Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Molecular Biology of the Cell

• Publication date

  1999-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.10.11.3787PMID 10564271PMCID PMC25679
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.

  1999cited by this paper
• Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

  1999cited by this paper
• The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex.

  1999cited by this paper
• Protein Serine/Threonine Phosphatase Ptc2p Negatively Regulates the Unfolded-Protein Response by Dephosphorylating Ire1p Kinase

  1998cited by this paper
• Palindrome with Spacer of One Nucleotide Is Characteristic of thecis-Acting Unfolded Protein Response Element inSaccharomyces cerevisiae *

  1998cited by this paper
• The unfolded protein response: an intracellular signalling pathway with many surprising features.

  1998cited by this paper
• Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

  1998cited by this paper
• Endoplasmic Reticulum Stress Proteins Block Oxidant-induced Ca2+ Increases and Cell Death*

  1998cited by this paper
• Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins

  1998cited by this paper
• The unfolded protein response : an intracellular signalling pathway with many surprising features

  1998cited by this paper
• Roles for proteolysis and trafficking in notch maturation and signal transduction.

  1998cited by this paper
• Unconventional Splicing of HAC1/ERN4 mRNA Required for the Unfolded Protein Response

  1998cited by this paper
• Cloning of mammalian Ire1 reveals diversity in the ER stress responses

  1998cited by this paper
• A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.

  1998cited by this paper
• The eS-Sence of -SH in the ER.

  1998cited by this paper
• Immunoglobulin Binding Protein (BiP) Function Is Required to Protect Cells from Endoplasmic Reticulum Stress but Is Not Required for the Secretion of Selective Proteins*

  1997cited by this paper
• The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane.

  1997cited by this paper
• The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.

  1997cited by this paper
• The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response.

  1997cited by this paper
• Interaction of ATF6 and serum response factor

  1997influential reference
• Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response.

  1997cited by this paper
• Endoplasmicreticulum-induced signal transduction and gene expression.

  1997cited by this paper
• Translational attenuation mediated by an mRNA intron.

  1997influential reference
• A Novel Mechanism for Regulating Activity of a Transcription Factor That Controls the Unfolded Protein Response

  1996influential reference
• tRNA ligase is required for regulated mRNA splicing in the unfolded protein response.

  1996cited by this paper
• Saccharomyces cerevisiae IRE 2 / HAC 1 is involved in IRE 1-mediated KAR 2 expression

  1996cited by this paper
• The Unfolded Protein Response Pathway in Saccharomyces cerevisiae

  1996cited by this paper
• Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment.

  1996cited by this paper
• Calcium-sensitive Transcriptional Activation of the Proximal CCAAT Regulatory Element of the grp78/BiP Promoter by the Human Nuclear Factor CBF/NF-Y*

  1996cited by this paper
• Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.

  1996cited by this paper
• Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic‐leucine zipper motif is required for the unfolded protein‐response pathway

  1996influential reference
• Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression.

  1996influential reference
• A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response.

  1996cited by this paper
• Generation of a Mammalian Cell Line Deficient in Glucose-regulated Protein Stress Induction through Targeted Ribozyme Driven by a Stress-inducible Promoter (*)

  1995cited by this paper
• The dynamic properties and possible functions of nuclear lamins.

  1995cited by this paper
• Transduction of calcium stress through interaction of the human transcription factor CBF with the proximal CCAAT regulatory element of the grp78/BiP promoter

  1995cited by this paper
• SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.

  1994cited by this paper
• The cellular response to unfolded proteins: intercompartmental signaling.

  1994cited by this paper
• The unfolded-protein-response pathway in yeast.

  1994cited by this paper
• Transactivation of the grp78 promoter by Ca2+ depletion. A comparative analysis with A23187 and the endoplasmic reticulum Ca(2+)-ATPase inhibitor thapsigargin.

  1993cited by this paper
• A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus.

  1993influential reference
• Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase.

  1993influential reference
• SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.

  1993cited by this paper
• The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum

  1993cited by this paper
• Protein folding in the cell

  1992cited by this paper
• Phosphorylation of eukaryotic initiation factor (eIF) 2 alpha and inhibition of eIF-2B in GH3 pituitary cells by perturbants of early protein processing that induce GRP78.

  1992cited by this paper
• The endoplasmic reticulum as a protein-folding compartment.

  1992cited by this paper
• A 22 bp cis‐acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.

  1992cited by this paper
• IRE1 encodes a putative protein kinase containing a membrane‐spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae

  1992cited by this paper
• Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I

  1991cited by this paper
• Analysis of polypeptide transit through yeast secretory pathway.

  1991cited by this paper
• Competitive inhibition of a set of endoplasmic reticulum protein genes (GRP78, GRP94, and ERp72) retards cell growth and lowers viability after ionophore treatment

  1991cited by this paper
• SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane.

  1991cited by this paper
• KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene.

  1989cited by this paper
• S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP.

  1989cited by this paper
• The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

  1988cited by this paper
• The subnuclear localization of tRNA ligase in yeast

  1987cited by this paper
• Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells

  1987cited by this paper
• Cellular and biochemical events in mammalian cells during and after recovery from physiological stress

  1986influential reference
• Eukaryotic gene transcription with purified components.

  1983cited by this paper
• A simple method for displaying the hydropathic character of a protein.

  1982cited by this paper
• Transactivation of the grp 78 Promoter by Malfolded Proteins , Glycosylation Block , and Calcium lonophore Is Mediated through a Proximal Region Containing a CCAAT Motif Which Interacts with CTF / NFI

  year unknowncited by this paper
• Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 a -Subunit Kinase, PEK, Involved in Translational Control

  year unknowninfluential reference

• A non-canonical role for UPRER during heat stress in C. elegans

  2026cites this paper
• BIP orchestrates bidirectional ER protein trafficking via co-chaperone complexes.

  2026cites this paper
• Marine-Derived Curdepsidone A Inhibits HeLa Cell Proliferation by Modulating ER Stress and PERK/ATF4/CHOP Pathway.

  2026cites this paper
• Adaptive inter-tissue proteostasis networks in aging and neurodegeneration

  2026cites this paper
• Cannabinoids and the autophagy-related signaling in brain Tumors: From mechanistic insights to therapeutic Frontiers in glioblastoma.

  2026cites this paper
• Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

  2026cites this paper
• Proteostasis, Disease and the Ageing Neuron: Compartmental Complexity in Non-Renewing Cells.

  2026cites this paper
• Manipulation of the Unfolded Protein Response by Intracellular Bacterial Pathogens: Mechanisms of ER Hijacking and Therapeutic Implications

  2026cites this paper
• ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets.

  2026cites this paper
• Whole Grain-Derived Functional Components in the Modulation of Hepatic Endoplasmic Reticulum Stress: Mechanisms, Evidence, and Research Gaps

  2026cites this paper
• Mechanism of endoplasmic reticulum stress: Insights for potential therapeutic benefits in burns.

  2026cites this paper
• Mannose metabolic pathway senses glucose supply and regulates cell fate decisions.

  2026cites this paper
• Atf6-/- mouse photoreceptors exhibit novel ciliary rootlet defect

  2026cites this paper
• Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation.

  2026cites this paper
• Genome-Wide Identification and Functional Characterization of Transmembrane Proteins in Citrus sinensis During Plant-Pathogen Interaction

  2026cites this paper
• Molecular Characterization of Endoplasmic Reticulum (ER) Stress-Associated BiP, IRE1, and XBP1 Genes in Diaphorina citri and Their Roles During Candidatus Liberibacter asiaticus Infection

  2026cites this paper
• Unfolded protein response in endoplasmic reticulum stress associated with retinal degenerative diseases: A promising therapeutic target

  2025cites this paper
• IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells.

  2025cites this paper
• Aging and voluntary exercise's effects on Aβ1-42 levels, endoplasmic reticulum stress factors, and apoptosis in the hippocampus of old male rats.

  2025cites this paper
• Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders

  2025cites this paper
• Type 2 calreticulin mutations activate ATF6 to promote BCL-xL-mediated survival in myeloproliferative neoplasms.

  2025cites this paper
• The role of mitochondria-endoplasmic reticulum crosstalk in colorectal cancer

  2025cites this paper
• Activation of PERK/eIF2α/ATF4 signaling inhibits ERα expression in breast cancer

  2025cites this paper
• Transcriptome analysis of atad3-null zebrafish embryos elucidates possible disease mechanisms

  2025cites this paper
• Lipotoxicity: A New Perspective in Type 2 Diabetes Mellitus

  2025cites this paper
• Human biliary atresia extrahepatic cholangiocyte organoids express increased ER and oxidative stress, altered drug metabolism and cell polarity changes

  2025cites this paper
• Solving Mazes of Organelle‐Targeted Therapies with DNA Nanomachines

  2025cites this paper
• Perinuclear organelle trauma at the nexus of cardiomyopathy pathogenesis arising from loss of function LMNA mutation

  2025cites this paper
• Mesencephalic astrocyte-derived neurotrophic factor upregulates CHOP and ATF6 in the rat retina with retinitis pigmentosa

  2025cites this paper
• Decoding Cellular Stress States for Toxicology Using Single-Cell Transcriptomics

  2025cites this paper
• Irisin: muscle’s novel player in endoplasmic reticulum stress and disease

  2025cites this paper
• Unfolded protein responses: Dynamic machinery in wound healing.

  2025cites this paper
• Spatiotemporal dynamics of DNA repair proteins between the Golgi and nucleus maintain genomic stability

  2025cites this paper
• Development of an Adaptive, Economical, and Easy-to-Use SP3-TMT Automated Sample Preparation Workflow for Quantitative Proteomics

  2025cites this paper
• Endoplasmic Reticulum Stress: Implications in Diseases

  2025cites this paper
• Hijacking the unfolded protein response (UPR) pathway: Balancing viral infection and host cell survival

  2025cites this paper
• Advances in targeting organelle photosensitizers for photodynamic therapy

  2025cites this paper
• Mammalian Cells Integrate Endoplasmic Reticulum and Nuclear Envelope signals to time mitotic entry

  2025cites this paper
• Crucial roles of GALNT6-mediated O-glycosylation of GRP78/Bip in proliferation of breast cancer cells.

  2025cites this paper
• Autophagy Induction in TNBC cells by 5,15-Diazaporphyrins: Synthesis, X-ray structure, ROS Generation and Photodynamic Efficiencies

  2025cites this paper
• Unfolded Protein Response: a Key Coordinator of Endoplasmic Reticulum Stress and Pathogenicity in Human Fungal Pathogens

  2025cites this paper
• Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

  2025cites this paper
• MLKL as an emerging machinery for modulating organelle dynamics: regulatory mechanisms, pathophysiological significance, and targeted therapeutics

  2025cites this paper
• Unveiling the molecular mechanisms of recurrent miscarriage through endoplasmic reticulum stress related gene expression

  2025cites this paper
• Molecular and therapeutic insight into ER stress signalling in NSCLC

  2025cites this paper
• Adaptation of Natural Killer Cells to Hypoxia: A Review of the Transcriptional, Translational, and Metabolic Processes

  2025cites this paper
• Melatonin Induces PERK‐ATF4 Unfolded Protein Response and Apoptosis in Human Choriocarcinoma Cells

  2025cites this paper
• HaloPROTAC3 treatment activates the unfolded protein response of the endoplasmic reticulum in non-engineered mammalian cell lines.

  2025cites this paper
• Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry

  2025cites this paper
• The unfolded protein response is a potential therapeutic target in pathogenic fungi

  2025influential citation
• Structure and Functions of NDR1/HIN1‐Like (NHL) Proteins in Plant Development and Response to Environmental Stresses

  2025cites this paper
• Glucose sensing and the unfolded protein response

  2025cites this paper
• Impact of ER stress and the unfolded protein response on Fabry disease

  2025cites this paper
• Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors

  2025cites this paper
• Potential role of endoplasmic reticulum quality control in retinal degenerative diseases.

  2025cites this paper
• Vulnerability of the Nrl-/- Cone-Dominant Retina to Endoplasmic Reticulum Stress.

  2025cites this paper
• Inhibition of vascular smooth muscle cell PERK/ATF4 ER stress signaling protects against abdominal aortic aneurysms

  2025cites this paper
• Pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseases

  2025cites this paper
• The role of the unfolded protein response pathway in bone homeostasis and potential therapeutic target in cancer-associated bone disease

  2025cites this paper
• FICD (FIC Domain Protein Adenylyl Transferase) Deficiency Protects Mice From Hypertrophy‐Induced Heart Failure and Promotes BiP (Binding Immunoglobulin Protein) ‐Mediated Activation of the Unfolded Protein Response and Endoplasmic Reticulum‐Selective Autophagy in Cardiomyocytes

  2025cites this paper
• Development of an Adaptive, Economical, and Easy-to-Use SP3-TMT Automated Sample Preparation Workflow for Quantitative Proteomics

  2025cites this paper
• Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells

  2025cites this paper
• Time-resolved photocatalytic proximity labeling uncovers ER proteome dynamics underlying UPR-to-apoptosis transition

  2025cites this paper
• Transcriptomic Profiling of Small Molecule Atf6 Modulators in the Retina

  2025cites this paper
• Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma Using Data-Independent Acquisition Mass Spectrometry

  2025cites this paper
• When Proteins Go Berserk: The Unfolded Protein Response and ER Stress

  2025cites this paper
• Spatial protein redistribution: wandering but not lost

  2025cites this paper
• STK26 Promotes the Stabilization of ATF6 to Facilitate the Progression of Colorectal Cancer

  2025cites this paper
• Non-Canonical, Strongly Selective Protein Disulfide Isomerases as Anticancer Therapeutic Targets

  2025cites this paper
• Genetic Variants in the ATF6 Gene and Their Relationship with Milk-Quality Traits in Yaks

  2025cites this paper
• Endoplasmic Reticulum Stress and Ca2+ Homeostasis in Oral Diseases

  2025cites this paper
• Elucidate biomarkers and the molecular pathways associated with genetic variants that contribute to the etiology of Parkinson’s disease

  2025cites this paper
• Endoplasmic reticulum stress at the forefront of fatty liver diseases and cancer.

  2025cites this paper
• Metabolite import via SLC33A1 enables ATF6 activation by endoplasmic reticulum stress

  2025cites this paper
• From stress to homeostasis: Mass spectrometry-based insights into the unfolded protein response (UPR) and proteostasis.

  2025cites this paper
• Endoplasmic Reticulum Stress in Cancer Progression: A Comprehensive Review of Its Role and Mechanisms

  2025cites this paper
• Distinct responses to non-autonomous UPRER mediated by glutamatergic and octopaminergic neurons

  2025cites this paper
• Hypoxia-driven perturbations of proteostasis and therapeutic vulnerabilities in cancer.

  2025cites this paper
• A mechano-resistance mechanism in skin adapts to terrestrial locomotion.

  2025cites this paper
• Maturity-Onset Diabetes of the Young 10 (MODY10): A Comprehensive Review of Genetics, Clinical Features, and Therapeutic Advances

  2025cites this paper
• MBTPS1: a membrane-bound transcription factor protease implicated in the pathogenesis of several skin and skeletal disorders

  2025cites this paper
• Coupling the MAPK Slt2/ERK1 Pathway and IRE1-driven UPR Through Transcription Factor Rlm1/MEF2

  2025cites this paper
• Peering into the bacterial cell: from transcription to functional genomics.

  2025cites this paper
• “Sticki-ER”: Functions of the Platelet Endoplasmic Reticulum

  2024influential citation
• A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

  2024cites this paper
• Protein aggregation and biomolecular condensation in hypoxic environments (Review)

  2024cites this paper
• Endoplasmic reticulum stress and related diseases

  2024cites this paper
• A new role for IFRD1 in regulation of ER stress in bladder epithelial homeostasis

  2024influential citation
• Endoplasmic Reticulum Membrane Homeostasis and the Unfolded Protein Response.

  2024cites this paper
• Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response

  2024cites this paper
• Endoplasmic reticulum stress signaling actively contributes to therapy resistance in colorectal cancer

  2024cites this paper
• Novel Targeted Therapies for Rheumatoid Arthritis Based on Intracellular Signalling and Immunometabolic Changes: A Narrative Review.

  2024cites this paper
• Protein-rich foods, sea foods, and gut microbiota amplify immune responses in chronic diseases and cancers - Targeting PERK as a novel therapeutic strategy for chronic inflammatory diseases, neurodegenerative disorders, and cancer.

  2024cites this paper
• Curcumin affects apoptosis of colorectal cancer cells through ATF6‐mediated endoplasmic reticulum stress

  2024cites this paper
• UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

  2024cites this paper
• ATF6 protects against protein misfolding during cardiac hypertrophy.

  2024cites this paper
• A stress paradox: the dual role of the unfolded protein response in the placenta

  2024cites this paper
• Insights into the molecular underlying mechanisms and therapeutic potential of endoplasmic reticulum stress in sensorineural hearing loss

  2024cites this paper
• Pseudorabies virus inhibits the unfolded protein response for viral replication during the late stages of infection.

  2024cites this paper
• Protein phosphatase-1 regulates the binding of filamin C to FILIP1 in cultured skeletal muscle cells under mechanical stress

  2024cites this paper