal Cell–derived Factor 1 (SDF-1)/CXCL12

  2003cited by this paper
• IFN-γ-Inducible Protein 10 (IP-10; CXCL10)-Deficient Mice Reveal a Role for IP-10 in Effector T Cell Generation and Trafficking1

  2002cited by this paper
• Herpes simplex encephalitis

  2002cited by this paper
• The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.

  2002cited by this paper
• Poly I:CLC Induction of the Interferon System in Mice: An Initial Study of Four Detection Methods

  2002cited by this paper
• Pivotal Role of Dendritic Cell–derived CXCL10 in the Retention of T Helper Cell 1 Lymphocytes in Secondary Lymph Nodes

  2002cited by this paper
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  2002cited by this paper
• A Functional IFN-γ-Inducible Protein-10/CXCL10-Specific Receptor Expressed by Epithelial and Endothelial Cells That Is Neither CXCR3 Nor Glycosaminoglycan1

  2001cited by this paper
• The Ligands of CXC Chemokine Receptor 3, I-TAC, Mig, and IP10, Are Natural Antagonists for CCR3*

  2001cited by this paper
• Human interferon-inducible 10-kDa protein and human interferon-inducible T cell alpha chemoattractant are allotopic ligands for human CXCR3: differential binding to receptor states.

  2001cited by this paper
• Type I interferons and herpes simplex virus infection

  2001cited by this paper
• The nature of the principal type 1 interferon-producing cells in human blood

  2000cited by this paper
• Active movement of T cells away from a chemokine

  2000cited by this paper
• The role of natural killer cells in protection of mice against death and corneal scarring following ocular HSV-1 infection.

  2000cited by this paper
• Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring

  2000cited by this paper
• Chemokines: a new classification system and their role in immunity.

  2000cited by this paper
• Requirement of the Chemokine Receptor CXCR3 for Acute Allograft Rejection

  2000cited by this paper
• Viral encephalitis.

  1999cited by this paper
• The nature of the principal type 1 interferon-producing cells in human blood.

  1999cited by this paper
• Chemokines and leukocyte traffic

  1998cited by this paper
• Binding and Functional Properties of Recombinant and Endogenous CXCR3 Chemokine Receptors*

  1998cited by this paper
• Chemokines and T lymphocytes: more than an attraction.

  1998cited by this paper
• T-cell subsets: chemokine receptors guide the way.

  1998cited by this paper
• Interferon‐inducible protein‐10 and lymphotactin induce the chemotaxis and mobilization of intracellular calcium in natural killer cells through pertussis toxin‐sensitive and ‐insensitive heterotrimeric G‐proteins

  1997cited by this paper
• Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias

  1995cited by this paper
• Human Mig chemokine: biochemical and functional characterization

  1995cited by this paper
• Roles of different T-cell subsets in control of herpes simplex virus infection determined by using T-cell-deficient mouse-models

  1995cited by this paper
• Anti-CD8 impairs clearance of herpes simplex virus from the nervous system: implications for the fate of virally infected neurons

  1992cited by this paper
• Identification of an immunodominant cytotoxic T-lymphocyte recognition site in glycoprotein B of herpes simplex virus by using recombinant adenovirus vectors and synthetic peptides

  1991cited by this paper
• A leukocyte subset bearing HLA-DR antigens is responsible for in vitro alpha interferon production in response to viruses.

  1985cited by this paper
• Properties of human natural interferon‐producing cells stimulated by tumor cell lines

  1983cited by this paper
• Herpes Simplex Encephalitis

  1966cited by this paper

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• Generation of cynomolgus monkey capsid-specific positive control cells for IFNγ ELISpot assays for adeno-associated gene therapy applications

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• Antiviral Activity of the Chemokine CXCL10 against West Nile Virus

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• Herpes simplex virus infection induces necroptosis of neurons and astrocytes in human fetal organotypic brain slice cultures

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• Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus CNS infection

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• Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses

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• Tofacitinib Treatment in Primary Herpes Simplex Encephalitis Interferes With Antiviral Response

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• CXCL10 Chemokine: A Critical Player in RNA and DNA Viral Infections

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• CXCR3 deletion aggravates corneal neovascularization in a corneal alkali-burn model.

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• RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis

  2022cites this paper
• Role of Dendritic Cells in Viral Brain Infections

  2022cites this paper
• Suppression of annexin A1 and its receptor reduces herpes simplex virus 1 lethality in mice

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• Microglia Activate Early Antiviral Responses upon Herpes Simplex Virus 1 Entry into the Brain to Counteract Development of Encephalitis-Like Disease in Mice

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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
• Chemokine CXCL10 and Coronavirus-Induced Neurologic Disease

  2019cites this paper
• Pathogenesis of herpes simplex keratitis: The host cell response and ocular surface sequelae to infection and inflammation.

  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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• Immunomodulatory Properties of HLA-G in Infectious Diseases

  2014cites this paper
• Herpes keratitis.

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• Global gene expression changes in BV2 microglial cell line during rabies virus infection.

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• Inactivation of Intergenic Enhancers by EBNA3A Initiates and Maintains Polycomb Signatures across a Chromatin Domain Encoding CXCL10 and CXCL9

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• Brain dendritic cells: biology and pathology

  2012cites this paper
• Trafficking of Immune Cells in the Cornea and Ocular Surface

  2012cites this paper
• Neurite outgrowth is differentially impacted by distinct immune cell subsets.

  2012cites this paper
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  2012cites this paper
• Innate-adaptive crosstalk: how dendritic cells shape immune responses in the CNS.

  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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