Characterization of hK4 (prostase), a prostate-specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Biochemistry

• Publication date

  2001-11-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1021/BI015775EPMID 11735417
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of a Prostate-specific Tyrosine Phosphatase by Mutagenesis and Expression in Human Prostate Cancer Cells*

  2001cited by this paper
• Molecular Cloning of the Human Kallikrein 15 Gene (KLK15)

  2001cited by this paper
• Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR.

  2001cited by this paper
• Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates*

  2000cited by this paper
• Activation of Hepatocyte Growth Factor and Urokinase/Plasminogen Activator by Matriptase, an Epithelial Membrane Serine Protease*

  2000cited by this paper
• New nomenclature for the human tissue kallikrein gene family.

  2000cited by this paper
• Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue.

  1999cited by this paper
• Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.

  1999cited by this paper
• Molecular Cloning of cDNA for Matriptase, a Matrix-degrading Serine Protease with Trypsin-like Activity*

  1999cited by this paper
• Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression.

  1999cited by this paper
• Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors.

  1999cited by this paper
• Use of human glandular kallikrein 2 for the detection of prostate cancer: preliminary analysis.

  1999cited by this paper
• Localization of a New Prostate-specific Antigen-related Serine Protease Gene, KLK4, Is Evidence for an Expanded Human Kallikrein Gene Family Cluster on Chromosome 19q13.3–13.4*

  1999cited by this paper
• Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated.

  1999cited by this paper
• Purification, Characterization, and Cloning of Enamel Matrix Serine Proteinase 1

  1998cited by this paper
• Consensus-degenerate hybrid oligonucleotide primers for amplification of distantly related sequences.

  1998cited by this paper
• Human Kallikrein 2 (hK2) and prostate-specific antigen (PSA): two closely related, but distinct, kallikreins in the prostate.

  1998cited by this paper
• Expression of pro form of prostate-specific antigen by mammalian cells and its conversion to mature, active form by human kallikrein 2.

  1997cited by this paper
• Characterization of the Precursor of Prostate-specific Antigen

  1997cited by this paper
• Activation of the zymogen form of prostate-specific antigen by human glandular kallikrein 2.

  1997cited by this paper
• Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.

  1997cited by this paper
• Urokinase-type plasminogen activator expression in human prostate carcinomas.

  1996cited by this paper
• Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen.

  1996cited by this paper
• Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts.

  1996cited by this paper
• Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo.

  1994cited by this paper
• Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland.

  1994cited by this paper
• Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.

  1992cited by this paper
• The plasminogen-plasmin system in malignancy

  1992cited by this paper
• The coagulation cascade: initiation, maintenance, and regulation.

  1991cited by this paper
• Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

  1989cited by this paper
• Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

  1988cited by this paper
• Molecular cloning of human prostate specific antigen cDNA

  1987cited by this paper
• Activation of plasminogen by pro-urokinase. I. Mechanism.

  1986cited by this paper
• A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein.

  1985cited by this paper
• Human skin collagenase: isolation of precursor and active forms from both fibroblast and organ cultures.

  1977cited by this paper

• Comparative functional analyses of the prostate-specific KLK3 enzyme in primates reveals the impact of sexual selection.

  2025cites this paper
• A sensitive and specific assay to characterize plasma kallikrein activity in plasma from patients with hereditary angioedema

  2025cites this paper
• Remodeling of the extracellular matrix by serine proteases as a prerequisite for cancer initiation and progression.

  2024cites this paper
• Extracellular proteolysis in cancer: Proteases, substrates, and mechanisms in tumor progression and metastasis

  2024cites this paper
• Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer

  2024cites this paper
• KLK4 promotes proliferation, migration, invasion, and pro-angiogenesis of endometrial stromal cells via regulation of regulation of BDNF production in endometriosis.

  2023cites this paper
• Remodelling of the tumour microenvironment by the kallikrein-related peptidases

  2022cites this paper
• Immunoinformatics and reverse vaccinology methods to design peptide-based vaccines

  2022cites this paper
• Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer.

  2021cites this paper
• Heparin Blocks the Inhibition of Tissue Kallikrein 1 by Kallistatin through Electrostatic Repulsion

  2020cites this paper
• Serine proteases in ovarian cancer

  2020cites this paper
• Pathogenesis of Molar Hypomineralisation: Hypomineralised 6-Year Molars Contain Traces of Fetal Serum Albumin

  2020cites this paper
• Mechanism of semen liquefaction and its potential for a novel non-hormonal contraception†

  2020influential citation
• KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors

  2019cites this paper
• Crystal structure of the inhibitor-free form of the serine protease kallikrein-4

  2019cites this paper
• Crystal structure of the inhibitor-free form of the serine protease kallikrein-4.

  2019cites this paper
• Prostate-specific markers to identify rare prostate cancer cells in liquid biopsies

  2018cites this paper
• Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types

  2018cites this paper
• Inhibitors of kallikrein‐related peptidases: An overview

  2018cites this paper
• Cyclic Peptide Serine Protease Inhibitors Based on the Natural Product SFTI‐1

  2018cites this paper
• Serine Proteases and Their Inhibitors in Human Health and Disease

  2017cites this paper
• Proteinases as Biomarkers in Breast Cancer Prognosis and Diagnosis.

  2017cites this paper
• Mass spectrometry based proteomics analyses in kallikrein-related peptidase research: implications for cancer research and therapy

  2017cites this paper
• Role of Serine Proteases and Inhibitors in Cancer

  2017cites this paper
• INVESTIGATION OF THE PUTATIVE BIOLOGICAL SUBSTRATES FOR HUMAN KALLIKREIN-RELATED PEPTIDASE 7

  2017cites this paper
• Protease, an Advance Therapeutic Target in Cancer

  2017cites this paper
• Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer

  2017cites this paper
• Kallikrein-related peptidase expression in odontogenic cysts and tumors: An immunohistochemical comparative study.

  2017cites this paper
• Adaptive Evolution Favoring KLK4 Downregulation in East Asians.

  2016cites this paper
• OV-MZ-6 ovarian cancer cells overexpressing kallikrein-related peptidases KLK4, 5, 6 and 7: effects on expression of cancer-related genes

  2016cites this paper
• Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics

  2016cites this paper
• Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1.

  2016cites this paper
• Mutational Analysis of Prostate‐Specific Antigen Defines the Intrinsic Proteolytic Activity of the proPSA Zymogen

  2016cites this paper
• Proteinases, Their Extracellular Targets, and Inflammatory Signaling

  2016cites this paper
• Quantification of Human Kallikrein-Related Peptidases in Biological Fluids by Multiplatform Targeted Mass Spectrometry Assays *

  2016cites this paper
• Kallikrein-related peptidases (KLKs) as emerging therapeutic targets: focus on prostate cancer and skin pathologies

  2016cites this paper
• Kallikrein-related peptidases (KLKs) and the hallmarks of cancer

  2016cites this paper
• Testing the variability of PSA expression by different human prostate cancer cell lines by means of a new potentiometric device employing molecularly antibody assembled on graphene surface.

  2016cites this paper
• Total and Free PSA, PCA3, PSA Density and Velocity

  2016cites this paper
• Docetaxel resistance in castration resistant prostate cancer: the role of c-Jun and the androgen receptor

  2015cites this paper
• Improving the early diagnostic of prostate cancer by multiple biomarker detection with new biosensing devices

  2015cites this paper
• The first potent diphenyl phosphonate KLK4 inhibitors with unexpected binding kinetics

  2015cites this paper
• Determining the kallikrein-related peptidase 4-regulated transcriptome and degradome in the prostate tumour microenvironment

  2015cites this paper
• Epigenetic Analysis of the Kallikrein Gene Family and Associated Pathways as a Novel Panel of Prostate Cancer Biomarkers

  2015cites this paper
• Neue Biomarker im Serum und im Urin zur Detektion des Prostatakarzinoms

  2015cites this paper
• Expression of Human Kallikrein Protein and mRNA in Maxillofacial Cysts and Tumors

  2015cites this paper
• Clinical significance of kallikrein-related peptidase-4 in oral cancer.

  2015cites this paper
• Kallikrein-related peptidases in prostate cancer: from molecular function to clinical application

  2014cites this paper
• Connecting the dots among the vascular actions of trypsin and thrombin , the proteolytic action of KLKs , and PARs

  2014cites this paper
• Enzyme-triggered gelation: targeting proteases with internal cleavage sites.

  2014cites this paper
• Inflammation-mediating proteases: structure, function in (patho) physiology and inhibition.

  2014cites this paper
• Prostate-specific antigen and other serum and urine markers in prostate cancer.

  2014cites this paper
• Nitroreductase suicide gene and immunotherapy in locally relapsed, castrate resistant prostate cancer

  2014cites this paper
• Proteomic and other analyses to determine the functional consequences of deregulated kallikrein‐related peptidase (KLK) expression in prostate and ovarian cancer

  2014cites this paper
• Function and clinical relevance of kallikrein-related peptidases and other serine proteases in gynecological cancers

  2014cites this paper
• Early Biomarkers in Breast Cancer

  2014cites this paper
• Kallikrein-Related Peptidases in Prostate Cancer: From Molecular Function to Clinical Application

  2014influential citation
• Targeting kallikrein-related peptidases in prostate cancer

  2014cites this paper
• Activation of membrane-bound proteins and receptor systems: a link between tissue kallikrein and the KLK-related peptidases

  2014cites this paper
• Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity

  2014influential citation
• Antiangiogenic and proteolytic activities of prostate-specific antigen

  2014cites this paper
• Metastasis of ovarian cancer is mediated by kallikrein related peptidases

  2013cites this paper
• Dental Enamel Development: Proteinases and Their Enamel Matrix Substrates

  2013cites this paper
• Kallikrein-related peptidase 4 (KLK4) mRNA predicts short-term relapse in colorectal adenocarcinoma patients.

  2013cites this paper
• From prostate‐specific antigen (PSA) to precursor PSA (proPSA) isoforms: a review of the emerging role of proPSAs in the detection and management of early prostate cancer

  2013cites this paper
• Clinical significance of kallikrein-related peptidase (KLK10) mRNA expression in colorectal cancer.

  2013cites this paper
• Kallikrein-Related Peptidase 4

  2013cites this paper
• Proteases in Cancer: Significance for Invasion and Metastasis

  2013cites this paper
• Paclitaxel Resistance and Multicellular Spheroid Formation Are Induced by Kallikrein-Related Peptidase 4 in Serous Ovarian Cancer Cells in an Ascites Mimicking Microenvironment

  2013cites this paper
• Human Kallikrein-related Peptidase 3, the Prostate-specific Antigen

  2013cites this paper
• Kallikrein-related peptidases in prostate, breast, and ovarian cancers: from pathobiology to clinical relevance

  2012cites this paper
• Protease-Activated Drug Development

  2012cites this paper
• Toward an Integrative Analysis of the Tumor Microenvironment in Ovarian Epithelial Carcinoma

  2012cites this paper
• From prostate-specifi c antigen (PSA) to precursor PSA (proPSA) isoforms: a review of the emerging role of proPSAs in the detection and management of early prostate cancer

  2012cites this paper
• Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14

  2012cites this paper
• Enzymatically active prostate‐specific antigen promotes growth of human prostate cancers

  2011cites this paper
• Expression of kallikrein-related peptidase 4 in dental and non-dental tissues.

  2011cites this paper
• Kallikrein‐related peptidase 4 gene (KLK4) in prostate tumors: Quantitative expression analysis and evaluation of its clinical significance

  2011influential citation
• Identification of PSA peptide mimotopes using phage display peptide library.

  2011cites this paper
• PSA affects prostate cancer cell invasion in vitro and induces an osteoblastic phenotype in bone in vivo

  2011cites this paper
• Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates.

  2011cites this paper
• Impact of expression differences of kallikrein-related peptidases and of uPA and PAI-1 between primary tumor and omentum metastasis in advanced ovarian cancer.

  2011cites this paper
• Kallikrein-related peptidases: bridges between immune functions and extracellular matrix degradation

  2010cites this paper
• Surface Integrity Governs the Proteome of Hypomineralized Enamel

  2010cites this paper
• Expression of proteinase‐activated receptor‐2 (PAR2) is androgen‐dependent in stromal cell line (hPCPs) from benign prostatic hyperplasia

  2010cites this paper
• Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs)

  2010cites this paper
• Human kallikrein-related peptidase 6 (KLK6) and 13 (KLK13) are involved in ovarian carcinoma pathogenesis

  2010cites this paper
• Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis

  2010cites this paper
• Interdependence of kallikrein-related peptidases in proteolytic networks

  2010cites this paper
• Kallikrein-Related Peptidase 5

  2010cites this paper
• A New Activator of the Aberrantly Expressed Protease-Activated Receptor 1 in Colon Cancer Cells

  2010cites this paper
• Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells.

  2010cites this paper
• Kallikrein‐related peptidase‐4 initiates tumor–stroma interactions in prostate cancer through protease‐activated receptor‐1

  2010cites this paper
• Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus.

  2010cites this paper
• Polyclonal antibodies against kallikrein-related peptidase 4 (KLK4): immunohistochemical assessment of KLK4 expression in healthy tissues and prostate cancer

  2010cites this paper
• Natural and engineered kallikrein inhibitors: an emerging pharmacopoeia

  2010cites this paper
• Prostate‐specific antigen (PSA) is activated by KLK2 in prostate cancer ex vivo models and in prostate‐targeted PSA/KLK2 double transgenic mice

  2010influential citation
• DEVELOPMENT OF NOVEL ASSAYS FOR MEASURING DIFFERENT MOLECULAR FORMS OF PROSTATE SPECIFIC ANTIGEN

  2009cites this paper
• The human kallikrein gene family: new biomarkers for ovarian cancer.

  2009cites this paper
• Optimization of peptide-based inhibitors of prostate-specific antigen (PSA) as targeted imaging agents for prostate cancer.

  2009cites this paper