Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Blood

• Publication date

  2000-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V96.3.1125.015K19_1125_1129PMID 10910932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transferrin receptors on circulating monocytes in hereditary haemochromatosis.

  2009cited by this paper
• Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

  2000cited by this paper
• Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene.

  1999cited by this paper
• Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum.

  1999cited by this paper
• The C282Y mutation causing hereditary hemochromatosis does not produce a null allele.

  1999cited by this paper
• Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis.

  1999cited by this paper
• Co-trafficking of HFE, a Nonclassical Major Histocompatibility Complex Class I Protein, with the Transferrin Receptor Implies a Role in Intracellular Iron Regulation*

  1998cited by this paper
• The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.

  1998cited by this paper
• HFE gene knockout produces mouse model of hereditary hemochromatosis.

  1998cited by this paper
• Iron release from human monocytes after erythrophagocytosis in vitro: an investigation in normal subjects and hereditary hemochromatosis patients.

  1998cited by this paper
• Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor.

  1998cited by this paper
• Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma.

  1998cited by this paper
• Kupffer cell staining by an HFE‐specific monoclonal antibody: implications for hereditary haemochromatosis

  1998cited by this paper
• The Hemochromatosis Founder Mutation in HLA-H Disrupts β2-Microglobulin Interaction and Cell Surface Expression*

  1997cited by this paper
• Oral somatic transgene vaccination using attenuated S. typhimurium.

  1997cited by this paper
• Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells.

  1997cited by this paper
• Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis.

  1997cited by this paper
• Hemochromatosis: The genetic disorder of the twenty–first century

  1996cited by this paper
• Salmonellosis: host immune responses and bacterial virulence determinants.

  1996cited by this paper
• beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism.

  1996cited by this paper
• A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

  1996cited by this paper
• Haemochromatosis and HLA–H

  1996cited by this paper
• Haemochromatosis and HLA–H

  1996cited by this paper
• Duodenal ferritin synthesis in genetic hemochromatosis.

  1995cited by this paper
• The transferrin receptor.

  1993cited by this paper
• Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi

  1992cited by this paper
• Iron metabolism.

  1986cited by this paper
• [IRON METABOLISM].

  1964cited by this paper

• HFE-Related Hemochromatosis May Be a Primary Kupffer Cell Disease

  2025cites this paper
• Severe anaemia, iron deficiency, and susceptibility to invasive bacterial infections

  2023cites this paper
• A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages

  2022cites this paper
• Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin

  2021cites this paper
• Higher iron stores and the HFE 187C>G variant delay onset of peripheral neuropathy during combination antiretroviral therapy

  2020cites this paper
• Association of the polymorphisms of the genes APOC3 (rs2854116), ESR2 (rs3020450), HFE (rs1799945), MMP1 (rs1799750) and PPARG (rs1801282) with lipodystrophy in people living with HIV on antiretroviral therapy: a systematic review

  2020cites this paper
• The development of gene-based vectors for immunization

  2020cites this paper
• Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice

  2020cites this paper
• Classical and intermediate monocytes scavenge non-transferrin-bound iron and damaged erythrocytes

  2019cites this paper
• Haemochromatosis

  2018cites this paper
• The role of HFE genotype in macrophage phenotype

  2018cites this paper
• Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response

  2017cites this paper
• The hemochromatosis protein HFE 20 years later: An emerging role in antigen presentation and in the immune system

  2017cites this paper
• Human macrophage ferroportin biology and the basis for the ferroportin disease

  2017cites this paper
• Development of Gene-Based Vectors for Immunization

  2017cites this paper
• In vitro responses of chicken macrophage-like monocytes following exposure to pathogenic and non-pathogenic E. coli ghosts loaded with a rational design of conserved genetic materials of influenza and Newcastle disease viruses.

  2016cites this paper
• Metabolic reprogramming and cell fate regulation in alcoholic liver disease.

  2015cites this paper
• Investigating Novel Biological Mechanisms of Head and Neck Cancers

  2014cites this paper
• Molecular basis of HFE-hemochromatosis

  2014cites this paper
• Molecular basis of HFE-hemochromatosis

  2014cites this paper
• levels independently of transferrin receptor 1 in TRVb cells The hereditary hemochromatosis protein, HFE, lowers intracellular iron

  2013cites this paper
• expression of hereditary hemochromatosis promoter polymorphisms influence the phenotypic α Tumor necrosis factor

  2013cites this paper
• Hemochromatosis Enhances Tumor Progression via Upregulation of Intracellular Iron in Head and Neck Cancer

  2013cites this paper
• Kinetics of manganese transport and gene expressions of manganese transport carriers in Caco-2 cell monolayers

  2013cites this paper
• Iron and the Reticuloendothelial System

  2012cites this paper
• Plasma Iron and Iron Delivery to the Tissues

  2012cites this paper
• Hfe Deficiency Impairs Pulmonary Neutrophil Recruitment in Response to Inflammation

  2012cites this paper
• Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project.

  2012cites this paper
• Post-transcriptional regulation of HFE gene expression

  2011cites this paper
• Hepcidin messenger RNA expression in human lymphocytes

  2010cites this paper
• Iron metabolism in macrophages from HFE hemochromatosis patients.

  2010cites this paper
• The Ethnospecific Distribution of the HFE Haplotypes for IVS2(+4)t/c, IVS4(−44)t/c, and IVS5(−47)g/a in Populations of Russia and Possible Effects of These Single-Nucleotide Polymorphisms in Splicing

  2010cites this paper
• Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation.

  2010cites this paper
• Huh‐7: A human “hemochromatotic” cell line

  2010cites this paper
• Genetic Determinants of Cognitive Function and Age-Related Brain Changes

  2010cites this paper
• World J Gastroenterol

  2010cites this paper
• Transplantation of a liver with the C282Y mutation into a recipient heterozygous for H63D results in iron overload.

  2009cites this paper
• Iron metabolism in the anemia of chronic disease.

  2009cites this paper
• Pharmacogenetics of nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy.

  2009cites this paper
• HFE hemochromatosis and hepatic sarcoid.

  2009cites this paper
• Iron metabolism in the mononuclear phagocyte system

  2008cites this paper
• Protein (IRE/IRP) Regulatory Network

  2008cites this paper
• Nramp1 equips macrophages for efficient iron recycling.

  2008cites this paper
• Function of the hemochromatosis protein HFE: Lessons from animal models.

  2008cites this paper
• Ironing out haemochromatosis : a study of an Indian family

  2008cites this paper
• Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy.

  2008cites this paper
• Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis.

  2008cites this paper
• Survival Advantage of the Hemochromatosis C282Y Mutation

  2008cites this paper
• An MHC class Ib–restricted CD8 T cell response confers antiviral immunity

  2008cites this paper
• Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network.

  2008cites this paper
• The hereditary hemochromatosis protein HFE and its chaperone beta2-microglobulin localise predominantly to the endosomal-recycling compartment.

  2007cites this paper
• Overexpression of HFE in HepG2 cells reveals differences in intracellular distribution and co-localization of wt- and mutated forms.

  2007cites this paper
• The relevance of the intestinal crypt and enterocyte in regulating iron absorption

  2007cites this paper
• Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages

  2007cites this paper
• Iron overload and immunity.

  2007cites this paper
• HFE gene in primary and secondary hepatic iron overload.

  2007cites this paper
• The Regulation of Cellular Iron Metabolism

  2007cites this paper
• [Pathophysiology and genetics of classic HFE (type 1) hemochromatosis].

  2007cites this paper
• Physiopathologie et génétique de l'hémochromatose HFE de type 1

  2007cites this paper
• Regulation of transferrin receptor 2 stability and trafficking in hepatoma cells

  2006cites this paper
• Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.

  2006cites this paper
• Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy

  2006influential citation
• Régulation de l'absorption du fer : données nouvelles

  2006cites this paper
• Release of the Soluble Transferrin Receptor Is Directly Regulated by Binding of Its Ligand Ferritransferrin*

  2006cites this paper
• Confocal FRET and FLIM microscopy to characterize the distribution of transferrin receptors in membranes

  2006cites this paper
• [Erythrophagocytosis and recycling of heme iron in normal and pathological conditions; regulation by hepcidin].

  2005cites this paper
• The role of hereditary hemochromatosis in aseptic loosening following primary total hip arthroplasty

  2005cites this paper
• Changes in erythropoiesis in hereditary hemochromatosis are not mediated by HFE expression in nucleated red cells.

  2005cites this paper
• Genetic hemochromatosis update.

  2005cites this paper
• Mouse HFE inhibits Tf‐uptake and iron accumulation but induces non‐transferrin bound iron (NTBI)‐uptake in transformed mouse fibroblasts

  2005cites this paper
• The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells.

  2005cites this paper
• Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload

  2005cites this paper
• Iron accumulation in chronic hepatitis C: relation of hepatic iron distribution, HFE genotype, and disease course.

  2005cites this paper
• Intracellular bacteria as DNA carriers in vitro and in vivo

  2005cites this paper
• Modification of iron regulation by the inflammatory response.

  2005cites this paper
• The Macrophage: A Cellular Factory at the Interphase Between Iron and Immunity for the Control of Infections

  2005cites this paper
• Hepcidin in iron metabolism.

  2005cites this paper
• Iron in mammals: pathophysiological mechanisms of overload and deficiency in relation to disease

  2005cites this paper
• Erythrophagocytose et recyclage du fer héminique dans les conditions normales et pathologiques ; régulation par l'hepcidine

  2005cites this paper
• Iron Accumulation in Chronic Hepatitis C

  2005cites this paper
• DNA-loaded bacterial ghosts efficiently mediate reporter gene transfer and expression in macrophages.

  2005cites this paper
• Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading.

  2005cites this paper
• The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation

  2005cites this paper
• Hemochromatosis and the enigma of misplaced iron: Implications for infectious disease and survival

  2004influential citation
• Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes.

  2004cites this paper
• Expression of the Hereditary Hemochromatosis Protein HFE Increases Ferritin Levels by Inhibiting Iron Export in HT29 Cells*

  2004cites this paper
• Manipulation of iron to determine survival

  2004cites this paper
• HFE and Transferrin Directly Compete for Transferrin Receptor in Solution and at the Cell Surface*

  2004cites this paper
• Pathogenesis of hereditary hemochromatosis.

  2004cites this paper
• Hereditary hemochromatosis--a new look at an old disease.

  2004cites this paper
• [Update on hemochromatosis].

  2004cites this paper
• Transferrin [corrected] receptor association and endosomal localization of soluble HFE are not sufficient for regulation of cellular iron homeostasis.

  2004cites this paper
• Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability

  2004cites this paper
• Intestinal absorption of iron in HFE-1 hemochromatosis: local or systemic process?

  2004influential citation
• Iron, the HFE gene, and hepatitis C.

  2004cites this paper
• Bacteria as DNA vaccine carriers for genetic immunization.

  2004cites this paper
• Liver transplantation: An “in vivo” model for the pathophysiology of hemochromatosis?

  2004cites this paper
• Bacteria-mediated DNA transfer in gene therapy and vaccination

  2004cites this paper
• Actualités sur l’hémochromatose

  2004cites this paper
• Tranferrins receptor association and endosomal localization of soluble HFE are not sufficient for regulation of cellular iron homeostasis

  2004cites this paper