The modular nature of apoptotic signaling proteins

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Cellular and Molecular Life Sciences (CMLS)

• Publication date

  1999-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s000180050361PMID 10442092PMCID PMC11146888
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Developmental cell death: morphological diversity and multiple mechanisms

  2004cited by this paper
• Apoptosis and cancer chemotherapy

  2000cited by this paper
• The Bcl-2 family and cell death regulation.

  1998cited by this paper
• An Induced Proximity Model for Caspase-8 Activation*

  1998cited by this paper
• Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.

  1998cited by this paper
• Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex*

  1998cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• The fight of viruses against apoptosis.

  1998cited by this paper
• Signal transduction pathways activated by the IL‐1 receptor family: ancient signaling machinery in mammals, insects, and plants

  1998cited by this paper
• RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.

  1998cited by this paper
• RIP2 Is a Novel NF-κB-activating and Cell Death-inducing Kinase*

  1998cited by this paper
• Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.

  1998cited by this paper
• NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

  1998cited by this paper
• The mitochondrial death/life regulator in apoptosis and necrosis.

  1998cited by this paper
• Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.

  1998cited by this paper
• Apoptosis signaling by death receptors.

  1998cited by this paper
• Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment.

  1998cited by this paper
• Viral interference with apoptosis.

  1998cited by this paper
• MyD88, an Adapter Protein Involved in Interleukin-1 Signaling*

  1998cited by this paper
• Cell death attenuation by `Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

  1998cited by this paper
• To die or not to die: an overview of apoptosis and its role in disease.

  1998cited by this paper
• Profile hidden Markov models

  1998cited by this paper
• Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.

  1998cited by this paper
• BCL-2 family: regulators of cell death.

  1998cited by this paper
• RICK, a Novel Protein Kinase Containing a Caspase Recruitment Domain, Interacts with CLARP and Regulates CD95-mediated Apoptosis*

  1998cited by this paper
• An antagonist decoy receptor and a death domain-containing receptor for TRAIL.

  1997cited by this paper
• The Caenorhabditis elegans death protein Ced‐4 contains a motif with similarity to the mammalian ‘death effector domain’

  1997cited by this paper
• NMR structure of the death domain of the p75 neurotrophin receptor

  1997cited by this paper
• Early events in TNF signaling: a story of associations and dissociations

  1997cited by this paper
• TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).

  1997cited by this paper
• MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

  1997cited by this paper
• The CARD domain: a new apoptotic signalling motif.

  1997cited by this paper
• RAIDD is a new 'death' adaptor molecule

  1997cited by this paper
• Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

  1997cited by this paper
• Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.

  1997cited by this paper
• Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

  1997cited by this paper
• Inhibition of death receptor signals by cellular FLIP

  1997cited by this paper
• p53 and apoptosis.

  1997cited by this paper
• The Receptor for the Cytotoxic Ligand TRAIL

  1997cited by this paper
• CASH, a Novel Caspase Homologue with Death Effector Domains*

  1997cited by this paper
• Caspases: Intracellular Minireview Signaling by Proteolysis

  1997cited by this paper
• Apoptosis, cancer and cancer therapy.

  1997cited by this paper
• A Novel Family of Viral Death Effector Domain-containing Molecules That Inhibit Both CD-95- and Tumor Necrosis Factor Receptor-1-induced Apoptosis*

  1997cited by this paper
• A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

  1997cited by this paper
• Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL*

  1997cited by this paper
• TRAIL‐R2: a novel apoptosis‐mediating receptor for TRAIL

  1997cited by this paper
• Caspases: the executioners of apoptosis.

  1997cited by this paper
• Substrate Specificities of Caspase Family Proteases*

  1997cited by this paper
• Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.

  1997cited by this paper
• p53 and ATM: cell cycle, cell death, and cancer.

  1997cited by this paper
• Neuronal cell death: when, why and how.

  1997cited by this paper
• The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system.

  1997cited by this paper
• IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.

  1997cited by this paper
• Cell death induction by receptors of the TNF family: towards a molecular understanding

  1997cited by this paper
• Structural features and biochemical properties of TNF-alpha converting enzyme (TACE).

  1997cited by this paper
• CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis.

  1997cited by this paper
• Direct physical interaction between the Caenorhabditis elegans ‘death proteins’ CED‐3 and CED‐4

  1997cited by this paper
• NMR structure of the death domain of the p 75 neurotrophin receptor affinity binding sites ( Hempstead et al . , 1991 ; Mahadeo

  1997cited by this paper
• Apoptosis by death factor.

  1997cited by this paper
• Pfam: A comprehensive database of protein domain families based on seed alignments

  1997cited by this paper
• The PROSITE database, its status in 1997

  1997cited by this paper
• Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

  1997cited by this paper
• Three-dimensional structures of proteins involved in programmed cell death.

  1997cited by this paper
• TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.

  1997cited by this paper
• Metalloprotease-disintegrins: links to cell adhesion and cleavage of TNF alpha and Notch.

  1997cited by this paper
• Characterization of two receptors for TRAIL.

  1997cited by this paper
• MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death.

  1997cited by this paper
• The importance of oxidative stress in apoptosis.

  1997cited by this paper
• Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

  1997cited by this paper
• Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death.

  1996cited by this paper
• A conserved signaling pathway: the Drosophila toll-dorsal pathway.

  1996cited by this paper
• Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

  1996cited by this paper
• NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

  1996cited by this paper
• A death-domain-containing receptor that mediates apoptosis

  1996cited by this paper
• Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.

  1996cited by this paper
• Apoptosis: Telling cells their time is up

  1996cited by this paper
• A Flexible Motif Search Technique Based on Generalized Profiles

  1996cited by this paper
• Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

  1996cited by this paper
• A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other

  1996cited by this paper
• FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.

  1996cited by this paper
• TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.

  1996cited by this paper
• Transducers of life and death: TNF receptor superfamily and associated proteins.

  1996cited by this paper
• Evasion of apoptosis by DNA viruses

  1996cited by this paper
• Sacrifice in the face of foes: pathogen-induced programmed cell death in plants.

  1996cited by this paper
• PHD: predicting one-dimensional protein structure by profile-based neural networks.

  1996cited by this paper
• Programmed cell death: a way of life for plants.

  1996cited by this paper
• Recognition of apoptotic cells by phagocytes

  1996cited by this paper
• Apoptotic Activity of REAPER Is Distinct from Signaling by the Tumor Necrosis Factor Receptor 1 Death Domain*

  1996cited by this paper
• FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis (*)

  1996cited by this paper
• Apoptosis and cancer chemotherapy.

  1996cited by this paper
• Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

  1996cited by this paper
• The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.

  1995cited by this paper
• The death domain motif found in Fas (Apo‐1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance

  1995cited by this paper
• Programmed cell death in development.

  1995cited by this paper
• Apoptosis, oncosis, and necrosis. An overview of cell death.

  1995cited by this paper
• RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death.

  1995cited by this paper
• The death domain: a module shared by proteins with diverse cellular functions.

  1995cited by this paper
• Apoptosis, cancer and the p53 tumour suppressor gene

  1995cited by this paper
• A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain (*)

  1995cited by this paper
• Mechanisms of action of the tumor necrosis factor and lymphotoxin ligand-receptor system.

  1995cited by this paper

• 10 things you wish you knew about inflammatory caspases: A holistic review of their biochemistry, activation, and signalling

  2025cites this paper
• TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling

  2024cites this paper
• A Bayesian network structure learning approach to identify genes associated with stress in spleens of chickens

  2021cites this paper
• The Evolutionary Origins of Programmed Cell Death Signaling.

  2019cites this paper
• Caspases: Regulatory Mechanisms and Their Implications in Pathogenesis and Therapeutics

  2017cites this paper
• Gamma-Tocotrienol Inhibits Proliferation of Human Chronic Myeloid Leukemic Cells via Activation of Extrinsic and Intrinsic Apoptotic Pathways

  2016cites this paper
• De novo assembly and transcriptome analysis of Atlantic salmon macrophage/dendritic-like TO cells following type I IFN treatment and Salmonid alphavirus subtype-3 infection

  2015cites this paper
• N-Terminal and C-Terminal Domains of Calmodulin Mediate FADD and TRADD Interaction

  2015cites this paper
• Involvement of Caspases in the Pathophysiology of Neurodegeneration and Stroke

  2014cites this paper
• Biological and medical physics, biomedical engineering

  2014cites this paper
• MiR-221: A critical player in apoptosis as a target of Caspase-3

  2014cites this paper
• Computational analysis of 3′UTR region of CASP3 with respect to miRSNPs and SNPs in targetting miRNAs

  2014cites this paper
• Effects of aging and exercise training on apoptosis in the heart

  2013influential citation
• Reactive oxygen species induced oxidative stress, neuronal apoptosis and alternative death pathways

  2013cites this paper
• Ectodermal dysplasias: a clinical and molecular review.

  2013cites this paper
• Ectodermal dysplasias: a clinical and molecular review.

  2013cites this paper
• Type I Interferons Induce Apoptosis by Balancing cFLIP and Caspase-8 Independent of Death Ligands

  2012cites this paper
• The Role of PIDD in Apoptosis and Innate Antiviral Immunity

  2012cites this paper
• Role of histone deacetylase inhibitors in the treatment of lymphomas and multiple myeloma.

  2012cites this paper
• Susceptibilidade ao pênfigo foliáceo e o polimorfismo de genes da família NLR

  2011cites this paper
• CFLAR (CASP8 and FADD-like apoptosis regulator)

  2011cites this paper
• Ultra High Dilution of triiodothyronine modifies cellular apoptosis in Rana catesbeiana tadpole tail in vitro

  2011cites this paper
• Estudio del rol de la proteína VMP1 en los procesos de autofagia, muerte y sobrevida celular en la fisiopatología pancreática

  2010cites this paper
• Targeting histone deacetyalses in the treatment of B- and T-cell malignancies

  2010cites this paper
• Emerging role of epigenetic therapies in cutaneous T-cell lymphomas

  2010cites this paper
• Molecular Background of Ectodermal Dysplasia

  2010cites this paper
• Association between decreases in type V collagen and apoptosis in mouse lung chemical carcinogenesis: a preliminary model to study cancer cell behavior

  2010cites this paper
• NMR backbone dynamics studies of human PED/PEA‐15 outline protein functional sites

  2010cites this paper
• The Nature of Protein Domain Evolution: Shaping the Interaction Network

  2010cites this paper
• Inflammasomes in infection and inflammation

  2009cites this paper
• The Regulation of Drosophila Inhibitor of Apoptosis Protein I in Apoptosis and Cell Survival.

  2009cites this paper
• Molecular Pathways of Different Types of Cell Death: Many Roads to Death

  2009cites this paper
• Expression of ASC in Renal Tissues of Familial Mediterranean Fever Patients with Amyloidosis: Postulating a Role for ASC in AA Type Amyloid Deposition

  2008cites this paper
• Cell death in mammalian development.

  2008cites this paper
• Evolution of protein domain promiscuity in eukaryotes.

  2008cites this paper
• Evolution of protein domain promiscuity in eukaryotes data

  2008cites this paper
• Caspases - an update.

  2008cites this paper
• ERK MAP Kinase

  2008cites this paper
• ARC contributes to the inhibitory effect of preconditioning on cardiomyocyte apoptosis

  2007cites this paper
• NALP Inflammasomes: a central role in innate immunity

  2007influential citation
• Metastatic progression and gene expression between breast cancer cell lines from African American and Caucasian women

  2007cites this paper
• Virusi i apoptoza

  2007cites this paper
• Prédiction structurale et ingénierie des assemblages macromoléculaires par bioinformatique

  2007cites this paper
• The PYRIN domain in signal transduction.

  2007cites this paper
• The Biology of Caspases in Central Nervous System Trauma

  2007cites this paper
• Original paper Arachidonic acid metabolism in TNF, CD178 (CD95 ligand) and ceramide-mediated cytotoxicity

  2007cites this paper
• Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon

  2006cites this paper
• Toxoplasma gondii inhibits ultraviolet light‐induced apoptosis through multiple interactions with the mitochondrion‐dependent programmed cell death pathway

  2006cites this paper
• Substitutions of prolines examine their role in kinetic trap formation of the caspase recruitment domain (CARD) of RICK

  2006cites this paper
• Cell death: initiation, propagation and clearance

  2006cites this paper
• Aus der Universitätsklinik für Radioonkologie mit Poliklinik Tübingen

  2006cites this paper
• A functional role of flip in conferring resistance of Crohn's disease lamina propria lymphocytes to FAS-mediated apoptosis.

  2006cites this paper
• Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses.

  2006cites this paper
• Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Behçet's Disease

  2006cites this paper
• cFLIP regulation of lymphocyte activation and development

  2006cites this paper
• Fooling the Fas ligand in death

  2006cites this paper
• Pathways of myocyte death: implications for development of clinical laboratory biomarkers.

  2005cites this paper
• Caspases: pharmacological manipulation of cell death.

  2005cites this paper
• Novel mutations in the EDAR gene in two Pakistani consanguineous families with autosomal recessive hypohidrotic ectodermal dysplasia

  2005cites this paper
• A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis.

  2005cites this paper
• The Ectodysplasin and NFkappaB signalling pathways in odontogenesis.

  2005cites this paper
• Type V collagen regulates the expression of apoptotic and stress response genes by breast cancer cells

  2005cites this paper
• Exercise training modulates apoptotic signaling in the aging rat heart

  2005cites this paper
• Apoptotic Pathways and Their Regulation

  2005cites this paper
• The Ectodysplasin and NFκB signalling pathways in odontogenesis

  2005cites this paper
• Protein domains in eukaryotic signal transduction systems

  2005cites this paper
• APOPTOTIC PATHWAYS AND THEIR REGULATION Chapter I

  2005cites this paper
• A rare case of hypohidrotic ectodermal dysplasia caused by compound heterozygous mutations in the EDAR gene.

  2004cites this paper
• Calcium Binding of ARC Mediates Regulation of Caspase 8 and Cell Death

  2004cites this paper
• The protein structures that shape caspase activity, specificity, activation and inhibition.

  2004cites this paper
• Novel Functional Interaction between the Plasma Membrane Ca2+ Pump 4b and the Proapoptotic Tumor Suppressor Ras-associated Factor 1 (RASSF1)*

  2004cites this paper
• Kinetic traps in the folding/unfolding of procaspase‐1 CARD domain

  2004cites this paper
• The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities.

  2004cites this paper
• Fire and death: the pyrin domain joins the death-domain superfamily.

  2004cites this paper
• Mechanisms underlying the manipulation of host apoptotic pathways by Toxoplasma gondii.

  2004cites this paper
• Costimulatory Molecules in T CeII Activation and Transplantation

  2004cites this paper
• INCA, a Novel Human Caspase Recruitment Domain Protein That Inhibits Interleukin-1β Generation*

  2004cites this paper
• Expression of CD30 and Ox40 on T lymphocyte subsets is controlled by distinct regulatory mechanisms

  2004cites this paper
• Characterization of rat parotid and submandibular acinar cell apoptosis in primary culture

  2003cites this paper
• The death effector domain protein family: regulators of cellular homeostasis

  2003cites this paper
• Chromosomal translocations involved in non-Hodgkin lymphomas.

  2003cites this paper
• Down‐regulation of ARC contributes to vulnerability of hippocampal neurons to ischemia/hypoxia

  2003cites this paper
• Apoptotic Regulation of Caspase Activity

  2003cites this paper
• Identification of a New Murine Tumor Necrosis Factor Receptor Locus That Contains Two Novel Murine Receptors for Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)*

  2003cites this paper
• Assembly of Cell Regulatory Systems Through Protein Interaction Domains

  2003cites this paper
• T47-D Cells and Type V Collagen: A Model for the Study of Apoptotic Gene Expression by Breast Cancer Cells

  2003cites this paper
• Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK.

  2003cites this paper
• Cell Communication and Signaling

  2003cites this paper
• Mechanisms of dengue virus-induced cell death.

  2003cites this paper
• Cellular FLICE-inhibitory protein: an attractive therapeutic target?

  2003cites this paper
• Caspases as Regulators of Apoptosis and Other Cell Functions

  2003cites this paper
• Biochemistry of apoptotic cell death.

  2003cites this paper
• Viruses and the TNF-related cytokines, an evolving battle.

  2003cites this paper
• RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF‐κB and is processed during apoptosis

  2002cites this paper
• Recognition of ERK MAP kinase by PEA‐15 reveals a common docking site within the death domain and death effector domain

  2002influential citation
• Upregulation of p21(WAF1/Cip1) precedes tumor necrosis factor-induced necrosis-like cell death.

  2002cites this paper
• Fire and ICE: the role of pyrin domain-containing proteins in inflammation and apoptosis.

  2002cites this paper
• Death receptors couple to both cell proliferation and apoptosis.

  2002cites this paper
• Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells.

  2002cites this paper
• The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.

  2002cites this paper