Globally Distributed Mycobacterial Fish Pathogens Produce a Novel Plasmid-Encoded Toxic Macrolide, Mycolactone F

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Infection and Immunity

• Publication date

  2006-08-21

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1128/IAI.00970-06PMID 16923788PMCID PMC1695495
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Newly Discovered Mycobacterial Pathogen Isolated from Laboratory Colonies of Xenopus Species with Lethal Infections Produces a Novel Form of Mycolactone, the Mycobacterium ulcerans Macrolide Toxin

  2005influential reference
• Mycobacterium ulcerans toxic macrolide, mycolactone modulates the host immune response and cellular location of M. ulcerans in vitro and in vivo

  2005influential reference
• Genotyping Mycobacterium ulcerans and Mycobacterium marinum by Using Mycobacterial Interspersed Repetitive Units

  2005cited by this paper
• Mycobacterium marinum Infections in Fish and Humans in Israel

  2005influential reference
• Mycobacterium pseudoshottsii sp. nov., a slowly growing chromogenic species isolated from Chesapeake Bay striped bass (Morone saxatilis).

  2005cited by this paper
• Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.

  2004cited by this paper
• Mycobacterium marinum Strains Can Be Divided into Two Distinct Types Based on Genetic Diversity and Virulence

  2004cited by this paper
• [Mycobacterium shinshuense isolated from cutaneous ulcer lesion of right lower extremity in a 37-year-old woman].

  2004cited by this paper
• Piscine mycobacteriosis: a literature review covering the agent and the disease it causes in fish and humans.

  2004cited by this paper
• One-tube cell lysis and DNA extraction procedure for PCR-based detection of Mycobacterium ulcerans in aquatic insects, molluscs and fish.

  2004cited by this paper
• Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex.

  2004influential reference
• Characterization of a Mycobacterium ulcerans-like infection in a colony of African tropical clawed frogs (Xenopus tropicalis).

  2004cited by this paper
• Potential Role for Fish in Transmission of Mycobacterium ulcerans Disease (Buruli Ulcer): an Environmental Study

  2004cited by this paper
• Uptake and cellular actions of mycolactone, a virulence determinant for Mycobacterium ulcerans.

  2003cited by this paper
• Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans.

  2003cited by this paper
• Mycolactones and Mycobacterium ulcerans disease.

  2003cited by this paper
• The primary mechanism of attenuation of bacillus Calmette–Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue

  2003cited by this paper
• Heterogeneity of Mycolactones Produced by Clinical Isolates of Mycobacterium ulcerans: Implications for Virulence

  2003influential reference
• Strain Variation in Mycobacterium marinum Fish Isolates

  2003cited by this paper
• Aquatic Insects as a Vector for Mycobacterium ulcerans

  2002cited by this paper
• Strain Variation in Mycobacteriummarinum Fish Isolates

  2002cited by this paper
• Suspension cultivation of Mycobacterium ulcerans for the production of mycolactones.

  2001cited by this paper
• Detection of a New Mycobacterium Species in Wild Striped Bass in the Chesapeake Bay

  2001cited by this paper
• Comparative Genetic Analysis of Mycobacterium ulcerans and Mycobacterium marinum Reveals Evidence of Recent Divergence

  2000cited by this paper
• A Mycobacterium ulcerans Toxin, Mycolactone, Causes Apoptosis in Guinea Pig Ulcers and Tissue Culture Cells

  2000cited by this paper
• Mycobacteriosis in wild rabbitfish Siganus rivulatus associated with cage farming in the Gulf of Eilat, Red Sea.

  2000cited by this paper
• Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence.

  1999cited by this paper
• Characterization of Novel Macrolide Toxins, Mycolactones A and B, from a Human Pathogen, Mycobacterium ulcerans

  1999cited by this paper
• Identification and Characterization of IS2404 and IS2606: Two Distinct Repeated Sequences for Detection of Mycobacterium ulcerans by PCR

  1999cited by this paper
• Emergence of a unique group of necrotizing mycobacterial diseases.

  1999cited by this paper
• Mycobacterium ulcerans infection.

  1999cited by this paper
• Differentiation of Mycobacterium ulcerans, M. marinum, and M. haemophilum: Mapping of Their Relationships to M. tuberculosis by Fatty Acid Profile Analysis, DNA-DNA Hybridization, and 16S rRNA Gene Sequence Analysis

  1998cited by this paper
• Partial purification and characterization of biological effects of a lipid toxin produced by Mycobacterium ulcerans.

  1998cited by this paper
• A systemic mycobacteriosis in the European sea bass Dicentrarchus labrax cultured in Eilat (Red Sea).

  1992cited by this paper
• Epidemiology of Mycobacterium ulcerans infection.

  1973cited by this paper
• Mycobacterium ulcerans infection (with comments on pathogenesis).

  1965cited by this paper
• A new mycobacterial infection in man.

  1948cited by this paper

• Mycobacterium ulcerans ecovar infection in wild Kemp's ridley Lepidochelys kempii and loggerhead Caretta caretta sea turtles.

  2025cites this paper
• Canonical fact versus hypothesis testing to decipher transmission of non-tuberculous and tuberculous mycobacteria: a comparative review

  2025cites this paper
• Pathological Progress of Two Types of Nodules in Micropterus salmoides Infected with Nocardia seriolae

  2024cites this paper
• High-mortality epizootic Mycobacterium ulcerans ecovar Liflandii in a colony of Zaire Dwarf Clawed Frogs (Hymenochirus boettgeri)

  2024cites this paper
• Mycobacterium ulcerans challenge strain selection for a Buruli ulcer controlled human infection model

  2024cites this paper
• Exploring Mycolactone—The Unique Causative Toxin of Buruli Ulcer: Biosynthetic, Synthetic Pathways, Biomarker for Diagnosis, and Therapeutic Potential

  2024cites this paper
• Mycolactone A vs. B: Multiscale Simulations Reveal the Roles of Localization and Association in Isomer-Specific Toxicity

  2023cites this paper
• Buruli ulcer caused by Mycobacterium ulcerans subsp. shinshuense: A case report.

  2023cites this paper
• Actinobacteria from Arctic and Atlantic deep-sea sediments—Biodiversity and bioactive potential

  2023cites this paper
• Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer

  2023cites this paper
• Mycobacterium ulcerans Disease and Host Immune Responses

  2023cites this paper
• What about Current Diversity of Mycolactone-Producing Mycobacteria? Implication for the Diagnosis and Treatment of Buruli Ulcer

  2023cites this paper
• Detection of Mycolactone by Thin Layer Chromatography.

  2022cites this paper
• Complete Genome and Partial Megaplasmid Sequences of Mycobacterium pseudoshottsii Strain NJB1907-Z4, Isolated from an Aquarium-Reared Japanese Sardine (Sardinops melanostictus) in Japan

  2022cites this paper
• Host–Pathogen Interactions of Marine Gram-Positive Bacteria

  2022cites this paper
• A need for null models in understanding disease transmission: the example of Mycobacterium ulcerans (Buruli Ulcer Disease).

  2021cites this paper
• Mycobacterium pseudoshottsii in Mediterranean Fish Farms: New Trouble for European Aquaculture?

  2020cites this paper
• The immunology of other mycobacteria: M. ulcerans, M. leprae

  2020cites this paper
• Lipids of Clinically Significant Mycobacteria

  2020cites this paper
• Buruli ulcer: The Efficacy of Innate Immune Defense May Be a Key Determinant for the Outcome of Infection With Mycobacterium ulcerans

  2020cites this paper
• The diversity of mycolactone-producing mycobacteria.

  2020cites this paper
• Buruli Ulcer in Japan

  2019cites this paper
• Buruli Ulcer: History and Disease Burden

  2019cites this paper
• Mycobacterium ulcerans mycolactones-fungi crosstalking

  2019cites this paper
• Population Genomics and Molecular Epidemiology of Mycobacterium ulcerans

  2019cites this paper
• Membrane perturbing properties of toxin mycolactone from Mycobacterium ulcerans

  2018cites this paper
• Mycobacterium marinum

  2017cites this paper
• Molecular Characterization of Mycolactone Producing Mycobacteria from Aquatic Environments in Buruli Ulcer Non-Endemic Areas in Côte d’Ivoire

  2017cites this paper
• Buruli Ulcer, a Prototype for Ecosystem-Related Infection, Caused by Mycobacterium ulcerans

  2017cites this paper
• The chemistry and biology of mycolactones

  2017cites this paper
• Investigating the mechanism behind the tissue necrosis in mycobacterium ulcerans infection.

  2017cites this paper
• Mycobacterium marinum skin infection

  2017cites this paper
• Mycobacterium ulcerans infection

  2017cites this paper
• Mycolactone-producing Mycobacterium marinum infection in captive Hong Kong warty newts and pathological evidence of impaired host immune function.

  2017influential citation
• Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin

  2016cites this paper
• Detection of Mycobacterium ulcerans DNA in the Environment, Ivory Coast

  2016cites this paper
• Mycobacterium ulcerans and Buruli Ulcer

  2015cites this paper
• Recent advances: role of mycolactone in the pathogenesis and monitoring of Mycobacterium ulcerans infection/Buruli ulcer disease

  2015cites this paper
• Heterogeneity among Mycobacterium ulcerans from French Guiana Revealed by Multilocus Variable Number Tandem Repeat Analysis (MLVA)

  2015cites this paper
• Bacterial zoonoses of fishes: a review and appraisal of evidence for linkages between fish and human infections.

  2015cites this paper
• Virulence factors expressed by Mycobacterium ulcerans strains: Results of a descriptive study

  2015cites this paper
• Mycobacterium ulcerans Disease (Buruli Ulcer): Potential Reservoirs and Vectors

  2015cites this paper
• Epidemiology and disease burden of Buruli ulcer: a review

  2015cites this paper
• Short Convergent Synthesis of the Mycolactone Core Through Lithiation–Borylation Homologations

  2015cites this paper
• Clonality of Mycobacterium ulcerans by Using VNTR-MIRU Typing in Ivory Coast (Côte d’Ivoire), West Africa

  2015cites this paper
• Genotyping Tools for Mycobacterium ulcerans-Drawbacks and Future Prospects

  2014cites this paper
• Genetic Diversity of PCR-Positive, Culture-Negative and Culture-Positive Mycobacterium ulcerans Isolated from Buruli Ulcer Patients in Ghana

  2014cites this paper
• Mycobacterium ulcerans Fails to Infect through Skin Abrasions in a Guinea Pig Infection Model: Implications for Transmission

  2014cites this paper
• Late Onset of the Serological Response against the 18 kDa Small Heat Shock Protein of Mycobacterium ulcerans in Children

  2014cites this paper
• Biosynthesis of mycobacterial lipids by polyketide synthases and beyond

  2014cites this paper
• Clinical considerations on Buruli ulcer employing two molecular tests for the detection of Mycobacterium ulcerans in 100 skin biopsies

  2014cites this paper
• Order Hemiptera: The true host involved in Mycobacterium ulcerans transmission, or is it an innocent by-stander?

  2014cites this paper
• ORDER HEMIPTERA: THE TRUE HOST INVOLVED IN

  2014cites this paper
• History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease).

  2013cites this paper
• Genotypic characteristics of a Mycobacterium sp. isolated from yellowtail Seriola quinqueradiata and striped jack Pseudocaranx dentex in Japan

  2013cites this paper
• Fish and amphibians as potential reservoirs of Mycobacterium ulcerans, the causative agent of Buruli ulcer disease

  2013cites this paper
• Environmental Distribution and Seasonal Prevalence of Mycobacterium ulcerans in Southern Louisiana

  2013cites this paper
• Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans

  2013cites this paper
• Buruli ulcer and mycolactone-producing mycobacteria.

  2013cites this paper
• Laboratory procedures for the detection and identification of cutaneous non‐tuberculous mycobacterial infections

  2013cites this paper
• Photodegradation of the Mycobacterium ulcerans Toxin, Mycolactones: Considerations for Handling and Storage

  2012cites this paper
• Mycobacterium ulcerans causes minimal pathogenesis and colonization in medaka (Oryzias latipes): an experimental fish model of disease transmission.

  2012cites this paper
• A quick and cost effective method for the diagnosis of Mycobacterium ulcerans infection

  2012cites this paper
• Mycobacterium pseudoshottsii isolated from 24 farmed fishes in western Japan.

  2012cites this paper
• The genome, evolution and diversity of Mycobacterium ulcerans.

  2012cites this paper
• Aerobic Gram-Positive Rods and Cocci

  2012cites this paper
• Highly stereoselective total synthesis of fully hydroxy-protected mycolactones A and B and their stereoisomerization upon deprotection.

  2011cites this paper
• MYCOBACTERIUM MARINUM INFECTION CAUSING EXTENSIVE TISSUE DESTRUCTION IN A HYPOXIC COPD PATIENT

  2011cites this paper
• The role of free-living amoebae as reservoir in the transmission of Mycobacterium Ulcerans

  2011cites this paper
• Epidemic mortalities in the dusky grouper, Epinephelus marginatus (Lowe, 1834) in Egyptian coastal waters

  2011cites this paper
• Striped Bass Bacterial Diseases

  2011cites this paper
• Effects of Concurrent Phenathrene and Mycobacterium marinum Exposure in the Zebrafish (Danio rerio)

  2011cites this paper
• Mycobacterium liflandii Outbreak in a Research Colony of Xenopus (Silurana) tropicalis Frogs

  2011cites this paper
• Characterization of photochromogenic Mycobacterium spp. from Chesapeake Bay striped bass Morone saxatilis.

  2011cites this paper
• FIRST RECORD OF MYCOBACTERIOSIS IN THE DUSKY GROUPER (EPINEPHELUS MARGINATUS) FROM MEDITERRANEAN COASTAL SHORES OF MARSA MATROUH PROVINCE, EGYPT

  2011cites this paper
• Regulation of the 18 kDa heat shock protein in Mycobacterium ulcerans: an alpha‐crystallin orthologue that promotes biofilm formation

  2010cites this paper
• Understanding Buruli Ulcer (Mycobacterium ulcerans Disease)

  2010cites this paper
• Synthetic studies on the mycolactone core.

  2010cites this paper
• Neglected diseases caused by bacterial infections.

  2010cites this paper
• Buruli ulcer caused by "Mycobacterium ulcerans subsp. shinshuense".

  2010cites this paper
• Mycolic Acid/Cyclopropane Fatty Acid/Fatty Acid Biosynthesis and Health Relations

  2010cites this paper
• Highly sensitive, operationally simple, cost/time effective detection of the mycolactones from the human pathogen Mycobacterium ulcerans.

  2010cites this paper
• Synthesis and structure assignment of the minor metabolite arising from the frog pathogen Mycobacterium liflandii.

  2010cites this paper
• Scalable and efficient synthesis of the mycolactone core.

  2010cites this paper
• [Buruli ulcer or Mycobacterium ulcerans infection].

  2010cites this paper
• Quantitative PCR Assay for Mycobacterium pseudoshottsii and Mycobacterium shottsii and Application to Environmental Samples and Fishes from the Chesapeake Bay

  2010cites this paper
• Ecology and Transmission of Buruli Ulcer Disease: A Systematic Review

  2010cites this paper
• Immunosuppression and treatment-associated inflammatory response in patients with Mycobacterium ulcerans infection (Buruli ulcer)

  2009cites this paper
• Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

  2009cites this paper
• Chronic Mycobacterium marinum infection acts as a tumor promoter in Japanese Medaka (Oryzias latipes).

  2009cites this paper
• Large Sequence Polymorphisms Unveil the Phylogenetic Relationship of Environmental and Pathogenic Mycobacteria Related to Mycobacterium ulcerans

  2009cites this paper
• Expanded range and new host species of Mycobacterium shottsii and M. pseudoshottsii.

  2009cites this paper
• Historical presence (1975-1985) of mycobacteriosis in Chesapeake Bay striped bass Morone saxatilis.

  2009cites this paper
• Ins and outs of mycobacterial plasmids.

  2009cites this paper
• Lipids of pathogenic Mycobacteria: contributions to virulence and host immune suppression.

  2009cites this paper
• Approaches to improve treatment and early diagnosis of Buruli ulcer. the role of local and systemic immune responses

  2009cites this paper
• The pMUM Megaplasmid of Mycobacterium ulcerans and Closely Related Mycobacteria: A Blueprint for the Synthesis of Mycolactones

  2009cites this paper
• Laboratory Models of Infection and Transmission of Mycobacterium ulcerans; causative agent of Buruli ulcer disease

  2009cites this paper
• The Use of Spectroscopic Techniques in the Characterization of Mycobacterial Metabolites

  2009cites this paper
• Heterogeneity in the stereochemistry of mycolactones isolated from M. marinum: toxins produced by fresh vs. saltwater fish pathogens.

  2009cites this paper