The potential role of nucleophosmin (NPM1) in the development of cancer

Nucleophosmin (NPM1) is a well‐known nucleocytoplasmic shuttling protein that performs several cellular functions such as ribosome biogenesis, chromatin remodeling, genomic stability, cell cycle progression, and apoptosis. NPM1 has been identified to be necessary for normal cellular functions, and its altered regulation by overexpression, mutation, translocation, loss of function, or sporadic deletion can lead to cancer and tumorigenesis. In this review, we focus on the gene and protein structure of NPM1 and its physiological roles. Finally, we discuss the association of NPM1 with various types of cancer including solid tumors and leukemia.

• Publication year

  2021

• Venue

  Journal of Cellular Physiology

• Publication date

  2021-05-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jcp.30406PMID 33959979
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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