CCR2+CCR5+ T Cells Produce Matrix Metalloproteinase-9 and Osteopontin in the Pathogenesis of Multiple Sclerosis

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Immunology

• Publication date

  2012-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1202026PMID 23071279PMCID PMC3496198
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CX(3)CR1 drives cytotoxic CD4(+)CD28(-) T cells into the brain of multiple sclerosis patients.

  2012cited by this paper
• Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots

  2011cited by this paper
• Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis

  2011cited by this paper
• CCR2 Identifies a Stable Population of Human Effector Memory CD4+ T Cells Equipped for Rapid Recall Response

  2010cited by this paper
• T cell migration into the central nervous system during health and disease: Different molecular keys allow access to different central nervous system compartments

  2010cited by this paper
• Expression of Chemokines and Their Receptors by Human Brain Endothelium: Implications for Multiple Sclerosis

  2009cited by this paper
• Shifting therapeutic attention in MS to osteopontin, type 1 and type 2 IFN

  2009cited by this paper
• Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology.

  2009cited by this paper
• Preferential recruitment of interferon‐γ–expressing TH17 cells in multiple sclerosis

  2009cited by this paper
• C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

  2009cited by this paper
• Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

  2009cited by this paper
• Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.

  2008cited by this paper
• Th17 Cells and autoimmune encephalomyelitis (EAE/MS).

  2008cited by this paper
• Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study.

  2008cited by this paper
• A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis

  2008cited by this paper
• Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR61

  2008cited by this paper
• Multiple sclerosis: an immune or neurodegenerative disorder?

  2008cited by this paper
• Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

  2007cited by this paper
• Cutting Edge: Human Th17 Cells Are Identified as Bearing CCR2+CCR5− Phenotype1

  2007cited by this paper
• Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells

  2007influential reference
• Multiple sclerosis: a complicated picture of autoimmunity

  2007cited by this paper
• Metalloproteinases Control Brain Inflammation Induced by Pertussis Toxin in Mice Overexpressing the Chemokine CCL2 in the Central Nervous System1

  2006cited by this paper
• Modulating CCR2 and CCL2 at the blood-brain barrier: relevance for multiple sclerosis pathogenesis.

  2006cited by this paper
• Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis

  2006cited by this paper
• T-bet-dependent expression of osteopontin contributes to T cell polarization.

  2005cited by this paper
• Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis.

  2005cited by this paper
• CCL2 and CCL5 mediate leukocyte adhesion in experimental autoimmune encephalomyelitis--an intravital microscopy study.

  2005influential reference
• Central memory and effector memory T cell subsets: function, generation, and maintenance.

  2004cited by this paper
• The regulatory role of natural killer cells in multiple sclerosis.

  2004cited by this paper
• Three or more routes for leukocyte migration into the central nervous system

  2003cited by this paper
• Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis.

  2003cited by this paper
• Chemokine receptors: multifaceted therapeutic targets

  2002cited by this paper
• T‐cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking

  2002cited by this paper
• Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood–Brain Barrier in Experimental Autoimmune Encephalomyelitis

  2001cited by this paper
• Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

  2001cited by this paper
• Serum and CSF levels of MCP-1 and IP-10 in multiple sclerosis patients with acute and stable disease and undergoing immunomodulatory therapies.

  2001cited by this paper
• Chemokines: immunology's high impact factors

  2001cited by this paper
• Lymphocyte traffic control by chemokines

  2001cited by this paper
• Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival.

  2001influential reference
• The Influence of the Proinflammatory Cytokine, Osteopontin, on Autoimmune Demyelinating Disease

  2001cited by this paper
• Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)

  2000influential reference
• Understanding dendritic cell and T‐lymphocyte traffic through the analysis of chemokine receptor expression

  2000cited by this paper
• CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions.

  1999cited by this paper
• Selective expression of a novel surface molecule by human Th2 cells in vivo.

  1999cited by this paper
• Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients.

  1999cited by this paper
• Matrix metalloproteinase-9 (gelatinase B) is selectively elevated in CSF during relapses and stable phases of multiple sclerosis.

  1998cited by this paper
• Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

  1996cited by this paper
• Interferon beta-1b decreases the migration of T lymphocytes in vitro: effects on matrix metalloproteinase-9.

  1996cited by this paper
• Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

  1995cited by this paper
• Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

  1994cited by this paper
• Exacerbations of multiple sclerosis in patients treated with gamma interferon.

  1987cited by this paper
• Exacerbations of multiple sclerosis in patients treated with gamma interferon

  1987cited by this paper

• Engineered immunological niche directs therapeutic development in models of progressive multiple sclerosis

  2025cites this paper
• 3D protein structure of chemokines in multiple sclerosis

  2025cites this paper
• Migration arrest and transendothelial trafficking of human pathogenic-like Th17 cells are mediated by differentially positioned chemokines

  2025cites this paper
• Harnessing the therapeutic potential of TIMP-1 in autoimmune inflammation: A prospective insight.

  2025cites this paper
• Whole-Body Cryostimulation in Multiple Sclerosis: A Scoping Review

  2024cites this paper
• Multiple Sclerosis Patient Macrophages Impaired Metabolism Leads to an Altered Response to Activation Stimuli

  2024cites this paper
• PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection

  2024cites this paper
• CCR5 and Inflammatory Storm.

  2024cites this paper
• High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro

  2023cites this paper
• Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells

  2023cites this paper
• Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity

  2023cites this paper
• Effect of Whole-Body Cryotherapy on Oxidant–Antioxidant Imbalance in Women with Multiple Sclerosis

  2023cites this paper
• Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis

  2023cites this paper
• An overall view of the most common experimental models for multiple sclerosis.

  2023cites this paper
• Immune Profiling Reveals the T-Cell Effect of Ocrelizumab in Early Relapsing-Remitting Multiple Sclerosis

  2023influential citation
• Chemokine-Driven Migration of Pro-Inflammatory CD4+ T Cells in CNS Autoimmune Disease

  2022cites this paper
• Microglial expression of CD83 governs cellular activation and restrains autoimmune neuroin ammation

  2022cites this paper
• Comparative analysis of caseins in Saanen goat milk from 3 different regions of China using quantitative proteomics.

  2022cites this paper
• CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation

  2022cites this paper
• Application of a triple‐helical peptide inhibitor of MMP‐2/MMP‐9 to examine T‐cell activation in experimental autoimmune encephalomyelitis

  2022cites this paper
• A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis

  2022cites this paper
• Two dimensional nanosheets as immunoregulator improve HIV vaccine efficacy

  2021cites this paper
• Diagnostic Role of Osteopontin in Interstitial Lung Disease

  2021cites this paper
• Dysregulated functional and metabolic response in multiple sclerosis patient macrophages correlate with a more inflammatory state, reminiscent of trained immunity

  2021influential citation
• Maraviroc attenuates the pathogenesis of experimental autoimmune encephalitis.

  2020cites this paper
• Effect of intensive medical management and weight loss on urinary biomarkers of diabetic kidney disease in the Zucker Diabetic Sprague Dawley (ZDSD) rat

  2020cites this paper
• Potential Pathological Biomarkers in Multiple Sclerosis

  2020influential citation
• CSF biomarkers in multiple sclerosis: beyond neuroinflammation

  2020cites this paper
• Fasciola helminth defense molecule‐1 protects against experimental arthritis by inhibiting osteoclast formation and function without modulating the systemic immune response

  2020cites this paper
• Matrix Metalloproteinase 9 and Osteopontin Interact to Support Synaptogenesis in the Olfactory Bulb after Mild Traumatic Brain Injury

  2019cites this paper
• Abnormal effector and regulatory T cell subsets in paediatric-onset multiple sclerosis

  2019cites this paper
• Failed immune responses across multiple pathologies share pan-tumor and circulating lymphocytic targets.

  2019cites this paper
• Dual CCR5/CCR2 targeting: opportunities for the cure of complex disorders

  2019cites this paper
• Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis.

  2019cites this paper
• Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment

  2019cites this paper
• Dimethyl fumarate therapy reduces memory T cells and the CNS migration potential in patients with multiple sclerosis.

  2019cites this paper
• Biomarkers of Multiple Sclerosis

  2019cites this paper
• C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation

  2018cites this paper
• Advances in Biomarker-Guided Therapy for Pediatric- and Adult-Onset Neuroinflammatory Disorders: Targeting Chemokines/Cytokines

  2018cites this paper
• THE STUDY OF THE LEVELS OF METALLOPROTEINASES, CYTOKINES AND LYMPHOCYTE ACTIVATION MARKERS IN SEMINAL PLASMA OF MEN, DEPENDING ON FERTILITY

  2018influential citation
• The flavonoid kurarinone inhibits clinical progression of EAE through inhibiting Th1 and Th17 cell differentiation and proliferation

  2018cites this paper
• CCR5Δ32 - A piece of protection in the inflammatory puzzle of multiple sclerosis susceptibility.

  2018cites this paper
• Osteopontin: its potential role in cancer of children and young adults.

  2017cites this paper
• Influenza virus infection exacerbates experimental autoimmune encephalomyelitis disease by promoting type I T cells infiltration into central nervous system.

  2017cites this paper
• An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8+ T cells involved in multiple sclerosis.

  2017cites this paper
• Matrix Metalloproteinases and Leukocyte Activation.

  2017cites this paper
• The Role of Matrix Metalloproteinase 9 and Osteopontin in Synaptogenesis and Reinnervation of the Olfactory Bulb Following Brain Injury

  2016cites this paper
• Immune response genes receptors expression and polymorphisms in relation to multiple sclerosis susceptibility and response to INF‐β therapy

  2016cites this paper
• CCR5 blockade for neuroinflammatory diseases — beyond control of HIV

  2016cites this paper
• Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice.

  2016cites this paper
• Increasing Prevalence of Multiple Sclerosis: Biomarkers Theranostic Strategy from Bench to Bedside- A Review

  2016cites this paper
• Thymocyte development in the absence of matrix metalloproteinase-9/gelatinase B

  2016cites this paper
• Cellular Immunity and Multiple Sclerosis: Current Understanding

  2016cites this paper
• Leukocyte Gene Expression and Plasma Concentration in Multiple Sclerosis: Alteration of Transforming Growth Factor-βs, Claudin-11, and Matrix Metalloproteinase-2

  2016cites this paper
• IFN-β inhibits T cells accumulation in the central nervous system by reducing the expression and activity of chemokines in experimental autoimmune encephalomyelitis.

  2015cites this paper
• Changes in chondroitin sulphate proteoglycan in multiple sclerosis : a role for ADAMTS-9

  2015cites this paper
• Gatekeeper role of brain antigen‐presenting CD11c+ cells in neuroinflammation

  2015cites this paper
• CCL2-CCR2 Signaling in Disease Pathogenesis.

  2015cites this paper
• CCL2/CCR2-Dependent Recruitment of Th17 Cells but Not Tc17 Cells to the Lung in a Murine Asthma Model

  2015cites this paper
• Cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain predict multiple sclerosis development and disability after optic neuritis

  2015cites this paper
• Immunology of relapse and remission in multiple sclerosis.

  2014cites this paper
• Target-Bound Generated Pharmacophore Model to Improve the Pharmacophore-Based Virtual Screening: Identification of G-Protein Coupled Human CCR2 Receptors Inhibitors as Anti-Inflammatory Drugs

  2014cites this paper
• Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes

  2014cites this paper
• Peripheral inflammation remotely triggers global gene expression changes in the brain

  2014cites this paper
• Chemokine receptors on T cells in multiple sclerosis

  2014influential citation
• Natalizumab in progressive MS

  2014cites this paper
• Immunophenotyping of cerebrospinal fluid cells in multiple sclerosis: in search of biomarkers.

  2014cites this paper
• Regulation of an Autoimmune Model for Multiple Sclerosis in Th2-Biased GATA3 Transgenic Mice

  2014cites this paper
• Nonconventional MRI biomarkers for in vivo monitoring of pathogenesis in multiple sclerosis

  2014cites this paper
• MMP-9 deficiency shelters endothelial PECAM-1 expression and enhances regeneration of steatotic livers after ischemia and reperfusion injury.

  2014cites this paper
• [Chemokine receptor expression of T cells in the cerebrospinal fluid of relapsing multiple sclerosis].

  2014cites this paper
• Etude pré-clinique d'une stratégie de thérapie génique de l'infection par le VIH combinant l'expression de deux inhibiteurs d'entrée

  2014cites this paper
• The significance of matrix metalloproteinases in the immunopathogenesis and treatment of multiple sclerosis.

  2014cites this paper
• Studies of risk loci in multiple sclerosis

  2014cites this paper
• Chemokines and Chemokine Receptors in Multiple Sclerosis

  2014cites this paper
• Th1‐mediated experimental autoimmune encephalomyelitis is CXCR3 independent

  2013cites this paper
• Biomarkers in Multiple Sclerosis: An Up-to-Date Overview

  2013cites this paper
• Evidence for a Role for the Adaptive Immune Response in Human Term Parturition

  2013cites this paper