Antibacterial and modulatory activities of β-cyclodextrin complexed with (+)-β-citronellol against multidrug-resistant strains.

The present study aimed to investigate the antibacterial and modulatory activities of (+)-β-citronellol (βCT), β-cyclodextrin (β-CD), and their complex βCT/β-CD and characterize them using infrared spectroscopy. Infrared spectra were recorded in the 750-4000 cm-1 region. The antibacterial effects of these compounds and their modulatory-antibiotic activities were determined using the minimum inhibitory concentration (MIC) test. Signatures of these pure compounds were detected in the infrared spectrum of the βCT/β-CD complex. The MIC of the βCT/β-CD complex against the tested strains was found to be 1024 μg/mL. The antagonistic and synergistic effects of these compounds were also observed using the modulation tests. βCT or β-CD alone did not exhibit any direct antibacterial activity. However, the βCT/β-CD complex in combination with gentamicin showed a synergistic effect against E. coli.

• Publication year

  2021

• Venue

  Microbial Pathogenesis

• Publication date

  2021-05-03

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.micpath.2021.104928PMID 33957243
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Encapsulation of essential oil components with methyl-β-cyclodextrin using ultrasonication: Solubility, characterization, DPPH and antibacterial assay.

  2020cited by this paper
• Structural, vibrational and electrochemical analysis and antibiotic activity study of chalcone (2E)-1-(3ʹ,-methoxy-4ʹ,-hydroxyphenyl)-3-(3-nitrophenyl)prop-2-en-1-one

  2020cited by this paper
• Cyclodextrin–Drug Inclusion Complexes: In Vivo and In Vitro Approaches

  2019cited by this paper
• Comparative analysis of the antibacterial and drug‐modulatory effect of D‐limonene alone and complexed with &bgr;‐cyclodextrin

  2019cited by this paper
• Ultrasound processed cuminaldehyde/2-hydroxypropyl-β-cyclodextrin inclusion complex: Preparation, characterization and antibacterial activity.

  2019cited by this paper
• Structural and Microbiological Characterization of 5-Hydroxy-3,7,4′-Trimethoxyflavone: A Flavonoid Isolated from Vitex gardneriana Schauer Leaves

  2019cited by this paper
• Crystal structures and molecular dynamics studies of the inclusion compounds of β-citronellol in β-cyclodextrin, heptakis(2,6-di-O-methyl)-β-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin

  2018cited by this paper
• Plasma-treated poly(ethylene oxide) nanofibers containing tea tree oil/beta-cyclodextrin inclusion complex for antibacterial packaging.

  2018cited by this paper
• Spectroscopic and microbiological characterization of labdane diterpene 15,16-epoxy-4-hydroxy-labda-13(16),14-dien-3,12-dione isolated from the stems of Croton jacobinensis

  2017cited by this paper
• Evaluation of the antibacterial and modulatory potential of α-bisabolol, β-cyclodextrin and α-bisabolol/β-cyclodextrin complex.

  2017cited by this paper
• Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin.

  2017cited by this paper
• Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance.

  2016cited by this paper
• Antimicrobial Resistance of Escherichia coli, Enterococci, Pseudomonas aeruginosa, and Staphylococcus aureus from Raw Fish and Seafood Imported into Switzerland.

  2016cited by this paper
• Inclusion of terpenes in cyclodextrins: Preparation, characterization and pharmacological approaches.

  2016cited by this paper
• Assessing the antibiotic susceptibility of freshwater Cyanobacteria spp.

  2015cited by this paper
• Comparative Evaluation of the Modulation of Antibiotic-Activity against Strains of Escherichia coli and Staphylococcus aureus

  2015cited by this paper
• Avaliação in vitro das características antimicrobianas de sugamadex

  2014cited by this paper
• A status review on the medicinal properties of essential oils

  2014cited by this paper
• Atividade antibacteriana, antifúngica e moduladora da atividade antimicrobiana de frações obtidas de Lygodium venustum SW

  2013cited by this paper
• Aminoglycosides: how should we use them in the 21st century?

  2013cited by this paper
• Investigation of inclusion complexes of citronella oil, citronellal and citronellol with β-cyclodextrin for mosquito repellent

  2012cited by this paper
• Atividade antimicrobiana de óleos essenciais em bactérias patogênicas de origem alimentar

  2012cited by this paper
• Atividade antibacteriana In vitro de Croton campestris A., Ocimum gratissimum L. e Cordia verbenacea DC.

  2010cited by this paper
• Interferência de extratos da Baccharis dracunculifolia DC., Asteraceae, sobre a atividade de antibióticos usados na clínica

  2010cited by this paper
• Enhancement of the Antibiotic Activity against a Multiresistant Escherichia coli by Mentha arvensis L. and Chlorpromazine

  2008cited by this paper
• In vitro anti-staphylococcal activity of Hyptis martiusii Benth against methicillin-resistant Staphylococcus aureus: MRSA strains

  2008cited by this paper
• Preparação e caracterização físico-química de complexos de inclusão entre anestésicos locais e hidroxipropil-beta-ciclodextrina

  2007cited by this paper
• Interaction of four monoterpenes contained in essential oils with model membranes: implications for their antibacterial activity.

  2007cited by this paper
• Molecular understanding of aminoglycoside action and resistance

  2006cited by this paper
• Essential oils: their antibacterial properties and potential applications in foods--a review.

  2004cited by this paper
• Resazurin Microtiter Assay Plate: Simple and Inexpensive Method for Detection of Drug Resistance in Mycobacterium tuberculosis

  2002cited by this paper
• Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?

  2002cited by this paper
• Screening of some plants from Northern Argentina for their antimicrobial activity

  2001cited by this paper
• Aminoglycosides: Activity and Resistance

  1999cited by this paper
• Chapter 17 - Thermal analysis and calorimetry of pharmaceuticals

  1999cited by this paper
• Structures of Gram-Negative Cell Walls and Their Derived Membrane Vesicles

  1999cited by this paper
• De Novo Antimicrobial Peptides with Low Mammalian Cell Toxicity

  1996cited by this paper
• De novo antimicrobial peptides with low mammalian cell toxicity.

  1996cited by this paper
• Mechanisms of membrane toxicity of hydrocarbons

  1995cited by this paper
• Mechanisms of membrane toxicity of hydrocarbons.

  1995cited by this paper
• Agents that increase the permeability of the outer membrane

  1992cited by this paper
• Agents that increase the permeability of the outer membrane.

  1992cited by this paper
• Crystal and molecular structure of cyclohepta-amylose dodecahydrate

  1982cited by this paper
• Stretching Frequencies as a Function of Distances in Hydrogen Bonds

  1955cited by this paper

• Enhancement of biopharmaceutical properties of oxytetracycline hydrochloride through β-cyclodextrin complexes and its photodegradation by metallic nanoparticles.

  2025cites this paper
• Protective effects of citronellol on Escherichia coli septicemia-derived liver lesions in Wistar rats

  2025cites this paper
• Advances in cyclodextrin-based materials: Anticancer and antimicrobial applications–A review (2021–2024)

  2025cites this paper
• Monodisperse oligo(ε-caprolactones) with terpenes and alkyl end-groups: synthesis, isolation, characterization, and antibacterial activity

  2025cites this paper
• Evaluation of the antibacterial and inhibitory activity of the NorA efflux pump in Staphylococcus aureus by citronellol

  2025cites this paper
• Antibacterial Activity and Modulatory Effects of Bowdichia virgilioides Ethanolic Extract and Its β-Cyclodextrin Inclusion Complex Against Multidrug-Resistant Bacteria

  2025cites this paper
• Chemoenzymatic oxidation of citronellol and geraniol: Synthesis and antibacterial activity assessment.

  2025cites this paper
• Essential Oils as Green Antibacterial Modifiers of Polymeric Materials

  2025cites this paper
• Preparation, structural analysis of alcohol aroma compounds/β-cyclodextrin inclusion complexes and the application in strawberry preservation.

  2024cites this paper
• Cornstarch aerogels with thymol, citronellol, carvacrol, and eugenol prepared by supercritical CO2- assisted techniques for potential biomedical applications.

  2024cites this paper
• Evaluation of the inhibitory effect of isopulegol (ISO) and its β-cyclodextrin inclusion complex (ISO/β-CD) on the reversal of Staphylococcus aureus efflux pump activity

  2024cites this paper
• Phytochemical profiling, antidiabetic, antiobesity, and antibacterial activities of Cometes abyssinica

  2024cites this paper
• Green Synthesis of Magnetic Supramolecules β-Cyclodextrin/Iron Oxide Nanoparticles for Photocatalytic and Antibacterial Applications

  2023cites this paper
• Optimization of solvent-free microwave extraction of essential oil from the fresh peel of Citrus medica L. var. arcodactylis Swingle by response surface methodology, chemical composition and activity characterization

  2023cites this paper
• Aromatherapeutic and Antibacterial Properties of Cotton Materials Treated with Emulsions Containing Peppermint Essential Oil (Menthae piperitae aetheroleum)

  2023cites this paper
• Antibacterial drugs and cyclodextrin inclusion complexes: a patent review

  2023cites this paper
• Potentiation of the Activity of Antibiotics against ATCC and MDR Bacterial Strains with (+)-α-Pinene and (-)-Borneol

  2022cites this paper
• Anticancer and antibacterial activities of embelin: micro and nano aspects

  2022cites this paper
• Discrimination of the Essential Oils Obtained from Four Apiaceae Species Using Multivariate Analysis Based on the Chemical Compositions and Their Biological Activity

  2021cites this paper
• Sustainable Biotechnological Production of Citronellol: Advances in Biosynthesis, Metabolic Engineering, and Applications

  year unknowncites this paper