The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Journal of Clinical Endocrinology and Metabolism

• Publication date

  1996-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/JCEM.81.9.8784087PMID 8784087
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome.

  1996cited by this paper
• Insulin infusion amplifies 17 alpha-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: apparent relative impairment of 17,20-lyase activity.

  1996cited by this paper
• Polycystic ovary syndrome.

  1995cited by this paper
• Metabolic effects of metformin in non-insulin-dependent diabetes mellitus.

  1995cited by this paper
• Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women.

  1995cited by this paper
• Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.

  1995cited by this paper
• Disparate effects of insulin reduction with diltiazem on serum dehydroepiandrosterone sulfate levels in obese hypertensive men and women.

  1994cited by this paper
• Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy.

  1994cited by this paper
• Evaluation of WHO and NDDG criteria for impaired glucose tolerance.

  1994cited by this paper
• Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone.

  1994cited by this paper
• Sex hormone-binding globulin: a marker for hyperinsulinemia and/or insulin resistance?

  1993cited by this paper
• The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries

  1993cited by this paper
• Metformin--an update.

  1993cited by this paper
• Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome

  1992cited by this paper
• Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome.

  1992cited by this paper
• Evidence for Distinctive and Intrinsic Defects in Insulin Action in Polycystic Ovary Syndrome

  1992cited by this paper
• New Oral Thiazolidinedione Antidiabetic Agents Act as Insulin Sensitizers

  1992cited by this paper
• Insulin as an effector of human ovarian and adrenal steroid metabolism.

  1991cited by this paper
• Acanthosis Nigricans, insulin action, and hyperandrogenism: clinical, histological, and biochemical findings.

  1991cited by this paper
• Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects.

  1991cited by this paper
• Effect of acute physiological elevations of insulin on circulating androgen levels in nonobese women.

  1991cited by this paper
• Clinical and biochemical parameters of androgen action in normal healthy Caucasian versus Chinese subjects.

  1991cited by this paper
• A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome.

  1991cited by this paper
• Effect of New Oral Antidiabetic Agent CS-045 on Glucose Tolerance and Insulin Secretion in Patients with NIDDM

  1991cited by this paper
• Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

  1991cited by this paper
• Evidence of heterogeneous mechanisms in lipoprotein lipid alterations in hyperandrogenic women.

  1990cited by this paper
• Inhibitory effect of sandostatin on secretion of luteinising hormone and ovarian steroids in polycystic ovary syndrome

  1990cited by this paper
• Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome.

  1989cited by this paper
• Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome

  1989cited by this paper
• Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome.

  1989cited by this paper
• Evaluation of WHO and NDDG Criteria for Impaired Glucose Tolerance: Results From Two National Samples

  1989cited by this paper
• Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin.

  1988cited by this paper
• Polycystic ovaries--a common finding in normal women.

  1988cited by this paper
• Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia.

  1987cited by this paper
• The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans.

  1987cited by this paper
• Modified protocols improve insulin sensitivity estimation using the minimal model.

  1987cited by this paper
• Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies.

  1987cited by this paper
• Non-sex hormone-binding globulin-bound testosterone as a marker for hyperandrogenism.

  1985cited by this paper
• Bioavailability of albumin-bound testosterone.

  1985cited by this paper
• Effect of body weight reduction on plasma androgens in obese, infertile women.

  1982cited by this paper
• Insulin enhancement of luteinizing hormone and follicle-stimulating hormone release by cultured pituitary cells.

  1981cited by this paper
• Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease.

  1980cited by this paper
• Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.

  1976cited by this paper

• Mechanisms of Adrenal Hyperandrogenism in Polycystic Ovary Syndrome.

  2025cites this paper
• The Mechanisms of Obesity and its Effect on Female Infertility

  2025cites this paper
• RNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms underlying the progression of polycystic ovary syndrome

  2024cites this paper
• A review on critical appraisal and pathogenesis of polycystic ovarian syndrome

  2024cites this paper
• Diagnosis , Management of Polycystic ovarian syndrome

  2023cites this paper
• Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha

  2023cites this paper
• Clinical and Biochemical Potential of Antioxidants in Treating Polycystic Ovary Syndrome

  2022cites this paper
• A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS)

  2022cites this paper
• Polycystic Ovary Syndrome: A Disorder of Reproductive Age, Its Pathogenesis, and a Discussion on the Emerging Role of Herbal Remedies

  2022cites this paper
• Key signalling pathways underlying the aetiology of polycystic ovary syndrome.

  2022cites this paper
• Saponin-rich extract of Tribulus terrestris alleviates systemic inflammation and insulin resistance in dietary obese female rats: Impact on adipokine/hormonal disturbances.

  2022cites this paper
• The polycystic ovary syndrome: the first 150 years of study

  2022cites this paper
• Ayurvedic treatment of polycystic ovary syndrome (PCOS)

  2022cites this paper
• Experimentally Induced Hyperinsulinemia Fails to Induce Polycystic Ovary Syndrome-like Traits in Female Rhesus Macaques

  2022cites this paper
• Assessment of Early Markers of Cardiovascular Risk in Polycystic Ovary Syndrome.

  2021cites this paper
• Hyperandrogenism and malignant degeneration of hepatic adenomas in the setting of Abernethy malformation

  2020cites this paper
• Adjusting anti-Müllerian hormone levels for age and body mass index improves detection of polycystic ovary syndrome.

  2020cites this paper
• Developmental programming: gestational testosterone excess disrupts LH secretion in the female sheep fetus

  2020cites this paper
• Evaluation of the Effect of Nigella Sativa Hydro-alcoholic Extract and Honey on Gonadotropins and Sex Hormones Level in the Polycystic Ovarian Syndrome Model of Wistar Rat

  2020cites this paper
• Genetic polymorphisms associated with polycystic ovary syndrome among Iranian women

  2020cites this paper
• Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies

  2020cites this paper
• Effect of oral administration of pioglitazone on follicular dynamics in Holstein dairy cows

  2019cites this paper
• PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology

  2019cites this paper
• Polycystic Ovary Syndrome and Hyperandrogenic States

  2019cites this paper
• Efficacy of Metformin in the Treatment of Acne in Women with Polycystic Ovarian Syndrome: A Newer Approach to Acne Therapy.

  2019cites this paper
• Hyperandrogenemia is Common in Asymptomatic Women and is Associated with Increased Metabolic Risk

  2019cites this paper
• Elevated fasting insulin is associated with cardiovascular and metabolic risk in women with polycystic ovary syndrome.

  2019cites this paper
• Raw red onion intake and insulin resistance markers in overweight or obese patients with polycystic ovary syndrome: a randomized controlled-clinical trial

  2018cites this paper
• 7 Polycystic Ovary Syndrome and Cardiovascular Disease

  2018cites this paper
• Ff

  2018cites this paper
• [Long-term consequences of polycystic ovary syndrome].

  2017cites this paper
• Assessing Energy Requirements in Women With Polycystic Ovary Syndrome: A Comparison Against Doubly Labeled Water

  2017cites this paper
• Adverse Outcome Pathway: Peroxisome Proliferator-Activated Receptor α Activation and Reproductive Toxicity—Development and Application in Assessment of Endocrine Disruptors/Reproductive Toxicants

  2017cites this paper
• Human sex hormone-binding globulin does not provide metabolic protection against diet-induced obesity and dysglycemia in mice

  2017cites this paper
• PCOS in adolescence: effect of metformin on menstrual irregularities

  2017influential citation
• Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.

  2017cites this paper
• Non‐clinical safety evaluation and risk assessment to human of aleglitazar, a dual PPAR &agr;/&ggr; agonist, and its major human metabolite

  2017cites this paper
• Steroid induced Hyperglycemia during First 48 Hours of Steroid Therapy in Hospitalised Patients

  2017cites this paper
• Focus on BMI and subclinical hypothyroidism in adolescent girls first examined for amenorrhea or oligomenorrhea. The emerging role of polycystic ovary syndrome

  2016cites this paper
• High-fat diets exaggerate endocrine and metabolic phenotypes in a rat model of DHEA-induced PCOS.

  2016cites this paper
• HYPERANDROGENISM IN WOMEN WITH DIABETES MELLITUS: ROLE OF INSULIN RESISTANCE AND HYPERINSULINEMIA

  2016cites this paper
• Polycystic ovary syndrome and metabolic syndrome: the worrisome twosome?

  2016cites this paper
• Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS.

  2016cites this paper
• Sensibilizadores a la insulina

  2016cites this paper
• Steroid induced dysglycemia during first 48 hours of steroid therapy in hospitalized patients.

  2016cites this paper
• PCOS and Metabolic Syndrome: The Worrisome Twosome?

  2015cites this paper
• Targets to treat metabolic syndrome in polycystic ovary syndrome

  2015influential citation
• Increased insulin-like growth factor-1 in relation to cardiovascular function in polycystic ovary syndrome: friend or foe?

  2015influential citation
• Effect of Thiazolidinedione Amide on Insulin Resistance, Creactive Protein and Endothelial Function in Young Women with Polycystic Ovary Syndrome

  2015cites this paper
• Effect of Dietary Weight Loss on Menstrual Regularity in Obese Young Adult Women with Polycystic Ovary Syndrome.

  2015cites this paper
• An Association Study between INSR/NsiI (rs2059806) and INSR/PmlI (rs1799817) SNPs in Women with Polycystic Ovary Syndrome from West Azerbaijan Province, Iran

  2015cites this paper
• Randomized clinical trial evaluating metformin versus oral contraceptive pills in the treatment of adolescents with polycystic ovarian syndrome

  2015cites this paper
• Polycystic Ovarian Syndrome: Leading Cause of Female Infertility.

  2014cites this paper
• Effects of Acarbose on Polycystic Ovary Syndrome: A Meta-analysis

  2014cites this paper
• Does Metformin combined with Clomiphene Citrate improve fertility related outcomes in Clomiphene resistant women with PCOS: A systematic review

  2014cites this paper
• Efeito agudo do exercício aeróbio sobre as vias moleculares de captação de glicose no músculo esquelético em pacientes portadoras da síndrome dos ovários policísticos

  2014cites this paper
• Association of Dietary Factors With Male and Female Infertility: Review of Current Evidence

  2014cites this paper
• Polycystic Ovary Syndrome, Obesity and Insulin Resistance

  2014cites this paper
• Screening for glucose intolerance in polycystic ovary syndrome: hemoglobin A1C, fasting blood glucose or oral glucose tolerance test?

  2014cites this paper
• The utility of metformin therapy in reproductive-aged women with polycystic ovary syndrome (PCOS).

  2014cites this paper
• HERBAL REMEDIES FOR STEIN-LEVENTHAL SYNDROME, A FAST SPREADING INFERTILITY DISORDER: A REVIEW

  2014cites this paper
• Management of Type 2 diabetes mellitus in primary care

  2014cites this paper
• Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome.

  2014cites this paper
• Genetic variants associated with insulin signaling and glucose homeostasis in the pathogenesis of insulin resistance in polycystic ovary syndrome: a systematic review

  2013cites this paper
• Effect of non-esterified fatty acids on insulin resistance and cardiovascular risk in polycystic ovary syndrome

  2013cites this paper
• Polycystic ovarian syndrome during puberty and adolescence.

  2013cites this paper
• Predictors of Rosiglitazone Success in Ovulation Induction among Women with Polycystic Ovary Syndrome Resistant to Clomiphene Citrate

  2013cites this paper
• Diabetes and the female reproductive system.

  2013cites this paper
• Similar causes of various reproductive disorders in early life

  2013cites this paper
• EFFECT OF METFORMIN THERAPY IN FEMALE VISITING DERMATOLOGIST FOR ACNE VULGARIS HAVING ENDOCRINE AND SONOGRAPHIC CHARACTERISTICS OF POLYCYSTIC OVARY SYNDROME (PCOS)

  2013cites this paper
• Effects of Aqueous Extract of Cnestis ferruginea (Vahl Ex DC) Root on the Biochemical and Clinical Parameters of Anastrozole-Induced Polycystic Ovarian Syndrome Rat Model

  2013cites this paper
• Induction of Ovulation

  2013cites this paper
• Metabolic and other effects of pioglitazone as an add-on therapy to metformin in the treatment of polycystic ovary syndrome (PCOS)

  2013cites this paper
• Effect of PCOS on glucose metabolism

  2013influential citation
• Evolving utility of sex hormone-binding globulin measurements in clinical medicine

  2012cites this paper
• Polycystic Ovary Syndrome and Cardiovascular Disease

  2012cites this paper
• Insulin Resistance and Polycystic Ovary Syndrome

  2012cites this paper
• Should all women with PCOS be treated for insulin resistance?

  2012cites this paper
• Reproduction and Metabolism: Insights from Polycystic Ovary Syndrome

  2012cites this paper
• Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.

  2012cites this paper
• Thiazolidinediones in Type 2 Diabetes Mellitus

  2012cites this paper
• Pioglitazone safe, so save.

  2012cites this paper
• Natural Remedies for Polycystic Ovarian Syndrome (PCOS) : A Review

  2012cites this paper
• Effects of elevated testosterone levels on reproductive neuroendocrine function and behavior in female rheus macaques (macaca mulatta)

  2012influential citation
• Advances in Treatment Options for Polycystic Ovary Syndrome

  2012cites this paper
• Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome.

  2012cites this paper
• Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications.

  2012cites this paper
• A New Era in Diabetic Agents: Hope for Diabetics

  2012cites this paper
• An approach to the patient with hirsutism.

  2012cites this paper
• Pharmacologic Approaches to Type 2 Diabetes and Obesity in Children and Adolescents

  2011cites this paper
• Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome.

  2011cites this paper
• State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS)

  2011cites this paper
• CHAPTER 17 – Physiology and Pathology of the Female Reproductive Axis

  2011cites this paper
• Clomiphene Resistant PCOS: Treatment Options

  2011cites this paper
• Achieving a successful pregnancy in women with polycystic ovary syndrome.

  2011cites this paper
• COMPLICATIONS OF PREGNANCY IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

  2011cites this paper
• Altered multihormone synchrony in obese patients with polycystic ovary syndrome.

  2011cites this paper
• Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization.

  2011influential citation
• The link between polycystic ovary syndrome and Type 2 diabetes: what do we know today?

  2011cites this paper
• Drospirenone/ethinyl estradiol versus rosiglitazone treatment in overweight adolescents with polycystic ovary syndrome: comparison of metabolic, hormonal, and cardiovascular risk factors.

  2011cites this paper