Induction of regulatory T cells by the immunomodulating cytokines α‐melanocyte‐stimulating hormone and transforming growth factor‐β2

Recently, we have reported that the cytokines α‐melanocyte‐stimulating hormone (α‐MSH) and transforming growth factor‐β2 (TGF‐β2) work in synergy to induce the activation of regulatory T (Treg) cells. When we used α‐MSH and TGF‐β2 to generate ocular autoantigen‐specific Treg cells and adoptively transferred them into mice susceptible to experimental autoimmune uveoretinitis (EAU), there was suppression in the incidence and severity of EAU. Specificity to a retinal autoantigen was required for the Treg cells to suppress EAU. When stimulated, these Treg cells produced TGF‐β1, and their production of interferon‐γ, interleukin (IL)‐10, and IL‐4 was suppressed. Also, the Treg cells are suppressed in their proliferative response. Our results demonstrate that α‐MSH with TGF‐β2 induce Treg cells that can subdue a tissue‐specific autoimmune response. This also promotes the possibility of using these immunomodulating cytokines to purposely induce antigen‐specific Treg cells to prevent and suppress autoimmune disease.

• Publication year

  2002

• Venue

  Journal of Leukocyte Biology

• Publication date

  2002-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1189/jlb.72.5.946
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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