Biosynthesis of the nucleoside antibiotic angustmycins: identification and characterization of the biosynthetic gene cluster reveal unprecedented dehydratase required for exo-glycal formation

No abstract is available for this paper.

• Publication year

  2021

• Venue

  Journal of antibiotics (Tokyo. 1968)

• Publication date

  2021-08-17

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/s41429-021-00466-7PMID 34404922
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Coordinated Biosynthesis of the Purine Nucleoside Antibiotics Aristeromycin and Coformycin in Actinomycetes

  2018cited by this paper
• Synthesis of exo-glycals and their biochemical applications

  2018cited by this paper
• Pen and Pal Are Nucleotide-Sugar Dehydratases That Convert UDP-GlcNAc to UDP-6-Deoxy-d-GlcNAc-5,6-ene and Then to UDP-4-Keto-6-deoxy-l-AltNAc for CMP-Pseudaminic Acid Synthesis in Bacillus thuringiensis*♦

  2014cited by this paper
• Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.

  2013cited by this paper
• Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates.

  2012cited by this paper
• Reclassification of Streptomyces hygroscopicus strains as Streptomyces aldersoniae sp. nov., Streptomyces angustmyceticus sp. nov., comb. nov., Streptomyces ascomycinicus sp. nov., Streptomyces decoyicus sp. nov., comb. nov., Streptomyces milbemycinicus sp. nov. and Streptomyces wellingtoniae sp. no

  2010cited by this paper
• Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.

  2009cited by this paper
• Synthesis and Uses of exo-Glycals.

  2004cited by this paper
• Mechanism of action of S-ribosylhomocysteinase (LuxS).

  2004cited by this paper
• Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.

  2002cited by this paper
• Catalytic Mechanism ofS-Adenosylhomocysteine Hydrolase

  2002cited by this paper
• Functional Analysis of relA andrshA, Two relA/spoT Homologues ofStreptomyces coelicolor A3(2)

  2001cited by this paper
• THE CHEMISTRY OF 4′,5′-UNSATURATED NUCLEOSIDES. A REVIEW

  1999cited by this paper
• The D-allose operon of Escherichia coli K-12

  1997cited by this paper
• Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: significance of the stringent response (ppGpp) and GTP content in relation to A factor

  1987cited by this paper
• THE BIOSYNTHESIS OF PSICOFURANINE.

  1965cited by this paper
• Angustmycin A and decoyinine

  1964cited by this paper
• MECHANISM OF ACTION OF PSICOFURANINE

  1960cited by this paper
• Studies on angustmycin. III.

  1956cited by this paper
• Studies on a new antibiotic, angustmycin.

  1954cited by this paper
• Studies on a new antibiotic, angustmycin. I.

  1954cited by this paper

• New insights into the microbiome of the deep-sea sponge Inflatella pellicula and the secondary metabolic potential of metagenome-assembled genomes and the wider microbiome

  2026cites this paper
• Biosynthesis and genome mining strategies for purine-derived N-nucleoside antibiotics

  2025cites this paper
• Preparation of nucleoside analogues: opportunities for innovation at the interface of synthetic chemistry and biocatalysis

  2025cites this paper
• Synthetic Biology in Natural Product Biosynthesis.

  2025cites this paper
• Coordinated regulation of two LacI family regulators, GvmR and GvmR2, on guvermectin production in Streptomyces caniferus

  2024cites this paper
• Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology

  2024cites this paper
• Development and Application of the Novel Plant Growth Regulator Guvermectin: A Perspective.

  2024cites this paper
• A guide for the synthesis of key nucleoside scaffolds in drug discovery

  2023cites this paper
• Guvermectin Biosynthesis Revealing the Key Role of a Phosphoribohydrolase and Structural Insight into the Active Glutamate of a Noncanonical Adenine Phosphoribosyltransferase.

  2023cites this paper
• Efficient biosynthesis of nucleoside cytokinin angustmycin A containing an unusual sugar system

  2021cites this paper