Probenecid Inhibits the Metabolic and Renal Clearances of Zidovudine (AZT) in Human Volunteers

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Pharmaceutical Research

• Publication date

  1990-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1023/A:1015835826114PMID 2362917
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of probenecid on the renal and nonrenal clearances of zidovudine and its distribution into cerebrospinal fluid in the rabbit.

  1989cited by this paper
• Probenecid and zidovudine metabolism.

  1989cited by this paper
• The effect of probenecid on the renal elimination of cimetidine

  1989cited by this paper
• A sensitive liquid-chromatographic method for determination of 3'-azido-3'-deoxythymidine (AZT) in plasma and urine.

  1988cited by this paper
• Results of continued monitoring of participants in the placebo-controlled trial of zidovudine for serious human immunodeficiency virus infection.

  1988cited by this paper
• A membrane transporter mediates access of uridine 5'-diphosphoglucuronic acid from the cytosol into the endoplasmic reticulum of rat hepatocytes: implications for glucuronidation reactions.

  1988cited by this paper
• Pharmacokinetics and bioavailability of zidovudine in humans.

  1988cited by this paper
• Reversibility by dipyridamole of thallium-201 myocardial scan defects in patients with sarcoidosis.

  1988cited by this paper
• 3'-azido-3'-deoxythymidine. An unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion.

  1987cited by this paper
• The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.

  1987cited by this paper
• Plasma and cerebrospinal fluid pharmacokinetics of 3′‐azido‐3′‐deoxythymidine: A Novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

  1987cited by this paper
• Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation.

  1985cited by this paper
• 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

  1985cited by this paper
• Renal organic anion transport system: pharmacological, physiological, and biochemical aspects.

  1982cited by this paper
• Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans

  1982cited by this paper
• Renal tubule transport of organic cations.

  1981cited by this paper
• Apparent effect of probenecid on the distribution of penicillins in man

  1968cited by this paper
• RENAL TUBULAR MECHANISMS FOR EXCRETION OF ORGANIC ACIDS AND BASES.

  1964cited by this paper
• On the mechanism of action of probenecid on renal tubular secretion.

  1960cited by this paper
• Inhibition of Urinary 17-Ketosteroid Excretion Produced by “Benemid”.∗

  1951cited by this paper

• Transmembrane pH gradient imaging in rodent glioma models

  2024cites this paper
• Pharmacokinetic Drug-Drug Interactions Involving Antiretroviral Agents: an Update.

  2023cites this paper
• How Science Is Driving Regulatory Guidances.

  2021cites this paper
• Renal Drug Transporters and Drug Interactions

  2017cites this paper
• Physiological scaling factors and mechanistic models for prediction of renal clearance from in vitro data

  2016cites this paper
• Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas

  2016cites this paper
• Towards longitudinal mapping of extracellular pH in gliomas

  2016cites this paper
• Warfarin is an effective modifier of multiple UDP-glucuronosyltransferase enzymes: evaluation of its potential to alter the pharmacokinetics of zidovudine.

  2015cites this paper
• Proliferation imaging with ¹⁸F-fluorothymidine PET/computed tomography: physiologic uptake, variants, and pitfalls.

  2014cites this paper
• Physiologic Uptake, Variants, and Pitfalls

  2014cites this paper
• Advances in brain targeting and drug delivery of anti-HIV therapeutic agents

  2013cites this paper
• Quantitative prediction of renal transporter-mediated clinical drug-drug interactions.

  2013cites this paper
• Renal Disposition of Drugs and Translation to Dosing Strategies

  2013cites this paper
• Zidovudine

  2012cites this paper
• Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

  2011cites this paper
• Therapeutic implications of renal anionic drug transporters.

  2010cites this paper
• Update on the molecular physiology of organic anion transporters

  2008cites this paper
• Pharmacokinetic and Pharmacodynamic Considerations in the Development of Biotechnology Products and Large Molecules

  2007cites this paper
• Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3).

  2007cites this paper
• Clinical Relevance: Drug–Drug Interactions, Pharmacokinetics, Pharmacodynamics, and Toxicity

  2006cites this paper
• Drugdrug interactions involving membrane transporters in the human kidney

  2006cites this paper
• Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance

  2005cites this paper
• A simplified analysis of [18F]3′-deoxy-3′-fluorothymidine metabolism and retention

  2005influential citation
• Factors affecting delivery of antiviral drugs to the brain

  2005cites this paper
• The Pharmacology of Antiretroviral Nucleoside and Nucleotide Reverse Transcriptase Inhibitors: Implications for Once-Daily Dosing

  2005cites this paper
• Effect of probenecid on the formation and elimination kinetics of the sulphate and glucuronide conjugates of diflunisal

  2004cites this paper
• Probenecid Interacts with the Pharmacokinetics of Morphine-6-glucuronide in Humans

  2004cites this paper
• Interaction of Zidovudine (Azidothymidine) with Isoprinosine and Probenecid in Macaca fascicularis

  2004cites this paper
• Detoxification systems, passive and specific transport for drugs at the blood-CSF barrier in normal and pathological situations.

  2004cites this paper
• Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro.

  2003cites this paper
• Drug-drug interactions: an important negative attribute in drugs.

  2003cites this paper
• Drug Interactions Between Antiretroviral Drugs and Comedicated Agents

  2003cites this paper
• Choroid plexus controls brain availability of anti-HIV nucleoside analogs via pharmacologically inhibitable organic anion transporters

  2003cites this paper
• Probenecid-induced changes in the clearance of pranoprofen enantiomers.

  2003cites this paper
• Rapid internal acyl migration and protein binding of synthetic probenecid glucuronides.

  2002cites this paper
• Mechanisms and clinical implications of renal drug excretion*

  2001cites this paper
• Novel approaches for designing 5'-O-ester prodrugs of 3'-azido-2', 3'-dideoxythymidine (AZT).

  2000cites this paper
• Investigation of distribution, transport and uptake of anti-HIV drugs to the central nervous system.

  1999cites this paper
• Pharmacokinetics of oral ganciclovir alone and in combination with zidovudine, didanosine, and probenecid in HIV-infected subjects.

  1998cites this paper
• In vitro mechanisms of probenecid-associated alterations in acetaminophen glucuronide hepatic disposition.

  1997cites this paper
• Consensus symposium on combined antiviral therapy. International Society for Antiviral Research and the National Institutes of Allergy and Infectious Diseases.

  1996cites this paper
• A pharmacokinetic interaction study of didanosine coadministered with trimethoprim and/or sulphamethoxazole in HIV seropositive asymptomatic male patients.

  1996cites this paper
• Renal Drug Transport: A Review

  1996cites this paper
• The Effect of Probenecid on the Pharmacokinetics of Zalcitabine in HIV-Positive Patients

  1996cites this paper
• Strategies for control of zidovudine concentrations in serum

  1995cites this paper
• Antiretroviral drug interactions.

  1995cites this paper
• Renal Disposition and Drug Interaction Screening of (–)-2′-deoxy-3′-thiacytidine (3TC) in the Isolated Perfused Rat Kidney

  1995cites this paper
• Pharmacokinetics of simultaneously administered zidovudine and didanosine in HIV-seropositive male patients.

  1995cites this paper
• In Vitro and in Vivo Transport of Zidovudine (AZT) Across the Blood–Brain Barrier and the Effect of Transport Inhibitors

  1994cites this paper
• Pharmacokinetic Drug Interactions with Antimicrobial Agents

  1993cites this paper
• Pharmacokinetics of zidovudine alone and in combination with oxazepam in the HIV infected patient.

  1993cites this paper
• Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis.

  1993cites this paper
• Microdialysis study of zidovudine (AZT) transport in rat brain.

  1993cites this paper
• Effect of Age on Distribution of Zidovudine (Azidothymidine) into the Cerebrospinal Fluid of Macaca nemestrina

  1993cites this paper
• Ketoprofen-probenecid interaction in the rat: a probenecid concentration-dependent stereoselective process.

  1993cites this paper
• Effect of 3'-azido-3'-deoxythymidine (AZT) on organic ion transport in rat renal brush border membrane vesicles.

  1992cites this paper
• Pharmacokinetics of Single and Chronic Dose Zidovudine in Two HIV Positive Patients Undergoing Continuous Ambulatory Peritoneal Dialysis (CAPD)

  1992cites this paper
• Glucuronidation of 3'-azido-3'-deoxythymidine in human liver microsomes: enzyme inhibition by drugs and steroid hormones.

  1992cites this paper
• Competitive Inhibition of Zidovudine Clearance by Probenecid During Continuous Coadministration

  1992cites this paper
• Analysis of Zidovudine Distribution to Specific Regions in Rabbit Brain Using Microdialysis

  1992cites this paper
• Probenecid-impaired biliary excretion of acetaminophen glucuronide and sulfate in the rat.

  1992cites this paper
• Glucuronidation of 3'-azido-3'-deoxythymidine catalyzed by human liver UDP-glucuronosyltransferase. Significance of nucleoside hydrophobicity and inhibition by xenobiotics.

  1991cites this paper
• Pharmacokinetic evaluation of drug interactions with zidovudine. I: Probenecid and zidovudine in monkeys.

  1991cites this paper
• Zidovudine and Other Reverse Transcriptase Inhibitors in the Management of Human Immunodeficiency Virus‐Related Disease

  1991cites this paper
• Probenecid enhances central nervous system uptake of 2',3'-dideoxyinosine by inhibiting cerebrospinal fluid efflux.

  1991cites this paper
• A nonprimate animal model applicable to zidovudine pharmacokinetics in humans: inhibition of glucuronidation and renal excretion of zidovudine by probenecid in rats.

  1991cites this paper
• Renal aspects of therapy for human immunodeficiency virus and associated opportunistic infections.

  1991cites this paper
• Interaction of 3'-azido-3'-deoxythymidine with organic ion transport in rat renal basolateral membrane vesicles.

  1991cites this paper