Synthetic lethal screen identification of chemosensitizer loci in cancer cells

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature

• Publication date

  2007-04-12

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nature05697PMID 17429401
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Matter of Life and Death

  2008cited by this paper
• Microarray data analysis: from disarray to consolidation and consensus

  2006cited by this paper
• Statistical practice in high-throughput screening data analysis

  2006cited by this paper
• Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.

  2005cited by this paper
• Role of gemcitabine in cancer therapy.

  2005cited by this paper
• Bortezomib-based combinations in the treatment of non-small-cell lung cancer.

  2005cited by this paper
• Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint.

  2004cited by this paper
• Microtubules as a target for anticancer drugs

  2004cited by this paper
• Immortalization of Human Bronchial Epithelial Cells in the Absence of Viral Oncoproteins

  2004cited by this paper
• Salicylihalamide A Inhibits the V0 Sector of the V-ATPase through a Mechanism Distinct from Bafilomycin A1*

  2004cited by this paper
• The cancer/testis genes: review, standardization, and commentary.

  2004cited by this paper
• Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

  2004cited by this paper
• Proton translocation driven by ATP hydrolysis in V‐ATPases

  2003cited by this paper
• RAL GTPases are linchpin modulators of human tumour‐cell proliferation and survival

  2003cited by this paper
• Statistical Adjustment of Signal Censoring in Gene Expression Experiments

  2003cited by this paper
• A matter of life and death.

  2002cited by this paper
• Total synthesis and initial structure-function analysis of the potent V-ATPase inhibitors salicylihalamide A and related compounds.

  2002cited by this paper
• Gamma-tubulin complexes and microtubule nucleation.

  2001cited by this paper
• Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases.

  2001cited by this paper
• γ-Tubulin complexes and microtubule nucleation

  2001cited by this paper
• The use and action of drugs in analyzing mitosis.

  1999cited by this paper
• Controlling the false discovery rate: a practical and powerful approach to multiple testing

  1995cited by this paper
• New colorimetric cytotoxicity assay for anticancer-drug screening.

  1990cited by this paper

• Mitotic spindle-organizing protein MZT2A promotes cisplatin resistance through NEMO ubiquitination and NF-κB activation.

  2026cites this paper
• Pathological modulation of genome maintenance by cancer/testes antigens (CTAs).

  2025cites this paper
• Schisandra chinensis mixture attenuates diabetic kidney disease via VDAC1/Grp75/IP3R-mediated MAMs stabilization and apoptosis-autophagy regulation.

  2025cites this paper
• The Cancer/Testis Antigen FATE1 Antagonizes Fission and Preserves Mitochondrial Network Integrity under Cytotoxic Stress

  2025cites this paper
• Top 100 most-cited articles on apoptosis of non-small cell lung cancer over the past two decades: a bibliometrics analysis

  2025cites this paper
• Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome

  2025cites this paper
• Synthetic lethality in cancer drug discovery: challenges and opportunities

  2025cites this paper
• Multiple Heterogeneous Networks Representation With Latent Space for Synthetic Lethality Prediction

  2024cites this paper
• Advancing pharmaceutical research: A comprehensive review of cutting-edge tools and technologies

  2024cites this paper
• Biology of Cancer-Testis Antigens and Their Therapeutic Implications in Cancer

  2023cites this paper
• Epigenetic modifications: Key players in cancer heterogeneity and drug resistance

  2023cites this paper
• Latent space feature representation on multiple biological network for synthetic lethality interaction prediction

  2023cites this paper
• TARSL: Triple-Attention Cross-Network Representation Learning to Predict Synthetic Lethality for Anti-Cancer Drug Discovery

  2023cites this paper
• SLOAD: a comprehensive database of cancer-specific synthetic lethal interactions for precision cancer therapy via multi-omics analysis

  2022cites this paper
• A Novel CRISPR Interference Effector Enabling Functional Gene Characterization with Synthetic Guide RNAs

  2022cites this paper
• Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal

  2022cites this paper
• New paradigm in combination therapy of siRNA with chemotherapeutic drugs for effective cancer therapy

  2022cites this paper
• The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA

  2022cites this paper
• Characterization of a prognostic model for lung squamous cell carcinoma based on eight stemness index-related genes

  2022cites this paper
• Translocon-associated protein subunit SSR3 determines and predicts susceptibility to paclitaxel in breast cancer and glioblastoma.

  2022cites this paper
• Heme Sequestration as an Effective Strategy for the Suppression of Tumor Growth and Progression

  2021influential citation
• Designing libraries for pooled CRISPR functional screens of long noncoding RNAs

  2021cites this paper
• Synthetic lethality theory approaches to effective substance discovery and functional mechanisms elucidation of anti-cancer phytomedicine.

  2021cites this paper
• Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development

  2021cites this paper
• Functional Genomics Approaches to Elucidate Vulnerabilities of Intrinsic and Acquired Chemotherapy Resistance

  2021cites this paper
• ACRBP (Sp32) is involved in priming sperm for the acrosome reaction and the binding of sperm to the zona pellucida in a porcine model

  2021cites this paper
• Integrative Multi-Omics Approaches in Cancer Research: From Biological Networks to Clinical Subtypes

  2021cites this paper
• Tumor Microenvironment-Responsive Nanococktails for Synergistic Enhancement of Cancer Treatment via Cascade Reactions.

  2021cites this paper
• Integrated RNAi screening identifies the NEDDylation pathway as a synergistic partner of azacytidine in acute myeloid leukemia

  2021cites this paper
• Noncoding RNA therapeutics — challenges and potential solutions

  2021cites this paper
• Molecularly Targeted Clinical Trials.

  2021cites this paper
• Emerging Biomimetic Approaches in the Optimization of Drug Therapies

  2021cites this paper
• Regulation of the Ras-Related Signaling Pathway by Small Molecules Containing an Indole Core Scaffold: A Potential Antitumor Therapy

  2020cites this paper
• “The Loss of Golden Touch”: Mitochondria-Organelle Interactions, Metabolism, and Cancer

  2020cites this paper
• MiR-323-3p Targeting Transmembrane Protein with EGF-Like and 2 Follistatin Domain (TMEFF2) Inhibits Human Lung Cancer A549 Cell Apoptosis by Regulation of AKT and ERK Signaling Pathways

  2020cites this paper
• Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort

  2020cites this paper
• A Gene Expression High-Throughput Screen (GE-HTS) for Coordinated Detection of Functionally Similar Effectors in Cancer

  2020cites this paper
• Cancer biology functional genomics: From small RNAs to big dreams

  2020cites this paper
• Targeting and extending the eukaryotic druggable genome with natural products.

  2020cites this paper
• The vacuolar H+ ATPase proton pump

  2020cites this paper
• Phenotypic screening using large-scale genomic libraries to identify drug targets for the treatment of cancer

  2020cites this paper
• Immortalized normal human lung epithelial cell models for studying lung cancer biology.

  2020cites this paper
• Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC

  2020cites this paper
• Multi-responsive nanococktails with programmable targeting capacity for imaging-guided mitochondrial phototherapy combined with chemotherapy.

  2020cites this paper
• EXP2SL: A Machine Learning Framework for Cell-Line-Specific Synthetic Lethality Prediction

  2020cites this paper
• EWSR1-FLI1 Activation of the Cancer/Testis Antigen FATE1 Promotes Ewing Sarcoma Survival

  2019cites this paper
• Synthetic Lethality in Lung Cancer—From the Perspective of Cancer Genomics

  2019cites this paper
• A Road Map to Personalizing Targeted Cancer Therapies Using Synthetic Lethality.

  2019cites this paper
• ER-mitochondria interactions: Both strength and weakness within cancer cells.

  2019cites this paper
• Genome‐Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1

  2019cites this paper
• Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non-Small Cell Lung Cancer Cells.

  2019influential citation
• Generating Single Cell–Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9

  2019cites this paper
• Exploring and analyzing omics using bioinformatics tools and techniques

  2018cites this paper
• Silencing of Intestinal Glycoprotein CD98 by Orally Targeted Nanoparticles Enhances Chemosensitization of Colon Cancer.

  2018cites this paper
• Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

  2018cites this paper
• Target discovery screens using pooled shRNA libraries and next-generation sequencing: A model workflow and analytical algorithm

  2018cites this paper
• 6mer Seed Toxicity Determines Strand Selection in miRNAs

  2018cites this paper
• High-Content Screening Approaches That Minimize Confounding Factors in RNAi, CRISPR, and Small Molecule Screening.

  2018cites this paper
• NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model.

  2018cites this paper
• Microtubule nucleation by γ-tubulin complexes and beyond

  2018cites this paper
• CRISPR/Cas9-Based Chemogenomic Profiling in Mammalian Cells.

  2018cites this paper
• High Content Screening

  2018cites this paper
• γ-TuRC Heterogeneity Revealed by Analysis of Mozart1

  2018cites this paper
• Harnessing synthetic lethality to predict the response to cancer treatment

  2018cites this paper
• The application of gene silencing in proteomics: from laboratory to clinic

  2018cites this paper
• Emerging Contributions of Cancer/Testis Antigens to Neoplastic Behaviors.

  2018cites this paper
• Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

  2018cites this paper
• Systems-level interference strategies to decipher host factors involved in bacterial pathogen interaction: from RNAi to CRISPRi.

  2017cites this paper
• Identification of effective new drugs combinations exploiting the ability of trabectedin to modulate transcription

  2017cites this paper
• A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans

  2017cites this paper
• HTSvis: a web app for exploratory data analysis and visualization of arrayed high-throughput screens

  2017cites this paper
• Criblage par ARN interférence pour l'identification de nouveaux gènes impliqués dans la différenciation myogénique

  2017cites this paper
• Alterations in Ca2+ Signalling via ER-Mitochondria Contact Site Remodelling in Cancer.

  2017cites this paper
• The ER-mitochondria couple: In life and death from steroidogenesis to tumorigenesis.

  2017cites this paper
• MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development

  2017cites this paper
• Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer

  2017cites this paper
• Host modulators of H 1 N 1 cytopathogenicity WARD

  2017cites this paper
• Utilizing somatic mutation data from numerous studies for cancer research: proof of concept and applications

  2017cites this paper
• Covalent Modulators of the Vacuolar ATPase.

  2017cites this paper
• Aurora B Inhibitor TAK-901 Synergizes with BCL-xL Inhibition by Inducing Active BAX in Cancer Cells.

  2017cites this paper
• miR-21 modulates the effect of EZH2 on the biological behavior of human lung cancer stem cells in vitro

  2017cites this paper
• Combine and conquer: challenges for targeted therapy combinations in early phase trials

  2017cites this paper
• Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity.

  2017cites this paper
• Nanoparticle-mediated co-delivery of chemotherapeutic agent and siRNA for combination cancer therapy

  2017cites this paper
• Analysis of human germ lines genes for clinical applications

  2017cites this paper
• Self-Assembled Cell Microarray (SAMcell) for High-Throughput RNAi Screening.

  2016cites this paper
• Three-Dimensional Spheroid Cell Culture Model for Target Identification Utilizing High-Throughput RNAi Screens.

  2016cites this paper
• In Vitro-Pooled shRNA Screening to Identify Determinants of Radiosensitivity.

  2016cites this paper
• In Vitro High-Throughput RNAi Screening to Accelerate the Process of Target Identification and Drug Development.

  2016cites this paper
• XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer

  2016cites this paper
• Cancer: fundamentals behind pH targeting and the double-edged approach

  2016cites this paper
• A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors

  2016cites this paper
• Understanding the Genetic Mechanisms of Cancer Drug Resistance Using Genomic Approaches.

  2016cites this paper
• Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells

  2016cites this paper
• Data Analysis for High-Throughput RNAi Screening.

  2016cites this paper
• Mitotic spindle perturbations

  2016cites this paper
• miRNA-148b regulates radioresistance in non-small lung cancer cells via regulation of MutL homologue 1

  2016cites this paper
• Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic Instability

  2016cites this paper
• Synthetic Lethal Interactions with E-cadherin for Cancer Therapy

  2016cites this paper
• Synlet: an R package for systemically analyzing synthetic lethal RNA interference screen data

  2016cites this paper