Importance of Bioactive Substances in Sheep’s Milk in Human Health

Sheep’s milk is an important source of bioactive substances that have health-promoting functions for the body. The valuable composition of sheep’s milk is due to the high content of fatty acids, immunoglobulins, proteins, hormones, vitamins and minerals. Many biopeptides found in milk have antibacterial, antiviral and anti-inflammatory properties. The bioactive substances of sheep’s milk also show anticancer properties. Sheep’s milk, thanks to its content of CLA and orotic acid, prevents the occurrence of type 2 diabetes, Alzheimer’s disease and cancer. Sheep’s milk, as a product rich in bioactive substances, can be used as a medical aid to support the body in the fight against neurological and cancer diseases.

• Publication year

  2021

• Venue

  International Journal of Molecular Sciences

• Publication date

  2021-04-22

• Fields of study

  Medicine

• Identifiers
  DOI 10.3390/ijms22094364PMID 33921992PMCID 8122369
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• sheep milk

  2022cited by this paper
• Apple Fermented Products: An Overview of Technology, Properties and Health Effects

  2021cited by this paper
• MiRNA-138-5p: A strong tumor suppressor targeting PD-L-1 inhibits proliferation and motility of breast cancer cells and induces apoptosis.

  2021cited by this paper
• The Effect of Kefir Supplementation on Improving Human Endurance Exercise Performance and Antifatigue

  2021cited by this paper
• Lactoferrin/phenylboronic acid-functionalized hyaluronic acid nanogels loading doxorubicin hydrochloride for targeting glioma.

  2021cited by this paper
• Intranasal insulin improves the structure-function of the brain mitochondrial ATP-sensitive Ca2+ activated potassium channel and respiratory chain activities under diabetic conditions.

  2021cited by this paper
• Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment

  2021cited by this paper
• Yogurts supplemented with lipid emulsions rich in omega-3 fatty acids: New insights into the fortification, microencapsulation, quality properties, and health-promoting effects

  2021cited by this paper
• Leptin regulation of hippocampal synaptic function in health and disease.

  2021cited by this paper
• Bayesian inference for parameter estimation in lactoferrin-mediated iron transport across blood-brain barrier.

  2020cited by this paper
• Small RNA deep sequencing reveals the expressions of microRNAs in ovine mammary gland development at peak-lactation and during the non-lactating period.

  2020cited by this paper
• Impact of Photoperiod Length and Treatment with Exogenous Melatonin during Pregnancy on Chemical Composition of Sheep’s Milk

  2020cited by this paper
• The Link between the Consumer and the Innovations in Food Product Development

  2020influential reference
• Yoghurt fermentation alters the composition and antiplatelet properties of milk polar lipids.

  2020cited by this paper
• Cortico-hippocampal morphology and behavioural indices improved in maternal deprivation model of schizophrenia following vitamin B complex supplementation

  2020cited by this paper
• Upregulation of miRNA-9-5p promotes angiogenesis after traumatic brain injury by inhibiting Ptch-1.

  2020cited by this paper
• Leptin stimulates synaptogenesis in hippocampal neurons via KLF4 and SOCS3 inhibition of STAT3 signaling.

  2020cited by this paper
• Blood plasma B vitamins in depression and the therapeutic response to electroconvulsive therapy

  2020cited by this paper
• Vitamin B12 Regulates Glial Migration and Synapse Formation through Isoform-Specific Control of PTP-3/LAR PRTP Expression

  2020cited by this paper
• Amyloid β-protein and beyond: the path forward in Alzheimer's disease.

  2020cited by this paper
• Vitamin A regulates neural stem cell proliferation in rats after hypoxic-ischemic brain damage via RARɑ-mediated modulation of the β-catenin pathway.

  2020cited by this paper
• Lactoferrin improves cognitive function and attenuates brain senescence in aged mice

  2020cited by this paper
• Contributions of DNA Damage to Alzheimer’s Disease

  2020cited by this paper
• The Many Faces of Kefir Fermented Dairy Products: Quality Characteristics, Flavour Chemistry, Nutritional Value, Health Benefits, and Safety

  2020cited by this paper
• Cow's milk polar lipids reduce atherogenic lipoprotein cholesterol, modulate gut microbiota and attenuate atherosclerosis development in LDL-receptor knockout mice fed a Western-type diet.

  2020cited by this paper
• Genetic analysis of orotic acid predicted with Fourier transform infrared milk spectra.

  2020influential reference
• Dezhou donkey (Equus asinus) milk a potential treatment strategy for type 2 diabetes.

  2020cited by this paper
• Leptin enhances adult neurogenesis and reduces pathological features in a transgenic mouse model of Alzheimer's disease.

  2020cited by this paper
• Lactoferrin coated or conjugated nanomaterials as an active targeting approach in nanomedicine.

  2020cited by this paper
• Deep small RNA-Seq reveals microRNAs expression profiles in lactating mammary gland of 2 sheep breeds with different milk performance.

  2020cited by this paper
• Associations Among Maternal Adiposity, Insulin, and Adipokines in Circulation and Human Milk

  2020cited by this paper
• Association of peripartum plasma insulin concentration with milk production, colostrum insulin levels, and plasma metabolites of Holstein cows.

  2019cited by this paper
• Maternal suppplementation with conjugated linoleic acid reduce anxiety and lipid peroxidation in the offspring brain.

  2019cited by this paper
• Supramolecular nanoassembly of lysozyme and α-lactalbumin (apo α-LA) exhibits selective cytotoxicity and enhanced bioavailability of curcumin to cancer cells.

  2019cited by this paper
• A metabolomics comparison between sheep's and goat's milk.

  2019cited by this paper
• Sheep milk: A pertinent functional food

  2019cited by this paper
• Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis

  2019cited by this paper
• Kefir reduces the incidence of pre-neoplastic lesions in an animal model for colorectal cancer

  2019influential reference
• Native and iron-saturated bovine lactoferrin differently hinder migration in a model of human glioblastoma by reverting epithelial-to-mesenchymal transition-like process and inhibiting interleukin-6/STAT3 axis.

  2019cited by this paper
• Identification of microRNA-21 target genes associated with hair follicle development in sheep

  2019cited by this paper
• Lactoferrin (LF): a natural antimicrobial protein

  2019cited by this paper
• Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging.

  2019cited by this paper
• Insulin treatment protects the brain against neuroinflammation by reducing cerebral cytokines and modulating mitochondrial function.

  2019cited by this paper
• Functional lipid components for obesity management: a review

  2019cited by this paper
• The effect of ovine milk fermentation on the antithrombotic properties of polar lipids

  2019influential reference
• Milk MicroRNAs in Health and Disease.

  2019cited by this paper
• Hormones in Breast Milk and Effect on Infants’ Growth: A Systematic Review

  2019cited by this paper
• DNA repair in cancer initiation, progression, and therapy—a double-edged sword

  2019cited by this paper
• Effects of leptin on neurocognitive and motor functions in juvenile rats in a preterm brain damage model.

  2018cited by this paper
• Dairy Fats and Cardiovascular Disease: Do We Really Need to Be Concerned?

  2018cited by this paper
• Adiponectin attenuates neuronal apoptosis induced by hypoxia‐ischemia via the activation of AdipoR1/APPL1/LKB1/AMPK pathway in neonatal rats

  2018cited by this paper
• Expression and Purification of the Main Component Contained in Camel Milk and Its Antimicrobial Activities Against Bacterial Plant Pathogens

  2018cited by this paper
• Expression profiles of circular RNAs in sheep skeletal muscle

  2018cited by this paper
• Inhibition of microRNA‐21‐3p suppresses proliferation as well as invasion and induces apoptosis by targeting RNA‐binding protein with multiple splicing through Smad4/extra cellular signal‐regulated protein kinase signalling pathway in human colorectal cancer HCT116 cells

  2018cited by this paper
• Integrated miRNA-mRNA analysis reveals regulatory pathways underlying the curly fleece trait in Chinese tan sheep

  2018cited by this paper
• Lactoferrin: Major Physiological Functions and Applications.

  2018cited by this paper
• The role of monoamines in the development of Alzheimer's disease and neuroprotective effect of a proline rich polypeptide

  2018cited by this paper
• Lactoferrin functionalized PEG-PLGA nanoparticles of shikonin for brain targeting therapy of glioma.

  2018cited by this paper
• Invited review: Current production trends, farm structures, and economics of the dairy sheep and goat sectors.

  2018cited by this paper
• Overexpression of adiponectin alleviates intracerebral hemorrhage-induced brain injury in rats via suppression of oxidative stress.

  2018cited by this paper
• Kefir Accelerates Burn Wound Healing Through Inducing Fibroblast Cell Migration In Vitro and Modulating the Expression of IL-1ß, TGF-ß1, and bFGF Genes In Vivo

  2018cited by this paper
• Kefir Supplementation Modifies Gut Microbiota Composition, Reduces Physical Fatigue, and Improves Exercise Performance in Mice

  2018cited by this paper
• Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

  2018cited by this paper
• The Content of Conjugated Linoleic Acid and Vaccenic Acid in The Breast Milk of Women from Gdansk and The Surrounding District, As Well As In, Infant Formulas and Follow-up Formulas. Nutritional Recommendation for Nursing Women

  2018cited by this paper
• IL28B, IL29 and micro-RNA 548 in subacute sclerosing panencephalitis as a rare disease.

  2018cited by this paper
• Regulation of microRNA function in animals

  2018cited by this paper
• Associations of breast milk adiponectin, leptin, insulin and ghrelin with maternal characteristics and early infant growth: a longitudinal study

  2018cited by this paper
• Effects of Waiting Period before Milking on Orotic, Uric and Hippuric Acid Contents of Milks from Shami and Kilis Goats

  2018cited by this paper
• [Effect of leptin on long-term spatial memory of rats with white matter damage in developing brain].

  2017cited by this paper
• Downregulation of inflammatory markers by conjugated linoleic acid isomers in human cultured astrocytes

  2017cited by this paper
• A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow’s milk

  2017cited by this paper
• Associations between Maternal Body Composition and Appetite Hormones and Macronutrients in Human Milk

  2017cited by this paper
• DNA damage repair in breast cancer and its therapeutic implications.

  2017cited by this paper
• Targeting progesterone metabolism in breast cancer with l-proline derived new 14-azasteroids.

  2017cited by this paper
• Associations between Yogurt Consumption and Weight Gain and Risk of Obesity and Metabolic Syndrome: A Systematic Review.

  2017cited by this paper
• Milk and dairy products in human nutrition

  2017cited by this paper
• MicroRNAs: Milk's epigenetic regulators.

  2017cited by this paper
• Evaluation of sensory and in vitro anti-thrombotic properties of traditional Greek yogurts derived from different types of milk

  2017cited by this paper
• Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials

  2017cited by this paper
• Fatty acids and fat-soluble vitamins in ewe's milk predicted by near infrared reflectance spectroscopy. Determination of seasonality.

  2017cited by this paper
• Atheroprotective effects of conjugated linoleic acid.

  2017cited by this paper
• Orotate (orotic acid): An essential and versatile molecule

  2016cited by this paper
• Medicinal Values of Camel Milk

  2016cited by this paper
• Evaluation of the in vitro anti-atherogenic activities of goat milk and goat dairy products

  2016cited by this paper
• Preparation of lactoferrin modified poly (vinyl alcohol) nanospheres for brain drug delivery

  2016cited by this paper
• Human vascular endothelial cells transport foreign exosomes from cow's milk by endocytosis.

  2016cited by this paper
• Human milk miRNAs primarily originate from the mammary gland resulting in unique miRNA profiles of fractionated milk

  2016cited by this paper
• Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine

  2016cited by this paper
• Through ruminant nutrition to human health: role of fatty acids

  2016cited by this paper
• Consumption of dairy foods and diabetes incidence: a dose-response meta-analysis of observational studies.

  2016cited by this paper
• Antibacterial Effects of a Cell-Penetrating Peptide Isolated from Kefir.

  2016cited by this paper
• Lower levels of human milk adiponectin predict offspring weight for age: a study in a lean population of Filipinos.

  2016cited by this paper
• DNA damage and the balance between survival and death in cancer biology

  2015cited by this paper
• Impaired DNA damage repair as a common feature of neurodegenerative diseases and psychiatric disorders.

  2015cited by this paper
• Maternal Characteristics Associated with Milk Leptin Content in a Sample of Filipino Women and Associations with Infant Weight for Age

  2015cited by this paper
• DNA Damage, DNA Repair, Aging, and Neurodegeneration.

  2015cited by this paper
• Assessment of lactation stage and breed effect on sheep milk fatty acid profile and lipid quality indices

  2015cited by this paper
• Consumption of raw or heated milk from different species: An evaluation of the nutritional and potential health benefits

  2014cited by this paper
• In vitro anti-atherogenic properties of traditional Greek cheese lipid fractions

  2014cited by this paper
• Leptin regulation of hippocampal synaptic function in health and disease

  2014cited by this paper

• A Comprehensive Review on Equine Milk: Composition, Functional Properties, Technological Applications, and Future Perspectives

  2026cites this paper
• Characterization of the different volatile organic compounds in human and ruminant milk using electronic nose analysis and headspace gas chromatography–mass spectrometry

  2026cites this paper
• The Effect of Photoperiod on the Profile of Prolactin, Leptin, Insulin and the Content of Bioactive Substances in Sheep Milk During the Rearing Period of Lambs.

  2026cites this paper
• Sheep milk protects while cow milk exacerbates DSS-induced colitis by differentially modulating the Akkermansia–short chain fatty acids–barrier axis

  2026cites this paper
• Diet-Induced Proteomic and Metabolomic Signatures in Chronic Kidney Disease: A Precision Nutrition Approach

  2025cites this paper
• Comparative analysis of proteomics and transcriptomics reveals novel mechanism underlying the antibacterial activity and immune-enhancing properties of horse milk

  2025cites this paper
• Revealing the Potential of Bioactive Peptides from Sheep Milk Casein and Whey: An In-silico Exploration

  2025cites this paper
• High spoilage potential and multidrug resistance of P. aeruginosa strains isolated from sheep milk

  2025cites this paper
• Involvement of Orotic Acid in Mitochondrial Activity of Ovarian Granulosa Cells and Oocyte Meiotic Maturation

  2025cites this paper
• Comparative analysis of sheep, goat, and cow milk based on non-targeted metabolomics

  2025cites this paper
• Natural Bioactive Compounds in Sheep Milk: Potential Biomedical Applications

  2025cites this paper
• Investigation of Antioxidants and Some Biochemical Parameters in Sheep and Cattle Infected With Toxoplasmosis

  2025cites this paper
• The anticancer activity of milk rich in conjugated linoleic acid

  2025cites this paper
• Raw Sheep Milk as a Reservoir of Multidrug-Resistant Staphylococcus aureus: Evidence from Traditional Farming Systems in Romania

  2025cites this paper
• Bioactive compounds in sheep milk: The therapeutic potential of CLA, lactoferrin, and orotic acid in skin cancer treatment

  2025cites this paper
• Causal Effects between Gut Flora Significantly Associated with Cervical Cancer and 1400 Metabolites: A Mendelian Randomized Study

  2025cites this paper
• Docking and Antimicrobial Potential of Lactoferrin in Capra hircus: An In-silico Approach

  2025cites this paper
• Exploring the molecular interaction of bioactive peptides with antioxidative, antidiabetic and anti-inflammatory attributes from sheep milk fermented with lactobacillus and yeast

  2025cites this paper
• Obesity dietetics: Evidence-based mechanistic and nutritional perspectives

  2025cites this paper
• The variation patterns of microorganisms in sheep milk under different heat treatments and storage times

  2025cites this paper
• Preventive effects of sheep milk on DSS-induced colitis in mice: modulation of gut microbiota and inflammatory responses.

  2025cites this paper
• Identification of lipids and proteins associated with different heat treatments in sheep milk based on lipidomics and proteomics

  2025cites this paper
• Non-Genetic Factors Shaping Milk Composition in Early Lactation of Awassi Ewe

  2025cites this paper
• Lactobacillus rhamnosus -derived from raw sheep milk as natural prebiotic carriers: Probiotic properties, cholesterol absorption, folic acid and cobalamin synthesis

  2025cites this paper
• Effects of Olive Pomace Powder Incorporation on Physicochemical, Textural, and Rheological Properties of Sheep Milk Yogurt

  2025cites this paper
• Sheep Farming for Resilient Dryland Livelihoods – A Review

  2025cites this paper
• Unlocking the nutritional and bioactive potential of sheep milk: implications for food and health.

  2025cites this paper
• Metabolomics in ruminant food: bridging nutritional quality and safety evaluation

  2025cites this paper
• Establishment and characterization study of ovine mammary organoids

  2025cites this paper
• Fatty acid profile, Conjugated linoleic acid (CLA) content, microbiological and sensory properties of kefir produced from sheep milk using kefir grains and starter culture in comparison with the respective kefir from cow milk

  2024cites this paper
• Development of a functional Greek sheep yogurt incorporating a probiotic Lacticaseibacillus rhamnosus wild-type strain as adjunct starter culture

  2024cites this paper
• Mechanisms by which sheep milk consumption ameliorates insulin resistance in high-fat diet-fed mice.

  2024cites this paper
• Physical and chemical properties, hygienic quality and fatty acid profile in milk of lactating Lacaune dairy sheep

  2024cites this paper
• Effects of Nutritional Factors on Fat Content, Fatty Acid Composition, and Sensorial Properties of Meat and Milk from Domesticated Ruminants: An Overview

  2024cites this paper
• Comparison of Milk Kefirs Obtained from Cow’s, Ewe’s and Goat’s Milk: Antioxidant Role of Microbial-Derived Exopolysaccharides

  2024cites this paper
• Biochemical characterization of YoAlp®: a sheep-fermented milk obtained with autochthonous starter cultures

  2024cites this paper
• Differences in proteomic profiles and immunomodulatory activity of goat and cow milk fat globule membrane.

  2024cites this paper
• Circular RNA_015343 sponges microRNA‐25 to regulate viability, proliferation, and milk fat synthesis of ovine mammary epithelial cells via INSIG1

  2024cites this paper
• Multi-omics analysis of kidney tissue metabolome and proteome reveals the protective effect of sheep milk against adenine-induced chronic kidney disease in mice.

  2024cites this paper
• Healthy Effects of Milk and Dairy Product Consumption in the Mediterranean Area and Japan.

  2024cites this paper
• Label-free-based proteomics analysis reveals differential proteins of sheep, goat and cow milk.

  2024cites this paper
• Cow’s Milk Bioactive Molecules in the Regulation of Glucose Homeostasis in Human and Animal Studies

  2024cites this paper
• Functional yogurt: a comprehensive review of its nutritional composition and health benefits.

  2024cites this paper
• Características de las curvas de lactación en ovejas y factores que influyen en su variación: Revisión

  2024cites this paper
• Precise and panoramic study on the nutritional components of specific milk of goats and sheep.

  2024cites this paper
• Dietary protected fat and conjugated linoleic acid improves ewe milk fatty acid composition

  2023cites this paper
• Development and Chemico-Physical Characterization of Ovine Milk-Based Ingredients for Infant Formulae

  2023cites this paper
• Changes in the Quality of Plain Yogurt Made From Cow’s, Goat’s, and Sheep’s Milk Within the Shelf Life

  2023cites this paper
• Appraisal of some ethnic milk products from minor milch animal species around the world: a review

  2023cites this paper
• An overview on recent advances of reversible fluorescent probes and their biological applications.

  2023cites this paper
• Probiotic Fermented Goat’s and Sheep’s Milk: Effect of Type and Dose of Collagen on Survival of Four Strains of Probiotic Bacteria during Simulated In Vitro Digestion Conditions

  2023cites this paper
• Orotic acid induces apoptotic death in ovarian adult granulosa tumour cells and increases mitochondrial activity in normal ovarian granulosa cells.

  2023cites this paper
• Role of bioactive substances in sheep's milk and its products in the prevention of neurodegenerative diseases

  2023cites this paper
• Review: Research Progress of Dairy Sheep Milk Genes

  2022cites this paper
• Effects of Dietary Omega-3 Enrichment on the Chemical Composition and the Pathogenic Microbiota of Ovine Milk

  2022influential citation
• Milk Content and Milk Quality of Sheep of the Kazakh Fat-Tailed Semi-Rough-Haired Breed with Pasture Content

  2022cites this paper
• High Milk Somatic Cell Counts and Increased Teladorsagia Burdens Overshadow Non-Infection-Related Factors as Predictors of Fat and Protein Content of Bulk-Tank Raw Milk in Sheep and Goat Farms

  2022cites this paper
• BIOACTIVE ACIDS OF SHEEP`S MILK FROM THE AREA OF LIVNO AND TRAVNIK (VLAŠIĆ)

  2021cites this paper
• Comparative Characteristics of the Amino Acids Composition of Sheep Milk from Breeds of Northern Kazakhstan

  2021cites this paper
• Characteristics of lactation curves in ewes and factors influencing their variation: A review

  year unknowncites this paper