Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Nature Genetics

• Publication date

  2002-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ng1006PMID 12368914
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1985cited by this paper
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  1975cited by this paper
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  1968cited by this paper
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  1968cited by this paper
• Neuropathologic alterations in the ataxia (paralytic) mouse.

  1965cited by this paper
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