The Earliest Thymic Progenitors in Adults Are Restricted to T, NK, and Dendritic Cell Lineage and Have a Potential to Form More Diverse TCRβ Chains than Fetal Progenitors1

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Immunology

• Publication date

  2005-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.175.9.5848PMID 16237077
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision

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• T/B lineage choice occurs prior to intrathymic Notch signaling.

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• Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

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• The earliest subpopulation of mouse thymocytes contains potent T, significant macrophage, and natural killer cell but no B-lymphocyte potential.

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• Notch signaling controls the generation and differentiation of early T lineage progenitors

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  2004cited by this paper
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