Necroptosis: Molecular Signalling and Translational Implications

Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance. We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis.

• Publication year

  2014

• Venue

  International Journal of Cell Biology

• Publication date

  2014-01-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2014/490275PMID 24587805PMCID 3920604
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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