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Dietary Naringenin Preserves Insulin Sensitivity and Grip Strength and Attenuates Inflammation but Accelerates Weight Loss in a Mouse Model of Cancer Cachexia.

Deena B. Snoke,Y. Nishikawa,R. Cole,Ai Ni,A. Angelotti,Y. Vodovotz,M. Belury

Published 2021 in Molecular Nutrition & Food Research

ABSTRACT

SCOPE Cancer cachexia is characterized by the loss of skeletal muscle resulting in functional impairment, reduced quality of life and mortlity. Naringenin, a flavonoid found in citrus fruits, improves insulin sensitivity and reduces inflammation and tumor growth in preclinical models. Therefore, we hypothesized that dietary supplementation of naringenin would improve insulin sensitivity, decrease inflammation, slow body weight loss and delay tumor growth in a mouse model of cancer cachexia. METHODS & RESULTS Mice were fed 2 wt% dietary naringenin before and during initiation of cancer cachexia using inoculated adenocarcinoma-26 cells (C-26). Food intake, body weight, body composition, muscle function, insulin tolerance, and inflammatory status were assessed. Although naringenin-fed tumor-bearing mice exhibited reductions in body weight and food intake earlier than control diet-fed tumor-bearing mice, dietary naringenin was protective against loss of muscle strength, and attenuated the onset of insulin resistance and markers of inflammation. CONCLUSIONS Dietary supplementation of naringenin improved multiple aspects of metabolic disturbance and inflammation during cancer cachexia progression in [C-26 tumor-bearing] mice. However, the acceleration of anorexia and weight loss was also observed. These findings emphasize the link between inflammation and insulin resistance as a basis for understanding their roles in the pathogenesis of cancer cachexia. This article is protected by copyright. All rights reserved.

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