An updated reappraisal of synapsins: structure, function and role in neurological and psychiatric disorders.

No abstract is available for this paper.

• Publication year

  2021

• Venue

  Neuroscience and Biobehavioral Reviews

• Publication date

  2021-08-15

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neubiorev.2021.08.011PMID 34407457
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells

  2021cited by this paper
• Cannabinoid receptor activation acutely increases synaptic vesicle numbers by activating synapsins in human synapses

  2021cited by this paper
• Synapsin I Synchronizes GABA Release in Distinct Interneuron Subpopulations.

  2020cited by this paper
• Dysfunction of the serotonergic system in the brain of synapsin triple knockout mice is associated with behavioral abnormalities resembling synapsin-related human pathologies.

  2020cited by this paper
• Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies

  2020cited by this paper
• Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates.

  2020cited by this paper
• Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate.

  2020cited by this paper
• The genetics of bipolar disorder

  2020cited by this paper
• Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation.

  2020cited by this paper
• Autism spectrum disorder

  2020cited by this paper
• Design and Synthesis of Fluorescent Methylphenidate Analogues for a FRET‐Based Assay of Synapsin III Binding

  2020cited by this paper
• Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology

  2019cited by this paper
• Cystatin C promotes cognitive dysfunction in rats with cerebral microbleeds by inhibiting the ERK/synapsin Ia/Ib pathway.

  2019cited by this paper
• Synapsin 1 promotes Aβ generation via BACE1 modulation

  2019cited by this paper
• Leucine‐rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre‐synaptic sites

  2019cited by this paper
• Physical Activity Reduces Epilepsy Incidence: a Retrospective Cohort Study in Swedish Cross-Country Skiers and an Experimental Study in Seizure-Prone Synapsin II Knockout Mice

  2019cited by this paper
• Subtle Phenotype Differences in Psychiatric Patients With and Without Serum Immunoglobulin G Antibodies to Synapsin

  2019cited by this paper
• Intrinsically disordered proteins in synaptic vesicle trafficking and release

  2019cited by this paper
• Growth and excitability at synapsin II deficient hippocampal neurons

  2019cited by this paper
• Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses.

  2019cited by this paper
• Synaptic vesicle generation from activity‐dependent bulk endosomes requires a dephosphorylation‐dependent dynamin–syndapin interaction

  2019cited by this paper
• The readily-releasable pool dynamically regulates multivesicular release

  2019cited by this paper
• Synapsins regulate α-synuclein functions

  2019cited by this paper
• Synapsin I Controls Synaptic Maturation of Long-Range Projections in the Lateral Amygdala in a Targeted Selective Fashion

  2019cited by this paper
• Autoantibodies to synapsin I sequestrate synapsin I and alter synaptic function

  2019cited by this paper
• Synapsins are expressed at neuronal and non-neuronal locations in Octopus vulgaris

  2019cited by this paper
• PIMT-Mediated Protein Repair: Mechanism and Implications

  2019cited by this paper
• Reduced expression of synapsin II in a chronic phencyclidine preclinical rat model of schizophrenia

  2019cited by this paper
• Liquid-Liquid Phase Separation in Disease.

  2019cited by this paper
• Evaluation of Methylphenidate Safety and Maximum-Dose Titration Rationale in Attention-Deficit/Hyperactivity Disorder: A Meta-analysis.

  2019cited by this paper
• Can early dopamine transporter imaging serve as a predictor of Parkinson's disease progression and late motor complications?

  2018cited by this paper
• Hot water epilepsy and SYN1 variants

  2018cited by this paper
• Epilepsy

  2018cited by this paper
• The molecular language of membraneless organelles

  2018cited by this paper
• Presynaptic striatal dopaminergic depletion predicts the later development of freezing of gait in de novo Parkinson's disease: An analysis of the PPMI cohort.

  2018cited by this paper
• Molecular Mechanisms of Short-Term Plasticity: Role of Synapsin Phosphorylation in Augmentation and Potentiation of Spontaneous Glutamate Release

  2018cited by this paper
• Antecedent ADHD, dementia, and metabolic dysregulation: A U.S. based cohort analysis

  2018cited by this paper
• Synapsin III is a key component of α‐synuclein fibrils in Lewy bodies of PD brains

  2018cited by this paper
• A liquid phase of synapsin and lipid vesicles

  2018cited by this paper
• Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice

  2018cited by this paper
• Motor learning and metaplasticity in striatal neurons: relevance for Parkinson’s disease

  2018cited by this paper
• α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

  2018cited by this paper
• Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson’s disease

  2018cited by this paper
• Critical appraisal of pathology transmission in the &agr;‐synuclein fibril model of Lewy body disorders

  2018cited by this paper
• Differential Expression of Synapsin I and II upon Treatment by Lithium and Valproic Acid in Various Brain Regions

  2018cited by this paper
• Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures

  2018cited by this paper
• Biomolecular condensates: organizers of cellular biochemistry

  2017cited by this paper
• Synapsins regulate brain‐derived neurotrophic factor‐mediated synaptic potentiation and axon elongation by acting on membrane rafts

  2017cited by this paper
• Methylphenidate dose optimization for ADHD treatment: review of safety, efficacy, and clinical necessity

  2017cited by this paper
• Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain

  2017cited by this paper
• The Knockout of Synapsin II in Mice Impairs Social Behavior and Functional Connectivity Generating an ASD-like Phenotype

  2017cited by this paper
• Regulation of Neurotransmitter Release by Amyloid Precursor Protein Through Synapsin Phosphorylation

  2017cited by this paper
• Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid.

  2017cited by this paper
• Impaired GABAB-mediated presynaptic inhibition increases excitatory strength and alters short-term plasticity in synapsin knockout mice

  2017cited by this paper
• Intersectin associates with synapsin and regulates its nanoscale localization and function

  2017cited by this paper
• Acute stress is not acute: sustained enhancement of glutamate release after acute stress involves readily releasable pool size and synapsin I activation

  2017cited by this paper
• The End Is the Beginning: Parkinson’s Disease in the Light of Brain Imaging

  2017cited by this paper
• Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

  2017cited by this paper
• Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin

  2017cited by this paper
• Synapsin II Regulation of GABAergic Synaptic Transmission Is Dependent on Interneuron Subtype

  2017cited by this paper
• Parkinson disease

  2017cited by this paper
• Synaptic Vesicle Clusters at Synapses: A Distinct Liquid Phase?

  2017cited by this paper
• Synapsin-antibodies in psychiatric and neurological disorders: Prevalence and clinical findings.

  2017cited by this paper
• A novel SYN1 missense mutation in non-syndromic X-linked intellectual disability affects synaptic vesicle life cycle, clustering and mobility

  2017cited by this paper
• Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains

  2017cited by this paper
• The impact of synapsin III gene on the neurometabolite level alterations after single-dose methylphenidate in attention-deficit hyperactivity disorder patients

  2016cited by this paper
• Structural basis of synaptic vesicle assembly promoted by α-synuclein

  2016cited by this paper
• Huntingtin‐associated protein‐1 is a synapsin I‐binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking

  2016cited by this paper
• Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease

  2016cited by this paper
• DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression

  2016cited by this paper
• SORLA regulates calpain‐dependent degradation of synapsin

  2016cited by this paper
• Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia

  2016cited by this paper
• Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease.

  2016cited by this paper
• Review: Parkinson's disease: from synaptic loss to connectome dysfunction

  2016cited by this paper
• Synapsin Isoforms Regulating GABA Release from Hippocampal Interneurons

  2016cited by this paper
• Brain network analysis reveals affected connectome structure in bipolar I disorder

  2016cited by this paper
• Subconvulsant doses of pentylenetetrazol uncover the epileptic phenotype of cultured synapsin-deficient Helix serotonergic neurons in the absence of excitatory and inhibitory inputs.

  2016cited by this paper
• Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein

  2015cited by this paper
• Functions of synapsins in corticothalamic facilitation: important roles of synapsin I

  2015cited by this paper
• Huntington disease

  2015cited by this paper
• Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia.

  2015cited by this paper
• α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons

  2015cited by this paper
• Canonical and noncanonical Wnt signaling in neural stem/progenitor cells

  2015cited by this paper
• Unfreezing of gait in patients with Parkinson's disease.

  2015cited by this paper
• Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2

  2015cited by this paper
• Attention-deficit/hyperactivity disorder

  2015cited by this paper
• Reduced phosphorylation of synapsin I in the hippocampus of Engrailed-2 knockout mice, a model for autism spectrum disorders.

  2015cited by this paper
• Drugs That Bind to α-Synuclein: Neuroprotective or Neurotoxic?

  2015cited by this paper
• Synapsin III Acts Downstream of Semaphorin 3A/CDK5 Signaling to Regulate Radial Migration and Orientation of Pyramidal Neurons In Vivo

  2015cited by this paper
• SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation

  2015cited by this paper
• Knock-down of synapsin alters cell excitability and action potential waveform by potentiating BK and voltage-gated Ca(2+) currents in Helix serotonergic neurons.

  2015cited by this paper
• ATP Binding to Synaspsin IIa Regulates Usage and Clustering of Vesicles in Terminals of Hippocampal Neurons

  2015cited by this paper
• Phosphorylation by PKA and Cdk5 Mediates the Early Effects of Synapsin III in Neuronal Morphological Maturation

  2015cited by this paper
• Gene expression profiling predicts pathways and genes associated with Parkinson’s disease

  2015cited by this paper
• Functional distribution of synapsin I in human sperm

  2015cited by this paper
• Characterization and quantification of freezing of gait in Parkinson's disease: Can detection algorithms replace clinical expert opinion?

  2015cited by this paper
• Alzheimer's disease

  2015cited by this paper
• X‐linked focal epilepsy with reflex bathing seizures: Characterization of a distinct epileptic syndrome

  2015cited by this paper
• Treadmill exercise after social isolation increases the levels of NGF, BDNF, and synapsin I to induce survival of neurons in the hippocampus, and improves depression-like behavior

  2015cited by this paper
• MS-275 Inhibits Aroclor 1254–Induced SH-SY5Y Neuronal Cell Toxicity by Preventing the Formation of the HDAC3/REST Complex on the Synapsin-1 Promoter

  2015cited by this paper

• Accelerated Establishment of Limbic Seizures in Aging Krushinsky-Molodkina Audiogenic Rats Is Associated With Neurodegeneration and Downregulation of the Glutamatergic Transmission in the Hippocampus.

  2026cites this paper
• How Are Synaptic Vesicle Exocytosis and Endocytosis Affected in Parkinson Disease?

  2026cites this paper
• An investigation on Alzheimer’s disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure

  2025cites this paper
• Zhinao Capsule Improved Sleep and Memory Disorders in APP/PS1 Mice via cAMP/PKA/CREB Signaling Pathway Modulation

  2025cites this paper
• SUMOylation balance: a key determinant in synapse physiology

  2025cites this paper
• Neuroprotective role of DNTαβ Cell transplantation on modulating immune microenvironment in spinal cord injured mice

  2025cites this paper
• Fufang Gaoziban Pian alleviates anxiety and depression-like behavior in mice via the gut-brain axis: Involvement of the estrogen signaling pathway.

  2025cites this paper
• Review of the biological effects due to high-power microwaves exposure

  2025cites this paper
• Eleganolone, a diterpene isolated from seaweed Bifurcaria bifurcata (Phaeophyceae, Fucales), protects neuronal cells from oxidative stress-induced damage.

  2025cites this paper
• Preconditioning with an Enriched Environment Enhances Neuroplasticity and Functional Recovery Following Cerebral Ischemia-Reperfusion Injury.

  2025cites this paper
• A novel stable transgenic zebrafish line expressing mCherry-tagged human alpha-synuclein in the nervous system and exhibiting all the key features of Lewy body disorders at larval stage.

  2025cites this paper
• Single-cell profiling identifies hair cell SLC35F1 deficiency as a signature of primate cochlear aging

  2025cites this paper
• Terahertz Radiation Affects the Dynamics of Neurons by Decreasing Membrane Area Ratio.

  2025cites this paper
• Endosomal protein DENND10 promotes developmental competence of neurite extension

  2025cites this paper
• In-depth and high-throughput spatial proteomics for whole-tissue slice profiling by deep learning-facilitated sparse sampling strategy

  2025cites this paper
• Neuroprotective effect of nano-carboxymethyl chitosan from Doryteuthis sibogae against rotenone-induced Parkinson's Disease in the Zebrafish model.

  2025cites this paper
• Regulatory plasticity of the human genome.

  2025cites this paper
• 10H-phenothiazine exerts beneficial effects in spinal muscular atrophy in vitro and in vivo models

  2025cites this paper
• Integrative mRNA and miRNA Expression Profiles from Developing Zebrafish Head Highlight Brain-Preference Genes and Regulatory Networks

  2024cites this paper
• Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration.

  2024cites this paper
• Relationship between methylation pattern of the SYN2 gene and schizophrenia

  2024cites this paper
• Decoding molecular bases of rodent social hetero-grooming behavior using in silico analyses and bioinformatics tools.

  2024cites this paper
• A role for synapsin tetramerization in synaptic vesicle clustering

  2024cites this paper
• Electro‐Clinical Features and Functional Connectivity Analysis in SYN1 ‐Related Epilepsy

  2024cites this paper
• Biomarkers of mature neuronal differentiation and related diseases

  2024cites this paper
• The Impact of the Histone Deacetylase Inhibitor—Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia–Ischemia

  2024cites this paper
• A novel liquid-liquid phase separation-related gene signature for predicting prognosis in colon cancer

  2024cites this paper
• Labeling and isolating cell specific neuronal mitochondria and their functional analysis in mice post stroke.

  2024cites this paper
• miR-23a-3p and miR-181a-5p modulate SNAP-25 expression

  2023cites this paper
• Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study.

  2023cites this paper
• The effects of methylphenidate and atomoxetine on Drosophila brain at single-cell resolution and potential drug repurposing for ADHD treatment

  2023cites this paper
• The role of α-synuclein in exocytosis.

  2023cites this paper
• Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates

  2022influential citation
• Ca2+ binding to synapsin I regulates resting Ca2+ and recovery from synaptic depression in nerve terminals

  2022cites this paper
• Galnt17 loss-of-function leads to developmental delay and abnormal coordination, activity, and social interactions with cerebellar vermis pathology.

  2022cites this paper
• Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum.

  2022cites this paper
• An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD

  2022cites this paper
• A proteomic study to unveil lead toxicity-induced memory impairments invoked by synaptic dysregulation

  2022cites this paper
• The prion protein and its ligands: Insights into structure-function relationships.

  2022cites this paper
• Alpha‐Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction

  2022cites this paper
• Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype

  2022cites this paper
• A multi-environments-gene interaction study of anxiety, depression and self-harm in the UK Biobank cohort.

  2022cites this paper
• The different clinical facets of SYN1-related neurodevelopmental disorders

  2022influential citation
• Low p-SYN1 (Ser-553) Expression Leads to Abnormal Neurotransmitter Release of GABA Induced by Up-Regulated Cdk5 after Microwave Exposure: Insights on Protection and Treatment of Microwave-Induced Cognitive Dysfunction

  2021cites this paper
• Activation of α7 Nicotinic Acetylcholine Receptor by its Selective Agonist Improved Learning and Memory of Amyloid Precursor Protein/Presenilin 1 (APP/PS1) Mice via the Nrf2/HO-1 Pathway

  2021cites this paper
• Synapsin III Controls Early Phases of Dopaminergic Neurons Development in Fishes and Mammals by Acting Upstream of BDNF and Cdk5 Signaling

  2021cites this paper
• Synuclein Regulates Synaptic Vesicle Clustering and Docking at a Vertebrate Synapse

  2021cites this paper
• Integrated Analysis of Genes Related to Alzheimer’s Disease Pathogenesis Using Gene Co-expression Networks

  year unknowncites this paper