Multiple Cancer Testis Antigens Function To Support Tumor Cell Mitotic Fidelity

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Molecular and Cellular Biology

• Publication date

  2012-08-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.00686-12PMID 22869527PMCID PMC3457335
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1986cited by this paper
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  1986cited by this paper
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  1986cited by this paper

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