Voxel-based morphometry of herpes simplex encephalitis.

Voxel-based morphometry (VBM) is a powerful tool for analyzing changes in gray or white matter density of the brain. By using an automated segmentation procedure and standardized parametric statistics it avoids biases inherent in operator-dependent morphological operations (J. Ashburner and K. J. Friston, 2000, NeuroImage 11, 805-821). Since its introduction in 1995, VBM has been used to examine anatomical changes in a variety of diseases associated with neurologic and psychiatric dysfunction. Given the power of this technique for discerning subtle anatomical changes, we wanted to assess its performance on brains with gross structural abnormalities. Such results could have implications regarding the difficulties to be faced when examining other types of distorted brains (e.g., brains with changes due to degenerative disease). This report describes the use of VBM for examining individual and group changes in gray matter concentration in five patients who had recovered from herpes simplex encephalitis (HSE) compared with age- and sex-matched controls. Because HSE tends to affect a specific set of brain regions we thought that this would (1) provide an opportunity to assess the anatomical face validity of VBM, (2) allow us to assess the problems of this technique when used on distorted brains, and (3) provide an in vivo demonstration of the gray matter changes due to HSE. We found that, despite problems in normalizing and segmenting these severely distorted brains, VBM was able to identify correctly a number of the regional gray matter abnormalities in HSE. The results, while consistent with the well-known histopathology of the disease, also demonstrate potential difficulties with this method.

• Publication year

  2001

• Venue

  NeuroImage

• Publication date

  2001-04-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1006/NIMG.2000.0734PMID 11305891
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999cited by this paper
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  1999cited by this paper
• Detection and mapping of abnormal brain structure with a probabilistic atlas of cortical surfaces.

  1997cited by this paper
• Herpes simplex encephalitis treated with acyclovir: diagnosis and long term outcome

  1997cited by this paper
• Brain morphometry in Tourette's syndrome

  1996influential reference
• A unified statistical approach for determining significant signals in images of cerebral activation

  1996cited by this paper
• A voxel-based method for the statistical analysis of gray and white matter density applied to schizophrenia.

  1995cited by this paper
• The underestimated cerebellum

  1994cited by this paper
• An MRI-Based Probabilistic Atlas of Neuroanatomy

  1994cited by this paper
• Magnetic Resonance Scanning and Epilepsy

  1994cited by this paper
• Statistical parametric maps in functional imaging: A general linear approach

  1994cited by this paper
• 3D statistical neuroanatomical models from 305 MRI volumes

  1993cited by this paper
• An MRI-based stereotactic atlas from 250 young normal subjects

  1992cited by this paper
• Atypical herpes simplex encephalitis

  1992cited by this paper
• Medical progress : viral encephalitis

  1990cited by this paper
• Viral encephalitis.

  1990cited by this paper
• Magnetic resonance imaging–based brain morphometry: Development and application to normal subjects

  1989cited by this paper
• A CLINICO–PATHOLOGICAL STUDY OF HERPES SIMPLEX ENCEPHALITIS

  1988cited by this paper
• The limbic system and the localisation of herpes simplex encephalitis.

  1985cited by this paper
• Principles of behavioral neurology

  1985cited by this paper
• Herpes simplex encephalitis: An immunohistological study of the distribution of viral antigen within the brain

  1982cited by this paper
• Distribution of herpes simplex virus in acute necrotising encephalitis

  1979cited by this paper
• Herpes simplex encephalitis: a clinical and pathological analysis of twenty-two cases

  1973cited by this paper
• Herpes encephalitis

  1969cited by this paper
• Herpes Simplex Encephalitis. Report of 20 Cases.

  1966cited by this paper
• Herpes simplex encephalitis. Report of 20 cases.

  1966cited by this paper

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