Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Drug metabolism reviews (Softcover ed.)

• Publication date

  2005-01-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1081/DMR-200028812PMID 15747500
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Paracetamol and Phenacetin

  2012cited by this paper
• Zimelidine: A Review of its Pharmacological Properties and Therapeutic Efficacy in Depressive Illness

  2012cited by this paper
• Resolution of human mercapt- and nonmercaptalbumin by high-performance liquid chromatography.

  2009cited by this paper
• Metabolism of lidocaine in human liver in vitro.

  2009cited by this paper
• Multiplicity of biliary excretion mechanisms for the camptothecin derivative irinotecan (CPT-11), its metabolite SN-38, and its glucuronide: role of canalicular multispecific organic anion transporter and P-glycoprotein

  2009cited by this paper
• A review of the pharmacological and clinical profile of mirtazapine.

  2006cited by this paper
• PATHWAYS OF CARBAMAZEPINE BIOACTIVATION IN VITRO: II. THE ROLE OF HUMAN CYTOCHROME P450 ENZYMES IN THE FORMATION OF 2-HYDROXYIMINOSTILBENE

  2005cited by this paper
• Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease

  2005cited by this paper
• Imipramine and 2-hydroxyimipramine: comparative cardiotoxicity and pharmacokinetics in swine

  2005cited by this paper
• Herbal hepatotoxicity.

  2005cited by this paper
• Biliary excretion of reduced haloperidol glucuronide

  2005influential reference
• N-hydroxylation of 4,4′-diaminodiphenylsulphone (Dapsone) by liver microsomes, and in dogs and humans

  2004cited by this paper
• Effect of probenecid on the formation and elimination kinetics of the sulphate and glucuronide conjugates of diflunisal

  2004cited by this paper
• The effect of probenecid on paracetamol metabolism and pharmacokinetics

  2004cited by this paper
• Cytochrome P450 enzymes and UDP-Glucuronosyltransferases as hepatocellular autoantigens

  2004cited by this paper
• Autoantibody to the nucleosome subunit (H2A-H2B)-DNA is an early and ubiquitous feature of lupus-like conditions

  2004cited by this paper
• Drug treatment of Parkinson's disease

  2004cited by this paper
• Leponex — associated granulocytopenia: a review of the situation

  2004influential reference
• Herbal Medicine

  2003cited by this paper
• Strategies to modify levodopa treatment.

  2003cited by this paper
• Identification and quantification of in vitro adduct formation between protein reactive xenobiotics and a lysine‐containing model peptide

  2003cited by this paper
• Role of P-Glycoprotein in Pharmacokinetics

  2003cited by this paper
• Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase

  2003cited by this paper
• Acyl Glucuronide Drug Metabolites: Toxicological and Analytical Implications

  2003cited by this paper
• Acetaminophen-induced hepatotoxicity.

  2003cited by this paper
• Amodiaquine for treating malaria.

  2003cited by this paper
• Interactions of Herbs with Cytochrome P450

  2003cited by this paper
• Update on clinical role of tamoxifen

  2003cited by this paper
• Effects of acetaminophen on constitutive and inducible prostanoid biosynthesis in human blood cells

  2003cited by this paper
• Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid.

  2003cited by this paper
• Mycophenolate mofetil: new applications for this immunosuppressant.

  2003cited by this paper
• Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol.

  2003cited by this paper
• Thalidomide-induced suppression of embryo fibroblast proliferation requires CYP1A1-mediated activation.

  2003cited by this paper
• Tamoxifen for Prevention of Breast Cancer

  2003cited by this paper
• Effect of troleandomycin on the pharmacokinetics of imipramine in Chinese: the role of CYP3A.

  2003cited by this paper
• Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts.

  2003cited by this paper
• Pharmacokinetics and Renal Effects of Cidofovir with a Reduced Dose of Probenecid in HIV‐Infected Patients with Cytomegalovirus Retinitis

  2003cited by this paper
• Dopaminergic drugs in development for Parkinson's disease.

  2003cited by this paper
• Separation and detection methods for covalent drug-protein adducts.

  2003cited by this paper
• The second generation of COX-2 inhibitors: what advantages do the newest offer?

  2003cited by this paper
• Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway.

  2003cited by this paper
• In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity.

  2003cited by this paper
• Immunopharmacology of hypersensitivity reactions to drugs

  2003cited by this paper
• Hydrogen peroxide overproduction in megamitochondria of troglitazone‐treated human hepatocytes

  2003cited by this paper
• Levodopa Is Toxic to Dopamine Neurons in an in Vitro but Not an in Vivo Model of Oxidative Stress

  2003cited by this paper
• Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells.

  2003cited by this paper
• Dapsone and sulfones in dermatology: overview and update.

  2003cited by this paper
• Simultaneous determination of oleuropein and its metabolites in plasma by high-performance liquid chromatography.

  2003cited by this paper
• Relationship between steroid hormone contraceptives and HPV, cervical intraepithelial neoplasia and cervical carcinoma

  2003cited by this paper
• Aristolochic Acid and ‘Chinese Herbs Nephropathy’

  2003cited by this paper
• Potentially Significant Drug Interactions of Class III Antiarrhythmic Drugs

  2003cited by this paper
• Herbal medicine.

  2002cited by this paper
• Clinical and laboratory investigations in herbal poisonings.

  2002cited by this paper
• Thalidomide in Cancer Treatment

  2002cited by this paper
• Nimesulide and hepatic adverse effects: roles of reactive metabolites and host factors.

  2002cited by this paper
• Drug-induced lupus erythematosus by amiodarone.

  2002cited by this paper
• Hepatitis associated with Chinese herbs.

  2002cited by this paper
• Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism.

  2002influential reference
• Thalidomide in solid malignancies.

  2002cited by this paper
• Glutathione in Defense and Signaling

  2002cited by this paper
• Inflammatory Cytokines, but Not Bile Acids, Regulate Expression of Murine Hepatic Anion Transporters in Endotoxemia

  2002cited by this paper
• Correlation of Simultaneous Differential Gene Expression in the Blood and Heart with Known Mechanisms of Adriamycin-Induced Cardiomyopathy in the Rat

  2002cited by this paper
• Antioxidant and other biological activities of phenols from olives and olive oil

  2002cited by this paper
• On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics.

  2002influential reference
• Bioactivation of tamoxifen by recombinant human cytochrome p450 enzymes.

  2002cited by this paper
• Clinical Pharmacokinetics and Pharmacodynamics of Cholinesterase Inhibitors

  2002cited by this paper
• Valproic Acid Toxicity: Overview and Management

  2002cited by this paper
• Reactive intermediates and the dynamics of glutathione transferases.

  2002cited by this paper
• Tamoxifen ("Nolvadex"): a review.

  2002cited by this paper
• Stereoselective hydroxylation of 4-methyl-2-cyclohexenone in rats: its relevance to R-(+)-pulegone-mediated hepatotoxicity.

  2002cited by this paper
• Mechanisms of NSAID-Induced Hepatotoxicity

  2002cited by this paper
• Biological Properties of Olive Oil Phytochemicals

  2002cited by this paper
• Diclofenac-induced inactivation of CYP3A4 and its stimulation by quinidine.

  2002cited by this paper
• Ma huang toxicity.

  2002cited by this paper
• Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation.

  2002cited by this paper
• Haptenation of sulfonamide reactive metabolites to cellular proteins.

  2002cited by this paper
• Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.

  2002cited by this paper
• Thalidomide in cancer treatment: a potential role in the elderly?

  2002cited by this paper
• The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9.

  2002influential reference
• A review of the common properties of drugs with idiosyncratic hepatotoxicity and the "multiple determinant hypothesis" for the manifestation of idiosyncratic drug toxicity.

  2002cited by this paper
• The International Sepsis Forum's controversies in sepsis: corticosteroids should be used to treat septic shock

  2002cited by this paper
• Hepatotoxicity of Commonly Used Drugs: Nonsteroidal Anti-Inflammatory Drugs, Antihypertensives, Antidiabetic Agents, Anticonvulsants, Lipid-Lowering Agents, Psychotropic Drugs

  2002cited by this paper
• The role of novel antipsychotics in bipolar disorders.

  2002cited by this paper
• Interactions Between Antiretroviral Drugs and Drugs Used for the Therapy of the Metabolic Complications Encountered During HIV Infection

  2002cited by this paper
• Cytochrome P450 pharmacogenetics in drug development: in vitro studies and clinical consequences.

  2002cited by this paper
• Pharmacokinetics and Protein Adduct Formation of the Pharmacologically Active Acyl Glucuronide Metabolite of Mycophenolic Acid in Pediatric Renal Transplant Recipients

  2002cited by this paper
• Inhibition by atovaquone of CYP2C9-mediated sulphamethoxazole hydroxylamine formation

  2002cited by this paper
• Toxicity of the Chinese Herb Mu Tong (Aristolochia manshuriensis)

  2002cited by this paper
• Neuroprotective and neurotoxic roles of levodopa (L-DOPA) in neurodegenerative disorders relating to Parkinson's disease

  2002cited by this paper
• 4‐Hydroxytamoxifen sulfation metabolism

  2002influential reference
• Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites

  2002cited by this paper
• Phase II trial of thalidomide for patients with advanced renal cell carcinoma.

  2002cited by this paper
• Interactions between drugs for erectile dysfunction and drugs for cardiovascular disease

  2002cited by this paper
• Targeting HIV: antiretroviral therapy and development of drug resistance.

  2002cited by this paper
• Interaction of irinotecan (CPT-11) and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) with human cytochrome P450 enzymes.

  2002influential reference
• Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H2 synthases

  2002cited by this paper
• Review: metabolism of immunosuppressant drugs.

  2002cited by this paper
• Allergic adverse reactions to sulfonamides

  2002cited by this paper
• Multiple mechanisms in indomethacin-induced impairment of hepatic cytochrome P450 enzymes in rats.

  2002cited by this paper
• Thalidomide metabolism by the CYP2C subfamily.

  2002cited by this paper

• InterDIA: Interpretable Prediction of Drug-induced Autoimmunity through Ensemble Machine Learning Approaches.

  2025cites this paper
• Review on Traditional Chinese Medicine-Induced Liver Injury.

  2025cites this paper
• Identification of potential COVID-19 Mpro inhibitors through covalent drug docking, molecular dynamics simulation, and MMGBSA calculation

  2025cites this paper
• Targeted Drug Delivery Strategies in Overcoming Antimicrobial Resistance: Advances and Future Directions

  2025cites this paper
• Euodiae Fructus: a review of botany, application, processing, phytochemistry, quality control, pharmacology, and toxicology

  2025cites this paper
• Bromodomain containing protein 4 (BRD4) and cancer therapy: A glimpse at dual-target drug development.

  2025cites this paper
• Screening and identification of reactive metabolic compounds of Cortex Periplocae based on glutathione capture-mass spectrometry

  2024cites this paper
• Predicting non-chemotherapy drug-induced agranulocytosis toxicity through ensemble machine learning approaches

  2024cites this paper
• Nanoencapsulated Curcumin Mitigates Liver Injury and Drug-Metabolizing Enzymes Induction in Diclofenac-Treated Mice

  2024cites this paper
• Transformation of the drug ibuprofen by Priestia megaterium: reversible glycosylation and generation of hydroxylated metabolites

  2024cites this paper
• Oridonin inhibits bladder cancer survival and immune escape by covalently targeting HK1.

  2024cites this paper
• The skin sensitization adverse outcome pathway: exploring the role of mechanistic understanding for higher tier risk assessment

  2024cites this paper
• Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling.

  2023cites this paper
• Factors Determining the Susceptibility of Fish to Effects of Human Pharmaceuticals

  2023cites this paper
• A review of challenges and prospects of 3D cell-based culture models used for studying drug induced liver injury during early phases of drug development

  2023cites this paper
• Applications of covalent chemistry in targeted protein degradation.

  2022cites this paper
• Computational Investigation of the Bisphenolic Drug Metabolism by Cytochrome P450: What Factors Favor Intramolecular Phenol Coupling.

  2022cites this paper
• AHNAK-modified microbubbles for the intracranial delivery of triptolide: In-vitro and in-vivo investigations.

  2022cites this paper
• Inverse Drug Discovery identifies weak electrophiles affording protein conjugates.

  2022cites this paper
• Fasting Enhances the Acute Toxicity of Acrylonitrile in Mice via Induction of CYP2E1

  2022cites this paper
• The progression of chronicity and autoimmune hepatitis in recurrent drug-induced liver injury.

  2022cites this paper
• Cytochrome P450 enzymes and metabolism of drugs and neurotoxins within the mammalian brain.

  2022cites this paper
• The endoplasmic reticulum participated in drug metabolic toxicity.

  2022cites this paper
• Recruitment of chalcone's potential in drug discovery of anti‐SARS‐CoV‐2 agents

  2022cites this paper
• Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors.

  2022cites this paper
• Molecular Alterations and Severe Abnormalities in Spermatozoa of Young Men Living in the “Valley of Sacco River” (Latium, Italy): A Preliminary Study

  2022cites this paper
• The exciting and magical journey of components from compound formulae to where they fight

  2022cites this paper
• Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs.

  2022cites this paper
• Safety and efficacy of a feed additive consisting of an essential oil from the leaves of Agathosma betulina (P.J. Bergius) Pillans (buchu leaf oil) for use in all animal species (FEFANA asbl)

  2022cites this paper
• Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design.

  2021cites this paper
• Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids

  2021cites this paper
• Metabolic pathway and biological significance of glutathione detoxification of aristolochic acid I

  2021cites this paper
• Hepatic sinusoidal obstruction syndrome caused by the ingestion of Gynura segetum in a patient with alcoholic cirrhosis: a case report

  2021cites this paper
• Mechanism of hepatotoxicity of first-line tyrosine kinase inhibitors: gefitinib and afatinib.

  2021cites this paper
• Prospects of Covalent Approaches in Drug Discovery: An Overview

  2021cites this paper
• Modeling the Bioactivation and Subsequent Reactivity of Drugs.

  2021cites this paper
• Fasting augments pyrrolizidine alkaloid-induced hepatotoxicity

  2021cites this paper
• Microfluidic Electrochemistry Meets Trapped Ion Mobility Spectrometry and High-Resolution Mass Spectrometry-In Situ Generation, Separation, and Detection of Isomeric Conjugates of Paracetamol and Ethoxyquin.

  2021cites this paper
• Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors

  2021cites this paper
• Characteristics of Major Drug Metabolizing Cytochrome P450 Enzymes

  2021cites this paper
• Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease

  2021cites this paper
• Clinical, clinicopathologic, and hepatic histopathologic features associated with probable ketoconazole-induced liver injury in dogs: 15 cases (2015-2018).

  2020cites this paper
• Synergy between Experiments and Computations: A Green Channel for Revealing Metabolic Mechanism of Xenobiotics in Chemical Toxicology.

  2020cites this paper
• Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

  2020cites this paper
• Investigation of Clozapine and Olanzapine Reactive Metabolite Formation and Protein Binding by Liquid Chromatography-Tandem Mass Spectrometry.

  2020cites this paper
• Differences in xanthotoxin metabolites in seven mammalian liver microsomes.

  2020cites this paper
• Advance on the absorption, metabolism, and efficacy exertion of quercetin and its important derivatives

  2020cites this paper
• Resonant waveguide grating based assays for colloidal aggregate detection and promiscuity characterization in natural products

  2019cites this paper
• Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry

  2019cites this paper
• Argyrin B, a non‐competitive inhibitor of the human immunoproteasome exhibiting preference for β1i

  2019cites this paper
• Identification of the chemical components and metabolites of tripterygium glycoside tablets in mice by HPLC-Q/TOF MS.

  2019cites this paper
• 5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma

  2019cites this paper
• Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.

  2019cites this paper
• Application of cytochrome P450 reactivity on the characterization of chemical compounds and its association with repeated-dose toxicity.

  2019cites this paper
• Pyrrole-protein adducts – A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity

  2018cites this paper
• Identification of hepatotoxic and nephrotoxic potential markers of triptolide in mice with delayed‐type hypersensitivity

  2018cites this paper
• 1.14 – Free Radicals and Reactive Oxygen Species☆

  2018cites this paper
• schisandrin B elicits the Keap1-nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver

  2018cites this paper
• Regulation of Human CYP2D6

  2018cites this paper
• Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver

  2018cites this paper
• Chemo-Enzymatic Synthesis, Structural and Stereochemical Characterization, and Intrinsic Degradation Kinetics of Diastereomers of 1-β-O-Acyl Glucuronides Derived from Racemic 2-{4-[(2-Methylprop-2-en-1-yl)amino]phenyl}propanoic Acid

  2018cites this paper
• Efficient Removal Approach of Micropollutants in Wastewater Using Membrane Bioreactor

  2018cites this paper
• The Discovery and Development of Seletalisib : A Potent and Selective PI3Kδ Inhibitor for Inflammatory Diseases

  2017cites this paper
• Drug metabolism and liver disease: a drug–gene–environment interaction

  2017cites this paper
• Review on fate and mechanism of removal of pharmaceutical pollutants from wastewater using biological approach.

  2017cites this paper
• Significance of metabolites in the environmental risk assessment of pharmaceuticals consumed by human.

  2017cites this paper
• Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development

  2017cites this paper
• The Opportunities of Metabolomics in Drug Safety Evaluation

  2017cites this paper
• Metabolic Activation and Toxicities of bis-Benzylisoquinoline Alkaloids

  2017cites this paper
• Coordination Mechanism and Bio-Evidence: Reactive γ-Ketoenal Intermediated Hepatotoxicity of Psoralen and Isopsoralen Based on Computer Approach and Bioassay

  2017cites this paper
• Proteomic Analysis of Thiol Modifications and Assessment of Structural Changes in Hemoglobin Induced by the Aniline Metabolites N-Phenylhydroxylamine and Nitrosobenzene

  2017cites this paper
• Some Drugs and Herbal Products.

  2016influential citation
• Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future

  2016cites this paper
• Oxidation and adduct formation of xenobiotics in a microfluidic electrochemical cell with boron doped diamond electrodes and an integrated passive gradient rotation mixer.

  2016cites this paper
• In vitro methods in the study of reactive drug metabolites with liquid chromatography / mass spectrometry

  2016cites this paper
• Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes

  2016cites this paper
• Mechanism-Based Inhibitors from Phytomedicine: Risks of Hepatotoxicity and their Potential Hepatotoxic Substructures.

  2016cites this paper
• Cysteine-Based Protein Adduction by Epoxide-Derived Metabolite(s) of Benzbromarone.

  2016cites this paper
• Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor

  2016cites this paper
• New drug design with covalent modifiers

  2016cites this paper
• Biotransformation of Cobicistat: Metabolic Pathways and Enzymes.

  2016cites this paper
• 3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors.

  2016cites this paper
• Intrinsic reactivity profile of electrophilic moieties to guide covalent drug design: N-α-acetyl-L-lysine as an amine nucleophile

  2016cites this paper
• A 674 Toni Lassila IN VITRO METHODS IN THE STUDY OF REACTIVE DRUG METABOLITES WITH LIQUID CHROMATOGRAPHY / MASS SPECTROMETRY

  2016cites this paper
• In silico investigation by conceptual DFT and molecular docking of antitrypanosomal compounds for understanding cruzain inhibition

  2016cites this paper
• Non-cytochrome P450-mediated bioactivation and its toxicological relevance

  2016cites this paper
• METABOLITE TECHNOLOGY: QUALITATIVE AND QUANTITATIVE

  2016cites this paper
• Metabolic activation and drug‐induced liver injury: in vitro approaches for the safety risk assessment of new drugs

  2016cites this paper
• Targeted Covalent Inhibitors for Drug Design.

  2016cites this paper
• Zielgerichtete kovalente Inhibitoren für das Wirkstoffdesign

  2016cites this paper
• The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice.

  2016cites this paper
• 3. Metabolism: Principle, Methods, and Applications

  2015cites this paper
• Multidimensional LC–MS/MS analysis of liver proteins in rat, mouse and human microsomal and S9 fractions

  2015cites this paper
• Synthesis and Performance of a Biomimetic Indicator for Alkylating Agents.

  2015cites this paper
• Characterization of a highly sensitive and selective novel trapping reagent, stable isotope labeled glutathione ethyl ester, for the detection of reactive metabolites.

  2015cites this paper
• Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health

  2015cites this paper
• Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues*

  2015cites this paper
• Quantitative whole-body autoradiography: past, present and future.

  2015cites this paper
• Structural analysis of 20S Proteasome and Development of Structure-Based Virtual Screening Methods

  2015cites this paper
• Theory and Applications of Covalent Docking in Drug Discovery: Merits and Pitfalls

  2015cites this paper