Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptors.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Brain Research

• Publication date

  2000-05-19

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0006-8993(00)02246-0PMID 10814735
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study.

  1999cited by this paper
• Selective blockade of serotonin2C/2B receptors enhances dopamine release in the rat nucleus accumbens.

  1998cited by this paper
• 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential.

  1998cited by this paper
• A subset of ventral tegmental area neurons is inhibited by dopamine, 5-hydroxytryptamine and opioids.

  1997cited by this paper
• Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats

  1997cited by this paper
• SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.

  1997cited by this paper
• BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats.

  1997cited by this paper
• Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system.

  1997cited by this paper
• Regional effects of MK-801 on dopamine release: effects of competitive NMDA or 5-HT2A receptor blockade.

  1996cited by this paper
• 5HT2C receptor agonists exhibit antidepressant-like properties in the anhedonia model of depression in rats.

  1996cited by this paper
• Actions of 5-hydroxytryptamine on ventral tegmental area neurons of the rat in vitro.

  1994cited by this paper
• International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

  1994cited by this paper
• Serotonin-dopamine interaction in the rat ventral tegmental area: an electrophysiological study in vivo.

  1994cited by this paper
• Synaptic structure and connectivity of serotonin terminals in the ventral tegmental area: potential sites for modulation of mesolimbic dopamine neurons.

  1994cited by this paper
• Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors.

  1994cited by this paper
• 5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.

  1989cited by this paper
• The control of firing pattern in nigral dopamine neurons: burst firing

  1984cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: A horseradish peroxidase study in the rat

  1979cited by this paper
• An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat

  1978cited by this paper

• The therapeutic potential of psilocybin beyond psychedelia through shared mechanisms with ketamine

  2025cites this paper
• Revisiting the Role of Serotonin in Attention-Deficit Hyperactivity Disorder: New Insights from Preclinical and Clinical Studies

  2025cites this paper
• 5-HT2A receptors shape whole-brain monoaminergic coherence in male mice.

  2025cites this paper
• Serotonin 5-HT2C Receptor Signaling Analysis Reveals Psychedelic Biased Agonism.

  2025cites this paper
• Classical psychedelics' action on brain monoaminergic systems.

  2024cites this paper
• Innate cocaine-seeking vulnerability arising from loss of serotonin-mediated aversive effects of cocaine in rats.

  2023cites this paper
• Acute anxiogenic effects of escitalopram are associated with mild alterations in d-amphetamine-induced behavior and social approach evoked by playback of 50-kHz ultrasonic vocalizations.

  2023cites this paper
• Open-label pilot of lorcaserin (a serotonin 2C-receptor agonist) for cannabis use disorder

  2023cites this paper
• Modafinil acquires reinforcing effects when combined with citalopram.

  2022cites this paper
• Effects of pimavanserin and lorcaserin on alcohol self-administration and reinstatement in male and female rats.

  2022cites this paper
• Lateral Habenula 5-HT2C Receptor Function Is Altered by Acute and Chronic Nicotine Exposures

  2021cites this paper
• Serotonin 2B Receptor Interactions with Dopamine Network: Implications for Therapeutics in Schizophrenia

  2021cites this paper
• Measuring mania‐like elevated mood through amphetamine‐induced 50‐kHz ultrasonic vocalizations in rats

  2021cites this paper
• Serotonin/dopamine interaction: Electrophysiological and neurochemical evidence.

  2021cites this paper
• Progression of anorexia nervosa: An insight into neurological and biological mechanisms influencing the personality patterns of anorexics

  2021cites this paper
• The serotonin 2C receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge‐like ethanol drinking

  2021cites this paper
• The serotonin2B receptor and neurochemical regulation in the brain

  2020cites this paper
• Lorcaserin: a review of its preclinical and clinical pharmacology and therapeutic potential.

  2020cites this paper
• Cognitive flexibility in humans and other laboratory animals

  2020cites this paper
• Serotonin-2B receptor antagonism increases the activity of dopamine and glutamate neurons in the presence of selective serotonin reuptake inhibition

  2020cites this paper
• Investigating the Potential Role of Serotonin-2B Receptor Antagonism in the Neuronal Actions of Adjunctive Aripiprazole

  2020cites this paper
• Constitutive activity of 5-HT receptors: Factual analysis.

  2020cites this paper
• Neurochemical impact of the 5‐HT2C receptor agonist WAY‐163909 on monoamine tissue content in the rat brain

  2019cites this paper
• Effect of the 5-HT2C Receptor Agonist WAY-163909 on Serotonin and Dopamine Metabolism across the Rat Brain: A Quantitative and Qualitative Neurochemical Study

  2019cites this paper
• Effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on ethanol consumption and place conditioning in male mice

  2019cites this paper
• Lorcaserin bidirectionally regulates dopaminergic function site-dependently and disrupts dopamine brain area correlations in rats.

  2019cites this paper
• Impact of Sleep–Wake-Associated Neuromodulators and Repetitive Low-Frequency Stimulation on Human iPSC-Derived Neurons

  2019cites this paper
• Preclinical evidence for combining the 5‐HT2C receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence

  2019cites this paper
• 5‐HT2C receptors in the ventral tegmental area, but not in the arcuate nucleus, mediate the hypophagic and hypolocomotor effects of the selective 5‐HT2C receptor agonist AR231630 in rats

  2018cites this paper
• Serotonergic Psychedelics: Experimental Approaches for Assessing Mechanisms of Action.

  2018cites this paper
• The central serotonin2B receptor as a new pharmacological target for the treatment of dopamine‐related neuropsychiatric disorders: Rationale and current status of research

  2018cites this paper
• Lorcaserin as a potential opioid-sparing adjunct

  2018cites this paper
• A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment

  2017cites this paper
• History Of The 5-HT 2 C Receptor : From The Choroid Plexus To Depression , Obesity And Addiction Treatment

  2017cites this paper
• Effect of Lorcaserin Alone and in Combination with Phentermine on Food Cravings after 12 week-treatment: Randomized Sub-study

  2017cites this paper
• Effects of 5-HT1A, 5-HT2A and 5-HT2C receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate

  2017cites this paper
• El agonista del receptor de serotonina-2C Ro 60-0175 decrementa la expresión de la sensibilización locomotora inducida por etanol

  2017cites this paper
• Increased temporal discounting after chronic stress in CHL1-deficient mice is reversed by 5-HT2C agonist Ro 60-0175.

  2017cites this paper
• El agonista del receptor de serotonina-2C Ro 60-0175 decrementa la expresión de la sensibilización locomotora inducida por etanol

  2017cites this paper
• Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice

  2017cites this paper
• An Examination of Goal-Directed Motivation in Mice: The Role of Dopamine D2 and Serotonin 2C Receptors

  2017cites this paper
• Investigating the Mechanisms by which Serotonin Influences Incentive Motivation

  2017cites this paper
• Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications

  2017influential citation
• 5-HT2C receptors in psychiatric disorders: A review.

  2016cites this paper
• Activation of serotonin 5-HT(2C) receptor suppresses behavioral sensitization and naloxone-precipitated withdrawal symptoms in morphine-dependent mice.

  2016cites this paper
• Progress in Neurobiology How serotonin receptors regulate morphogenic signalling in neurons

  2016cites this paper
• New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders.

  2016cites this paper
• The effects of pharmacological modulation of the serotonin 2C receptor on goal-directed behavior in mice

  2016cites this paper
• Reward-Induced Eating: Therapeutic Approaches to Addressing Food Cravings

  2016cites this paper
• Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation

  2016cites this paper
• The serotonin 5-HT2C receptor and the non-addictive nature of classic hallucinogens

  2016influential citation
• New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders.

  2016cites this paper
• Fluoxetine Administration Exacerbates Oral Tremor and Striatal Dopamine Depletion in a Rodent Pharmacological Model of Parkinsonism

  2015cites this paper
• HTR1A Gene Polymorphisms and 5-HT1A Receptor Partial Agonist Antipsychotics Efficacy in Schizophrenia

  2015cites this paper
• Antinociceptive activity of the new triple reuptake inhibitor NS18283 in a mouse model of chemotherapy‐induced neuropathic pain

  2015cites this paper
• Acute effects of the designer drugs benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) using functional magnetic resonance imaging (fMRI) and the Stroop task—a pilot study

  2015cites this paper
• 5-HT2C Receptor Desensitization Moderates Anxiety in 5-HTT Deficient Mice: From Behavioral to Cellular Evidence

  2015cites this paper
• The effects of systemic administration and local microinjection into the central nervous system of the selective serotonin 5-HT2C receptor agonist RO-600175 on sleep and wakefulness in the rat

  2015cites this paper
• HTR1A Polymorphisms and Clinical Efficacy of Antipsychotic Drug Treatment in Schizophrenia: A Meta-Analysis

  2015cites this paper
• Dorsal raphe 5-HT(2C) receptor and GABA networks regulate anxiety produced by cocaine withdrawal.

  2015cites this paper
• COCAINE-INDUCED BEHAVIORAL SENSITIZATION AND CONDITIONED PLACE PREFERENCE IN JAPANESE QUAIL ( COTURNIX JAPONICA ): A FOCUS ON SEX DIFFERENCES AND DOPAMINERGIC MECHANISMS

  2015cites this paper
• Characteristics of Tremorogenesis and Tremorolytic Agents in a Pharmacological Rodent Model of Parkinsonism: Evidence from Behavioral, Neurochemical, and Electrophysiological Studies

  2015cites this paper
• Abnormal Development of Monoaminergic Neurons Is Implicated in Mood Fluctuations and Bipolar Disorder

  2015cites this paper
• Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity.

  2015cites this paper
• Role of 5-HT2C receptors in effects of monoamine releasers on intracranial self-stimulation in rats

  2015cites this paper
• Environmental and Pharmacological Modulation of Amphetamine-Induced 50-kHz Ultrasonic Vocalizations in Rats

  2015influential citation
• Critical involvement of 5-HT2C receptor function in amphetamine-induced 50-kHz ultrasonic vocalizations in rats

  2015cites this paper
• Activation of serotonin 5-HT(2C) receptor suppresses behavioral sensitization and naloxone-precipitated withdrawal symptoms in heroin-treated mice.

  2015cites this paper
• Therapeutic Potential of 5-HT2C Receptor Agonists for Addictive Disorders.

  2015cites this paper
• Lorcaserin, a selective 5-HT(2C) receptor agonist, decreases alcohol intake in female alcohol preferring rats.

  2014cites this paper
• Responding for a conditioned reinforcer, and its enhancement by nicotine, is blocked by dopamine receptor antagonists and a 5-HT(2C) receptor agonist but not by a 5-HT(2A) receptor antagonist.

  2014cites this paper
• RESEARCH AND REVIEWS: JOURNAL OF PHARMACOLOGY AND TOXICOLOGICAL STUDIES Effect of Antidepressant Fluoxetine A SSRI on Dopamine Dependent Behaviours in Rats.

  2014cites this paper
• Role of Central Serotonin Receptors in Nicotine Addiction

  2014cites this paper
• Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5‐HT)2A and DA D2 antagonism and 5‐HT1A partial agonism

  2014cites this paper
• Whole tobacco smoke extracts to model tobacco dependence in animals.

  2014cites this paper
• Insights into the influence of 5-HT2c aminoacidic variants with the inhibitory action of serotonin inverse agonists and antagonists

  2014cites this paper
• Determinants of Abuse-Related Effects of Monoamine Releasers in Rats

  2013cites this paper
• Antagonizing 5-HT₂A receptors with M100907 and stimulating 5-HT₂C receptors with Ro60-0175 blocks cocaine-induced locomotion and zif268 mRNA expression in Sprague-Dawley rats.

  2013cites this paper
• Interaction between serotonin transporter and dopamine D2/D3 receptor radioligand measures is associated with harm avoidant symptoms in anorexia and bulimia nervosa.

  2013cites this paper
• Multiple controls exerted by 5-HT2C receptors upon basal ganglia function: from physiology to pathophysiology

  2013cites this paper
• Differential responses to anticipation of reward after an acute dose of the designer drugs benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) alone and in combination using functional magnetic resonance imaging (fMRI)

  2013cites this paper
• From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists.

  2013cites this paper
• Harmine augments electrically evoked dopamine efflux in the nucleus accumbens shell

  2013cites this paper
• Relations astrocytes-neurones et mécanismes d'action des inhibiteurs sélectifs de recapture de la sérotonine : rôle du BDNF et des récepteurs 5-HT2A

  2013cites this paper
• Serotonin (2C) receptor regulation of cocaine-induced conditioned place preference and locomotor sensitization.

  2013cites this paper
• 5‐HT2A receptor blockade and 5‐HT2C receptor activation interact to reduce cocaine hyperlocomotion and fos protein expression in the caudate‐putamen

  2012cites this paper
• 5-HT 2 ligands in the treatment of anxiety and depression

  2012cites this paper
• The Regulation of Brain Serotonergic and Dopaminergic Neurons: The Modulatory Effects of Selective Serotonin Reuptake Inhibitors, Atypical Neuroleptics and Environmental Enrichment

  2012cites this paper
• Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement.

  2012cites this paper
• 5-HT2 ligands in the treatment of anxiety and depression

  2012cites this paper
• Current status of functional imaging in eating disorders.

  2012cites this paper
• Investigating the effects of an acute dose of benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) alone and in combination on the human brain using functional Magnetic Resonance Imaging (fMRI)

  2012influential citation
• Effets neurophysiologiques de la stimulation du nerf vague : implication dans le traitement de la dépression résistante et optimisation des paramètres de stimulation

  2012cites this paper
• A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference.

  2011cites this paper
• Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons.

  2011cites this paper
• The Role of 5-HT2C Receptors in the Pathophysiology and Treatment of Depression

  2011cites this paper
• 5-HT2C Receptors in Learning

  2011cites this paper
• The Constitutive Activity of 5-HT2C Receptors as an Additional Modality of Interaction of the Serotonergic System

  2011cites this paper
• The Role of 5-HT2A/2C Receptors in Sleep and Waking

  2011cites this paper
• Ethanol Modulation of GABAergic Inhibition in Midbrain Dopamine Neurons: Implications for the Development of Alcohol-Seeking Behaviors

  2011cites this paper