Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Nitric oxide

• Publication date

  2010-02-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.niox.2009.12.004PMID 20044016PMCID PMC2851168
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nitrite as regulator of hypoxic signaling in mammalian physiology

  2009cited by this paper
• Blood vessel specific vaso-activity to nitrite under normoxic and hypoxic conditions.

  2009cited by this paper
• Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall.

  2008influential reference
• Nitric Oxide Production from Nitrite Occurs Primarily in Tissues Not in the Blood

  2008cited by this paper
• Nitric Oxide Production from Nitrite Occurs Primarily in Tissues not in the Blood: Critical Role of Xanthine Oxidase and Aldehyde Oxidase

  2008influential reference
• The functional nitrite reductase activity of the heme-globins.

  2008cited by this paper
• The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

  2008cited by this paper
• Nitrite Reductase Activity of Cytochrome c*

  2008cited by this paper
• Nitrite Reductase Function of Deoxymyoglobin: Oxygen Sensor and Regulator of Cardiac Energetics and Function

  2007cited by this paper
• Effects of dietary nitrate on blood pressure.

  2007cited by this paper
• Deoxymyoglobin Is a Nitrite Reductase That Generates Nitric Oxide and Regulates Mitochondrial Respiration

  2007cited by this paper
• Nitric oxide synthase reduces nitrite to NO under anoxia

  2006cited by this paper
• Characterization of the Mechanism of Cytochrome P450 Reductase-Cytochrome P450-mediated Nitric Oxide and Nitrosothiol Generation from Organic Nitrates*

  2006influential reference
• Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation.

  2006cited by this paper
• Effects of dietary nitrate on blood pressure in healthy volunteers.

  2006cited by this paper
• Immunohistochemical localization of aldehyde and xanthine oxidase in rat tissues using polyclonal antibodies

  2005cited by this paper
• The existence and significance of a mitochondrial nitrite reductase

  2005cited by this paper
• Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control.

  2005cited by this paper
• Hemoglobin as a nitrite reductase regulating red cell-dependent hypoxic vasodilation.

  2005cited by this paper
• Xanthine Oxidase Catalyzes Anaerobic Transformation of Organic Nitrates to Nitric Oxide and Nitrosothiols

  2005cited by this paper
• The Reaction between Nitrite and Deoxyhemoglobin

  2005cited by this paper
• The emerging biology of the nitrite anion

  2005cited by this paper
• Quantitative measurements of NO reaction kinetics with a Clark-type electrode.

  2005cited by this paper
• Characterization of the Effects of Oxygen on Xanthine Oxidase-mediated Nitric Oxide Formation*

  2004influential reference
• Involvement of protein radical, protein aggregation, and effects on NO metabolism in the hypochlorite-mediated oxidation of mitochondrial cytochrome c.

  2004cited by this paper
• Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

  2003cited by this paper
• Ion implicated in blood pact

  2003cited by this paper
• Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues.

  2003influential reference
• Analytical implications of iron dithiocarbamates for measurement of nitric oxide.

  2002cited by this paper
• Nitric Oxide Uptake by Erythrocytes Is Primarily Limited by Extracellular Diffusion Not Membrane Resistance*

  2002cited by this paper
• Whole body detection and imaging of nitric oxide generation in mice following cardiopulmonary arrest: Detection of intrinsic nitrosoheme complexes

  2001cited by this paper
• Myoglobin: A scavenger of bioactive NO.

  2001cited by this paper
• Characterization of the Magnitude and Kinetics of Xanthine Oxidase-catalyzed Nitrite Reduction

  2001influential reference
• Redox properties of iron-dithiocarbamates and their nitrosyl derivatives: implications for their use as traps of nitric oxide in biological systems.

  2000cited by this paper
• Reduction of Nitrite to Nitric Oxide Catalyzed by Xanthine Oxidoreductase*

  2000influential reference
• Mitochondria recycle nitrite back to the bioregulator nitric monoxide.

  2000cited by this paper
• Nitrite reductase activity is a novel function of mammalian mitochondria

  1999cited by this paper
• Non-enzymatic nitric oxide synthesis in biological systems.

  1999influential reference
• Development of chemiluminescence-based methods for specific quantitation of nitrosylated thiols.

  1998cited by this paper
• Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions

  1998cited by this paper
• An improved assay for measurement of nitric oxide synthase activity in biological tissues.

  1998cited by this paper
• Evaluation of the magnitude and rate of nitric oxide production from nitrite in biological systems.

  1998cited by this paper
• Generation of nitric oxide by a nitrite reductase activity of xanthine oxidase: a potential pathway for nitric oxide formation in the absence of nitric oxide synthase activity.

  1998cited by this paper
• Direct measurement of nitric oxide generation from nitric oxide synthase.

  1997cited by this paper
• Measurement of Nitric Oxide and Peroxynitrite Generation in the Postischemic Heart

  1996cited by this paper
• cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.

  1996cited by this paper
• Spatial mapping of nitric oxide generation in the ischemic heart using electron paramagnetic resonance imaging

  1996cited by this paper
• Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.

  1996cited by this paper
• Organ distribution and molecular forms of human xanthine dehydrogenase/xanthine oxidase protein.

  1996cited by this paper
• Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

  1995cited by this paper
• Enzyme-independent formation of nitric oxide in biological tissues

  1995influential reference
• Direct Measurement of Nitric Oxide Generation in the Ischemic Heart Using Electron Paramagnetic Resonance Spectroscopy (*)

  1995cited by this paper
• Substrate Control of Free Radical Generation from Xanthine Oxidase in the Postischemic Heart (*)

  1995cited by this paper
• Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: a technique for imaging tissue metabolism and oxygenation.

  1994cited by this paper
• Stomach NO synthesis

  1994cited by this paper
• Intragastric nitric oxide production in humans: measurements in expelled air.

  1994cited by this paper
• Endothelium‐derived relaxing and contracting factors

  1991cited by this paper
• Nitric oxide: physiology, pathophysiology, and pharmacology.

  1991cited by this paper
• Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

  1990cited by this paper
• Ischaemic injury mediator

  1990cited by this paper
• Endothelium‐derived relaxing and contracting factors

  1989cited by this paper
• Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

  1988cited by this paper
• Free radicals and myocardial ischemia: overview and outlook.

  1988cited by this paper
• Molybdenum hydroxylases: biological distribution and substrate-inhibitor specificity.

  1987cited by this paper
• Tissue distribution of the molybdenum hydroxylases, aldehyde oxidase and xanthine oxidase, in male and female guinea pigs.

  1987cited by this paper
• Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

  1987cited by this paper
• Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

  1987cited by this paper
• Oxygen-derived free radicals in postischemic tissue injury.

  1985cited by this paper
• Free radicals and myocardial ischemia. The role of xanthine oxidase.

  1985cited by this paper
• Free Radicals and Myocardial Ischemia

  1985cited by this paper
• Xanthine oxidase as a source of free radical damage in myocardial ischemia.

  1985cited by this paper
• Free radicals and myocardial ischemia. The role of xanthine oxidase.

  1985cited by this paper

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• Stepwise Nitrate → Dinitrogen Transformation Mediated by a Series of Synthetic Heme/Cobalt and Heme/Copper Assemblies: Modeling Denitrification with Cytochrome c Oxidase Mimics

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• Renal replacement therapy removes a large number of nitric oxide donors responsible for the nitrate–nitrite–nitric oxide pathway

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• A physiologically relevant role for NO stored in vascular smooth muscle cells: A novel theory of vascular NO signaling

  2022cites this paper
• Quantitative aspects of nitric oxide production from nitrate and nitrite

  2022cites this paper
• Indirect Antioxidant Effects of the Nitrite Anion: Focus on Xanthine Oxidase

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• Quantitative aspects of nitric oxide production in the heart

  2022cites this paper
• The C2H2 Zinc Finger Protein MaNCP1 Contributes to Conidiation through Governing the Nitrate Assimilation Pathway in the Entomopathogenic Fungus Metarhizium acridum

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• Elevated Nitrite/Nitrate Ratio as a Potential Biomarker for the Differential Diagnosis of Pleural Effusions

  2022cites this paper
• The expanding roles of neuronal nitric oxide synthase (NOS1)

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• Binuclear Manganese(II)-Thiolate Complexes: Synthesis, Characterization and Nitrite Induced Structural Changes

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• Immune Modulation as a Key Mechanism for the Protective Effects of Remote Ischemic Conditioning After Stroke

  2021cites this paper
• Safety and toxicology assessment of sodium nitrite administered by intramuscular injection.

  2021cites this paper
• Progress and Prospects of Regulatory Functions Mediated by Nitric Oxide on Immunity and Immunotherapy

  2021cites this paper
• Nitrite and tempol combination promotes synergic effects and alleviates right ventricular wall stress during acute pulmonary thromboembolism.

  2021cites this paper
• Body mass-normalized moderate dose of dietary nitrate intake improves endothelial function and walking capacity in patients with peripheral artery disease.

  2021cites this paper
• Bio-inspired nitrogen oxide (NOx) interconversion reactivities of synthetic heme Compound-I and Compound-II intermediates.

  2021cites this paper
• Nitric oxide in cellular adaptation and disease

  2020cites this paper
• Consistent gastric pH-dependent effects of suppressors of gastric acid secretion on the antihypertensive responses to oral nitrite.

  2020cites this paper
• Muscle fiber type differences in nitrate and nitrite storage and nitric oxide signaling in rats

  2020cites this paper
• Oral Administration of Sodium Nitrate to Metabolic Syndrome Patients Attenuates Mild Inflammatory and Oxidative Responses to Acute Exercise

  2020cites this paper
• The role of hemoglobin in nitric oxide transport in vascular system

  2020cites this paper
• The Solution Chemistry of Nitric Oxide and Other Reactive Nitrogen Species.

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• Oral nitrite treatment increases S-nitrosylation of vascular protein kinase C and attenuates the responses to angiotensin II

  2020cites this paper
• Nitric oxide as a developmental and metabolic signal in filamentous fungi

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• Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin

  2019cites this paper
• Inhaled nebulized nitrite and nitrate therapy in a canine model of hypoxia-induced pulmonary hypertension.

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• Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

  2019cites this paper
• Oxidative Stress in Metabolic Syndrome: Experimental Model of Biomarkers

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• Study of respiratory chain dysfunction in heart disease

  2018cites this paper
• Sodium nitrite augments lung S-nitrosylation and reverses chronic hypoxic pulmonary hypertension in juvenile rats.

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• Structure, function and the related mechanism of cytoglobin

  2018cites this paper
• Nitrite Reduction in Aqueous Solution Mediated by Amavadin Homologues: N2 O Formation and Water Oxidation.

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• Nitrite‐dependent nitric oxide synthesis by molybdenum enzymes

  2018cites this paper
• Does dietary nitrate say NO to cardiovascular ageing? Current evidence and implications for research

  2018cites this paper
• Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase.

  2018cites this paper
• Nitrate and Nitrite in Health and Disease

  2018cites this paper
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  2018cites this paper
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  2016cites this paper
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  2013cites this paper
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