Xanthine Alkaloids: Occurrence, Biosynthesis, and Function in Plants.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Progress in the chemistry of organic natural products

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1007/978-3-319-49712-9_1PMID 28194561
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Degradation of exogenous caffeine by Populus alba and its effects on endogenous caffeine metabolism

  2016cited by this paper
• Short Term Effect of Caffeine on Purine, Pyrimidine and Pyridine Metabolism in Rice (Oryza sativa) Seedlings

  2015cited by this paper
• Metabolism of Purine Alkaloids and Xanthine in Leaves of Maté (Ilex paraguariensis)

  2015cited by this paper
• RP-HPLC and transcript profile indicate increased leaf caffeine in Coffea canephora plants by light

  2015cited by this paper
• Plant Biochemistry: Trigonelline Biosynthesis in Coffea arabica and Coffea canephora

  2015cited by this paper
• Effect of Purine Alkaloids on the Proliferation of Lettuce Cells Derived from Protoplasts

  2015cited by this paper
• Trigonelline and related nicotinic acid metabolites: occurrence, biosynthesis, taxonomic considerations, and their roles in planta and in human health

  2015cited by this paper
• Salicylic acid and methyljasmonate restore the transcription of caffeine biosynthetic N-methyltransferases from a transcription inhibition noticed during late endosperm maturation in coffee

  2015cited by this paper
• Revisiting Caffeine Biosynthesis – Speculations about the Proximate Source of its Purine Ring

  2015cited by this paper
• Biosynthesis of Caffeine Underlying the Diversity of Motif B’ Methyltransferase

  2015cited by this paper
• Low Caffeine Content in Novel Grafted Tea with Camellia sinensis as Scions and Camellia oleifera as Stocks

  2015cited by this paper
• Effect of Caffeine on the Expression Pattern of Water-Soluble Proteins in Rice (Oryza sativa) Seedlings

  2015cited by this paper
• METABOLISM OF PURINE NUCLEOSIDES AND BASES IN SUSPENSION-CULTURED ARABIDOPSIS THALIANA CELLS

  2014cited by this paper
• Conversion of nicotinic acid to trigonelline is catalyzed by N-methyltransferase belonged to motif B' methyltransferase family in Coffea arabica.

  2014cited by this paper
• The coffee genome provides insight into the convergent evolution of caffeine biosynthesis

  2014cited by this paper
• Quantum Mechanical/Molecular Mechanical Study of Catalytic Mechanism and Role of Key Residues in Methylation Reactions Catalyzed by Dimethylxanthine Methyltransferase in Caffeine Biosynthesis

  2014cited by this paper
• Molecular and biochemical characterization of caffeine synthase and purine alkaloid concentration in guarana fruit.

  2014cited by this paper
• Differential regulation of caffeine metabolism in Coffeaarabica (Arabica) and Coffea canephora (Robusta)

  2014cited by this paper
• The purine metabolite allantoin enhances abiotic stress tolerance through synergistic activation of abscisic acid metabolism.

  2014cited by this paper
• Development of a New Method for Bioassay of Allelopathy Using Protoplasts of a Leguminous Plant Mucuna pruriens With a High Content of the Allelochemical L-DOPA

  2013cited by this paper
• Like Cures Like: Caffeine Immunizes Plants Against Biotic Stresses

  2013cited by this paper
• Profiles of phenolic compounds and purine alkaloids during the development of seeds of Theobroma cacao cv. Trinitario.

  2013cited by this paper
• Biosynthesis and Catabolism of Purine Alkaloids

  2013cited by this paper
• Immunohistochemical localization of caffeine in young Camellia sinensis (L.) O. Kuntze (tea) leaves

  2012cited by this paper
• Novel, Highly Specific N-Demethylases Enable Bacteria To Live on Caffeine and Related Purine Alkaloids

  2012cited by this paper
• Espresso coffees, caffeine and chlorogenic acid intake: potential health implications.

  2012cited by this paper
• Characterization of a broad-specificity non-haem iron N-demethylase from Pseudomonas putida CBB5 capable of utilizing several purine alkaloids as sole carbon and nitrogen source.

  2011cited by this paper
• Biosynthesis of secondary metabolites in tea plants

  2011cited by this paper
• Pharmacokinetics and metabolism of natural methylxanthines in animal and man.

  2011cited by this paper
• Producing low-caffeine tea through post-transcriptional silencing of caffeine synthase mRNA

  2011cited by this paper
• Resistance against beet armyworms and cotton aphids in caffeine-producing transgenic chrysanthemum

  2011cited by this paper
• Teas, cocoa and coffee: plant secondary metabolites and health.

  2011cited by this paper
• Convergent evolution in plant specialized metabolism.

  2011cited by this paper
• Adenosine Kinase Contributes to Cytokinin Interconversion in Arabidopsis1[W][OA]

  2011cited by this paper
• Simultaneous activation of salicylate production and fungal resistance in transgenic Chrysanthemum producing caffeine

  2011cited by this paper
• Purine Alkaloid Metabolism

  2011cited by this paper
• Plant vaccination: Stimulation of defense system by caffeine production in planta

  2010cited by this paper
• Fate of caffeine in the environment and ecotoxicological considerations

  2010cited by this paper
• Tea caffeine: Metabolism, functions, and reduction strategies

  2010cited by this paper
• Expression for Caffeine Biosynthesis and Related Enzymes in Camellia sinensis

  2010cited by this paper
• Profiles of purine metabolism in leaves and roots of Camellia sinensis seedlings.

  2010cited by this paper
• Caffeine Biosynthesis and Degradation in Tea [Camellia sinensis (L.) O. Kuntze] is under Developmental and Seasonal Regulation

  2009cited by this paper
• An update of the Angiosperm Phylogeny Group classification for the orders and families of flowering plants:

  2009cited by this paper
• Occurrence of theobromine synthase genes in purine alkaloid-free species of Camellia plants

  2009cited by this paper
• Two Distinct Pathways for Metabolism of Theophylline and Caffeine Are Coexpressed in Pseudomonas putida CBB5

  2009cited by this paper
• Purine alkaloids and phenolic compounds in three Cola species and Garcinia kola grown in Cameroon

  2008cited by this paper
• Pathogen resistance of transgenic tobacco plants producing caffeine.

  2008cited by this paper
• Secondary transport as an efficient membrane transport mechanism for plant secondary metabolites

  2008cited by this paper
• Caffeine and related purine alkaloids: biosynthesis, catabolism, function and genetic engineering.

  2008cited by this paper
• Dimerization of N-methyltransferases involved in caffeine biosynthesis.

  2008cited by this paper
• Fine control of caffeine biosynthesis in tissue cultures of Camellia sinensis

  2008cited by this paper
• The Leaf Epidermome of Catharanthus roseus Reveals Its Biochemical Specialization[W][OA]

  2008cited by this paper
• Expression of Caffeine Biosynthesis Genes in Tea (Camellia sinensis)

  2008cited by this paper
• Evidence for localization of N-methyltransferase (MMT) of caffeine biosynthetic pathway in vacuolar surface of Coffea canephora endosperm elucidated through localization of GUS reporter gene driven by NMT promoter.

  2007cited by this paper
• Expression and location of caffeine synthase in tea plants

  2007cited by this paper
• Structural, Biochemical, and Phylogenetic Analyses Suggest That Indole-3-Acetic Acid Methyltransferase Is an Evolutionarily Ancient Member of the SABATH Family1[W][OA]

  2007cited by this paper
• Involvement of rapid nucleotide synthesis in recovery from phosphate starvation of Catharanthus roseus cells.

  2007cited by this paper
• The Structure of Two N-Methyltransferases from the Caffeine Biosynthetic Pathway1[W][OA]

  2007cited by this paper
• Methylation of Gibberellins by Arabidopsis GAMT1 and GAMT2[W]

  2007cited by this paper
• A Novel Caffeine Dehydrogenase in Pseudomonas sp. Strain CBB1 Oxidizes Caffeine to Trimethyluric Acid

  2007cited by this paper
• Transgenic tobacco plants producing caffeine: a potential new strategy for insect pest control

  2006cited by this paper
• Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme

  2006cited by this paper
• Changes in content and biosynthetic activity of caffeine and trigonelline during growth and ripening of Coffea arabica and Coffea canephora fruits

  2006cited by this paper
• Metabolism and ecology of purine alkaloids.

  2006cited by this paper
• The cup that cheers: Caffeine biosynthesis: biochemistry and molecular biology

  2006cited by this paper
• Pyrimidine and purine biosynthesis and degradation in plants.

  2006cited by this paper
• A classification for extant ferns

  2006cited by this paper
• Degradation of ureidoglycolate in French bean (Phaseolus vulgaris) is catalysed by a ubiquitous ureidoglycolate urea-lyase

  2006cited by this paper
• Dual function of pyrimidine metabolism in potato (Solanum tuberosum) plants : Pyrimidine salvage and supply of β-alanine to pantothenic acid synthesis

  2006cited by this paper
• Caffeine biosynthesis and adenine metabolism in transgenic Coffea canephora plants with reduced expression of N-methyltransferase genes.

  2006cited by this paper
• An Arabidopsis thaliana methyltransferase capable of methylating farnesoic acid.

  2006cited by this paper
• Developmental expression of stress response genes in Theobroma cacao leaves and their response to Nep1 treatment and a compatible infection by Phytophthora megakarya.

  2005cited by this paper
• Caffeine Production in Tobacco Plants by Simultaneous Expression of Three Coffee N-methyltrasferases and Its Potential as a Pest Repellant

  2005cited by this paper
• The map-based sequence of the rice genome

  2005cited by this paper
• Metabolon formation and metabolic channeling in the biosynthesis of plant natural products.

  2005cited by this paper
• Metabolic engineering of caffeine production

  2005cited by this paper
• Diversity of Methylxanthine Content inIlex cassine L. andIlex vomitoria Ait.: Assessing Sources of the North American Stimulant Cassina

  2005cited by this paper
• Gene expression in leaves of Theobroma cacao in response to mechanical wounding, ethylene, and/or methyl jasmonate

  2005cited by this paper
• Our Everyday Cup of Coffee: The Chemistry behind Its Magic.

  2005cited by this paper
• Plant biochemistry: A naturally decaffeinated arabica coffee

  2004cited by this paper
• Application of RNAi to confirm theobromine as the major intermediate for caffeine biosynthesis in coffee plants with potential for construction of decaffeinated varieties

  2004cited by this paper
• Catabolism of caffeine in plants and microorganisms.

  2004cited by this paper
• Molecular analysis of "de novo" purine biosynthesis in solanaceous species and in Arabidopsis thaliana.

  2004cited by this paper
• Characterization of Arabidopsis Glutamine Phosphoribosyl Pyrophosphate Amidotransferase-Deficient Mutants1

  2004cited by this paper
• Caffeine synthase and related methyltransferases in plants.

  2004cited by this paper
• Distribution, biosynthesis and function of purine and pyridine alkaloids in Coffea arabica seedlings

  2004cited by this paper
• Biosynthesis, accumulation and degradation of theobromine in developing Theobroma cacao fruits.

  2004cited by this paper
• Isolation of a new dual‐functional caffeine synthase gene encoding an enzyme for the conversion of 7‐methylxanthine to caffeine from coffee (Coffea arabica L.)1

  2003cited by this paper
• Structural Basis for Substrate Recognition in the Salicylic Acid Carboxyl Methyltransferase Family Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.014548.

  2003cited by this paper
• Chapter eleven The SABATH family of MTS in Arabidopsis Thaliana and other plant species

  2003cited by this paper
• The first committed step reaction of caffeine biosynthesis: 7‐methylxanthosine synthase is closely homologous to caffeine synthases in coffee (Coffea arabica L.)1

  2003cited by this paper
• Caffeine as a novel toxicant for slugs and snails

  2003cited by this paper
• Purine alkaloids in Paullinia.

  2003cited by this paper
• Molecular Cloning and Functional Characterization of Three Distinct N-Methyltransferases Involved in the Caffeine Biosynthetic Pathway in Coffee Plants1

  2003cited by this paper
• Metabolism of purine bases, nucleosides and alkaloids in theobromine-forming Theobroma cacao leaves

  2003cited by this paper
• Theacrine (1,3,7,9-tetramethyluric acid) synthesis in leaves of a Chinese tea, kucha (Camellia assamica var. kucha).

  2002cited by this paper
• Pest Control: Caffeine as a repellent for slugs and snails

  2002cited by this paper
• Caffeine: a well known but little mentioned compound in plant science.

  2001cited by this paper
• A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S‐adenosyl‐L‐methionine cycle

  2001cited by this paper
• Developmental variation of sugars, carboxylic acids, purine alkaloids, fatty acids, and endoproteinase activity during maturation of Theobroma cacao L. seeds.

  2001cited by this paper

• Functional Observation Battery Test for Single Intravenous Caffeine Exposure in Male ICR Mice

  2025cites this paper
• Targeted metabolomics for quantitative assessment of polyphenols and methylxanthines in fermented and unfermented cocoa beans from 18 genotypes of the Brazilian Amazon.

  2025cites this paper
• Morphological and physiological plasticity of alpine medicinal plants along an elevational gradient

  2024cites this paper
• Methylxanthine and polyphenol distribution in guarana cultivars

  2024cites this paper
• Optimized theophylline administration across diverse model organisms: insights from Nicotiana tabacum L. comparison to Escherichia coli and Chlamydomonas reinhardtii

  2024cites this paper
• Strigolactone enhances tea plant adaptation to drought and Phyllosticta theicola petch by regulating caffeine content via CsbHLH80.

  2024cites this paper
• Bioactive Compound Production in Yerba Mate Clones with Increasing Nitrogen in Semi-Hydroponic System

  2024cites this paper
• Impact of coffee and its bioactive compounds on the risks of type 2 diabetes and its complications: A comprehensive review.

  2024cites this paper
• Enhancing water stress tolerance of bread wheat during seed germination and seedling emergence: caffeine-induced modulation of antioxidative defense mechanisms

  2024cites this paper
• Characterization of a new Camellia plant resource with low caffeine and high theobromine for production of a novel natural low-caffeine tea

  2024cites this paper
• Synthesis and Medicinal Applications of N‐Heterocyclic Carbene Complexes Based on Caffeine and Other Xanthines

  2024cites this paper
• Functional characterisation of Artemisia annua jasmonic acid carboxyl methyltransferase: a key enzyme enhancing artemisinin biosynthesis

  2024cites this paper
• Molecular structure analysis of xanthine alkaloids using terahertz spectroscopy

  2024cites this paper
• CsXDH1 gene promotes caffeine catabolism induced by continuous strong light in tea plant

  2023cites this paper
• IBA and melatonin increase trigonelline and caffeine during the induction and initiation of adventitious roots in Coffea arabica L. cuttings

  2023cites this paper
• Caffeine Synthesis and Its Mechanism and Application by Microbial Degradation, A Review

  2023cites this paper
• Metabolomic and transcriptomic analyses reveal the biosynthetic mechanisms of pigments and main taste compounds in an albino tea cultivar.

  2023cites this paper
• Ag(I) catalyzed oxidation of hypoxanthine and xanthine by Mn (VII) in aqueous Bronsted acid solutions: A kinetic and mechanistic study

  2023cites this paper
• Introduction to herbal biomolecules

  2022cites this paper
• Adaptive potential of Coffea canephora from Uganda in response to climate change

  2022cites this paper
• UHPLC-Q-TOF-MS/MS-based Metabolite Profiling of Ganpu Tea in Rat Urine and Feces

  2022cites this paper
• Integrative analysis of transcriptome and metabolome reveals the mechanism of foliar application of Bacillus amyloliquefaciens to improve summer tea quality (Camellia sinensis).

  2022cites this paper
• Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

  2022cites this paper
• The medicinal and aromatic plants as ingredients in functional beverage production

  2022cites this paper
• Metabolome and RNA-seq Analysis of Responses to Nitrogen Deprivation and Resupply in Tea Plant (Camellia sinensis) Roots

  2022cites this paper
• Recent Advances in the Synthesis of Xanthines: A Short Review

  2022cites this paper
• Bioactive constituents from Coffea canephora Pierre ex A. Froehner (Rubiaceae)

  2022cites this paper
• Micromorphology and Histology of the Secretory Apparatus of Diospyros villosa (L.) de Winter Leaves and Stem Bark

  2022cites this paper
• Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals

  2022cites this paper
• Purine alkaloids in tea plants: component, biosynthetic mechanism and genetic variation

  2022cites this paper
• Fine cocoa beans production: Tracking aroma precursors through a comprehensive analysis of flavor attributes formation.

  2021cites this paper
• Removal of multi-contaminants from water by association of poplar and Brassica plants in a short-term growth chamber experiment

  2021cites this paper
• Cultivation and Genome Sequencing of Bacteria Isolated From the Coffee Berry Borer (Hypothenemus hampei), With Emphasis on the Role of Caffeine Degradation

  2021cites this paper
• Brønsted Acid Catalysis in the Oxidation of Purine Based Alkaloids by Mn(VII) in Aqueous Acetonitrile and Sodium Fluoride Medium: A Kinetic Approach

  2021cites this paper
• Quantification of Acetaminophen, Caffeine and Ibuprofen in Solid Dosage Forms by UV Spectroscopy coupled with Multivariate analysis

  2021cites this paper
• RATE ENHANCEMENTS DUE TO AQUEOUS SULFURIC ACID IN Mn (III) OXIDATION OF CERTAIN PURINE ALKALOIDS - KINETIC ANALYSIS OF ACIDITY FUNCTIONS

  2021cites this paper
• Genomic and transcriptomic inventory of membrane transporters in coffee: Exploring molecular mechanisms of metabolite accumulation.

  2021cites this paper
• Antiinflammatory and antiinfective effect of caffeine in a mouse model of disseminated salmonellosis

  2021cites this paper
• Biosynthesis of Purine Alkaloids

  2020cites this paper
• Occurrence of Nucleotides and Related Metabolites in Plants

  2020cites this paper
• Occurrence of Purine Alkaloids

  2020cites this paper
• Phytochemistry divergence among guarana genotypes as a function of agro‐industrial characters

  2020cites this paper
• Metabolite and Transcriptome Profiling on Xanthine Alkaloids-Fed Tea Plant (Camellia sinensis) Shoot Tips and Roots Reveal the Complex Metabolic Network for Caffeine Biosynthesis and Degradation

  2020influential citation
• Exploring plant metabolic genomics: chemical diversity, metabolic complexity in the biosynthesis and transport of specialized metabolites with the tea plant as a model

  2020influential citation
• Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea

  2020cites this paper
• Manipulating Biosynthesis of Plant Natural Products

  2020cites this paper
• Evaluation of canavanine as an allelochemical in etiolated seedlings of Vicia villosa Roth: protoplast co-culture method with digital image analysis

  2019cites this paper
• Uptake of adenine by purine permeases of Coffea canephora

  2019cites this paper
• Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

  2019cites this paper
• Inhibition of enzymatic browning in sweet potato (Ipomoea batatas(L.)) with chemical and natural anti‐browning agents

  2019cites this paper
• Methylxanthines: Potential Therapeutic Agents for Glioblastoma

  2019cites this paper
• Is coffee bad for reproduction? Maybe not, after all.

  2019cites this paper
• Enantiomeric Trimethylallantoin Monomers, Dimers, and Trimethyltriuret: Evidence for an Alternative Catabolic Pathway of Caffeine in Tea Plant.

  2019cites this paper
• Integrated transcriptomic and phytochemical analyses provide insights into characteristic metabolites variation in leaves of 1-year-old grafted tea (Camellia sinensis)

  2019cites this paper
• A linear gradient sequential injection chromatography method exploiting programmable fluidics for the determination of three methylxanthines.

  2019cites this paper
• Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS.

  2018influential citation
• Mesoporous silica loaded caffeine inhibits inflammatory markers in lipopolysaccharide-activated rat macrophage cells

  2018cites this paper
• Inside the horn of plenty: Leaf-mining micromoth manipulates its host plant to obtain unending food provisioning

  2018cites this paper
• The Integration of Metabolomics and Next-Generation Sequencing Data to Elucidate the Pathways of Natural Product Metabolism in Medicinal Plants

  2018cites this paper
• Purine salvage in plants.

  2018cites this paper
• Relationship between aluminum stress and caffeine biosynthesis in suspension cells of Coffea arabica L.

  2017cites this paper