Effect of testosterone on insulin sensitivity, oxidative metabolism and body composition in aging men with type 2 diabetes on metformin monotherapy

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Diabetes, obesity and metabolism

• Publication date

  2016-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/dom.12701PMID 27265844
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Endogenous and exogenous testosterone and the risk of prostate cancer and increased prostate‐specific antigen (PSA) level: a meta‐analysis

  2016cited by this paper
• Testosterone and "Age-Related Hypogonadism"--FDA Concerns.

  2015cited by this paper
• Serum Testosterone (T) Level Variability in T Gel-Treated Older Hypogonadal Men: Treatment Monitoring Implications.

  2015cited by this paper
• Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 Diabetes

  2015influential reference
• Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: the BLAST study.

  2014cited by this paper
• Testosterone Supplementation Improves Carbohydrate and Lipid Metabolism in Some Older Men with Abdominal Obesity

  2014cited by this paper
• Comment on Gianatti et al. Effect of Testosterone Treatment on Glucose Metabolism in Men With Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Care 2014;37:2098–2107

  2014cited by this paper
• Testosterone with dutasteride, but not anastrazole, improves insulin sensitivity in young obese men: a randomized controlled trial.

  2014cited by this paper
• Effect of Testosterone Treatment on Glucose Metabolism in Men With Type 2 Diabetes: A Randomized Controlled Trial

  2014cited by this paper
• Metabolism and insulin signaling in common metabolic disorders and inherited insulin resistance.

  2014influential reference
• Late-onset hypogonadism: Current concepts and controversies of pathogenesis, diagnosis and treatment

  2014cited by this paper
• Words of wisdom. Re: Gonadal steroids and body composition, strength, and sexual function in men.

  2013influential reference
• Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials

  2013cited by this paper
• Gonadal steroids and body composition, strength, and sexual function in men.

  2013cited by this paper
• Similar reference intervals for total testosterone in healthy young and elderly men: results from the Odense Androgen Study

  2013cited by this paper
• Testosterone therapy increased muscle mass and lipid oxidation in aging men

  2011cited by this paper
• Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndrome (the TIMES2 Study)

  2011cited by this paper
• Comment on: Jones et al. Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndrome (the TIMES2 Study). Diabetes Care 2011;34:828–837

  2011cited by this paper
• Low testosterone in men with type 2 diabetes: significance and treatment.

  2011cited by this paper
• Adverse events associated with testosterone administration.

  2010cited by this paper
• Testosterone Concentrations in Diabetic and Nondiabetic Obese Men

  2010cited by this paper
• Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double‐blinded placebo‐controlled Moscow study

  2010influential reference
• Identification of late-onset hypogonadism in middle-aged and elderly men.

  2010cited by this paper
• Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline.

  2010cited by this paper
• Treatment of hypogonadism with testosterone in patients with type 2 diabetes mellitus.

  2010influential reference
• Sex steroids deficiency impairs glucose transporter 4 expression and its translocation through defective Akt phosphorylation in target tissues of adult male rat.

  2009cited by this paper
• Testosterone stimulates extra‐hepatic but not hepatic fat oxidation (Fox): comparison of oral and transdermal testosterone administration in hypopituitary men

  2009influential reference
• Low testosterone levels are common and associated with insulin resistance in men with diabetes.

  2008cited by this paper
• Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle.

  2008cited by this paper
• Effects of graded doses of testosterone on erythropoiesis in healthy young and older men.

  2008cited by this paper
• Prevalence of symptomatic androgen deficiency in men.

  2007cited by this paper
• Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men.

  2007influential reference
• Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes.

  2006influential reference
• Androgens, insulin resistance and vascular disease in men

  2005cited by this paper
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  2005influential reference
• Acid Ceramidase Overexpression Prevents the Inhibitory Effects of Saturated Fatty Acids on Insulin Signaling*

  2005cited by this paper
• Skeletal muscle fat oxidation: timing and flexibility are everything.

  2005cited by this paper
• A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene.

  2004cited by this paper
• The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men.

  2004cited by this paper
• Use and abuse of HOMA modeling.

  2004cited by this paper
• Pharmacokinetics of transdermal testosterone gel in hypogonadal men: application of gel at one site versus four sites: a General Clinical Research Center Study.

  2000cited by this paper
• Differential response of rat skeletal muscle glycogen metabolism to testosterone and estradiol.

  1999cited by this paper
• Effects of insulin on glucose turnover rates in vivo: isotope dilution versus constant specific activity technique.

  1996cited by this paper
• The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.

  1992cited by this paper
• Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

  1990influential reference
• Calculation of substrate oxidation rates in vivo from gaseous exchange.

  1983cited by this paper
• Endogenous and exogenous testosterone and the risk of prostate cancer and increased prostate specific antigen ( PSA ) : a meta-analysis

  year unknowncited by this paper

• Effects of weight loss on testosterone, sex hormone‐binding globulin, adiposity, and insulin sensitivity in women and men

  2025cites this paper
• Testosterone therapy is associated with reduced risk of acute kidney injury, kidney failure with renal replacement therapy, and cardiovascular events in men with diabetes and hypogonadism

  2025cites this paper
• Male Hypogonadism: The Korean Society of Men's Health and Aging Position Statement

  2025cites this paper
• The effects and safety of testosterone replacement therapy for men with hypogonadism: the TestES evidence synthesis and economic evaluation.

  2024cites this paper
• Effect of testosterone replacement therapy on lower urinary tract symptoms: A systematic review and network meta‐analysis

  2024cites this paper
• Evaluation of the effect of testosterone replacement therapy with a transdermal testosterone on glycemic control in men with type 2 diabetes mellitus

  2024cites this paper
• Cardiovascular safety of testosterone replacement therapy in men: an updated systematic review and meta-analysis

  2024cites this paper
• The Metabolic Syndrome, a Human Disease

  2024cites this paper
• Diagnosis and Effectiveness of Treatment of Male Hypogonadism in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

  2024cites this paper
• Whole‐body oxidative stress reduction during testosterone therapy in aging men: A randomized placebo‐controlled trial

  2023cites this paper
• Testosterone therapy increases the anticoagulant potential in men with opioid-induced hypogonadism: a randomized, placebo-controlled study

  2023cites this paper
• Hepcidin Reduction during Testosterone Therapy in Men with Type 2 Diabetes: A Randomized, Double-Blinded, Placebo-Controlled Study

  2023influential citation
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  2023cites this paper
• The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health

  2022cites this paper
• Baseline Testosterone Predicts Body Composition and Metabolic Response to Testosterone Therapy

  2022cites this paper
• Morbidity and mortality in men: Role of androgens.

  2022cites this paper
• Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis

  2022cites this paper
• Testicular function

  2022cites this paper
• Adult Onset Hypogonadism

  2022cites this paper
• Relationship between Testosterone and Sarcopenia in Older-Adult Men: A Narrative Review

  2022cites this paper
• Testosterone replacement therapy in men with type 2 diabetes mellitus and functional hypogonadism -an Integrated Diabetes and Endocrine Academy (IDEA) consensus guideline.

  2021cites this paper
• Testosterone therapy for prevention and reversal of type 2 diabetes in men with low testosterone.

  2021cites this paper
• Hypogonadism, Type-2 Diabetes Mellitus, and Bone Health: A Narrative Review

  2021cites this paper
• The Role of testosterone treatment in patients with metabolic disorders

  2021cites this paper
• Erectile dysfunction and diabetes: A melting pot of circumstances and treatments

  2021cites this paper
• Effects of Testosterone Replacement Therapy on Glycolipid Metabolism Among Hypogonadal Men withT2DM: A Meta-Analysis And System Review Of Randomized Controlled Trials

  2021cites this paper
• Efficacy of testosterone replacement therapy for treating metabolic disturbances in late-onset hypogonadism: a systematic review and meta-analysis

  2021cites this paper
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  2020cites this paper
• Androgen Therapy in Male Patients Suffering from Type 2 Diabetes: A Review of Benefits and Risks.

  2020cites this paper
• Testosterone deficiency in men with Type 2 diabetes: pathophysiology and treatment

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Association of high circulating testosterone with increased glycaemic variability in type 2 diabetes: A cross‐sectional study in China

  2019influential citation
• Glycemic Control During Gender-Affirming Therapy in a Patient With Type 1 Diabetes

  2019cites this paper
• Sex hormones, aging and cardiometabolic syndrome

  2019cites this paper
• Hypogonadotropic Hypogonadism in Men With Diabesity

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Cardiovascular impact of testosterone therapy for hypogonadism

  2018cites this paper
• Prevalence of andropause among Iranian men and its relationship with quality of life

  2018cites this paper
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  2018cites this paper
• Benefits and Health Implications of Testosterone Therapy in Men With Testosterone Deficiency.

  2018cites this paper
• Muscular responses to testosterone replacement vary by administration route: a systematic review and meta‐analysis

  2018cites this paper
• Body composition changes with testosterone replacement therapy following spinal cord injury and aging: A mini review

  2018cites this paper
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  2018cites this paper
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  2017cites this paper
• Circulating sex steroids coregulate adipose tissue immune cell populations in healthy men.

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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