Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Cell

• Publication date

  2009-06-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cell.2009.05.021PMID 19524512
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of RIP1 kinase as a specific cellular target of necrostatins.

  2008cited by this paper
• Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.

  2008cited by this paper
• TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death.

  2007cited by this paper
• IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

  2007cited by this paper
• Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis.

  2007influential reference
• IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.

  2007cited by this paper
• Inhibition of ADP/ATP Exchange in Receptor-Interacting Protein-Mediated Necrosis

  2006cited by this paper
• Cell Death in Pancreatitis

  2006cited by this paper
• Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response.

  2006influential reference
• Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

  2005cited by this paper
• Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

  2005influential reference
• Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation*

  2004influential reference
• A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death.

  2004influential reference
• A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

  2004cited by this paper
• Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4

  2004influential reference
• The CD95(APO-1/Fas) DISC and beyond

  2003cited by this paper
• A Role for Tumor Necrosis Factor Receptor-2 and Receptor-interacting Protein in Programmed Necrosis and Antiviral Responses*

  2003cited by this paper
• Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3*

  2002influential reference
• Cell death in health and disease

  2000cited by this paper
• Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.

  2000cited by this paper
• Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

  2000influential reference
• Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

  2000cited by this paper
• Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB.

  1999influential reference
• Identification of RIP3, a RIP-like kinase that activates apoptosis and NFκB

  1999influential reference
• Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.

  1999cited by this paper
• RIP3, a Novel Apoptosis-inducing Kinase*

  1999cited by this paper
• Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.

  1998cited by this paper
• Caspases: enemies within.

  1998cited by this paper
• Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.

  1998cited by this paper
• Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

  1998influential reference
• The death domain kinase RIP mediates the TNF-induced NF-kappaB signal.

  1998cited by this paper
• The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

  1998influential reference
• Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

  1998influential reference
• Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.

  1997cited by this paper
• TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.

  1996cited by this paper
• Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

  1988cited by this paper
• Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics

  1972cited by this paper

• IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

  2026cites this paper
• CD47 blockade-driven necroptosis complements BCL-2 inhibition-driven apoptosis in lymphoid malignancies

  2026cites this paper
• A viable kinase-inactive RIPK3 D143N mouse model reveals its scaffold function in driving TNF-induced inflammatory disorder.

  2026cites this paper
• BIRC3 and NOC2L synergistically promote P53 acetylation to accelerate necroptosis in sepsis-associated acute kidney injury.

  2026cites this paper
• Cell death and its interaction with mitochondrial dysfunction in pathogenesis of acute pancreatitis: a comprehensive review

  2026cites this paper
• RIPK3 Orchestrates Scar-Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis.

  2026cites this paper
• The role of necroptosis in adiposity-based chronic disease (ABCD): A review

  2026cites this paper
• Small-molecule modulators of the necroptotic pathway: A medicinal chemistry perspective.

  2026cites this paper
• The miR‐148/152 Family Suppresses Apoptosis and Necroptosis for Cancer Evasion Through Direct RIPK1 Repression

  2026cites this paper
• From Hit to Lead: Discovery of Novel Selective RIPK1 Inhibitor with Pyridoimidazole Scaffold for the Treatment of Autoimmune Diseases through Phenotypic Screening and Structural Optimization.

  2026cites this paper
• RIPK3 Protects Against Endothelial Activation and Vascular Permeability in a Mouse Model of Ischemia-Reperfusion Injury

  2025cites this paper
• Intercellular propagation of RIPK1/RIPK3 amyloid fibrils.

  2025cites this paper
• Chlamydia trachomatis subverts neutrophil cell death pathways through RIP3 and Mcl-1 manipulation

  2025cites this paper
• Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins.

  2025cites this paper
• New Insights into the Pathogenesis of Experimental Cytomegalovirus Retinal Necrosis with an Emphasis on Inflammasomes and Pyroptosis

  2025cites this paper
• IFN-γ enhances Poly(I:C)-induced necroptosis and immunogenic cell death via TLR3 upregulation in cholangiocarcinoma cells.

  2025cites this paper
• Arginine methylation in cancer: mechanisms and therapeutic implications

  2025cites this paper
• Mitochondria as Regulators of Nonapoptotic Cell Death in Cancer

  2025cites this paper
• A viral necrosome mediates direct RIPK3 activation to promote inflammatory necroptosis

  2025cites this paper
• Theaflavin suppresses necroptosis by attenuating RIPK1-RIPK3-MLKL signaling and mitigates cisplatin-induced kidney injury in mice.

  2025cites this paper
• Kaempferol enhances immunogenic cell death via premortem stress and necroptosis in cholangiocarcinoma: Insights from network pharmacology and mechanistic studies

  2025cites this paper
• Neutrophil Death-More Than Meets The Eye.

  2025cites this paper
• Reprogramming RIPK3-induced cell death in malignant B cells promotes immune-mediated tumor control

  2025cites this paper
• Discovery of Zharp1-163 as a dual inhibitor of ferroptosis and necroptosis for the treatment of inflammatory disorders and kidney injury

  2025cites this paper
• Shigella type-III secretion system effectors counteract the induction of host inflammation and cell death

  2025cites this paper
• RIPK3 activation promotes peritoneal dialysis-related peritoneal fibrosis via NLRP3/Caspase-1/IL-1β pathway.

  2025cites this paper
• Insights into O-GlcNAcylation and programmed cell death in cancer

  2025cites this paper
• PANoptosis: potential new targets and therapeutic prospects in digestive diseases

  2025cites this paper
• Necroptotic cell death consequences and disease relevance

  2025cites this paper
• ZBP1 orchestrates dynamic transitions between cell death pathways in response to arsenic and hyperosmotic stress

  2025cites this paper
• CO confers neuroprotection via activating the PERK-calcineurin pathway and inhibiting necroptosis

  2025cites this paper
• Three decades of caspases and RIPKs in life and death.

  2025cites this paper
• Development and validation of hierarchical signature for precision individualized therapy based on the landscape associated with necroptosis in clear cell renal cell carcinoma

  2025cites this paper
• Ferroptosis, necroptosis, and pyroptosis in calcium oxalate crystal-induced kidney injury.

  2025cites this paper
• Targeting the CXCR7 pathway with TC14012 to inhibit endothelial necroptosis and lung cancer metastasis.

  2025cites this paper
• Lytic coelomocyte death is tuned by cleavage but not phosphorylation of MLKL in echinoderms

  2025cites this paper
• TAK1 Governs Monocyte-Derived Macrophage Development in Acute Sterile Peritonitis.

  2025cites this paper
• Cadmium exposure induces Leydig cell injury via necroptosis caused by oxidative stress and TNF-α/TNFR1 signaling.

  2025cites this paper
• Exploring necroptosis: mechanistic analysis and antitumor potential of nanomaterials

  2025cites this paper
• The kinase domain of RIPK3 tunes its scaffolding functions

  2025cites this paper
• Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro

  2025cites this paper
• Necroptosis and its role in the pathogenesis and treatment of temporomandibular joint osteoarthritis: A narrative review.

  2025cites this paper
• Keratinocyte necroptosis promotes the progression of radiation-induced oral mucositis

  2025cites this paper
• Podocyte RIPK3 Deletion Improves Diabetic Kidney Disease by Attenuating NF‐κB p65 Driven Inflammation

  2025cites this paper
• Cell deaths conversion regulates the development of Apostichopus japonicus skin ulceration syndrome

  2025cites this paper
• Crosstalk between mitochondrial quality control and novel programmed cell death in pulmonary diseases.

  2025cites this paper
• Necroptosis in cancer: insight from epigenetic, post-transcriptional and post-translational modifications

  2025cites this paper
• Harnessing Immunogenic Cell Death to Boost the Impact of Radiation Therapy.

  2025cites this paper
• Burden of hypertension and type 2 diabetes in Tamale Metropolis: a case study of Tamale teaching hospital

  2025cites this paper
• Sex Differences in the Initiation and Progression of Necroptosis Following Kidney Ischemia–Reperfusion Injury

  2025cites this paper
• Methamphetamine Exposure Induces Neuronal Programmed Necrosis by Permeabilizing Mitochondria via the RIPK1–RIPK3–MLKL Axis

  2025cites this paper
• Cell death in multiple sclerosis.

  2025cites this paper
• Mycobacterium tuberculosis, Mycobacterium kansasii and Rhodococcus equi induce macrophage necroptosis in the presence of a caspase inhibitor acting on a non-canonical target(s)

  2025cites this paper
• Soluble tissue factor generated by necroptosis-triggered shedding is responsible for thrombosis

  2025cites this paper
• RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice.

  2025cites this paper
• Discovery of SARS-CoV-2 PLpro inhibitors and RIPK1 inhibitors with synergistic antiviral efficacy in a mouse COVID-19 model

  2025cites this paper
• Mechanism and role of regulated cell death in tumor immunity and immunotherapy

  2025cites this paper
• For Better or Worse: The Impact of Necrotic Cell Death Modalities.

  2025cites this paper
• Discovery of a 1H-Pyrazol-3-Amine Derivative as a Novel, Selective, and Orally Available RIPK1 Inhibitor for the Treatment of Inflammatory Disease.

  2025cites this paper
• Targeting cell death pathways in acute myeloid leukemia: Molecular mechanisms and clinical implications (Review)

  2025cites this paper
• Targeting the Met-RIPK1 signaling axis to enforce apoptosis and necroptosis in colorectal cancer

  2025cites this paper
• Reactive Oxygen Species Across Death Pathways: Gatekeepers of Apoptosis, Ferroptosis, Pyroptosis, Paraptosis, and Beyond

  2025cites this paper
• The Ways to Die: Cell Death in Liver Pathophysiology

  2025cites this paper
• Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review

  2025cites this paper
• Optogenetically Activatable MLKL as a Standalone Functional Module for Necroptosis and Therapeutic Applications in Antitumoral Immunity

  2025cites this paper
• CaMKII at the crossroads: calcium dysregulation, and post-translational modifications driving cell death.

  2025cites this paper
• Progress in Research on Regulated Cell Death in Cerebral Ischaemic Injury After Cardiac Arrest

  2025cites this paper
• Caspases in PANoptosis.

  2025cites this paper
• HMGB1: Different secretion pathways with pivotal role in epilepsy and major depressive disorder.

  2025cites this paper
• A bacterial effector manipulates host lysosomal protease activity–dependent plasticity in cell death modalities to facilitate infection

  2025cites this paper
• The Novel H10N3 Avian Influenza Virus Triggers Lethal Cytokine Storm by Activating Multiple Forms of Programmed Cell Death in Mammalian Lungs

  2025cites this paper
• Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke

  2025cites this paper
• Cell death in tumor microenvironment: an insight for exploiting novel therapeutic approaches

  2025cites this paper
• Coordination of Neutrophil and Apoptosis-Inducing Ligand in Inflammatory Diseases

  2025cites this paper
• Targeting regulated cell death: Apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis in anticancer immunity

  2025cites this paper
• Necroptosis in myocardial ischaemia-reperfusion injury: current update on mechanisms, therapeutic targets, and translational potential

  2025cites this paper
• Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR

  2025cites this paper
• Targeting inflammation and necroptosis in diabetic kidney disease: A novel approach via PPARα modulation.

  2025cites this paper
• Necroptosis: a significant and promising target for intervention of cardiovascular disease.

  2025cites this paper
• Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis

  2025cites this paper
• A bibliometric analysis of the literature published on autophagy, ferroptosis, necroptosis, and pyroptosis in cardiovascular disease from 2009 to 2023

  2025cites this paper
• Bardoxolone Derivatives as Novel Pseudo-Natural Necroptosis Inhibitors by Destabilizing HSP90 Client Proteins.

  2025cites this paper
• Necroptosis, Autophagy and Parthanatos in the Pathogenesis of Brain Diseases

  2025cites this paper
• Depletion of oxysterol-binding proteins by OSW-1 triggers RIP1/RIP3-independent necroptosis and sensitization to cancer immunotherapy

  2025cites this paper
• Receptor-interacting protein kinase 3: A macromolecule with multiple cellular actions and its perspective in the diagnosis and treatment of heart disease.

  2025cites this paper
• Repurposing of clinical-stage FLT3 inhibitor HYML-122 as a potent RIPK2 inhibitor for the treatment of inflammatory bowel disease.

  2025cites this paper
• Steamed panax notoginseng mitigates CA-MRSA USA300-induced necroptosis in human neutrophils

  2025cites this paper
• Osteocyte necroptosis drives osteoclastogenesis and alveolar bone resorption during orthodontic tooth movement

  2025cites this paper
• PARP12-mediated mono-ADP-ribosylation as a checkpoint for necroptosis and apoptosis

  2025cites this paper
• Lysosomal membrane permeabilization enhances the anticancer effects of POLR1 (RNA polymerase I) transcription inhibitors

  2025cites this paper
• Farnesoid X receptor inhibits proinflammatory cytokine-induced epithelial necroptosis in vitro: implications for preservation of intestinal barrier function.

  2025cites this paper
• RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation.

  2025cites this paper
• Acetyl-CoA Short-Chain Synthetase-2 Regulates Myocardial Ischemia/Reperfusion Injury by Targeting Histone Acetylation

  2025cites this paper
• MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction.

  2025cites this paper
• Roles of necroptosis and autophagy in a mouse model of sepsis-associated encephalopathy.

  2025cites this paper
• Necroptotic and Apoptotic Pathways in Sepsis: A Comparative Analysis of Pediatric and Adult ICU Patients

  2025cites this paper
• Screening of an FDA-Approved Drug Library: Menadione Induces Multiple Forms of Programmed Cell Death in Colorectal Cancer Cells via MAPK8 Cascades

  2025cites this paper
• Cigarette Smoke Extract–Induced Necroptosis Causes Mitochondrial DNA Release and Inflammation of Bronchial Epithelial Cells

  2025cites this paper
• Dovitinib Ameliorates Inflammation-Related Diseases by Inhibiting Necroptosis and Ferroptosis.

  2025cites this paper
• Elucidating the dual roles of apoptosis and necroptosis in diabetic wound healing: implications for therapeutic intervention

  2025influential citation