CFH and ARMS2 genetic polymorphisms predict response to antioxidants and zinc in patients with age-related macular degeneration.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Ophthalmology (Rochester, Minn.)

• Publication date

  2013-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ophtha.2013.07.039PMID 23972322
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
• CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration

  2006cited by this paper
• Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

  2006cited by this paper
• Encyclopedia of Measurement and Statistics

  2006cited by this paper
• Mitochondria: More Than Just a Powerhouse

  2006cited by this paper
• A simplified severity scale for age-related macular degeneration: AREDS Report No. 18.

  2005cited by this paper
• A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

  2005cited by this paper
• Hepatic lipase: a marker for cardiovascular disease risk and response to therapy

  2003cited by this paper
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  2001cited by this paper
• Mitochondrial abnormalities in ageing macular photoreceptors.

  2001cited by this paper
• The role of oxidative stress in the pathogenesis of age-related macular degeneration.

  2000cited by this paper
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  2000cited by this paper
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  1994cited by this paper
• Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group.

  1994cited by this paper
• Oligomeric domain structure of human complement factor H by X-ray and neutron solution scattering.

  1991cited by this paper
• Biostatistical Analysis (2nd ed.).

  1986cited by this paper

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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper