Prohibitins Regulate Membrane Protein Degradation by the m-AAA Protease in Mitochondria

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Molecular and Cellular Biology

• Publication date

  1999-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.19.5.3435PMID 10207067PMCID PMC84136
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sorting of d-Lactate Dehydrogenase to the Inner Membrane of Mitochondria

  1998cited by this paper
• Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease.

  1998cited by this paper
• The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m‐AAA protease

  1998cited by this paper
• Prohibitin Family Members Interact Genetically with Mitochondrial Inheritance Components in Saccharomyces cerevisiae

  1998influential reference
• Host regulation of lysogenic decision in bacteriophage lambda: transmembrane modulation of FtsH (HflB), the cII degrading protease, by HflKC (HflA).

  1997cited by this paper
• The prohibitin family of mitochondrial proteins regulate replicative lifespan.

  1997cited by this paper
• Endoplasmic reticulum degradation: reverse protein flow of no return

  1997cited by this paper
• ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together.

  1997cited by this paper
• ATP-dependent proteases that also chaperone protein biogenesis.

  1997cited by this paper
• Ubiquitin‐dependent internalization and down‐regulation of plasma membrane proteins

  1997cited by this paper
• The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria.

  1996influential reference
• AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP‐dependent degradation of inner membrane proteins in mitochondria.

  1996influential reference
• Afg3p, a mitochondrial ATP‐dependent metalloprotease, is involved in degradation of mitochondrially‐encoded Cox1, Cox3, Cob, Su6, Su8 and Su9 subunits of the inner membrane complexes III, IV and V

  1996cited by this paper
• A protease complex in the Escherichia coli plasma membrane: HflKC (HflA) forms a complex with FtsH (HflB), regulating its proteolytic activity against SecY.

  1996cited by this paper
• The role of protein degradation in mitochondrial function and biogenesis

  1996cited by this paper
• Prohibitin and the senescent phenotype.

  1996cited by this paper
• Mutations in RCA1 and AFG3 inhibit F1‐ATPase assembly in Saccharomyces cerevisiae

  1995cited by this paper
• Proteolytic breakdown of membrane-associated polypeptides in mitochondria of Saccharomyces cerevisiae.

  1995cited by this paper
• Multiple genes, including a member of the AAA family, are essential for degradation of unassembled subunit 2 of cytochrome c oxidase in yeast mitochondria

  1995influential reference
• Isolation and biochemical characterization of organelles from the yeast, Saccharomyces cerevisiae

  1995cited by this paper
• Prohibitin, an antiproliferative protein, is localized to mitochondria

  1995cited by this paper
• Isolation of yeast mitochondria and study of mitochondrial protein translation

  1994cited by this paper
• Mitochondrial morphological and functional defects in yeast caused by yme1 are suppressed by mutation of a 26S protease subunit homologue.

  1994influential reference
• A new member of a family of ATPases is essential for assembly of mitochondrial respiratory chain and ATP synthetase complexes in Saccharomyces cerevisiae.

  1994cited by this paper
• Yeast sequencing reports. Sequence of the AFG3 gene encoding a new member of the FtsH/Yme1/Tma subfamily of the AAA‐protein family

  1994cited by this paper
• New heterologous modules for classical or PCR‐based gene disruptions in Saccharomyces cerevisiae

  1994influential reference
• Yta10p is required for the ATP‐dependent degradation of polypeptides in the inner membrane of mitochondria

  1994cited by this paper
• Yta10p, a member of a novel ATPase family in yeast, is essential for mitochondrial function

  1994cited by this paper
• The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin‐related protein.

  1994cited by this paper
• Divalent metal ion-dependent mitochondrial degradation of unassembled subunits 2 and 3 of cytochrome c oxidase.

  1994cited by this paper
• Inactivation of YME1, a Member of the ftsH-SEC18-PAS1-CDC48 Family of Putative ATPase-Encoding Genes, Causes Increased Escape of DNA from Mitochondria in Saccharomyces cerevisiae

  1993cited by this paper
• Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells

  1991cited by this paper
• ATP10, a yeast nuclear gene required for the assembly of the mitochondrial F1-F0 complex.

  1990cited by this paper
• Isolation of a cDNA that hybrid selects antiproliferative mRNA from rat liver.

  1989cited by this paper
• Mitochondrial gene expression in saccharomyces cerevisiae. I. Optimal conditions for protein synthesis in isolated mitochondria.

  1984cited by this paper
• [6] Analysis of products of mitochondrial protein synthesis in yeast: Genetic and biochemical aspects

  1979cited by this paper
• Analysis of products of mitochondrial protein synthesis in yeast: genetic and biochemical aspects.

  1979cited by this paper

• Plasmodium falciparum stomatin-like protein forms a putative complex with a metalloprotease in distinct mitochondrial loci

  2026influential citation
• Mitophagy in the pathogenesis and management of disease

  2026cites this paper
• Molecular mechanisms of mitochondrial AAA+ proteases.

  2026cites this paper
• The mitochondrial cohibitin complex facilitates the biogenesis of inner membrane proteins

  2026cites this paper
• IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia

  2025cites this paper
• Structural basis for prohibitin-mediated regulation of mitochondrial m-AAA protease

  2025cites this paper
• Structures of human organellar SPFH protein complexes

  2025cites this paper
• The biological functions of FtsH in plant organelle protein homeostasis.

  2025cites this paper
• In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment

  2025cites this paper
• Cryo-EM structure of the prohibitin complex in open conformation

  2025cites this paper
• Dbi1 is an oxidoreductase and an assembly chaperone for mitochondrial inner membrane proteins

  2025cites this paper
• An Msp1-Protease Chimera Captures Transient AAA+ Interactions and Unveils Ost4 Mislocalization Errors

  2025cites this paper
• Role of Prohibitins as Guardians of mitochondrial homeostasis.

  2025cites this paper
• In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment

  2025influential citation
• The pre-mRNA splicing modulator pladienolide B inhibits Cryptococcus neoformans germination and growth

  2025cites this paper
• SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis

  2025cites this paper
• Targeting prohibitins activates the ISR through DELE1-HRI by impairing protein import into the mitochondrial matrix.

  2025cites this paper
• The SPFH complex HflK-HflC regulates aerobic respiration in bacteria

  2025cites this paper
• Proteomic Analysis Infers Optimized ATP‐Production in Guard Cell Mitochondria

  2025cites this paper
• Persistent mTORC1 activation underlies sex dimorphic progression of MASLD in mice with hepatocyte prohibitin-1 deficiency

  2025cites this paper
• Pt-LIS1 participates nuclear deformation and acrosome formation via regulating Dynein-1 during spermatogenesis in Portunus trituberculatus

  2025cites this paper
• OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase

  2024cites this paper
• Mitochondrial protein synthesis quality control

  2024cites this paper
• Proteolytic regulation of mitochondrial magnesium channel MRS2 by m-AAA protease and prohibitin complex.

  2024cites this paper
• COA5 has an essential role in the early stage of mitochondrial complex IV assembly

  2024cites this paper
• Unravelling the anti-apoptotic role of Plasmodium falciparum Prohibitin-2 (PfPhb2) in maintaining mitochondrial homeostasis.

  2024cites this paper
• Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance

  2024cites this paper
• In situ architecture of the human prohibitin complex

  2024cites this paper
• PHB2 inhibits WSSV replication by promoting the nuclear translocation of STAT.

  2024cites this paper
• CHCHD10S59L/+ mouse model: Behavioral and neuropathological features of frontotemporal dementia.

  2024cites this paper
• Early fate decision for mitochondrially encoded proteins by a molecular triage.

  2023cites this paper
• Characterization of Plasmodium falciparum prohibitins as novel targets to block infection in humans by impairing the growth and transmission of the parasite.

  2023cites this paper
• Targeting Ion Channels and Purkinje Neuron Intrinsic Membrane Excitability as a Therapeutic Strategy for Cerebellar Ataxia

  2023cites this paper
• SARM1 deletion delays cerebellar but not spinal cord degeneration in an enhanced mouse model of SPG7 deficiency.

  2023cites this paper
• The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury

  2023cites this paper
• The Effect of Prohibitins on Mitochondrial Function during Octopus tankahkeei Spermiogenesis

  2023cites this paper
• Early steps in the biogenesis of mitochondrially encoded oxidative phosphorylation subunits

  2023influential citation
• RNA interference of PHB1 enhances virulence of Vip3Aa to Sf9 cells and Spodoptera frugiperda larvae.

  2023cites this paper
• Structural insights into the membrane microdomain organization by SPFH family proteins

  2022cites this paper
• Prohibitin-1 plays a regulatory role in Leydig cell steroidogenesis

  2022cites this paper
• Recent Advances in Understanding the Structural and Functional Evolution of FtsH Proteases

  2022cites this paper
• Characterization of Mitochondrial Prohibitin in Opsariichthys bidens and Its Potential Functions in Spermatogenesis

  2022cites this paper
• Prohibitins in neurodegeneration and mitochondrial homeostasis

  2022cites this paper
• Prohibitin 1 regulates mtDNA release and downstream inflammatory responses

  2022cites this paper
• Characterization of prohibitins as novel target to block asexual and sexual stage growth of Plasmodium falciparum

  2022cites this paper
• Prohibitins: A Key Link between Mitochondria and Nervous System Diseases

  2022cites this paper
• PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing

  2022cites this paper
• CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viability.

  2022cites this paper
• Prohibitin Protein Expression During Spermatogenesis in the Large Yellow Croaker, Larimichthys crocea

  2022cites this paper
• Rhomboid protease RHBDL 4 promotes retrotranslocation of aggregation-prone 1 proteins for degradation 2 3

  2021cites this paper
• The Mitochondrial Prohibitin (PHB) Complex in C. elegans Metabolism and Ageing Regulation

  2021cites this paper
• Two interaction proteins between AtPHB6 and AtSOT12 regulate plant salt resistance through ROS signaling.

  2021cites this paper
• Discovery of bactericides as an acute mitochondrial membrane damage inducer

  2021cites this paper
• Platelet biomarkers for a descending cognitive function: A proteomic approach

  2021cites this paper
• AtPHB2 regulates salt stress response in Arabidopsis thaliana

  2021cites this paper
• The Expanding Role of Mitochondria, Autophagy and Lipophagy in Steroidogenesis

  2021cites this paper
• Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

  2021cites this paper
• Small mitochondrial protein NERCLIN regulates cardiolipin homeostasis and mitochondrial ultrastructure

  2021cites this paper
• C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly.

  2021cites this paper
• Regulation of PRKN-independent mitophagy

  2021cites this paper
• The mitochondrial AAA protease FTSH3 regulates Complex I abundance by promoting its disassembly.

  2021cites this paper
• Characterization and functional analysis of the proteins Prohibitin 1 and 2 in Trypanosoma cruzi

  2021cites this paper
• Ubiquitin and Receptor Dependent Mitophagy Pathways and Their Implication in Neurodegeneration.

  2020cites this paper
• Lipid Rafts in Exosome Biogenesis

  2020cites this paper
• Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells

  2020cites this paper
• PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

  2020cites this paper
• Characterisation, expression and possible functions of prohibitin during spermatogenesis in the silver pomfret Pampus argenteus.

  2020cites this paper
• Proteomic analysis of liver mitochondria of db/db mice treated with grape seed procyanidin B2.

  2020cites this paper
• Prohibitin S-Nitrosylation Is Required for the Neuroprotective Effect of Nitric Oxide in Neuronal Cultures

  2020cites this paper
• Molecular characterization of prohibitins and their differential responses to WSSV infection in hemocyte subpopulations of Fenneropenaeus chinensis.

  2020cites this paper
• Regulation of mitochondrial plasticity by the i-AAA protease YME1L

  2020cites this paper
• OMA1-An integral membrane protease?

  2020cites this paper
• Prohibitins: A Critical Role in Mitochondrial Functions and Implication in Diseases

  2019influential citation
• Mitochondrial stress response triggered by defects in protein synthesis quality control

  2019cites this paper
• In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way

  2019cites this paper
• NEEDLE1 encodes a mitochondria localized ATP-dependent metalloprotease required for thermotolerant maize growth

  2019cites this paper
• Intramembrane protease RHBDL4 interacts with erlin complex to target unstable soluble proteins for degradation

  2019cites this paper
• The basic machineries for mitochondrial protein quality control.

  2019cites this paper
• Caracterización molecular y funcional de las prohibitinas 1 y 2 de trypanosoma cruzi

  2019influential citation
• Dysfunction of Prohibitin 2 Results in Reduced Susceptibility to Multiple Antifungal Drugs via Activation of the Oxidative Stress-Responsive Transcription Factor Pap1 in Fission Yeast

  2018cites this paper
• Comparative proteomic analysis between two haemocyte subpopulations in shrimp Fenneropenaeus chinensis

  2018cites this paper
• The interactome of the yeast mitochondrial ribosome : Organization of mitochondrial post-transcriptional regulation, membrane protein insertion and quality control

  2018cites this paper
• Erratum to: Early emergence of the FtsH proteases involved in photosystem II repair

  2018cites this paper
• Glycogen synthase kinase-3: a role in ageing and metabolism

  2018cites this paper
• Deoxynivalenol Affects Cell Metabolism and Increases Protein Biosynthesis in Intestinal Porcine Epithelial Cells (IPEC-J2): DON Increases Protein Biosynthesis

  2018cites this paper
• 1 Mitochondrial quality control mechanisms and the PHB ( prohibitin ) complex 2

  2018cites this paper
• Mitochondrial Quality Control Mechanisms and the PHB (Prohibitin) Complex

  2018cites this paper
• Insertion Defects of Mitochondrially Encoded Proteins Burden the Mitochondrial Quality Control System

  2018influential citation
• An Unusual Prohibitin Regulates Malaria Parasite Mitochondrial Membrane Potential.

  2018cites this paper
• Early emergence of the FtsH proteases involved in photosystem II repair

  2018cites this paper
• PROHIBITIN3 Forms Complexes with ISOCHORISMATE SYNTHASE1 to Regulate Stress-Induced Salicylic Acid Biosynthesis in Arabidopsis1[OPEN]

  2018cites this paper
• AAA Proteases: Guardians of Mitochondrial Function and Homeostasis

  2018influential citation
• The expression pattern and potential functions of PHB in the spermiogenesis of Phascolosoma esculenta.

  2018cites this paper
• Redox Aspects of Chaperones in Cardiac Function

  2018cites this paper
• FtsH Protease in the Thylakoid Membrane: Physiological Functions and the Regulation of Protease Activity

  2018cites this paper
• PHB in Cardiovascular and Other Diseases: Present Knowledge and Implications.

  2017cites this paper
• Anilinopyrimidine Resistance in Botrytis cinerea Is Linked to Mitochondrial Function

  2017cites this paper
• Molecular mechanisms of autophagy and the effect of autophagy dysfunction on mitochondrial function

  2017cites this paper
• The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure

  2017cites this paper
• Mitochondrial prohibitin and its ubiquitination during spermatogenesis of the swimming crab Charybdis japonica.

  2017cites this paper