The thymus and T-cell commitment: the right niche for Notch?

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Nature reviews. Immunology

• Publication date

  2006-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nri1883PMID 16799474
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation.

  2006cited by this paper
• Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

  2005cited by this paper
• A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision

  2005cited by this paper
• T/B lineage choice occurs prior to intrathymic Notch signaling.

  2005cited by this paper
• Many roads, one destination for T cell progenitors

  2005cited by this paper
• Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors.

  2005cited by this paper
• Thymic Anlage Is Colonized by Progenitors Restricted to T, NK, and Dendritic Cell Lineages1

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• Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells

  2005cited by this paper
• Closer to the source: notch and the nature of thymus-settling cells.

  2005cited by this paper
• The earliest subpopulation of mouse thymocytes contains potent T, significant macrophage, and natural killer cell but no B-lymphocyte potential.

  2005cited by this paper
• Notch signaling controls the generation and differentiation of early T lineage progenitors

  2005cited by this paper
• Prethymic T‐cell development defined by the expression of paired immunoglobulin‐like receptors

  2005cited by this paper
• The Earliest Thymic Progenitors in Adults Are Restricted to T, NK, and Dendritic Cell Lineage and Have a Potential to Form More Diverse TCRβ Chains than Fetal Progenitors1

  2005cited by this paper
• Extrathymic Hemopoietic Progenitors Committed to T Cell Differentiation in the Adult Mouse1

  2005cited by this paper
• Regulation of lymphoid development, differentiation, and function by the Notch pathway.

  2005cited by this paper
• Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.

  2005cited by this paper
• Circulating hematopoietic progenitors with T lineage potential

  2004cited by this paper
• Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling.

  2004cited by this paper
• Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages.

  2004cited by this paper
• Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

  2004cited by this paper
• Maintenance of T Cell Specification and Differentiation Requires Recurrent Notch Receptor–Ligand Interactions

  2004cited by this paper
• Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

  2004cited by this paper
• T-cell development made simple

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• Entry into the Thymic Microenvironment Triggers Notch Activation in the Earliest Migrant T Cell Progenitors 1

  2003cited by this paper
• Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus

  2003cited by this paper
• Redefinition of lymphoid progenitors

  2002cited by this paper
• Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1.

  2001cited by this paper
• Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

  2001cited by this paper
• Notch ligand‐bearing thymic epithelial cells initiate and sustain Notch signaling in thymocytes independently of T cell receptor signaling

  2001cited by this paper
• An Essential Role for Thymic Mesenchyme in Early T Cell Development

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• A Role for Pref-1 and HES-1 in Thymocyte Development

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• Commitment of Common T/Natural Killer (Nk) Progenitors to Unipotent T and Nk Progenitors in the Murine Fetal Thymus Revealed by a Single Progenitor Assay

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• Deficient T cell fate specification in mice with an induced inactivation of Notch1.

  1999cited by this paper
• Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

  1999cited by this paper
• Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

  1999cited by this paper
• The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells.

  1998cited by this paper
• Presence of progenitors restricted to T, B, or myeloid lineage, but absence of multipotent stem cells, in the murine fetal thymus.

  1998cited by this paper
• Identification of pro‐thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization.

  1994cited by this paper

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• Notch signaling pathway: architecture, disease, and therapeutics

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• Thymic hypoplasia induced by copy number variations contributed to explaining sudden infant death based on forensic autopsies.

  2022cites this paper
• Integrated role of human thymic stromal cells in hematopoietic stem cell extravasation

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• Functional definition of a transcription factor hierarchy regulating T cell lineage commitment

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• T-cell egress from the thymus :

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• Consiglio di Amministrazione

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• Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors

  2016cites this paper
• Development and trafficking function of haematopoietic stem cells and myeloid cells during fetal ontogeny.

  2015cites this paper
• Optimising stem cell therapy for liver disease through modulation of sphingosine 1-phosphate signalling

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• Lymphoid Progenitor Emergence in the Murine Embryo and Yolk Sac Precedes Stem Cell Detection

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• T Cell–B Cell Thymic Cross-Talk: Maintenance and Function of Thymic B Cells Requires Cognate CD40–CD40 Ligand Interaction

  2014cites this paper
• This information is current as Interaction CD 40 Ligand − Requires Cognate CD 40 Maintenance and Function of Thymic B Cells B Cell Thymic Cross-Talk : − T Cell

  2014cites this paper
• Signalling mechanisms underlying priming and tolerance of T cells

  2013cites this paper
• Embryonic thymic epithelium differentiation in chicken : study of molecular signals involved in lymphoid progenitor cells colonization

  2012cites this paper
• Etude des mécanismes moléculaires impliqués dans l'infiltration cérébrale des lymphocytes T dans la maladie de Parkinson

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• Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.

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• Launching the T-Lineage Developmental Programme

  2011cites this paper
• The Role of Notch Signaling in Thymic Epithelium Development

  2011cites this paper
• Hematopoietic stem and progenitor cell trafficking.

  2011cites this paper
• The role of Notch signaling in thymic epithelium development

  2011cites this paper
• The role of Notch and GATA3 in postnatal and adult haematopoiesis

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• Notch Ligand Delta-Like 4 Regulates Development and Pathogenesis of Allergic Airway Responses by Modulating IL-2 Production and Th2 Immunity

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• Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.

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• This information is current as Production and Th 2 Immunity Airway Responses by Modulating IL-2 Development and Pathogenesis of Allergic Notch Ligand Delta-Like 4 Regulates

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• Adaptive immunity.

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• Thymus-homing precursors and the thymic microenvironment.

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