Regulation of adiponectin multimerization, signaling and function.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Best practice & research. Clinical endocrinology & metabolism

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.beem.2013.06.003PMID 24417943PMCID PMC3893790
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes

  2013cited by this paper
• Chronic effects of centrally administered adiponectin on appetite, metabolism and blood pressure regulation in normotensive and hypertensive rats.

  2012cited by this paper
• A highly conserved tryptophan in the N‐terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin

  2012cited by this paper
• MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

  2012cited by this paper
• Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity

  2012cited by this paper
• Fat-Specific DsbA-L Overexpression Promotes Adiponectin Multimerization and Protects Mice From Diet-Induced Obesity and Insulin Resistance

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• Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1.

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• Adiponectin-AdipoR1/2-APPL1 signaling axis suppresses human foam cell formation: differential ability of AdipoR1 and AdipoR2 to regulate inflammatory cytokine responses.

  2012cited by this paper
• Globular Adiponectin, Acting via AdipoR1/APPL1, Protects H9c2 Cells from Hypoxia/Reoxygenation-Induced Apoptosis

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• Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

  2011cited by this paper
• Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling.

  2011cited by this paper
• Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway.

  2011cited by this paper
• Decreased concentration of adiponectin together with a selective reduction of its high molecular weight oligomers is involved in metabolic complications of myotonic dystrophy type 1.

  2011cited by this paper
• Adiponectin Inhibits Osteoclastogenesis and Bone Resorption via APPL1-mediated Suppression of Akt1*

  2011cited by this paper
• The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway

  2011cited by this paper
• APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway.

  2011cited by this paper
• An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart.

  2010cited by this paper
• The Pleiotropic Actions of Adiponectin are Initiated via Receptor-Mediated Activation of Ceramidase Activity

  2010cited by this paper
• Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR*

  2010cited by this paper
• Autophagy: roles in obesity-induced ER stress and adiponectin downregulation in adipocytes.

  2010cited by this paper
• DsbA-L Alleviates Endoplasmic Reticulum Stress–Induced Adiponectin Downregulation

  2010cited by this paper
• Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways*

  2009cited by this paper
• Succination of Thiol Groups in Adipose Tissue Proteins in Diabetes

  2009cited by this paper
• Adiponectin multimer distribution in patients with familial combined hyperlipidemia.

  2008cited by this paper
• AdipoR1 mediates the anorexigenic and insulin/leptin‐like actions of adiponectin in the hypothalamus

  2008cited by this paper
• Post-translational modifications of adiponectin: mechanisms and functional implications.

  2008cited by this paper
• Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression*

  2008cited by this paper
• Plasma adiponectin complexes have distinct biochemical characteristics.

  2008cited by this paper
• Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice.

  2008cited by this paper
• A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization

  2008cited by this paper
• Secretion of the Adipocyte-Specific Secretory Protein Adiponectin Critically Depends on Thiol-Mediated Protein Retention

  2007cited by this paper
• Selective Downregulation of the High–Molecular Weight Form of Adiponectin in Hyperinsulinemia and in Type 2 Diabetes

  2007cited by this paper
• Essential Role of Mitochondrial Function in Adiponectin Synthesis in Adipocytes

  2007cited by this paper
• Adiponectin Secretion Is Regulated by SIRT1 and the Endoplasmic Reticulum Oxidoreductase Ero1-Lα

  2007cited by this paper
• Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.

  2007cited by this paper
• Adipose Tissue as an Endocrine Organ

  2006cited by this paper
• Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists*

  2006cited by this paper
• Endoplasmic reticulum stress signaling in disease.

  2006cited by this paper
• APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

  2006cited by this paper
• Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.

  2006cited by this paper
• Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications.

  2006cited by this paper
• Adipose Tissue

  2006cited by this paper
• Adiponectin and adiponectin receptors.

  2005cited by this paper
• Adiponectin Inhibits Cell Proliferation by Interacting with Several Growth Factors in an Oligomerization-dependent Manner*

  2005cited by this paper
• Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1.

  2005cited by this paper
• Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity*

  2004cited by this paper
• Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

  2004cited by this paper
• A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity.

  2004cited by this paper
• Adiponectin acts in the brain to decrease body weight

  2004cited by this paper
• Role of Disulfide Bonds in Acrp30/Adiponectin Structure and Signaling Specificity

  2003cited by this paper
• Adiponectin: more than just another fat cell hormone?

  2003cited by this paper
• Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes

  2003cited by this paper
• Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin

  2003cited by this paper
• Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

  2002cited by this paper
• Oligomerization State-dependent Activation of NF-κB Signaling Pathway by Adipocyte Complement-related Protein of 30 kDa (Acrp30)*

  2002cited by this paper
• Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation

  2002cited by this paper
• Hydroxylation and Glycosylation of the Four Conserved Lysine Residues in the Collagenous Domain of Adiponectin

  2002cited by this paper
• The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

  2001cited by this paper
• Endogenous glucose production is inhibited by the adipose-derived protein Acrp30.

  2001cited by this paper
• Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice.

  2001cited by this paper
• Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages.

  2000cited by this paper
• Adipose tissue as an endocrine organ.

  2000cited by this paper
• Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.

  1999cited by this paper
• The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor.

  1998cited by this paper

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