Neuropilin‐1 expression by tumor cells promotes tumor angiogenesis and progression

No abstract is available for this paper.

• Publication year

  2000

• Venue

  The FASEB Journal

• Publication date

  2000-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1096/fj.00-0250comPMID 11099472
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neuropilin-2 and Neuropilin-1 Are Receptors for the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF) and of Placenta Growth Factor-2, but Only Neuropilin-2 Functions as a Receptor for the 145-Amino Acid Form of VEGF*

  2000cited by this paper
• Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity.

  2000cited by this paper
• NEUROPILIN-2 AND NEUROPILIN-1 ARE RECEPTORS FOR VEGF165 AND PLGF-2, BUT ONLY NEUROPILIN-2 FUNCTIONS AS A RECEPTOR FOR VEGF145 .

  2000cited by this paper
• Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected].

  2000cited by this paper
• Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1*

  1999cited by this paper
• Antiangiogenic activity of the cleaved conformation of the serpin antithrombin.

  1999cited by this paper
• Vascular endothelial growth factor stimulates Schwann cell invasion and neovascularization of acellular nerve grafts.

  1999cited by this paper
• A requirement for neuropilin-1 in embryonic vessel formation.

  1999cited by this paper
• Vascular endothelial growth factor (VEGF) and its receptors

  1999cited by this paper
• Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis.

  1999cited by this paper
• Clinical applications of angiogenic growth factors and their inhibitors

  1999cited by this paper
• Molecular angiogenesis.

  1999cited by this paper
• Neuropilin-1 Mediates Collapsin-1/Semaphorin III Inhibition of Endothelial Cell Motility

  1999influential reference
• Neuropilin-1 is expressed on bone marrow stromal cells: a novel interaction with hematopoietic cells?

  1999cited by this paper
• Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System

  1999cited by this paper
• Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors.

  1998cited by this paper
• Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate.

  1998cited by this paper
• Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.

  1998cited by this paper
• Neuropilin-1 Is a Placenta Growth Factor-2 Receptor*

  1998cited by this paper
• Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity.

  1998cited by this paper
• Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

  1997cited by this paper
• Neuropilin is a receptor for the axonal chemorepellent Semaphorin III.

  1997influential reference
• Neuropilin is a semaphorin III receptor.

  1997influential reference
• Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice.

  1997cited by this paper
• Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound.

  1997cited by this paper
• Inhibition of Vascular Endothelial Growth Factor (VEGF)-induced Endothelial Cell Proliferation by a Peptide Corresponding to the Exon 7-Encoded Domain of VEGF165 *

  1997cited by this paper
• Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton.

  1997cited by this paper
• Ischemia-driven angiogenesis.

  1997cited by this paper
• Growth cones and the cues that repel them.

  1996cited by this paper
• Thymosin β15: A novel regulator of tumor cell motility upregulated in metastatic prostate cancer

  1996cited by this paper
• Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR.

  1996influential reference
• Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.

  1996cited by this paper
• Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer.

  1996cited by this paper
• The Molecular Biology of Axon Guidance

  1996cited by this paper
• Patterns and Emerging Mechanisms Review of the Angiogenic Switch during Tumorigenesis

  1996cited by this paper
• Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system.

  1996cited by this paper
• Characterization of Novel Vascular Endothelial Growth Factor (VEGF) Receptors on Tumor Cells That Bind VEGF via Its Exon 7-encoded Domain (*)

  1996cited by this paper
• Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs.

  1995cited by this paper
• Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

  1995cited by this paper
• Angiogenesis in cancer, vascular, rheumatoid and other disease

  1995cited by this paper
• Growth-associated expression of a membrane protein, neuropilin, in Xenopus optic nerve fibers.

  1995cited by this paper
• Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

  1994cited by this paper
• Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

  1994cited by this paper
• Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones.

  1993cited by this paper
• Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

  1993cited by this paper
• Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.

  1992cited by this paper
• The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor.

  1992cited by this paper
• Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

  1992cited by this paper
• Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

  1992cited by this paper
• Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

  1992cited by this paper

• Evaluation of CendR peptides mined from protein databases as potential inhibitors of neuropilin-1 using an in-silico molecular modeling approach.

  2026cites this paper
• Neuropilin-1 expression in primary and metastatic prostate cancer: Expression patterns and clinicopathological correlations

  2025cites this paper
• Sorafenib—Drug Delivery Strategies in Primary Liver Cancer

  2025cites this paper
• Neuropilin-1: A Multifaceted Target for Cancer Therapy

  2025influential citation
• Neuropilin1-dependent paracrine signaling of cancer cells mediated by miRNA exosomal cargo

  2025cites this paper
• Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

  2025cites this paper
• Vascular endothelial cells and angiogenesis.

  2025cites this paper
• Development and validation of a gastric cancer prognostic model utilizing lymphatic endothelial cell-related genes

  2025cites this paper
• Bulk RNA sequencing dataset of Claudin-low breast cancer cell lines with Neuropilin-1 knockdown

  2025cites this paper
• NRP1 and GFAP Expression in the Medulloblastoma Microenvironment: Implications for Angiogenesis and Tumor Progression

  2025cites this paper
• Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions

  2024cites this paper
• Achievements and prospects for further development of photodynamic therapy technology in the treatment of cerebral tumors

  2024cites this paper
• Tumor-penetrating iRGD facilitates penetration of poly(floxuridine-ketal)-based nanomedicine for enhanced pancreatic cancer therapy.

  2024cites this paper
• Proteomic profiling of small extracellular vesicles derived from mouse pancreatic cancer and stellate cells: Role in pancreatic cancer

  2024cites this paper
• TempEasy 3D Hydrogel Coculture System Provides Mechanistic Insights into Prostate Cancer Bone Metastasis

  2024cites this paper
• Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2-responding CD4+ T cells

  2023cites this paper
• The role of complement component C1q in angiogenesis

  2023cites this paper
• The Efficacy of Nanoparticle Delivery to Hypoxic Solid Tumors by ciRGD Co‐Administration Depends on Neuropilin‐1 and Neutrophil Levels

  2023cites this paper
• Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2 responding CD4+ T cells

  2023cites this paper
• Neuropilin-1 is uniquely expressed on small syncytiotrophoblast extracellular vesicles but not on medium/large vesicles from preeclampsia and normal placentae.

  2022cites this paper
• Early-stage multi-cancer detection using an extracellular vesicle protein-based blood test

  2022cites this paper
• A Biomolecular Toolbox for Precision Nanomotors

  2022cites this paper
• Differential dependency of human glioblastoma cells on vascular endothelial growth factor-A signaling via neuropilin-1

  2022cites this paper
• The Anti-VEGF(R) Drug Discovery Legacy: Improving Attrition Rates by Breaking the Vicious Cycle of Angiogenesis in Cancer

  2021cites this paper
• Crosstalk between MUC1 and VEGF in angiogenesis and metastasis: a review highlighting roles of the MUC1 with an emphasis on metastatic and angiogenic signaling

  2021cites this paper
• The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

  2021cites this paper
• The Evolution of Safe and Effective Coaguligands for Vascular Targeting and Precision Thrombosis of Solid Tumors and Vascular Malformations

  2021cites this paper
• Bi-Functional Peptides as a New Therapeutic Tool for Hepatocellular Carcinoma

  2021cites this paper
• Tumor-Penetrating Peptide-Functionalized Ferritin Enhances Antitumor Activity of Paclitaxel

  2021cites this paper
• Regulation of granulosa cell functions through NRP-1 mediated internalization of follicular fluid non-exosomal miR-210

  2021cites this paper
• The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis

  2020cites this paper
• Strength and duration of GIPC-dependent signaling networks as determinants in cancer

  2020cites this paper
• Possible role of glial cell line-derived neurotrophic factor for predicting cognitive impairment in Parkinson’s disease: a case-control study

  2020cites this paper
• Does Cysteine Rule (CysR) Complete the CendR Principle? Increase in Affinity of Peptide Ligands for NRP-1 Through the Presence of N-Terminal Cysteine

  2020cites this paper
• Retraction: Role of miR-132/methyl-CpG-binding protein 2 in the regulation of neural stem cell differentiation

  2020cites this paper
• Neuropilin-1 is associated with the prognosis of cervical cancer in Henan Chinese population

  2019cites this paper
• Identification of a prognostic immune signature for cervical cancer to predict survival and response to immune checkpoint inhibitors

  2019cites this paper
• Liposomal delivery of vascular endothelial growth factor/receptors and their inhibitors

  2019cites this paper
• Neuropilin-1 peptide-like ligands with proline mimetics, tested using the improved chemiluminescence affinity detection method.

  2019cites this paper
• The role of placental growth factor (PlGF) and its receptor system in retinal vascular diseases

  2019cites this paper
• Potencial empleo del heptapéptido ATWLPPR como agente de imagen molecular del angiogénesis tumoral

  2019cites this paper
• Chapter 14 Noncoding RNAs in Lung Cancer Angiogenesis

  2019cites this paper
• Characterization of receptor binding kinetics for vascular endothelial growth factor-A using SPR.

  2019cites this paper
• Neuropilin-1 is associated with the prognosis of cervical cancer in Henan Chinese population

  2019cites this paper
• Urea moiety as amide bond mimetic in peptide-like inhibitors of VEGF-A165/NRP-1 complex.

  2019cites this paper
• MicroRNA-148a/b-3p regulates angiogenesis by targeting neuropilin-1 in endothelial cells

  2019cites this paper
• MicroRNA-9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin-1

  2019cites this paper
• 5 Vascular-Targeted Photodynamic Therapy ( VTP )

  2018cites this paper
• Peptide-targeted, stimuli-responsive polymersomes for delivering a cancer stemness inhibitor to cancer stem cell microtumors.

  2018cites this paper
• Jack of many trades: Multifaceted role of neuropilins in pancreatic cancer

  2018cites this paper
• The Pro-Tumoral Activity of Heparan Sulfate 3-O-Sulfotransferase 3B (HS3ST3B) in Breast Cancer MDA-MB-231 Cells Is Dependent on the Expression of Neuropilin-1

  2018cites this paper
• Small Molecule Inhibitors Targeting New Targets of Protein-Protein Interactions

  2018cites this paper
• Targeting Protein-Protein Interactions by Small Molecules

  2018cites this paper
• Synergistic cross‐talk of hedgehog and interleukin‐6 signaling drives growth of basal cell carcinoma

  2018cites this paper
• Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner

  2018cites this paper
• The reversible effects of glial cell line-derived neurotrophic factor (GDNF) in the human brain.

  2018cites this paper
• Immunohistochemical study on neuropilin 1 (NRP1) immunoexpression in oral squamous cell carcinoma.

  2018cites this paper
• Involvement of NADPH Oxidase 1 in Liver Kinase B1-Mediated Effects on Tumor Angiogenesis and Growth

  2018cites this paper
• Architecture and hydration of the arginine‐binding site of neuropilin‐1

  2018cites this paper
• Heteromultivalent targeting of integrin αvβ3 and neuropilin 1 promotes cell survival via the activation of the IGF-1/insulin receptors.

  2018cites this paper
• Anti-neuropilin-1 monoclonal antibody suppresses the migration and invasion of human gastric cancer cells via Akt dephosphorylation

  2018cites this paper
• Design of a Simple and Practical Nanosystem Coordinates Tumor Targeting and Penetration for Improved Theranostics

  2018cites this paper
• Neuropilin-1 is a glial cell line-derived neurotrophic factor receptor in glioblastoma

  2017cites this paper
• Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality

  2017cites this paper
• Noncoding RNAs in Lung Cancer Angiogenesis

  2017cites this paper
• Noncoding RNAs in Lung Cancer Angiogenesis Noncoding RNAs in Lung Cancer Angiogenesis

  2017cites this paper
• Targeted Stimuli-Responsive Carriers for Efficient Delivery of Chemotherapeutic Drugs

  2017cites this paper
• Genetic status of KRAS modulates the role of Neuropilin-1 in tumorigenesis

  2017cites this paper
• The Neuropilins and Their Ligands in Hematogenous Metastasis of Salivary Adenoid Cystic Carcinoma-An Immunohistochemical Study.

  2017cites this paper
• The Role of the Neuropilins in Tumour Angiogenesis and Tumour Progression

  2017cites this paper
• Neuropilins as Signaling Hubs, Controlling Tyrosine Kinases and Other Cell Surface Receptors

  2017cites this paper
• Metastasized murine oral squamous cell carcinoma cells induce intratumoral polymorphonuclear myeloid derived suppressor cells.

  2017cites this paper
• Albumin Binding Domain Fusing R/K-X-X-R/K Sequence for Enhancing Tumor Delivery of Doxorubicin.

  2017cites this paper
• Neuropilin 1 and Neuropilin 2: Cancer Progression and Biomarker Analysis

  2017cites this paper
• Modulation of vascular endothelial growth factor receptor affinity by neuropilin-1 and heparan sulfate proteoglycans

  2016cites this paper
• A Novel Physiological Glycosaminoglycan-Deficient Splice Variant of Neuropilin-1 Is Anti-Tumorigenic In Vitro and In Vivo

  2016cites this paper
• Neuropilin-2 in pancreatic cancer and semaphorin-3F as a treatment

  2016cites this paper
• Carbohydrate-based peptidomimetics targeting neuropilin-1: Synthesis, molecular docking study and in vitro biological activities.

  2016cites this paper
• Neuropilin 1 Receptor Is Up-Regulated in Dysplastic Epithelium and Oral Squamous Cell Carcinoma.

  2016cites this paper
• VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors

  2016cites this paper
• Significance of neuropilin-1 mRNA expression in chronic myeloid leukemia

  2016cites this paper
• Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes

  2015cites this paper
• Neuropilin-1 as Therapeutic Target for Malignant Melanoma

  2015cites this paper
• GPNMB cooperates with neuropilin-1 to promote mammary tumor growth and engages integrin α5β1 for efficient breast cancer metastasis

  2015cites this paper
• Neuropilin Functions as an Essential Cell Surface Receptor*

  2015cites this paper
• MiR-152 regulates metastases of non-small cell lung cancer cells by targeting neuropilin-1.

  2015cites this paper
• Research progress of oncogene and tumor suppressor gene in bladder cancer.

  2015cites this paper
• The origin of prostate metastases: emerging insights

  2015cites this paper
• Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers

  2015cites this paper
• A Novel Association of Neuropilin-1 and MUC1 in Pancreatic Ductal Adenocarcinoma: Role in Induction of VEGF Signaling and Angiogenesis

  2015cites this paper
• Novel expression of Neuropilin 1 on human tumor-infiltrating lymphocytes in colorectal cancer liver metastases

  2015cites this paper
• Effects of RNA interference-mediated NRP-1 silencing on the proliferation and apoptosis of breast cancer cells.

  2015cites this paper
• Neuropilin 2 expression and function in melanocytes and melanoma

  2015cites this paper
• CpG ODN 1826 enhances radiosensitivity of the human lung cancer cell line A549 in a rat model.

  2015cites this paper
• In-vivo Humor degression

  2015cites this paper
• Role of Neuropilin-1 in Diabetic Nephropathy

  2015cites this paper
• Neuropilin 2 expression and function in melanocytes and melanoma

  2015cites this paper
• Short report Open Access

  2015cites this paper
• Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells

  2015cites this paper
• Neuropilin 2 expression and function in melanocytes and melanoma

  2015cites this paper