Thioltransferase in human red blood cells: kinetics and equilibrium.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Biochemistry

• Publication date

  1991-09-10

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI00100A023PMID 1888746
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thioredoxin and glutaredoxin systems.

  2019cited by this paper
• Thioltransferase in human red blood cells: purification and properties.

  1991cited by this paper
• Crystal structure of thioredoxin from Escherichia coli at 1.68 A resolution.

  1990cited by this paper
• Yeast thioltransferase--the active site cysteines display differential reactivity.

  1990cited by this paper
• Characterization of Escherichia coli thioredoxins with altered active site residues.

  1990cited by this paper
• High-level expression of pig liver thioltransferase (glutaredoxin) in Escherichia coli.

  1990cited by this paper
• Enzymatic oxidation of xenobiotic chemicals.

  1990cited by this paper
• A revised sequence of calf thymus glutaredoxin.

  1989cited by this paper
• Reduction of protein mixed disulfides (dethiolation) by Escherichia coli thioredoxin: a study with glycogen phosphorylase b and creatine kinase.

  1989cited by this paper
• Dissection of the catalytic mechanism of isozyme 4-4 of glutathione S-transferase with alternative substrates.

  1988cited by this paper
• Identification and reactivity of the catalytic site of pig liver thioltransferase.

  1987cited by this paper
• Purification and properties of thioltransferase.

  1986cited by this paper
• Thioredoxin.

  1985cited by this paper
• Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation.

  1985cited by this paper
• Glutaredoxin from Escherichia coli and calf thymus.

  1985cited by this paper
• [68] Glutaredoxin from Escherichia coli and calf thymus

  1985cited by this paper
• Relative contributions of thioltransferase-and thioredoxin-dependent systems in reduction of low-molecular-mass and protein disulphides.

  1983cited by this paper
• Differential reactivity of the functional sulfhydryl groups of cysteine-32 and cysteine-35 present in the reduced form of thioredoxin from Escherichia coli.

  1980cited by this paper
• Glutathione-dependent synthesis of deoxyribonucleotides. Characterization of the enzymatic mechanism of Escherichia coli glutaredoxin.

  1979cited by this paper
• Constant-ratio alternative substrate approach for differentiation of enzyme mechanisms.

  1977cited by this paper
• Evidence for a glutathione-dependent interconversion of two forms of a thioltransferase from rat liver catalyzing thiol-disulfide interchange.

  1974cited by this paper
• Thioredoxin. A localized conformational change accompanying reduction of the protein to the sulfhydryl form.

  1967cited by this paper
• Synthesis and characterization of sodium cysteine-S-sulfate monohydrate.

  1963cited by this paper
• Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase.

  1962cited by this paper
• A study of the 'reactive' sulphydryl groups of adenosine 5'-triphosphate-creatine phosphotransferase.

  1962cited by this paper
• A study of the kinetics of the reaction between thiol compounds and choloracetamide.

  1960cited by this paper

• Molecular basis for the enzymatic inactivity of class III glutaredoxin ROXY9 on standard glutathionylated substrates

  2025cites this paper
• Role of dithiol glutaredoxin 1 protein of Leishmania donovani in Amphotericin B resistance and redox homeostasis.

  2025cites this paper
• Cysteine-based biomolecules regulate cellular copper- and redox-homeostasis

  2025cites this paper
• Computational models as catalysts for investigating redoxin systems.

  2024cites this paper
• The dithiol mechanism of class I glutaredoxins promotes specificity for glutathione as a reducing agent

  2024cites this paper
• Deciphering the mechanism of glutaredoxin-catalyzed roGFP2 redox sensing reveals a ternary complex with glutathione for protein disulfide reduction

  2024cites this paper
• Structural and functional fine mapping of cysteines in mammalian glutaredoxin reveal their differential oxidation susceptibility

  2023cites this paper
• S-Glutathionylation-Controlled Apoptosis of Lung Epithelial Cells; Potential Implications for Lung Fibrosis

  2022cites this paper
• Convenient Unsymmetrical Disulfane Synthesis: Basic Zeolite‐Catalyzed Thiol‐Disulfane Exchange Reaction

  2021cites this paper
• Murine GRXCR1 Has a Different Function Than GRXCR2 in the Morphogenesis of Stereocilia

  2021cites this paper
• Metabolome Changes during In Vivo Red Cell Aging Reveal Disruption of Key Metabolic Pathways

  2020cites this paper
• Role of rockfish (Sebastes schlegelii) glutaredoxin 1 in innate immunity, and alleviation of cellular oxidative stress: Insights into localization, molecular characteristics, transcription, and function.

  2020cites this paper
• Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins

  2020cites this paper
• Dysregulation of the glutaredoxin/S-glutathionylation redox axis in lung diseases.

  2019cites this paper
• Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol-Disulfide Exchange between Protein Thiols and Glutathione.

  2019cites this paper
• Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites

  2018cites this paper
• Biochemical characterisation of the enzymatic activity of chloride intracellular ion channel proteins

  2018cites this paper
• Glutaredoxins employ parallel monothiol–dithiol mechanisms to catalyze thiol–disulfide exchanges with protein disulfides

  2017cites this paper
• Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting Bim

  2017cites this paper
• Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor

  2017cites this paper
• Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes.

  2017cites this paper
• New insights into the redox chemistry of protein thiols

  2017cites this paper
• Glutaredoxin catalysis requires two distinct glutathione interaction sites

  2017cites this paper
• Glutaredoxin-1 As A Therapeutic Target In Neurodegenerative Inflammation

  2017influential citation
• The Myeloablative Drug Busulfan Converts Cysteine to Dehydroalanine and Lanthionine in Redoxins.

  2016cites this paper
• The glutaredoxin mono- and di-thiol mechanisms for deglutathionylation are functionally equivalent: implications for redox systems biology

  2014cites this paper
• Redox sulfur chemistry of the copper chaperone Atox1 is regulated by the enzyme glutaredoxin 1, the reduction potential of the glutathione couple GSSG/2GSH and the availability of Cu(I).

  2014cites this paper
• Pleiotropic functions of glutathione S-transferase P.

  2014cites this paper
• The Glutathione System: A New Drug Target in Neuroimmune Disorders

  2014cites this paper
• Structure-guided activity enhancement and catalytic mechanism of yeast grx8.

  2014cites this paper
• Dynamics of the glutathione/glutaredoxin system.

  2014influential citation
• Understanding the pK a of Redox Cysteines: The Key Role of Hydrogen Bonding

  2013influential citation
• Mitochondrialer Proteinimport in Leishmania tarentolae und Charakterisierung der Hefeglutaredoxine 6-8

  2013influential citation
• Protein Posttranslational Modification

  2013cites this paper
• Kinetics and Mechanisms of Thiol–Disulfide Exchange Covering Direct Substitution and Thiol Oxidation-Mediated Pathways

  2013cites this paper
• Effects of Cadmium on Actin Glutathionylation and Focal Adhesions

  2013cites this paper
• Structural and functional characterization of HP0377, a thioredoxin-fold protein from Helicobacter pylori.

  2013cites this paper
• Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes.

  2013cites this paper
• The -Cys-X1-X2-Cys- motif of reduced glutaredoxins adopts a consensus structure that explains the low pK(a) of its catalytic cysteine.

  2012cites this paper
• The biological roles of glutaredoxins.

  2012cites this paper
• Electrostatics of cysteine residues in proteins: Parameterization and validation of a simple model

  2012cites this paper
• Site‐directed mutagenesis of rat thioltransferase: Effects of essential cysteine residues for the protection against oxidative stress

  2010cites this paper
• Thiol-disulfide exchange between glutaredoxin and glutathione.

  2010cites this paper
• The Dithiol Glutaredoxins of African Trypanosomes Have Distinct Roles and Are Closely Linked to the Unique Trypanothione Metabolism*

  2010cites this paper
• Biochemical characterization of glutaredoxins from Chlamydomonas reinhardtii: Kinetics and specificity in deglutathionylation reactions

  2010cites this paper
• Caracterização funcional de uma nova proteína antioxidante: Ohr (Organic Hydroperoxide Resistance Protein). Vias de redução e expressão em Xylella fastidiosa

  2010cites this paper
• Characterization of a monothiol glutaredoxin encoded by Chlorella virus PBCV-1

  2009cites this paper
• Structural aspects of the distinct biochemical properties of glutaredoxin 1 and glutaredoxin 2 from Saccharomyces cerevisiae.

  2009cites this paper
• Comparative characterization of the major human glutaredoxin isozymes and identification of a mechanism by which Grx1 regulates apoptosis in cardiomyocytes.

  2009influential citation
• An FAD-dependent pyridine nucleotide-disulfide oxidoreductase is involved in disulfide bond formation in FK228 anticancer depsipeptide.

  2009cites this paper
• Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: the catalytic redox mechanism redux.

  2009cites this paper
• Mechanistic and Kinetic Details of Catalysis of Thiol-Disulfide Exchange by Glutaredoxins and Potential Mechanisms of Regulation

  2009influential citation
• Structure-function studies of glutaredoxins and related oxidoreductases

  2008cites this paper
• Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

  2008cites this paper
• Kinetic and mechanistic characterization and versatile catalytic properties of mammalian glutaredoxin 2: implications for intracellular roles.

  2008cites this paper
• Glutathionylation‐triggered conformational changes of glutaredoxin Grx1 from the yeast Saccharomyces cerevisiae

  2008cites this paper
• Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pK(a) values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

  2008cites this paper
• Two novel monothiol glutaredoxins from Saccharomyces cerevisiae provide further insight into iron-sulfur cluster binding, oligomerization, and enzymatic activity of glutaredoxins.

  2008cites this paper
• Comprehensive Invited Review Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

  2008cites this paper
• Stabilization of the catalytic thiolate in a mammalian glutaredoxin: structure, dynamics and electrostatics of reduced pig glutaredoxin and its mutants.

  2007cites this paper
• Glutaredoxin Mediates Akt and eNOS Activation by Flow in a Glutathione Reductase-Dependent Manner

  2007cites this paper
• Redox properties and evolution of human glutaredoxins

  2007cites this paper
• Oxidation and S-Nitrosylation of Cysteines in Human Cytosolic and Mitochondrial Glutaredoxins

  2007cites this paper
• Glutathiolation Regulates Tumor Necrosis Factor-&agr;–Induced Caspase-3 Cleavage and Apoptosis: Key Role for Glutaredoxin in the Death Pathway

  2007cites this paper
• Reactive cysteine in proteins: protein folding, antioxidant defense, redox signaling and more.

  2007cites this paper
• Computational and mutational analysis of human glutaredoxin (thioltransferase): probing the molecular basis of the low pKa of cysteine 22 and its role in catalysis.

  2006cites this paper
• Structure and function in c-Myc and Grx 4 : two key proteins involved in transcriptional activation and oxidative stress

  2006cites this paper
• Selective inactivation of glutaredoxin by sporidesmin and other epidithiopiperazinediones.

  2006cites this paper
• Structural insight into poplar glutaredoxin C1 with a bridging iron-sulfur cluster at the active site.

  2006cites this paper
• Structure and function in c-Myc and Grx4: two key proteins involved in transcriptional activation and oxidative stress

  2006cites this paper
• Hemoglobin S-thiolation during peroxide-induced oxidative stress in chicken blood.

  2006cites this paper
• Catalysis of Thiol/Disulfide Exchange

  2005cites this paper
• ReviewRegulation of protein function by glutathionylation

  2005cites this paper
• Glutaredoxin: Role in Reversible Protein S-Glutathionylation and Regulation of Redox Signal Transduction and Protein Translocation

  2005cites this paper
• Biochemical and Biological Aspects of Protein Thiolation in Cells and Plasma

  2005cites this paper
• Human Mitochondrial Glutaredoxin Reduces S-Glutathionylated Proteins with High Affinity Accepting Electrons from Either Glutathione or Thioredoxin Reductase*

  2004cites this paper
• Biochemical properties of human glutaredoxins

  2004influential citation
• Structural and functional characterization of a thioredoxin-like protein (Mt0807) from Methanobacterium thermoautotrophicum.

  2003cites this paper
• Glutathione-Thiyl Radical Scavenging and Transferase Properties of Human Glutaredoxin (Thioltransferase)

  2003cites this paper
• Identification of a novel archaebacterial thioredoxin: determination of function through structure.

  2002cites this paper
• Complete 'H, 13C, and 15N NMR and secondary structure of human in the fully reduced form resonance assignments glutaredoxin rn

  2002cites this paper
• Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1.

  2002cites this paper
• GSTB1-1 from Proteus mirabilis

  2002cites this paper
• Thioredoxin and glutaredoxin isoforms.

  2002cites this paper
• Mutation in the Glucose-6-phosphate Dehydrogenase Gene Leads to Inactivation of Ku DNA End Binding during Oxidative Stress*

  2002cites this paper
• Identification and Characterization of a New Mammalian Glutaredoxin (Thioltransferase), Grx2*

  2001cites this paper
• Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems

  2001cites this paper
• Human lens thioltransferase: cloning, purification, and function.

  2001cites this paper
• Oxidation of cellular thiols by hydroxyethyldisulphide inhibits DNA double-strand-break rejoining in G6PD deficient mammalian cells.

  2000cites this paper
• Direct NMR observation of the Cys‐14 thiol proton of reduced Escherichia coli glutaredoxin‐3 supports the presence of an active site thiol‐thiolate hydrogen bond

  1999cites this paper
• Crystal structures of reduced and oxidized DsbA: investigation of domain motion and thiolate stabilization.

  1998cites this paper
• The NMR solution structure of human glutaredoxin in the fully reduced form.

  1998influential citation
• A single dipeptide sequence modulates the redox properties of a whole enzyme family.

  1998cites this paper
• Comparative study of the catalytic domain of phosphorylating glyceraldehyde-3-phosphate dehydrogenases from bacteria and archaea via essential cysteine probes and site-directed mutagenesis.

  1998cites this paper
• Complete 1H, 13C, and 15N NMR resonance assignments and secondary structure of human glutaredoxin in the fully reduced form

  1997cites this paper
• pH profiles indicative of rate-limiting nucleophilic displacement in thioltransferase catalysis.

  1997cites this paper
• Glutathione dependent reduction of alloxan to dialuric acid catalyzed by thioltransferase (glutaredoxin): a possible role for thioltransferase in alloxan toxicity.

  1997cites this paper
• On the reactivity and ionization of the active site cysteine residues of Escherichia coli thioredoxin.

  1996cites this paper
• Electrostatic interactions in the active site of the N-terminal thioredoxin-like domain of protein disulfide isomerase.

  1996cites this paper
• Nuclear magnetic resonance study of the thioltransferase-catalyzed glutathione/glutathione disulfide interchange reaction.

  1995cites this paper