Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR61

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Immunology

• Publication date

  2008-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.180.1.214PMID 18097022
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

  2007cited by this paper
• Cutting Edge: Human Th17 Cells Are Identified as Bearing CCR2+CCR5− Phenotype1

  2007cited by this paper
• MIP-3alpha neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice.

  2007cited by this paper
• Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

  2007cited by this paper
• Generation of gut‐homing T cells and their localization to the small intestinal mucosa

  2007cited by this paper
• Development, cytokine profile and function of human interleukin 17–producing helper T cells

  2007cited by this paper
• Phenotypic and functional features of human Th17 cells

  2007cited by this paper
• The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation [Current Opinion in Immunology 2006, 18:670–675]

  2007cited by this paper
• TH-17 cells in the circle of immunity and autoimmunity

  2007cited by this paper
• Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

  2007cited by this paper
• Functional characterization of two S-nitroso-L-cysteine transporters, which mediate movement of NO equivalents into vascular cells.

  2007cited by this paper
• Protective immunity and delayed type hypersensitivity reaction are uncoupled in experimental Leishmania major infection of CCR6-negative mice.

  2007cited by this paper
• Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL‐17

  2007influential reference
• Phenotype and Effector Function of CC Chemokine Receptor 9-Expressing Lymphocytes in Small Intestinal Crohn’s Disease1

  2007cited by this paper
• T-cell homing specificity and plasticity: new concepts and future challenges.

  2006cited by this paper
• The Majority of Human Peripheral Blood CD4+CD25highFoxp3+ Regulatory T Cells Bear Functional Skin-Homing Receptors1

  2006cited by this paper
• The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

  2006cited by this paper
• Development, trafficking, and function of memory T‐cell subsets

  2006cited by this paper
• CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches.

  2006cited by this paper
• The Vast Majority of CLA+ T Cells Are Resident in Normal Skin1

  2006cited by this paper
• The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation.

  2006cited by this paper
• Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease

  2006cited by this paper
• Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

  2006cited by this paper
• Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.

  2006cited by this paper
• T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17

  2006cited by this paper
• Response to Comment on “The Vast Majority of CLA+ T Cells Are Resident in Normal Skin”

  2006cited by this paper
• A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

  2005cited by this paper
• Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

  2005cited by this paper
• CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset.

  2005cited by this paper
• Inducing and expanding regulatory T cell populations by foreign antigen

  2005cited by this paper
• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

  2005cited by this paper
• From www.bloodjournal.org by on April 17, 2008. For personal use only.

  2005cited by this paper
• CCR6 regulates CD4+ T-cell-mediated acute graft-versus-host disease responses.

  2005cited by this paper
• Characterization of Human T Cells That Regulate Neutrophilic Skin Inflammation1

  2004cited by this paper
• Plasma cell-like morphology of Th1-cytokine-producing cells associated with the loss of CD3 expression.

  2004cited by this paper
• TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

  2004cited by this paper
• CCR6 has a non‐redundant role in the development of inflammatory bowel disease

  2003cited by this paper
• Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation

  2003influential reference
• Increased expression of interleukin 17 in inflammatory bowel disease

  2003cited by this paper
• Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

  2003cited by this paper
• Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

  2003cited by this paper
• Colonic epithelial cells are a major site of macrophage inflammatory protein 3α (MIP-3α) production in normal colon and inflammatory bowel disease

  2002cited by this paper
• Transcription: tantalizing times for T cells.

  2002cited by this paper
• Enhancing Effect of IL-1, IL-17, and TNF-α on Macrophage Inflammatory Protein-3α Production in Rheumatoid Arthritis: Regulation by Soluble Receptors and Th2 Cytokines1

  2001influential reference
• Rules of chemokine receptor association with T cell polarization in vivo.

  2001cited by this paper
• Requirement for the Chemokine Receptor Ccr6 in Allergic Pulmonary Inflammation

  2001cited by this paper
• CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses.

  2001cited by this paper
• Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19.

  2001cited by this paper
• Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential.

  2001cited by this paper
• Neutrophils produce biologically active macrophage inflammatory protein‐3α (MIP‐3α) / CCL20 and MIP‐3β / CCL19

  2001influential reference
• Expression of CCR6 and CD83 by cytokine-activated human neutrophils.

  2000influential reference
• Cutting Edge: C-C Chemokine Receptor 6 Is Essential for Arrest of a Subset of Memory T Cells on Activated Dermal Microvascular Endothelial Cells Under Physiologic Flow Conditions In Vitro

  2000cited by this paper
• CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue.

  2000cited by this paper
• Differential expression of the chemokine receptors by the Th1‐ and Th2‐type effect or populations within circulating CD4+ T cells

  2000cited by this paper
• Up-Regulation of Macrophage Inflammatory Protein-3α/CCL20 and CC Chemokine Receptor 6 in Psoriasis1

  2000cited by this paper
• Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.

  1999cited by this paper
• Divergent effects of interleukin-4 and interferon-gamma on macrophage-derived chemokine production: an amplification circuit of polarized T helper 2 responses.

  1998influential reference
• Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

  1998cited by this paper
• Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

  1998cited by this paper
• Mig and IP‐10: CXC chemokines that target lymphocytes

  1997cited by this paper
• CD3+ WT31− peripheral T lymphocytes lack T44 (CD28), a surface molecule involved in activation of T cells bearing the α/β heterodimer

  1987cited by this paper
• The Orphan Nuclear Receptor ROR g t Directs the Differentiation Program of Proinflammatory IL-17 + T Helper Cells

  year unknowncited by this paper

• Intestinal interleukin-22 enhances GLP-1 production via the STAT3 pathway to improve glucose homeostasis during high-fat diet induced obesity in a study with male mice.

  2026cites this paper
• Fc-enhanced anti-CCR6 antibody elicits robust therapeutic effects across multiple autoimmune diseases

  2026cites this paper
• Chemokines and their receptors: The importance of their expression for an appropriate regulation of the immune response in health and disease.

  2026cites this paper
• Inflammatory arthritis immune related adverse events represent a unique autoimmune disease entity primarily driven by T cells, but likely not autoantibodies

  2025cites this paper
• T cell signatures associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort

  2025cites this paper
• Migration arrest and transendothelial trafficking of human pathogenic-like Th17 cells are mediated by differentially positioned chemokines

  2025cites this paper
• Immune impacts of fire smoke exposure

  2025cites this paper
• Modulatory effects of M3 muscarinic acetylcholine receptor on inflammatory profiles of human memory T helper cells.

  2025cites this paper
• Irradiated umbilical cord mesenchymal stem cell-coated high oxygen-permeable hydrogel lenses inhibit corneal inflammation and neovascularization after corneal alkali burns

  2025cites this paper
• IL-23 drives uveitis by acting on a population of tissue-resident entheseal T cells

  2025cites this paper
• CCL20-CCR6 signaling alters the metabolic reprogramming to promote the pathogenic Th17 cell differentiation

  2025cites this paper
• Chemokine Receptor Profile of T Cells and Progression Rate of Geographic Atrophy Secondary to Age-related Macular Degeneration

  2024cites this paper
• The role of Th17 lymphocytes in the pathogenesis of chronic rhinosinusitis

  2024cites this paper
• Superficial Conjunctival Cells from Dupilumab-treated Atopic Dermatitis Patients with Ocular Adverse Events Display a Transcriptomic Psoriasis Signature.

  2024cites this paper
• Pro-Fibrotic Effects of CCL18 on Human Lung Fibroblasts Are Mediated via CCR6

  2024cites this paper
• Immune response induced by standard and fractional doses of 17DD yellow fever vaccine

  2024cites this paper
• Chemokine receptors in primary and secondary lymphoid tissues.

  2024cites this paper
• The Chemokine, CCL20, and Its Receptor, CCR6, in the Pathogenesis and Treatment of Psoriasis and Psoriatic Arthritis

  2023cites this paper
• E. coli LPS/TLR4/NF-κB Signaling Pathway Regulates Th17/Treg Balance Mediating Inflammatory Responses in Oral Lichen Planus

  2023cites this paper
• Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells

  2023cites this paper
• Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood.

  2023cites this paper
• Human CCR6+ Th Cells Show Both an Extended Stable Gradient of Th17 Activity and Imprinted Plasticity.

  2023cites this paper
• Signaling pathways and targeted therapies for psoriasis

  2023cites this paper
• Micro-CT Features of Lung Consolidation, Collagen Deposition and Inflammation in Experimental RSV Infection Are Aggravated in the Absence of Nrf2

  2023cites this paper
• Human CCR6+ Th cells show both an extended stable gradient of Th17 activity and imprinted plasticity

  2023cites this paper
• Combination Antiretroviral Therapy and Immunophenotype of Feline Immunodeficiency Virus

  2023cites this paper
• Effects of glycodelin on CCR6+ cell subpopulations of Th17-polarized helper T cells

  2023cites this paper
• Defining biomarkers in oral cancer according to smoking and drinking status

  2023cites this paper
• Friend or Foe – Tc17 cell generation and current evidence for their importance in human disease

  2023cites this paper
• High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL-17 against M. tuberculosis antigen

  2023cites this paper
• Possible involvement of CXCR3-CXCR6 + CD4 + T cells in Langerhans cell histiocytosis

  2023influential citation
• The β2-adrenergic receptor agonist terbutaline upregulates T helper-17 cells in a protein kinase A-dependent manner.

  2023cites this paper
• Cytokine Imbalance as a Biomarker of Intervertebral Disk Degeneration

  2023cites this paper
• A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation

  2023cites this paper
• Cellular characterisation of advanced osteoarthritis knee synovium

  2023cites this paper
• Th17 Cells: Orchestrators of Mucosal Inflammation and Potential Therapeutic Targets.

  2023cites this paper
• d-mannose blocks the interaction between keratinocytes and Th17 cells to alleviate psoriasis by inhibiting HIF-1α/CCL20 in mice.

  2023cites this paper
• Chemokine-Driven Migration of Pro-Inflammatory CD4+ T Cells in CNS Autoimmune Disease

  2022cites this paper
• ZNF395 facilitates macrophage polarization and impacts the prognosis of glioma.

  2022cites this paper
• Down-Regulated Th17 Cells in a Patient With Familial Mediterranean Fever Associated with AA Amyloidosis in the Treatment of Canakinumab.

  2022cites this paper
• The Exploration of Chemokines Importance in the Pathogenesis and Development of Endometrial Cancer

  2022cites this paper
• The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review

  2022cites this paper
• Involvement of Th1Th17 Cell Subpopulations in the Immune Responses of Mothers Who Gave Birth to Children with Congenital Zika Syndrome (CZS)

  2022cites this paper
• A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation

  2022cites this paper
• Intratumoural expression of IL-6/STAT3, IL-17 and FOXP3 immune cells in the immunosuppressive tumour microenvironment of colorectal cancer Immune cells-positive for IL-6, STAT3, IL-17 and FOXP3 and colorectal cancer development

  2022cites this paper
• Changes of Peripheral Th17 Cells Subset in Overweight and Obese Children After Body Weight Reduction

  2022influential citation
• Amino terminal recognition by a CCR6 chemokine receptor antibody blocks CCL20 signaling and IL-17 expression via β-arrestin

  2021cites this paper
• Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation

  2021cites this paper
• Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo

  2021cites this paper
• A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID

  2021cites this paper
• SOCS2 expression in hematopoietic and non-hematopoietic cells during Trypanosoma cruzi infection: Correlation with immune response and cardiac dysfunction.

  2021cites this paper
• Human Beta-Defensin 2 and 3 Inhibit HIV-1 Replication in Macrophages

  2021cites this paper
• Th17 Cells in Viral Infections—Friend or Foe?

  2021cites this paper
• Targeting the CCR6/CCL20 Axis in Entheseal and Cutaneous Inflammation

  2021cites this paper
• Association between long noncoding RNA taurine‐upregulated gene 1 and microRNA‐377 in vitiligo

  2021cites this paper
• A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood

  2021cites this paper
• Recent advances on the role of cytotoxic T lymphocytes in the pathogenesis of spondyloarthritis

  2021cites this paper
• The Th17/IL-17 Axis and Kidney Diseases, With Focus on Lupus Nephritis

  2021cites this paper
• Identification of human immune cell subtypes most responsive to IL-1β–induced inflammatory signaling using mass cytometry

  2021cites this paper
• Relationship between Th17 immune response and cancer

  2021cites this paper
• Bile acids improve psoriasiform dermatitis through inhibition of IL-17A expression and CCL20-CCR6 mediated trafficking of T cells.

  2021cites this paper
• Decreased MIP-3α Production from Antigen-Activated PBMCs in Symptomatic HIV-Infected Subjects

  2021cites this paper
• The role of Th17 cells in viral infections.

  2021cites this paper
• Proinflammatory T cell polarization is already present in patients with early knee osteoarthritis

  2021cites this paper
• Translational targeting of inflammation and fibrosis in frozen shoulder: Molecular dissection of the T cell/IL-17A axis

  2021cites this paper
• GFI1/HDAC1‐axis differentially regulates immunosuppressive CD73 in human tumor‐associated FOXP3+Th17 and inflammation‐linked Th17 cells

  2021cites this paper
• sLeX Expression Delineates Distinct Functional Subsets of Human Blood Central and Effector Memory T Cells

  2020cites this paper
• Differential requirement for CCR6 in IL-23-mediated skin and joint inflammation.

  2020cites this paper
• The Roles of CD8+ T Cell Subsets in Antitumor Immunity.

  2020cites this paper
• Circulating T Follicular Helper Cell Abnormalities Associated to Different Clinical Forms of Chronic Chagas Disease

  2020cites this paper
• Identification of Human Immune Cell Subtypes Most Vulnerable to IL-1β-induced Inflammatory Signaling Using Mass Cytometry

  2020cites this paper
• CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells

  2020cites this paper
• Deep immunophenotyping at the single-cell level identifies a combination of anti-IL-17 and checkpoint blockade as an effective treatment in a preclinical model of data-guided personalized immunotherapy

  2020cites this paper
• Immunological variables associated with clinical and endoscopic response to vedolizumab in patients with inflammatory bowel diseases.

  2020cites this paper
• The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis Patients

  2020cites this paper
• Interleukin-17A and Keratinocytes in Psoriasis

  2020cites this paper
• A fetal wave of human type-3 γδ T cells with restricted TCR diversity persists into adulthood

  2020cites this paper
• Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome

  2020cites this paper
• T-bet Expression in Peripheral Th17.0 Cells Is Associated With Pulmonary Function Changes in Sarcoidosis

  2020cites this paper
• The CCL20 and CCR6 axis in psoriasis

  2020cites this paper
• Synthetic retinoid AM80 inhibits IL‐17 production of gamma delta T cells and ameliorates biliary atresia in mice

  2020cites this paper
• Imbalance in PB IL-17-Secreting and Regulatory Cells in Pars Planitis Is Associated with Dysregulation of IFN-γ-Secreting Cells, Especially in Patients with Clinical Complications

  2020cites this paper
• Multi-level orchestration of γδ T cell development and central nervous system inflammation by retinoic acid

  2020cites this paper
• Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells

  2020cites this paper
• CD147 Expressed on Memory CD4+ T Cells Limits Th17 Responses in Patients With Rheumatoid Arthritis

  2020cites this paper
• High-Dimensional Analysis of Postsplenectomy Peripheral Immune Cell Changes

  2020cites this paper
• Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases

  2019cites this paper
• Effect of progestin-based hormonal contraceptives on genital inflammation and Th17 cell activation in adolescents at high risk for HIV infection

  2019cites this paper
• Reduced PD-1 expression on circulating CXCR5+ and CXCR5- FOXP3+ Treg cells marks type 1 diabetes initiation in children.

  2019cites this paper
• Cytokines and chemokines associated with Treg/Th17 response in chronic inflammatory periapical disease.

  2019cites this paper
• Simplified assay for enrichment of primed human Th17 and Tc17 lymphocytes from peripheral blood

  2019cites this paper
• Do Th17 Lymphocytes and IL-17 Contribute to Parkinson's Disease? A Systematic Review of Available Evidence

  2019cites this paper
• Are Adverse Health Effects from Air Pollution Exposure Passed on from Mother to Child

  2019cites this paper
• Relationship between Multiple Sclerosis-Associated IL2RA Risk Allele Variants and Circulating T Cell Phenotypes in Healthy Genotype-Selected Controls

  2019cites this paper
• Diverse Activity of IL-17+ Cells in Chronic Skin and Mucosa Graft-Versus-Host Disease

  2019cites this paper
• Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia

  2019cites this paper
• Dendritic cells: The driver of psoriasis

  2019cites this paper
• MAIT cell subtypes in multiple sclerosis.

  2019cites this paper
• Effects of Pregnancy and Hormones on T cell Immune Regulation in Multiple Sclerosis

  2019cites this paper
• T‐cell positioning by chemokines in autoimmune skin diseases

  2019cites this paper