Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

No abstract is available for this paper.

• Publication year

  2000

• Venue

  EMBO Reports

• Publication date

  2000-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/embo-reports/kvd018PMID 11256629PMCID PMC1083693
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Myelodysplastic syndromes: introduction.

  2001cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Use of CDC2 from etoposide-treated cells as substrate to assay CDC25 phosphatase activity.

  1999cited by this paper
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• A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2

  1999influential reference
• Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25.

  1999cited by this paper
• Ectopic Expression of Cdc25A Accelerates the G1/S Transition and Leads to Premature Activation of Cyclin E- and Cyclin A-Dependent Kinases

  1999influential reference
• CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase

  1999cited by this paper
• A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways.

  1999cited by this paper
• The cdc25B phosphatase is essential for the G2/M phase transition in human cells.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• cdc25 cell cycle-activating phosphatases and c-myc expression in human non-Hodgkin's lymphomas.

  1998cited by this paper
• Regulation of DNA-replication origins during cell-cycle progression

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• UBPY: a growth‐regulated human ubiquitin isopeptidase

  1998cited by this paper
• Elevated expression of the cdc25A protein phosphatase in colon cancer.

  1998cited by this paper
• Phosphorylation of Human CDC25B Phosphatase by CDK1-Cyclin A Triggers Its Proteasome-dependent Degradation*

  1997cited by this paper
• Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15

  1997cited by this paper
• Overexpression of Cyclin‐dependent Kinase‐activating CDC25B Phosphatase in Human Gastric Carcinomas

  1997cited by this paper
• Cdc25 protein phosphatases in cell proliferation.

  1997cited by this paper
• Overexpression of CDC25A and CDC25B in head and neck cancers.

  1997cited by this paper
• Pub1 acts as an E6‐AP‐like protein ubiquitiin ligase in the degradation of cdc25.

  1996cited by this paper
• Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells.

  1996cited by this paper
• Cdc25 cell-cycle phosphatase as a target of c-myc

  1996cited by this paper
• A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage.

  1995cited by this paper
• Requirement for tyrosine phosphorylation of Cdk4 in Gl arrest induced by ultraviolet irradiation

  1995cited by this paper
• CDC25 phosphatases as potential human oncogenes.

  1995cited by this paper
• Cdc25A is a novel phosphatase functioning early in the cell cycle.

  1994influential reference
• Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain.

  1994cited by this paper
• Activation of the phosphatase activity of human cdc25A by a cdk2‐cyclin E dependent phosphorylation at the G1/S transition.

  1994cited by this paper
• Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase.

  1993cited by this paper
• Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

  1992cited by this paper
• Recognition of the adenovirus type 2 origin of DNA replication by the virally encoded DNA polymerase and preterminal proteins.

  1992cited by this paper
• Mechanism of action of hydroxyurea.

  1992cited by this paper
• Cyclin A is required at two points in the human cell cycle.

  1992cited by this paper
• Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins.

  1991cited by this paper
• An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells.

  1991cited by this paper
• p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells.

  1991cited by this paper
• Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2.

  1990cited by this paper
• Inhibition of ribonucleoside diphosphate reductase by hydroxyurea.

  1968cited by this paper

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  2023cites this paper
• MAP kinases may mediate regulation of the cell cycle in rice by E2F2 phosphorylation

  2023cites this paper
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  2023cites this paper
• An autonomous mathematical model for the mammalian cell cycle

  2022cites this paper
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  2021cites this paper
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  2020cites this paper
• Less-well known functions of cyclin/CDK complexes.

  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019influential citation
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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• The interaction between Rad9 and Tousled-like kinase 1 in the cell cycle and the DNA damage response

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• 14-3-3 proteins as signaling integration points for cell cycle control and apoptosis.

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• Arabidopsis T-DNA insertional lines for CDC25 are hypersensitive to hydroxyurea but not to zeocin or salt stress.

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