UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, γ-H2AX formation, and Mre11 relocalization

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2001-12-26

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1073/pnas.231611798PMID 11756691PMCID PMC117544
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recombinational DNA double-strand breaks in mice precede synapsis

  2001cited by this paper
• Direct DNA binding by Brca1

  2001cited by this paper
• UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.

  2001cited by this paper
• DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex

  2001cited by this paper
• Cell cycle checkpoint signaling through the ATM and ATR kinases.

  2001cited by this paper
• Spontaneous DNA Damage, Minireview Genome Instability, and Cancer— When DNA Replication Escapes Control

  2001cited by this paper
• The DNA replication checkpoint response stabilizes stalled replication forks

  2001cited by this paper
• DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells.

  2001cited by this paper
• INTRODUCTION - Links between recombination and replication: Vital roles of recombination

  2001cited by this paper
• The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

  2001cited by this paper
• Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress*

  2001cited by this paper
• Rescue of arrested replication forks by homologous recombination

  2001cited by this paper
• Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

  2001cited by this paper
• ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

  2000cited by this paper
• ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

  2000cited by this paper
• Possible association of BLM in decreasing DNA double strand breaks during DNA replication

  2000cited by this paper
• Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

  2000cited by this paper
• Tokio kogoma (1939-1997)

  2000cited by this paper
• The Bloom's syndrome gene product promotes branch migration of holliday junctions.

  2000cited by this paper
• Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX.

  2000cited by this paper
• A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.

  2000cited by this paper
• Inaugural Article: Polymerase deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair

  2000cited by this paper
• Initiation of DNA Fragmentation during Apoptosis Induces Phosphorylation of H2AX Histone at Serine 139*

  2000cited by this paper
• Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

  2000cited by this paper
• Sister chromatid gene conversion is a prominent double‐strand break repair pathway in mammalian cells

  2000cited by this paper
• The recombination-replication interface.

  2000cited by this paper
• Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest

  2000cited by this paper
• A mechanistic basis for Mre11-directed DNA joining at microhomologies.

  2000cited by this paper
• Inhibition of DNA synthesis is a potent mechanism by which cytostatic drugs induce homologous recombination in mammalian cells.

  2000cited by this paper
• DNA damage-induced activation of p53 by the checkpoint kinase Chk2.

  2000cited by this paper
• The recombination-replication interface.

  2000cited by this paper
• Response to RAG-mediated V(D)J cleavage by NBS1 and γ-H2AX

  2000cited by this paper
• Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant.

  1999cited by this paper
• Stopping DNA Replication in Its Tracks

  1999cited by this paper
• The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

  1999cited by this paper
• Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members*

  1999cited by this paper
• Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand.

  1999cited by this paper
• Sister Chromatid Exchanges Are Mediated by Homologous Recombination in Vertebrate Cells

  1999cited by this paper
• hRAD30 mutations in the variant form of xeroderma pigmentosum.

  1999cited by this paper
• A role for ATR in the DNA damage-induced phosphorylation of p53.

  1999cited by this paper
• Long inverted repeats are an at-risk motif for recombination in mammalian cells.

  1999cited by this paper
• Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

  1999cited by this paper
• Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

  1999cited by this paper
• In situ visualization of DNA double-strand break repair in human fibroblasts.

  1998cited by this paper
• Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway.

  1998cited by this paper
• The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.

  1998cited by this paper
• Enhanced phosphorylation of p53 by ATM in response to DNA damage.

  1998cited by this paper
• DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*

  1998cited by this paper
• Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

  1998cited by this paper
• The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.

  1998cited by this paper
• Gene Conversion Tracts from Double-Strand Break Repair in Mammalian Cells

  1998cited by this paper
• Sites of UV-induced Phosphorylation of the p34 Subunit of Replication Protein A from HeLa Cells*

  1997cited by this paper
• Human cancer syndromes: clues to the origin and nature of cancer.

  1997cited by this paper
• Replication Fork Bypass of a Pyrimidine Dimer Blocking Leading Strand DNA Synthesis*

  1997cited by this paper
• DNA double‐strand breaks caused by replication arrest

  1997cited by this paper
• The Genetic Basis of Human Cancer

  1997cited by this paper
• hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

  1997cited by this paper
• Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.

  1997cited by this paper
• SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae.

  1996cited by this paper
• The Bloom's syndrome gene product is homologous to RecQ helicases.

  1995cited by this paper
• Isolation and characterization of the human MRE11 homologue.

  1995cited by this paper
• Cell checkpoint and radiosensitivity

  1993cited by this paper
• A new method for introducing double-strand breaks into cellular DNA.

  1993cited by this paper
• Inverted DNA repeats: a source of eukaryotic genomic instability

  1993cited by this paper
• An examination of the repair saturation hypothesis for describing shouldered survival curves.

  1991cited by this paper
• Mechanisms of inhibition of DNA replication by ultraviolet light in normal human and xeroderma pigmentosum fibroblasts.

  1981cited by this paper
• The relationship between pyrimidine dimers and replicating DNA in UV-irradiated human fibroblasts.

  1979cited by this paper
• Xeroderma pigmentosum variants have a slow recovery of DNA synthesis after irradiation with ultraviolet light.

  1979cited by this paper
• X-ray-induced inhibition of DNA synthesis in Chinese hamster ovary, human HeLa, and Mouse L cells.

  1975cited by this paper
• Xeroderma pigmentosum: variants with normal DNA repair and normal sensitivity to ultraviolet light.

  1972cited by this paper

• Wavelength-dependent DNA damage induced by single wavelengths of UV-C radiation (215 to 255 nm) in a human cornea model

  2025cites this paper
• Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis

  2025cites this paper
• Light-Induced Formation of DNA Interstrand Cross-Links from Oxidative DNA Lesion

  2025cites this paper
• UV-Induced DNA Damage Detection by ELISA Analysis.

  2025cites this paper
• Wavelength-Dependent DNA Damage Induced by Single Wavelengths of UVC Light (215 to 255 nm) in a Human Cornea Model

  2024cites this paper
• How Do Plants Cope with DNA Damage? A Concise Review on the DDR Pathway in Plants

  2023cites this paper
• Dissection of DNA damage and repair pathways in live cells by femtosecond laser microirradiation and free-electron modeling

  2023cites this paper
• Use of Atomic Force Microscopy in UVB-Induced Chromosome Damage Provides Important Bioinformation for Cell Damage Assessment.

  2023cites this paper
• Comparison of two pyrolytic graphite representatives in the construction of hybrid electrochemical DNA biosensors for monitoring DNA damage

  2022cites this paper
• Circadian effects on UV-induced damage and mutations.

  2022cites this paper
• Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis

  2021cites this paper
• miR-27b-3p a Negative Regulator of DSB-DNA Repair

  2021cites this paper
• DNA Damage Response during Replication Correlates with CIN70 Score and Determines Survival in HNSCC Patients

  2021cites this paper
• Applicability of flow cytometry γH2AX assay in population studies: suitability of fresh and frozen whole blood samples

  2021cites this paper
• Unscheduled MRE11 activity triggers cell death but not chromosome instability in polymerase eta-depleted cells subjected to UV irradiation

  2020cites this paper
• Evaluation of Inflammation by Cytokine Production Following Combined Exposure to Ultraviolet and Radiofrequency Radiation of Mobile Phones on 3D Reconstructed Human Skin In Vitro

  2020cites this paper
• UV‐induced DNA damage response in blood cells for cancer detection

  2020cites this paper
• NATHALIA QUINTERO RUIZ MUTAGENICITY PROFILE INDUCED BY UVA AND UVB LIGHT IN CELLS FROM PATIENTS WITH XERODERMA PIGMENTOSUM GROUP C

  2020cites this paper
• Deciphering the interstrand crosslink DNA repair network expressed by Trypanosoma brucei

  2019cites this paper
• Green tea extract promotes DNA repair in a yeast model

  2019cites this paper
• A PolH transcript with a short 3'UTR enhances PolH expression and mediates cisplatin resistance.

  2019cites this paper
• In Situ DNA Damaging Foci Analysis on Metaphase Chromosomes.

  2019cites this paper
• Transgenerational Inheritance of Environmentally Induced Epigenetic Alterations during Mammalian Development

  2019cites this paper
• Role of Radiation in DNA Damage and Radiation Induced Cancer

  2019cites this paper
• Formaldehyde inhibits UV-induced phosphorylation of histone H2AX.

  2019cites this paper
• DNA Interstrand Crosslink Repair in Trypanosoma brucei

  2018cites this paper
• Analysis of transcription factor and histone modification dynamics in the nucleus of single living cells using a novel antibody-based imaging approach

  2018cites this paper
• The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

  2018cites this paper
• Sei-1 promotes double minute chromosomes formation through activation of the PI3K/Akt/BRCA1-Abraxas pathway and induces double-strand breaks in NIH-3T3 fibroblasts

  2018cites this paper
• ATM Induces Cell Death with Autophagy in Response to H2O2 Specifically in Caenorhabditis elegans Nondividing Cells

  2018influential citation
• Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light

  2017cites this paper
• NR4A2 Promotes DNA Double-strand Break Repair Upon Exposure to UVR

  2017cites this paper
• Physiological Roles of DNA Double-Strand Breaks

  2017cites this paper
• γH2Ax Expression as a Potential Biomarker Differentiating between Low and High Grade Cervical Squamous Intraepithelial Lesions (SIL) and High Risk HPV Related SIL

  2017cites this paper
• Réponse des fibroblastes dermiques humains suite à un stress génotoxique induit par un régime d'irradiation chronique aux rayons ultraviolets de type-B

  2017cites this paper
• Association study of genetic variation in DNA repair pathway genes and risk of basal cell carcinoma

  2017cites this paper
• ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle

  2016cites this paper
• DNA damage-associated biomarkers in studying individual sensitivity to low-dose radiation from cardiovascular imaging.

  2016cites this paper
• The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster

  2016cites this paper
• The Roles of p21

  2016cites this paper
• Identification And Characterization Of DNA Repair Snf2/Swi2 Atpases In Tetrahymena Thermophila

  2016cites this paper
• A central role of TRAX in the ATM-mediated DNA repair

  2016cites this paper
• DNA Double Strand Breaks: A Common Theme in Neurodegenerative Diseases.

  2016cites this paper
• Stress factor – dependent differences in molecular mechanisms of premature cell senescence

  2015cites this paper
• RECA plays a dual role in the maintenance of chloroplast genome stability in Physcomitrella patens.

  2015cites this paper
• Investigation of checkpoint adaptation in human cancer cells treated with the genotoxic agent cisplatin

  2015cites this paper
• The Roles of p21Waf1/CIP1 and Hus1 in Generation and Transmission of Damage Signals Stimulated by Low-Dose Alpha-Particle Irradiation

  2015cites this paper
• Screening for Suppression of Inflammatory Responses Against UVB-Induced DNA Damage in Skin Cells Based on Natural Plant Extract Enhances DNA Repair-Related Polymerase Activity

  2015cites this paper
• Oxidatively Generated Damage to Cellular DNA by UVB and UVA Radiation ,

  2015cites this paper
• Agrobacterium tumefaciens Gene Transfer: How a Plant Pathogen Hacks the Nuclei of Plant and Nonplant Organisms.

  2015cites this paper
• ATR suppresses apoptosis after UVB irradiation by controlling both translesion synthesis and alternative tolerance pathways

  2015influential citation
• Loss of Caenorhabditis elegans BRCA1 Promotes Genome Stability During Replication in smc-5 Mutants

  2014cites this paper
• Polymerase η suppresses telomere defects induced by DNA damaging agents

  2014influential citation
• DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.

  2014cites this paper
• RhoB Promotes γH2AX Dephosphorylation and DNA Double-Strand Break Repair

  2014cites this paper
• Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20

  2014cites this paper
• The role of polymerase eta in protecting against genome instability and telomere defects caused by the generation of environmentally relevant DNA lesions

  2014influential citation
• Title G 1 checkpoint establishment in vivo during embryonic liverdevelopment

  2014cites this paper
• Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome.

  2014cites this paper
• , and DNA Double-Strand Break Repair H 2 AX Dephosphorylation γ RhoB Promotes

  2014cites this paper
• G1 checkpoint establishment in vivo during embryonic liver development

  2014cites this paper
• Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors

  2013cites this paper
• The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.

  2013cites this paper
• Dysregulation of DNA polymerase j recruitment to replication forks results in genomic instability

  2013cites this paper
• Translesion DNA synthesis and mutagenesis in eukaryotes.

  2013cites this paper
• Characterisation of UVA-induced DNA damage responses in human skin cells

  2013cites this paper
• Myosin 16 levels fluctuate during the cell cycle and are downregulated in response to DNA replication stress

  2013cites this paper
• Effects of chromatin decondensation on alternative NHEJ.

  2013cites this paper
• The NR4A2 Nuclear Receptor Is Recruited to Novel Nuclear Foci in Response to UV Irradiation and Participates in Nucleotide Excision Repair

  2013cites this paper
• filling and bypass at the replication fork are both active echanisms for tolerance of low-dose ultraviolet-induced DNA amage in the human genome

  2013cites this paper
• Dissertation zur Erlangung des Doktorgrades der Fakultät für Chemie und Pharmazie

  2013cites this paper
• Involvement of ribonucleotide reductase-M1 in 5-fluorouracil‑induced DNA damage in esophageal cancer cell lines.

  2013cites this paper
• Effects of proteasome inhibition on cisplatin induced DNA damage responses in human cells

  2012influential citation
• Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

  2012cites this paper
• Paternal DNA damage resulting from various sperm treatments persists after fertilization and is similar before and after DNA replication.

  2012cites this paper
• Roles of DNA polymerase eta and replication protein A (RPA) in undamaged and platinum-treated human cells

  2012cites this paper
• Expression pattern analysis of DNA repair-related and DNA damage response genes revealed by 55K oligomicroarray upon UV-B irradiation in the intertidal copepod, Tigriopus japonicus.

  2012cites this paper
• Implication de l'ADN polymérase eta dans la réponse aux dommages de l'ADN dans des cellules déficientes en réparation par excision de nucléotides

  2012influential citation
• Interaction of Saccharomyces cerevisiae HMO2 domains with distorted DNA.

  2012cites this paper
• Extra-Telomeric Roles of Telomeric Proteins

  2012cites this paper
• Repair of DNA Double-Strand Breaks

  2012cites this paper
• Dual effects of N-acetyl-L-cysteine dependent on NQO1 activity: suppressive or promotive of 9,10-phenanthrenequinone-induced toxicity.

  2012cites this paper
• UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages

  2012cites this paper
• UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells.

  2011cites this paper
• DNA polymerases and cancer

  2011cites this paper
• Expression of Arf Tumor Suppressor in Spermatogonia Facilitates Meiotic Progression in Male Germ Cells

  2011cites this paper
• The response of mammalian cells to UV-light reveals Rad54-dependent and independent pathways of homologous recombination.

  2011cites this paper
• Retention of γH2AX foci as an indication of lethal DNA damage.

  2011cites this paper
• Functional relevance of the histone γH2Ax in the response to DNA damaging agents

  2011cites this paper
• No formation of DNA double-strand breaks and no activation of recombination repair with UVA.

  2011cites this paper
• γH2Ax: Biomarker of Damage or Functional Participant in DNA Repair “All that Glitters Is not Gold!”

  2011cites this paper
• Structural and functional analysis of the eukaryotic DNA repair proteins Mre11 and Nbs1

  2011cites this paper
• Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability

  2011cites this paper
• PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.

  2011cites this paper
• Ultraviolet B retards growth, induces oxidative stress, and modulates DNA repair-related gene and heat shock protein gene expression in the monogonont rotifer, Brachionus sp.

  2011cites this paper
• Tumour suppressor ING1b maintains genomic stability upon replication stress

  2011influential citation
• UV stalled replication forks restart by re-priming in human fibroblasts

  2011influential citation
• DNA double-strand breaks induced by high NaCl occur predominantly in gene deserts

  2011cites this paper
• Réparation par excision de nucléotides spécifique au cycle cellulaire : implications pour la résistance à la chimiothérapie dans le cancer de l'ovaire humain

  2011cites this paper
• Role of the Asf1-Rad53 interaction in genomic stability in S.cerevisiae

  2011cites this paper