Drug transport across the blood-brain barrier

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Pharmaceutisch Weekblad

• Publication date

  1992-10-16

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/BF01977618PMID 1437514
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Blood-brain barrier transport of nutrients.

  2009cited by this paper
• Informational analysis of left-ventricle/systemic-arterial interaction

  2006cited by this paper
• Microscopical and ultrastructural investigations on the development of the blood-brain barrier in the chick embryo optic tectum

  2004cited by this paper
• Developmental microvascular architecture of the rat cerebellar cortex

  2004cited by this paper
• Development of membrane interactions between brain endothelial cells and astrocytes in vitro

  1988cited by this paper
• Myo-inositol transport through the blood-brain barrier

  1988cited by this paper
• Tight junction dynamics: is paracellular transport regulated?

  1988cited by this paper
• Selectivity of the endothelial monolayer: effects of increased permeability.

  1988cited by this paper
• Effect of alteration of cerebrospinal fluid bulk flow on nicotine cerebrospinal fluid exit transfer kinetics.

  1988cited by this paper
• Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs.

  1988cited by this paper
• Astrocytes induce blood–brain barrier properties in endothelial cells

  1987cited by this paper
• Caractéristiques du transport des analogues structuraux des hormones thyroïdiennes à travers la barrière hémato-encéphalique

  1987cited by this paper
• Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model.

  1987cited by this paper
• Current aspects of the development of the blood‐brain barrier

  1987cited by this paper
• [Characteristics of the transport of structural analogs of thyroid hormone through hemato-encephalic barrier].

  1987cited by this paper
• Blood-brain transport of nutrients. Introduction.

  1986cited by this paper
• Characterization of endothelial cell transport in the developing mouse blood-brain barrier.

  1986cited by this paper
• THE DEVELOPMENT OF THE HUMAN BLOOD‐BRAIN AND BLOOD‐CSF BARRIERS

  1986cited by this paper
• Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia

  1986cited by this paper
• Pharmacokinetic approaches to drug distribution in the cerebrospinal fluid based on ventricular administration in beagle dogs

  1985cited by this paper
• Lack of selectivity to small ions in paracellular pathways in cerebral and muscle capillaries of the frog.

  1984cited by this paper
• A study of intrathecal, cerebrospinal fluid-to-brain exchange.

  1984cited by this paper
• Transport of nutrients and hormones through the blood-brain barrier.

  1984cited by this paper
• Glial Cells Influence Polarity of the Blood‐Brain Barrier

  1983cited by this paper
• Comparison of lipid-mediated blood-brain-barrier penetrability in neonates and adults.

  1982cited by this paper
• Entry of bilirubin into the brain due to opening of the blood-brain barrier.

  1982cited by this paper
• Transport of nutrients and hormones through the blood-brain barrier

  1981cited by this paper
• The Concept of a Blood-Brain Barrier

  1980cited by this paper
• Drug transport into the central nervous system.

  1980cited by this paper
• Transport of proteins by diffusion, bulk flow and vesicular mechanisms.

  1980cited by this paper
• Transport of proteins by diffusion, bulk flow and vesicular mechanisms.

  1980cited by this paper
• gamma-Glutamyl transpeptidase in isolated brain endothelial cells: induction by glial cells in vitro.

  1980cited by this paper
• Carrier-mediated transport of thyroid hormones through the rat blood-brain barrier: primary role of albumin-bound hormone.

  1979cited by this paper
• THE EXCHANGE OF MATERIAL BETWEEN CEREBROSPINAL FLUID AND BRAIN

  1975cited by this paper
• Transport of material between brain extracellular fluid, brain cells and blood.

  1974cited by this paper
• Transport of material between brain extracellular fluid, brain cells and blood.

  1974cited by this paper
• FRACTURE FACES OF ZONULAE OCCLUDENTES FROM "TIGHT" AND "LEAKY" EPITHELIA

  1973cited by this paper
• A FINE STRUCTURAL ANALYSIS OF INTERCELLULAR JUNCTIONS IN THE MOUSE LIVER

  1970cited by this paper
• JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN

  1969cited by this paper
• FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

  1967cited by this paper
• Secretion of cerebrospinal fluid by the ventricular ependyma of the rabbit.

  1967cited by this paper
• Facilitated transfer of glucose from blood into brain tissue.

  1965cited by this paper
• The permeability of brain capillaries to non-electrolytes.

  1965cited by this paper
• Elektronenmikroskopische Befunde an den Capillaren der Hirnrinde

  1963cited by this paper
• [ELECTRON MICROSCOPIC FINDINGS IN THE CAPILLARIES OF THE CEREBRAL CORTEX].

  1963cited by this paper
• AN ELECTRON MICROSCOPIC STUDY OF THE BLOOD-BRAIN BARRIER IN THE RAT, EMPLOYING SILVER NITRATE AS A VITAL STAIN

  1955cited by this paper
• Transcapillary exchange of water and of other substances in certain organs of the dog.

  1955cited by this paper
• Filtration, diffusion and molecular sieving through peripheral capillary membranes; a contribution to the pore theory of capillary permeability.

  1951cited by this paper
• On the permeability of the blood-brain barrier.

  1948cited by this paper
• Croonian Lecture: The Active and Passive Exchanges of Inorganic Ions Through the Surfaces of Living Cells and Through Living Membranes Generally

  1946cited by this paper
• Die allgemeinen Grundlagen des Stoffaustausches zwischen dem Zentralnervensystem und dem übrigen Körper

  1934cited by this paper
• Die Bedeutung der vitalen Färbung für die Lehre vom Stoffaustausch zwischen dem Zentralnervensystem und dem übrigen Körper

  1934cited by this paper
• Die äussere und innere Sekretion des gesunden Organismus im Lichte der "vitalen Färbung"

  year unknowncited by this paper
• Journal of Cerebral Blood Flow and Metabolism Peering through the Windows of the Brain

  year unknowncited by this paper

• Deep Learning for Blood-Brain Barrier Permeability Prediction

  2025cites this paper
• Assessing central nervous system drug delivery

  2025cites this paper
• Computational Exploration of Bacterial Compounds Targeting Arginine-Specific Mono-Adp-Ribosyl-Transferase 1 (Art1): A Pathway to Novel Therapeutic Anticancer Strategies

  2025cites this paper
• Repurposing of CNS accumulating drugs Gemfibrozil and Doxylamine for enhanced sensitization of glioblastoma cells through modulation of autophagy

  2025cites this paper
• Blood-Brain Barrier: A Comprehensive Review of Its Structure, Function and Role in CNS Diseases

  2025cites this paper
• Nanoparticles as Game-Changers in Drug Delivery for Neurological Disorders

  2025cites this paper
• DREAM-B3P: Dual-Stream Transformer Network Enhanced by Feedback Diffusion Model for Blood-Brain Barrier Penetrating Peptide Prediction

  2025cites this paper
• Overcoming the Blood–Brain Barrier: Advanced Strategies in Targeted Drug Delivery for Neurodegenerative Diseases

  2025cites this paper
• Fingerprint-Based Explainable Machine Learning for Predicting Blood–Brain Barrier Permeability

  2025influential citation
• Emerging Role of Nanostructured Lipid Carriers in Overcoming Cancer Treatment Challenges.

  2025cites this paper
• Blood-brain barrier dysfunction in schizophrenia: Mechanisms and implications (Review)

  2025cites this paper
• Creation and Improvement of Nanoparticulate Drug Delivery Methods for Penetration of the Blood-Brain Barrier

  2025cites this paper
• A bottom-up approach to understanding ultrasound mediated blood–brain barrier opening using long and short pulses

  2025cites this paper
• A plug-and-play transepithelial/transendothelial electric resistance (TEER)-upgraded organ-on-chip system to measure barrier dynamics in real-time

  2025cites this paper
• Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases

  2025cites this paper
• Angulin-1/LSR inhibition transiently disrupts the blood-tumor barrier to enhance doxil permeability and impair malignant glioma progression

  2025cites this paper
• Computational Analysis of Biflavonoid Derivatives through Molecular Docking on ALK Kinase Receptor as Potential Inhibitors of A549 Cell Proliferation

  2025influential citation
• Effects of Luffa cylindrica (L.) Roem Extract on Microglial Activation-Mediated Mild Cognitive Impairment via Regulation of CREB Signaling Pathway

  2025cites this paper
• Exogenous Selenoprotein V Induces Apoptosis in Murine Testicular Teratoma Cells via Mitochondrial Dysfunction and ROS Overproduction

  2025cites this paper
• The Increasing Diagnostic Role of Exosomes in Inflammatory Diseases to Leverage the Therapeutic Biomarkers

  2024cites this paper
• Executive summary of the American Radium Society appropriate use criteria for brain metastases in epidermal growth factor receptor mutated-mutated and ALK-fusion non-small cell lung cancer

  2024cites this paper
• The potential of exosomal biomarkers: Revolutionizing Parkinson's disease: How do they influence pathogenesis, diagnosis, and therapeutic strategies?

  2024cites this paper
• A systematic review of normal tissue neurovascular unit damage following brain irradiation—Factors affecting damage severity and timing of effects

  2024cites this paper
• Multi-objective generative AI for designing novel brain-targeting small molecules

  2024cites this paper
• Anticancer effect of the oncolytic Newcastle disease virus harboring the PTEN gene on glioblastoma

  2024cites this paper
• Molecular Docking and Pharmacokinetic Profiling of Nab-paclitaxel as Advanced Chemotherapeutic Agent Against HER-2 Positive Breast Cancer Patients

  2024cites this paper
• Exploration of Type III effector Xanthomonas outer protein Q (XopQ) inhibitor from Picrasma quassioides as an antibacterial agent using chemoinformatics analysis

  2024cites this paper
• Drug Metabolism and Transport Capacity of Endothelial Cells, Pericytes, and Astrocytes: Implications for CNS Drug Disposition

  2024cites this paper
• Inverse stochastic resonance in adaptive small-world neural networks.

  2024cites this paper
• Systemic Treatment with siRNA Targeting Gamma-Secretase Activating Protein Inhibits Amyloid-β Accumulation in Alzheimer’s Disease

  2024cites this paper
• Formulation Development of Functional Oil Loaded Rizatriptan Benzoate Microemulsion: An In Vitro and Ex Vivo Insight

  2024cites this paper
• In-vitro gadolinium retro-microdialysis in agarose gel—a human brain phantom study

  2024cites this paper
• Therapeutic targeting of senescent cells in the CNS

  2024cites this paper
• Effect of sugammadex, rocuronium and sevoflurane on oxidative stress and apoptosis in cerebral ischemia reperfusion model in rats

  2024cites this paper
• Predictive bioactivity of compounds from Vitis gracilis leaf extract to counteract doxorubicin-induced cardiotoxicity via sirtuin 1 and adenosine monophosphate-activated protein kinase: An in-silico study

  2024cites this paper
• Revolutionizing neurotherapeutics: blood-brain barrier-on-a-chip technologies for precise drug delivery

  2024cites this paper
• Advancing cancer treatments: The role of oligonucleotide-based therapies in driving progress

  2024cites this paper
• Current clinical investigations of focused ultrasound blood-brain barrier disruption: A review

  2024cites this paper
• Recent Advances in Drug Delivery Systems for Targeting the Blood-Brain Barrier

  2024cites this paper
• Transporter-Mediated Drug Delivery

  2023cites this paper
• Silibinin effects on cognitive disorders: Hope or treatment?

  2023cites this paper
• Engineering Regionally-Activated Drugs for Neuroscience

  2023cites this paper
• Linezolid population pharmacokinetic model in plasma and cerebrospinal fluid among patients with tuberculosis meningitis

  2023cites this paper
• Linezolid Population Pharmacokinetic Model in Plasma and Cerebrospinal Fluid Among Patients With Tuberculosis Meningitis

  2023cites this paper
• Molecular and Pharmacokinetic Aspects of the Acetylcholinesterase-Inhibitory Potential of the Oleanane-Type Triterpenes and Their Glycosides

  2023cites this paper
• Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose

  2023cites this paper
• Targeting adverse effects of antiseizure medication on offspring: current evidence and new strategies for safety

  2023cites this paper
• Neostigmine and atropine as a treatment for postdural puncture headache after spinal anesthesia in cesarean section: A case report

  2023cites this paper
• Exosome Mediated Cancer Therapeutic Approach:Present Status and Future Prospectives

  2023cites this paper
• Molecular insight into the mechanism of action of some beneficial flavonoids for the treatment of Parkinson’s Disease

  2023cites this paper
• Thermal Threshold for Localized Blood-Brain Barrier Disruption

  2023cites this paper
• Selection of potential natural compounds for poly-ADP-ribose polymerase (PARP) inhibition in glioblastoma therapy by in silico screening methods

  2023cites this paper
• Nanoparticle-Based Drug Delivery Systems: Advances and Challenges in Nanomedicine

  2023cites this paper
• Synchronization in STDP-driven memristive neural networks with time-varying topology

  2023cites this paper
• Nanoparticle drug delivery to target breast cancer brain metastasis: Current and future trends

  2023cites this paper
• Therapeutic prospects of naturally occurring p38 MAPK inhibitors tanshinone IIA and pinocembrin for the treatment of SARS‐CoV‐2‐induced CNS complications

  2023cites this paper
• Alpha-synuclein expression in neuron modulates the Japanese encephalitis virus infection

  2023cites this paper
• Transport of nanocarriers to brain for treatment of glioblastoma multiforme: Routes and challenges

  2023cites this paper
• Lung infection by P. aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice

  2023cites this paper
• Aptamers in neuro-oncology: An emerging therapeutic modality

  2023cites this paper
• Considering developmental neurotoxicity in vitro data for human health risk assessment using physiologically-based kinetic modeling: deltamethrin case study

  2023cites this paper
• The Dysregulated MAD in Mad: A Neuro-theranostic Approach Through the Induction of Autophagic Biomarkers LC3B-II and ATG

  2023cites this paper
• Synergistic induction of blood–brain barrier properties

  2023cites this paper
• Comparing and contrasting the use of nanoparticle-assisted drug-delivery of antidepressants to that of the gold standard

  2023cites this paper
• A Comprehensive Study on Nanoparticle Drug Delivery to the Brain: Application of Machine Learning Techniques

  2023cites this paper
• Brain-Penetrating Peptide Shuttles across the Blood-Brain Barrier and Extracellular-like Space.

  2023cites this paper
• Advancement In Neuroplasticity Trainings in Multiple Fields Since 2018

  2023cites this paper
• Recent advances in the in vitro and in vivo methods to assess impact of P‐glycoprotein and breast cancer resistance protein transporters in central nervous system drug disposition

  2023cites this paper
• Bioinspired Approaches for Central Nervous System Targeted Gene Delivery.

  2023cites this paper
• Alzheimer's disease brain endothelial-like cells reveal differential drug transporter expression and modulation by potentially therapeutic focused ultrasound

  2023cites this paper
• Research progress on ferroptosis in gliomas (Review)

  2023cites this paper
• In-silico Investigation of Potential Inhibitors of 11-β-Hydroxysteroid Dehydrogenase

  2023cites this paper
• Are TrkB receptor agonists the right tool to fulfill the promises for a therapeutic value of the brain-derived neurotrophic factor?

  2023cites this paper
• Microfluidic Organ-on-a-Chip System for Disease Modeling and Drug Development

  2022cites this paper
• Selective brain entry of lipid nanoparticles in haemorrhagic stroke is linked to biphasic blood-brain barrier disruption

  2022cites this paper
• Nt5e deficiency does not affect post-stroke inflammation and lesion size in a murine ischemia/reperfusion stroke model

  2022cites this paper
• Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy

  2022cites this paper
• Establishing Novel Doxorubicin-Loaded Polysaccharide Hydrogel for Controlled Drug Delivery for Treatment of Pediatric Brain Tumors

  2022cites this paper
• A novel strategy for delivering Niemann‐Pick type C2 proteins across the blood–brain barrier using the brain endothelial‐specific AAV‐BR1 virus

  2022cites this paper
• Multidrug Resistance-1 C3435T Polymorphism and Carbamazepine Plasma Level in Indonesian Temporal Lobe Epilepsy Patients

  2022cites this paper
• Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics

  2022cites this paper
• Crossing the Blood-Brain Barrier: Advances in Nanoparticle Technology for Drug Delivery in Neuro-Oncology

  2022cites this paper
• Computational Assessment of Different Structural Models for Claudin-5 Complexes in Blood–Brain Barrier Tight Junctions

  2022cites this paper
• Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration

  2022cites this paper
• Direct CNS administration of rituximab and epratuzumab in a pediatric patient with relapsed refractory CNS B‐cell acute lymphoblastic leukemia

  2022cites this paper
• Histological reinterpretation of paraphysis cerebri in Ambystoma mexicanum.

  2022cites this paper
• Biosensors Integration in Blood–Brain Barrier-on-a-Chip: Emerging Platform for Monitoring Neurodegenerative Diseases

  2022cites this paper
• Engineering antibody and protein therapeutics to cross the blood–brain barrier

  2022influential citation
• Advances in Antibody-Based Therapeutics for Cerebral Ischemia

  2022cites this paper
• Semi-Automatic Medical Syringe Pump Development: Interface, Control, Alarm, and Feedback

  2022cites this paper
• A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics

  2022cites this paper
• Antibody-Based In Vivo Imaging of Central Nervous System Targets—Evaluation of a Pretargeting Approach Utilizing a TCO-Conjugated Brain Shuttle Antibody and Radiolabeled Tetrazines

  2022cites this paper
• Trotabresib, an oral potent bromodomain and extraterminal inhibitor, in patients with high-grade gliomas: A phase I, “window-of-opportunity” study

  2022cites this paper
• Comparison of Comprehensive Screening Results in Postmortem Blood and Brain Tissue by UHPLC–QTOF-MS

  2022cites this paper
• Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma

  2022cites this paper
• Membrane Vesicles Derived from Gut Microbiota and Probiotics: Cutting-Edge Therapeutic Approaches for Multidrug-Resistant Superbugs Linked to Neurological Anomalies

  2022cites this paper
• Antioxidant Intervention to Improve Cognition in the Aging Brain: The Example of Hydroxytyrosol and Resveratrol

  2022cites this paper
• 2D-QSAR and Molecular Docking based virtual screening of the herbal molecules against Alzheimer’s Disorder: An approach to predict CNS activity

  2022cites this paper
• Extracellular vesicle–based drug delivery system boosts phytochemicals’ therapeutic effect for neurodegenerative diseases

  2022cites this paper
• Regulation of pathological blood-brain barrier for intracranial enhanced drug delivery and anti-glioblastoma therapeutics

  2022cites this paper