N6-methyladenosine RNA modification: A promising regulator in central nervous system injury.

No abstract is available for this paper.

• Publication year

  2021

• Venue

  Experimental Neurology

• Publication date

  2021-07-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.expneurol.2021.113829PMID 34339678
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alteration of N6 -Methyladenosine mRNA Methylation in a Rat Model of Cerebral Ischemia–Reperfusion Injury

  2021cited by this paper
• RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression

  2021cited by this paper
• N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s disease

  2021cited by this paper
• METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial–mesenchymal transition of renal tubular cells in diabetic kidney disease

  2021cited by this paper
• Mettl14-mediated m6A modification modulates neuron apoptosis during the repair of spinal cord injury by regulating the transformation from pri‐mir‐375 to miR-375

  2021cited by this paper
• Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila

  2021cited by this paper
• m6A RNA methylation: from mechanisms to therapeutic potential

  2021cited by this paper
• Exposure to constant light impairs cognition with FTO inhibition and m6A-dependent TrκB repression in mouse hippocampus.

  2021cited by this paper
• The role of RNA N6-methyladenosine methyltransferase in cancers

  2021cited by this paper
• The role of m6A modification in the biological functions and diseases

  2021cited by this paper
• Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons

  2021cited by this paper
• The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs

  2020cited by this paper
• Genetic analysis of N6-methyladenosine modification genes in Parkinson's disease.

  2020cited by this paper
• M6A2Target: a comprehensive database for targets of m6A writers, erasers and readers

  2020cited by this paper
• A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA.

  2020cited by this paper
• m6A-Atlas: a comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome

  2020cited by this paper
• Cytotoxicity of cobalt chloride in brain cell lines - a comparison between astrocytoma and neuroblastoma cells.

  2020cited by this paper
• Mechanism of RNA modification N6-methyladenosine in human cancer

  2020cited by this paper
• Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke

  2020cited by this paper
• METTL3 regulates inflammatory pain by modulating m6A‐dependent pri‐miR‐365‐3p processing

  2020cited by this paper
• Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury

  2020cited by this paper
• Deep analysis of RNA N6-adenosine methylation (m6A) patterns in human cells

  2020cited by this paper
• Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease

  2020cited by this paper
• WITMSG: Large-scale Prediction of Human Intronic m6A RNA Methylation Sites from Sequence and Genomic Features

  2020cited by this paper
• Hypothermia protects neurons against ischemia/reperfusion-induced pyroptosis via m6A-mediated activation of PTEN and the PI3K/Akt/GSK-3β signaling pathway.

  2020cited by this paper
• Epitranscriptomic m6A regulation following spinal cord injury

  2020cited by this paper
• YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA

  2020cited by this paper
• Comprehensive epigenetic analysis of m6A modification in the hippocampal injury of diabetic rats.

  2020cited by this paper
• Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury

  2020cited by this paper
• RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain.

  2020cited by this paper
• Oxygen glucose deprivation/re-oxygenation-induced neuronal cell death is associated with Lnc-D63785 m6A methylation and miR-422a accumulation

  2020cited by this paper
• RMVar: an updated database of functional variants involved in RNA modifications

  2020cited by this paper
• microRNA-421-3p prevents inflammatory response in cerebral ischemia/reperfusion injury through targeting m6A Reader YTHDF1 to inhibit p65 mRNA translation.

  2020cited by this paper
• New Insights on the Role of N6-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System

  2020cited by this paper
• Global N6-methyladenosine profiling of cobalt-exposed cortex and human neuroblastoma H4 cells presents epitranscriptomics alterations in neurodegenerative disease-associated genes.

  2020cited by this paper
• Circular RNA TLK1 Aggravates Neuronal Injury and Neurological Deficits after Ischemic Stroke via miR-335-3p/TIPARP

  2019cited by this paper
• Changqin NO. 1 inhibits neuronal apoptosis via suppressing GAS5 expression in a traumatic brain injury mice model

  2019cited by this paper
• miR-335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke

  2019cited by this paper
• Traumatic brain injury in China.

  2019cited by this paper
• FTO controls reversible m6Am RNA methylation during snRNA biogenesis

  2019cited by this paper
• The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

  2019cited by this paper
• Transient Focal Ischemia Significantly Alters the m6A Epitranscriptomic Tagging of RNAs in the Brain.

  2019cited by this paper
• DRUM: Inference of Disease-Associated m6A RNA Methylation Sites From a Multi-Layer Heterogeneous Network

  2019cited by this paper
• Reading, writing and erasing mRNA methylation

  2019cited by this paper
• Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death.

  2019cited by this paper
• The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression

  2019cited by this paper
• Genome-wide screening of altered m6A-tagged transcript profiles in the hippocampus after traumatic brain injury in mice.

  2019cited by this paper
• WHISTLE: a high-accuracy map of the human N6-methyladenosine (m6A) epitranscriptome predicted using a machine learning approach

  2019cited by this paper
• Screening the expression of several miRNAs from TaqMan Low Density Array in traumatic brain injury: miR‐219a‐5p regulates neuronal apoptosis by modulating CCNA2 and CACUL1

  2019cited by this paper
• Global burden of traumatic brain and spinal cord injury.

  2019cited by this paper
• Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers.

  2019cited by this paper
• Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke

  2018cited by this paper
• Dexras1 is a homeostatic regulator of exercise-dependent proliferation and cell survival in the hippocampal neurogenic niche

  2018cited by this paper
• The Long Noncoding RNA D63785 Regulates Chemotherapy Sensitivity in Human Gastric Cancer by Targeting miR-422a

  2018cited by this paper
• m6A Demethylase FTO Regulates Dopaminergic Neurotransmission Deficits Caused by Arsenite

  2018cited by this paper
• iRNA(m6A)-PseDNC: Identifying N6-methyladenosine sites using pseudo dinucleotide composition.

  2018cited by this paper
• BERMP: a cross-species classifier for predicting m6A sites by integrating a deep learning algorithm and a random forest approach

  2018cited by this paper
• N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

  2018cited by this paper
• DeepM6ASeq: prediction and characterization of m6A-containing sequences using deep learning

  2018cited by this paper
• Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.

  2018cited by this paper
• Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation

  2018cited by this paper
• m6ASNP: a tool for annotating genetic variants by m6A function

  2018cited by this paper
• Dopaminergic abnormalities following traumatic brain injury

  2018cited by this paper
• VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

  2018cited by this paper
• Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d

  2018cited by this paper
• Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury

  2018cited by this paper
• Reading m6A in the Transcriptome: m6A-Binding Proteins.

  2017cited by this paper
• Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain

  2017cited by this paper
• MODOMICS: a database of RNA modification pathways. 2017 update

  2017cited by this paper
• MeT-DB V2.0: elucidating context-specific functions of N6-methyl-adenosine methyltranscriptome

  2017cited by this paper
• Regulation of m6A Transcripts by the 3'→5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline.

  2017cited by this paper
• MicroRNAs as Novel Biomarkers for the Diagnosis and Prognosis of Mild and Severe Traumatic Brain Injury

  2017cited by this paper
• m6A modulates haematopoietic stem and progenitor cell specification

  2017cited by this paper
• YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

  2017cited by this paper
• Brain injury with diabetes mellitus: evidence, mechanisms and treatment implications

  2017cited by this paper
• Human METTL16 is a N6‐methyladenosine (m6A) methyltransferase that targets pre‐mRNAs and various non‐coding RNAs

  2017cited by this paper
• Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis

  2017cited by this paper
• RMBase v2.0: deciphering the map of RNA modifications from epitranscriptome sequencing data

  2017cited by this paper
• ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells

  2017cited by this paper
• m6AVar: a database of functional variants involved in m6A modification

  2017cited by this paper
• S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1.

  2017cited by this paper
• Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

  2017cited by this paper
• m6aViewer: software for the detection, analysis, and visualization of N6-methyladenosine peaks from m6A-seq/ME-RIP sequencing data

  2017cited by this paper
• Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

  2017cited by this paper
• Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice

  2016cited by this paper
• m6A RNA methylation promotes XIST-mediated transcriptional repression

  2016cited by this paper
• SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features

  2016cited by this paper
• RNAMethPre: A Web Server for the Prediction and Query of mRNA m6A Sites

  2016cited by this paper
• Reversible methylation of m6Am in the 5′ cap controls mRNA stability

  2016cited by this paper
• Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.

  2016cited by this paper
• The Xist lncRNA directly interacts with SHARP to silence transcription through HDAC3

  2015cited by this paper
• N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions

  2015cited by this paper
• RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation

  2015cited by this paper
• Blast induced neurotrauma causes overpressure dependent changes to the DNA methylation equilibrium.

  2015cited by this paper
• Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential.

  2014cited by this paper
• Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain.

  2014cited by this paper
• Epigenetic Regulation by Heritable RNA

  2014cited by this paper
• Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites.

  2014cited by this paper
• Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

  2014cited by this paper
• A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

  2013cited by this paper

• Acupuncture Inhibits Ferroptosis to Attenuate Cerebral Ischemia-Reperfusion Injury Through FTO-Mediated m6A Modification of ACSL4.

  2026cites this paper
• Sp1‐Mettl14 Feedback Loop Promotes Ferroptosis in Mycobacterium tuberculosis–Infected Microglia by Activating Acsl4

  2026cites this paper
• Methyltransferase-like 14 mediated FOXP1 m6A modification alleviates osteoporosis by regulating the Wnt/β-catenin pathway

  2025cites this paper
• FTO promotes post-stroke neuroprotection by m6A demethylation of c-Jun

  2025cites this paper
• [Mechanisms of acupuncture in inhibition of ferroptosis in intracerebral hemorrhage mice based on RNA m6A methylation sequencing].

  2025cites this paper
• Overexpression of FTO alleviates traumatic brain injury induced posttraumatic epilepsy by upregulating NR4A2 expression via m6A demethylation

  2025cites this paper
• m6A-Induced lncRNA MEG3 Promotes Cerebral Ischemia-Reperfusion Injury Via Modulating Oxidative Stress and Mitochondrial Dysfunction by hnRNPA1/Sirt2 Axis

  2024cites this paper
• Exploring the prognostic potential of m6A methylation regulators in low-grade glioma: implications for tumor microenvironment modulation

  2024cites this paper
• Unraveling the molecular complexity: Wtap/Ythdf1 and Lcn2 in novel traumatic brain injury secondary injury mechanisms

  2024influential citation
• m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage

  2024cites this paper
• Demethylase FTO-Mediated m6A Modification of lncRNA MEG3 Activates Neuronal Pyroptosis via NLRP3 Signaling in Cerebral Ischemic Stroke

  2023cites this paper
• Transcriptome‐wide high‐throughput m6A sequencing of differential m6A methylation patterns in the decidual tissues from RSA patients

  2023cites this paper
• Maresin1 can be a potential therapeutic target for nerve injury.

  2023cites this paper
• Expression profiling of N6-methyladenosine-modified mRNA in PC12 cells in response to unconjugated bilirubin

  2023cites this paper
• Comprehensive analysis of m6A methylation modi�cation in chronic spinal cord injury in mice

  2022cites this paper
• Epigenetic Modifications and Their Potential Contribution to Traumatic Brain Injury Pathobiology and Outcome

  2022cites this paper
• Cerebroprotective Role of N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) After Experimental Stroke

  2022cites this paper
• Downregulation of METTL14 improves postmenopausal osteoporosis via IGF2BP1 dependent posttranscriptional silencing of SMAD1

  2022cites this paper
• Comprehensive Analysis and Functional Characteristics of Differential Expression of N6-Methyladenosine Methylation Modification in the Whole Transcriptome of Rheumatoid Arthritis

  2022cites this paper
• Comprehensive analysis of m6A methylation modification in chronic spinal cord injury in mice

  2022cites this paper
• Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries

  2022cites this paper
• Deciphering impact of single nucleotide polymorphisms on co-transcriptional modification in CCM gene mRNAs.

  2022cites this paper
• The Potential Role of m6A in the Regulation of TBI-Induced BGA Dysfunction

  2022cites this paper
• Transcriptome-Wide N6-Methyladenosine Methylome Alteration in the Rat Spinal Cord After Acute Traumatic Spinal Cord Injury

  2022cites this paper