Efficacy of testosterone replacement therapy for treating metabolic disturbances in late-onset hypogonadism: a systematic review and meta-analysis

No abstract is available for this paper.

• Publication year

  2021

• Venue

  International Urology and Nephrology

• Publication date

  2021-06-05

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s11255-021-02876-wPMID 34089171
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial.

  2021cited by this paper
• European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males

  2020cited by this paper
• Association between prostate‐specific antigen and serum testosterone: A systematic review and meta‐analysis

  2020cited by this paper
• Intervention meta-analysis: application and practice using R software

  2019cited by this paper
• Prostate-Specific Antigen Within the Reference Range, Subclinical Coronary Atherosclerosis, and Cardiovascular Mortality

  2019cited by this paper
• The impact of testosterone replacement therapy on glycemic control, vascular function, and components of the metabolic syndrome in obese hypogonadal men with type 2 diabetes

  2018cited by this paper
• Effects of testosterone replacement therapy on metabolic syndrome among Japanese hypogonadal men: A subanalysis of a prospective randomised controlled trial (EARTH study)

  2018cited by this paper
• The Efficacy and Adverse Events of Testosterone Replacement Therapy in Hypogonadal Men: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials

  2018influential reference
• Mitochondria, glycogen, and lipid droplets in skeletal muscle during testosterone treatment and strength training: a randomized, double‐blinded, placebo‐controlled trial

  2018cited by this paper
• Long‐term testosterone therapy in type 2 diabetes is associated with reduced mortality without improvement in conventional cardiovascular risk factors

  2018cited by this paper
• Role of androgens in energy metabolism affecting on body composition, metabolic syndrome, type 2 diabetes, cardiovascular disease, and longevity: lessons from a meta-analysis and rodent studies

  2018cited by this paper
• Effect of Testosterone Treatment on Adipokines and Gut Hormones in Obese Men on a Hypocaloric Diet

  2017cited by this paper
• Testosterone replacement therapy: improved sexual desire and erectile function in men with type 2 diabetes following a 30‐week randomized placebo‐controlled study

  2017cited by this paper
• Testosterone therapy preserves muscle strength and power in aging men with type 2 diabetes—a randomized controlled trial

  2017cited by this paper
• MR spectroscopy of hepatic fat and adiponectin and leptin levels during testosterone therapy in type 2 diabetes: a randomized, double-blinded, placebo-controlled trial.

  2017cited by this paper
• Testosterone Replacement Therapy: Long-Term Safety and Efficacy

  2017influential reference
• Effect of testosterone on insulin sensitivity, oxidative metabolism and body composition in aging men with type 2 diabetes on metformin monotherapy

  2016cited by this paper
• Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial

  2016cited by this paper
• THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study.

  2016cited by this paper
• Testosterone Replacement Therapy and Cardiovascular Risk: A Review

  2015influential reference
• AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON THE ASSOCIATION OF TESTOSTERONE AND CARDIOVASCULAR RISK.

  2015cited by this paper
• Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men

  2015cited by this paper
• Testosterone therapy and cardiovascular risk: advances and controversies.

  2015cited by this paper
• Influence of testosterone replacement therapy on metabolic disorders in male patients with type 2 diabetes mellitus and androgen deficiency

  2014cited by this paper
• Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men

  2014cited by this paper
• Testosterone supplementation and sexual function: a meta-analysis study.

  2014cited by this paper
• Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: the BLAST study.

  2014cited by this paper
• Injectable testosterone undecanoate for the treatment of hypogonadism

  2014cited by this paper
• The response to testosterone undecanoate in men with type 2 diabetes is dependent on achieving threshold serum levels (the BLAST study)

  2014cited by this paper
• ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

  2013influential reference
• Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndrome (the TIMES2 Study)

  2011cited by this paper
• Identification of late-onset hypogonadism in middle-aged and elderly men.

  2010cited by this paper
• Efficacy and safety of two different testosterone undecanoate formulations in hypogonadal men with metabolic syndrome

  2010cited by this paper
• Efficacy and safety of two different testosterone undecanoate formulations in hypogonadal men with metabolic syndrome.

  2010cited by this paper
• Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone.

  2009cited by this paper
• Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement

  2009cited by this paper
• Effect of 2 Years of Testosterone Replacement on Insulin Secretion, Insulin Action, Glucose Effectiveness, Hepatic Insulin Clearance, and Postprandial Glucose Turnover in Elderly Men

  2008cited by this paper
• Bmc Medical Research Methodology Open Access Using Reflexivity to Enhance In-depth Interviewing Skills for the Clinician Researcher

  2008cited by this paper
• Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer.

  2006cited by this paper
• Estimating the mean and variance from the median, range, and the size of a sample

  2005cited by this paper
• Androgen therapy improves insulin sensitivity and decreases leptin level in healthy adult men with low plasma total testosterone: a 3-month randomized placebo-controlled trial.

  2001cited by this paper
• The Effect of Endocrine Disorders on Lipids and Lipoproteins

  2000cited by this paper
• Promoting continence--continence advice.

  1989cited by this paper
• Meta-analysis in clinical trials.

  1986cited by this paper
• Discriminative effect of rifampin of RNA replication of various RNA bacteriophages

  1975cited by this paper

• Evaluation and research progress on rodent models of late-onset hypogonadism: a comprehensive review.

  2025cites this paper
• Cardiovascular Effects of Testosterone Replacement Therapy in Hypogonadal Men: A Systematic Review of Lipid Profiles, Inflammatory Markers, and Vascular Function

  2025cites this paper
• Testosterone and Obesity in an Aging Society

  2025cites this paper
• Bidirectional Mendelian Randomization Analysis Reveals Protective Effects of Bioavailable Testosterone Against Hypertensive Disorders of Pregnancy.

  2025cites this paper
• Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysis

  2024cites this paper
• Genetic determinants of plasma testosterone in male blood donors are associated with altered red blood cell characteristics and survival in cold storage and after transfusion.

  2024cites this paper
• The Role of Bone-Derived Osteocalcin in Testicular Steroidogenesis: Contributing Factor to Male Fertility

  2024cites this paper
• Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: A Systematic Review and Meta-Analysis

  2023cites this paper
• Elevated circulating follicle stimulating hormone level is associated with dyslipidemia in male type 2 diabetes mellitus patients: A cross‐sectional study

  2023cites this paper
• Systematic reviews and meta-analyses on androgen administration in humans: an umbrella review

  2023cites this paper
• EMAS position statement: Testosterone replacement therapy in older men.

  2023cites this paper
• Anabolic-Androgenic Steroids and Exercise Training: Breaking the Myths and Dealing With Better Outcome in Sarcopenia

  2022cites this paper
• The effect of concurrent endurance-resistance training on serum testosterone levels, body composition, muscular strength and international index of erectile function in older men

  2022cites this paper