A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts.

No abstract is available for this paper.

• Publication year

  2021

• Venue

  Biological Psychiatry

• Publication date

  2021-05-04

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.biopsych.2021.04.018PMID 34304866PMCID PMC8500913
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  year unknowninfluential reference
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