Genetic disruption of G proteins, Gi2α or Goα, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium

No abstract is available for this paper.

• Publication year

  2009

• Venue

  British Journal of Pharmacology

• Publication date

  2009-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1476-5381.2009.00441.xPMID 19906118PMCID PMC2795222
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A positive inotropic effect of adenosine in cardiac preparations of right atria from diseased human hearts

  2009cited by this paper
• Guide to Receptors and Channels (GRAC), 3rd edition

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• Guide to Receptors and Channels (GRAC), 2nd edition (2007 Revision).

  2007cited by this paper
• Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice.

  2007influential reference
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  2004cited by this paper
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  2003cited by this paper
• Pertussis toxin sensitive and insensitive effects of adenosine and carbachol in murine atria overexpressing A1‐adenosine receptors

  2003cited by this paper
• Analysis of the Chronotropic Effect of Acetylcholine on Sinoatrial Node Cells

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• Effects of ACh and adenosine mediated by Kir3.1 and Kir3.4 on ferret ventricular cells.

  2002cited by this paper
• Seven-transmembrane-spanning receptors and heart function

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• Quantitation of mRNAs for M(1) to M(5) subtypes of muscarinic receptors in rat heart and brain cortex.

  2002cited by this paper
• Lack of muscarinic regulation of Ca(2+) channels in G(i2)alpha gene knockout mouse hearts.

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• Lack of muscarinic regulation of Ca 2 1 channels in Gi 2 a gene knockout mouse hearts

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  2001cited by this paper
• Lack of muscarinic regulation of Ca2+ channels in Gi2α gene knockout mouse hearts

  2001cited by this paper
• Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart.

  2001cited by this paper
• Gαi2 but Not Gαi3 Is Required for Muscarinic Inhibition of Contractility and Calcium Currents in Adult Cardiomyocytes

  2000cited by this paper
• Galpha(i2) but not Galpha(i3) is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes.

  2000cited by this paper
• Muscarinic inhibitory and stimulatory regulation of the L‐type Ca2+ current is not altered in cardiac ventricular myocytes from mice lacking endothelial nitric oxide synthase

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  1999cited by this paper
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  1999cited by this paper
• G αi2, G αi3and G αoare all Required for Normal Muscarinic Inhibition of the Cardiac Calcium Channels in Nodal/Atrial-like Cultured Cardiocytes

  1999cited by this paper
• Galpha(i2), Galpha(i3)and Galpha(o) are all required for normal muscarinic inhibition of the cardiac calcium channels in nodal/atrial-like cultured cardiocytes.

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• Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase.

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  1998cited by this paper
• Multiple neurological abnormalities in mice deficient in the G protein Go.

  1998cited by this paper
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  1997cited by this paper
• Targeted inactivation of alphai2 or alphai3 disrupts activation of the cardiac muscarinic K+ channel, IK+Ach, in intact cells.

  1997cited by this paper
• Gαo is necessary for muscarinic regulation of Ca2+ channels in mouse heart

  1997influential reference
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  1997cited by this paper
• Targeted inactivation of αi2 or αi3 disrupts activation of the cardiac muscarinic K+ channel, IK+Ach, in intact cells

  1997cited by this paper
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• A direct negative inotropic effect of acetylcholine on rat ventricular myocytes.

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• G proteins and the heart

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• A pharmacological investigation of the contribution of muscarinic receptor-linked potassium channels to the reversal by carbachol of positive inotropic responses of rabbit left atrium to cyclic AMP-generating agents.

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• Mechanism of acetylcholine-induced inhibition of Ca current in bullfrog atrial myocytes

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• Dissociation of changes in apparent myofibrillar Ca2+ sensitivity and twitch relaxation induced by adrenergic and cholinergic stimulation in isolated ferret cardiac muscle

  1988cited by this paper
• Adenosine inhibits the positive inotropic effect of 3‐isobutyl‐1‐methylxanthine in papillary muscles without effect on cyclic AMP or cyclic GMP

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• The negative inotropic effect of acetylcholine on ferret ventricular myocardium.

  1988cited by this paper
• Two types of calcium channels in guinea pig ventricular myocytes.

  1986cited by this paper
• Role of guanine nucleotide-binding protein in the regulation by adenosine of cardiac potassium conductance and force of contraction. Evaluation with pertussis toxin

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• The parasympathetic neuroeffector junction of the heart.

  1985cited by this paper
• Muscarinic cholinergic inhibition of beta-adrenergic stimulation of phospholamban phosphorylation and Ca2+ transport in guinea pig ventricles.

  1985cited by this paper

• Cantharidin attenuates the anti-β-adrenergic or anti-histaminergic or anti-serotoninergic effect of A1-adenosine receptor stimulation in the isolated human atrium

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• Inhibition of protein phosphatases attenuates A1-adenosine receptor-stimulation induced negative inotropic effects of cAMP-increasing agents in the isolated human atrium

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  2024cites this paper
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• Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model.

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• Role of the Heterotrimeric Go Protein Alpha-subunit on the Cardiac Secretory Phenotype

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• Local Innervation and Atrial Fibrillation

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  2011cites this paper
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  2011cites this paper
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  2011cites this paper