Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome.

Irritable bowel syndrome (IBS) is regarded as a multifactorial disease in which alterations in the brain-gut axis signaling play a major role. The biopsychosocial model applied to the understanding of IBS pathophysiology assumes that psychosocial factors, interacting with peripheral/central neuroendocrine and immune changes, may induce symptoms of IBS, modulate symptom severity, influence illness experience and quality of life, and affect outcome. The present review focuses on the role of negative affects, including depression, anxiety, and anger, on pathogenesis and clinical expression of IBS. The potential role of the autonomic nervous system, stress-hormone system, and immune system in the pathophysiology of both negative affects and IBS are taken into account. Psychiatric comorbidity and subclinical variations in levels of depression, anxiety, and anger are further discussed in relation to the main pathophysiological and symptomatic correlates of IBS, such as sensorimotor functions, gut microbiota, inflammation/immunity, and symptom reporting.

• Publication year

  2014

• Venue

  World Journal of Gastroenterology

• Publication date

  2014-06-28

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.3748/wjg.v20.i24.7570PMID 24976697PMCID PMC4069288
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Anxiety and depression as markers of multiplicity of sites of functional gastrointestinal disorders: a gender issue?

  2013cited by this paper
• Varieties of Anger and the Inverse Link Between Education and Inflammation: Toward an Integrative Framework

  2013cited by this paper
• Altered colonic function and microbiota profile in a mouse model of chronic depression

  2013cited by this paper
• Mental Strain and Chronic Stress among University Students with Symptoms of Irritable Bowel Syndrome

  2013cited by this paper
• Gut microbiota and gastrointestinal health: current concepts and future directions

  2013cited by this paper
• Correlation between anxiety-depression status and cytokines in diarrhea-predominant irritable bowel syndrome

  2013cited by this paper
• Abdominal pain is associated with anxiety and depression scores in a sample of the general adult population with no signs of organic gastrointestinal disease

  2013cited by this paper
• Beyond phylotyping: understanding the impact of gut microbiota on host biology

  2013cited by this paper
• The microbiota link to irritable bowel syndrome

  2012cited by this paper
• Psychosocial determinants of irritable bowel syndrome.

  2012cited by this paper
• Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression.

  2012cited by this paper
• Evidence for alterations in central noradrenergic signaling in irritable bowel syndrome

  2012cited by this paper
• STRESS AND THE GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS

  2012cited by this paper
• Effects of personality traits on the manifestations of irritable bowel syndrome

  2012cited by this paper
• Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus

  2012cited by this paper
• Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options.

  2011cited by this paper
• Attention to pain words in irritable bowel syndrome: increased orienting and speeded engagement.

  2011cited by this paper
• Systematic review of modulators of benzodiazepine receptors in irritable bowel syndrome: is there hope?

  2011cited by this paper
• The brain-gut axis in abdominal pain syndromes.

  2011cited by this paper
• Immune suppression and immune activation in depression.

  2011cited by this paper
• An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota

  2011cited by this paper
• Centrally acting therapies for irritable bowel syndrome.

  2011cited by this paper
• Advances in imaging the brain-gut axis: functional gastrointestinal disorders.

  2011cited by this paper
• Abuse, Trauma, and GI Illness: Is There a Link?

  2011cited by this paper
• Maternal separation as a model of brain–gut axis dysfunction

  2011cited by this paper
• Gut feelings: the emerging biology of gut–brain communication

  2011cited by this paper
• Irritable bowel syndrome - An inflammatory disease involving mast cells

  2011cited by this paper
• Dimensions of depression and anxiety and the hypothalamo-pituitary-adrenal axis.

  2011cited by this paper
• Biopsychosocial Model of Irritable Bowel Syndrome

  2011cited by this paper
• Abdominal pain in Irritable Bowel Syndrome: a review of putative psychological, neural and neuro-immune mechanisms.

  2011cited by this paper
• Positive affect and psychobiological processes.

  2010cited by this paper
• Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome

  2010cited by this paper
• Regional gray matter density changes in brains of patients with irritable bowel syndrome.

  2010cited by this paper
• Anger and childhood sexual abuse are independently associated with irritable bowel syndrome.

  2010cited by this paper
• Depression, Anxiety and Anger in Subtypes of Irritable Bowel Syndrome Patients

  2010cited by this paper
• Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationships.

  2010cited by this paper
• A Molecular Analysis of Fecal and Mucosal Bacterial Communities in Irritable Bowel Syndrome

  2010cited by this paper
• Corticotropin-releasing factor signaling and visceral response to stress

  2010cited by this paper
• Behavioral Inhibition as a Risk Factor for the Development of Childhood Anxiety Disorders: A Longitudinal Study

  2010cited by this paper
• Hippocampal changes associated with early-life adversity and vulnerability to depression.

  2010cited by this paper
• Meta‐analysis: do irritable bowel syndrome symptoms vary between men and women?

  2010cited by this paper
• The absence of positive psychological (eudemonic) well-being as a risk factor for depression: a ten year cohort study.

  2010cited by this paper
• Plasma Cytokine Profiles in Females With Irritable Bowel Syndrome and Extra-Intestinal Co-Morbidity

  2010cited by this paper
• Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome.

  2009cited by this paper
• Efficacy of tricyclic antidepressants in irritable bowel syndrome: a meta-analysis.

  2009cited by this paper
• Burden and consequences of child maltreatment in high-income countries.

  2009cited by this paper
• Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study

  2009cited by this paper
• Psychological treatments for the management of irritable bowel syndrome.

  2009cited by this paper
• Immune activation and gut microbes in irritable bowel syndrome.

  2009cited by this paper
• Prevalence of irritable bowel syndrome and its relationship with psychological stress status in Chinese university students

  2009cited by this paper
• Brain imaging approaches to the study of functional GI disorders: A Rome Working Team Report

  2009cited by this paper
• Dysregulation of the hypothalamic‐pituitary‐adrenal (HPA) axis in irritable bowel syndrome

  2009cited by this paper
• Frequency and severity of the symptoms of irritable bowel syndrome across the anxiety disorders and depression.

  2009cited by this paper
• Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

  2009cited by this paper
• Stress and disorders of the stress system

  2009cited by this paper
• Recent insights on central processing and psychological processes in functional gastrointestinal disorders.

  2009cited by this paper
• Childhood trauma is associated with hypothalamic-pituitary-adrenal axis responsiveness in irritable bowel syndrome.

  2009cited by this paper
• The genetic basis of congenital hyperinsulinism

  2009cited by this paper
• Irritable bowel syndrome: towards biomarker identification.

  2009cited by this paper
• Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study

  2009cited by this paper
• Psychosocial Distress and Somatic Symptoms in Community Subjects With Irritable Bowel Syndrome: A Psychological Component Is the Rule

  2009cited by this paper
• Effects of psychological stress on the cerebral processing of visceral stimuli in healthy women

  2009cited by this paper
• The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease.

  2009cited by this paper
• Postinfectious irritable bowel syndrome.

  2009cited by this paper
• Risk factors for mental health: Translational models from behavioural neuroscience

  2009cited by this paper
• Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses.

  2009cited by this paper
• Epigenetic inheritance during the cell cycle

  2009cited by this paper
• Gastrointestinal symptoms in primary care: prevalence and association with depression and anxiety.

  2008cited by this paper
• Symptom severity but not psychopathology predicts visceral hypersensitivity in irritable bowel syndrome.

  2008cited by this paper
• Serotonin pharmacology in the gastrointestinal tract: a review

  2008cited by this paper
• Increased colonic pain sensitivity in irritable bowel syndrome is the result of an increased tendency to report pain rather than increased neurosensory sensitivity

  2008cited by this paper
• Small intestinal bacterial overgrowth in irritable bowel syndrome: association with colon motility, bowel symptoms, and psychological distress

  2008cited by this paper
• Enhanced Cholinergic-Mediated Increase in the Pro-Inflammatory Cytokine IL-6 in Irritable Bowel Syndrome: Role of Muscarinic Receptors

  2008cited by this paper
• Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain

  2008cited by this paper
• Impact of Depressive Symptoms on Visceral Sensitivity Among Patients With Different Subtypes of Irritable Bowel Syndrome

  2008cited by this paper
• Antagonistic characteristics are positively associated with inflammatory markers independently of trait negative emotionality.

  2008cited by this paper
• The association between neuroticism and self-reported common somatic symptoms in a population cohort.

  2007cited by this paper
• Personality traits, education, and health-related quality of life among older adult primary care patients.

  2007cited by this paper
• Relationship of functional gastrointestinal disorders and psychiatric disorders: implications for treatment.

  2007cited by this paper
• Comorbidity in Irritable Bowel Syndrome

  2007cited by this paper
• Continuum of care for maternal, newborn, and child health: from slogan to service delivery.

  2007cited by this paper
• Feeding and colonic distension provoke altered autonomic responses in irritable bowel syndrome

  2007cited by this paper
• Personality factors and profiles in variants of irritable bowel syndrome.

  2007cited by this paper
• Understanding the interaction between psychosocial stress and immune-related diseases: a stepwise progression.

  2007cited by this paper
• Functional GI disorders: from animal models to drug development

  2007cited by this paper
• Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome

  2007cited by this paper
• New insights into the pathogenesis and pathophysiology of irritable bowel syndrome.

  2007cited by this paper
• Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum

  2006cited by this paper
• Anger and ego-defence mechanisms in non-psychiatric patients with irritable bowel syndrome.

  2006cited by this paper
• Review article: modulation of the brain–gut axis as a therapeutic approach in gastrointestinal disease

  2006cited by this paper
• DS14: Standard Assessment of Negative Affectivity, Social Inhibition, and Type D Personality

  2005cited by this paper
• The association between burnout, depression, anxiety, and inflammation biomarkers: C-reactive protein and fibrinogen in men and women.

  2005cited by this paper
• Bulking agents, antispasmodic and antidepressant medication for the treatment of irritable bowel syndrome.

  2005cited by this paper
• Does positive affect influence health?

  2005cited by this paper
• Irritable bowel syndrome in developing countries – a disorder of civilization or colonization?

  2005cited by this paper
• Increased Somatic Complaints and Health-Care Utilization in Children: Effects of Parent IBS Status and Parent Response to Gastrointestinal Symptoms

  2004cited by this paper
• Irritable bowel syndrome: a model of the brain-gut interactions.

  2004cited by this paper
• The presentation of irritable bowel syndrome in the context of somatization disorder.

  2004cited by this paper
• The emotional brain

  2004cited by this paper
• The brain-gut axis in irritable bowel syndrome--clinical aspects.

  2004cited by this paper

• La place des antidépresseurs dans le syndrome du côlon irritable : Le point sur la littérature

  2025cites this paper
• Breaking the cycle: Psychological and social dimensions of pediatric functional gastrointestinal disorders

  2025cites this paper
• Coping with the burden of irritable bowel syndrome by emotional suppression—A cross sectional observational pilot study

  2025cites this paper
• KHẢO SÁT TÌNH TRẠNG RỐI LOẠN TRẦM CẢM Ở BỆNH NHÂN CÓ HỘI CHỨNG RUỘT KÍCH THÍCH

  2025cites this paper
• Fulfilled Mind, Healthy Gut? Relationships of Eudaimonic Psychological Well-Being With the Gut Microbiome in Postmenopausal Women

  2024cites this paper
• Trauma und Reizdarm

  2024cites this paper
• Integrated Approaches in the Management of Gastrointestinal Disorders: A Biopsychosocial Perspective

  2024cites this paper
• Putting the Vicious Cycle to the Test: Evidence for the Cognitive Behavioral Model of Persistent Somatic Symptoms From an Online Study

  2024cites this paper
• The Relationship between Canine Behavioral Disorders and Gut Microbiome and Future Therapeutic Perspectives

  2024cites this paper
• Gut feelings: associations of emotions and emotion regulation with the gut microbiome in women

  2023cites this paper
• When Gut Hormones Influence Brain Function in Depression

  2023cites this paper
• Self-Reported Impaired Wound Healing in Young Adults and Their Susceptibility to Experiencing Immune-Related Complaints

  2022cites this paper
• The specifics of emotional dysregulation in women with various types of irritable bowel syndrome

  2022cites this paper
• Deciphering the synergistic network regulation of active components from SiNiSan against irritable bowel syndrome via a comprehensive strategy: Combined effects of synephrine, paeoniflorin and naringin.

  2021cites this paper
• Abnormalities of intrinsic brain activity in irritable bowel syndrome (IBS)

  2021cites this paper
• Vision of the role of long-term social stress in the formation of "diseases of civilization". mechanisms of adaptation to stressor situations and factors of its failure

  2021cites this paper
• Effectiveness and safety of kamikihito, a traditional Japanese medicine, in managing anxiety among female patients with intractable chronic constipation.

  2021cites this paper
• A Resting-state Functional Magnetic Resonance Imaging Study of Whole-brain Functional Connectivity of Voxel Levels in Patients With Irritable Bowel Syndrome With Depressive Symptoms

  2021cites this paper
• The Association of Irritable Bowel Complaints and Perceived Immune Fitness among Individuals That Report Impaired Wound Healing: Supportive Evidence for the Gut–Brain–Skin Axis

  2021cites this paper
• Oral Health and Fibromyalgia Syndrome: A Systemic Review

  2020cites this paper
• Postprandial Symptoms in Patients With Functional Dyspepsia and Irritable Bowel Syndrome: Relations to Ultrasound Measurements and Psychological Factors

  2020cites this paper
• Convergent syndromic atrophy of pain and emotional systems in patients with irritable bowel syndrome and depressive symptoms.

  2020cites this paper
• Supraspinal Mechanisms of Intestinal Hypersensitivity

  2020cites this paper
• Network approach of mood and functional gastrointestinal symptom dynamics in relation to childhood trauma in patients with irritable bowel syndrome and comorbid panic disorder.

  2020cites this paper
• Spine and TMJ: A Pathophysiology Report

  2020cites this paper
• Negative Emotions in Skin Disorders: A Systematic Review

  2020cites this paper
• The wounds of childhood: Early trauma subtypes, salience and hyperarousal in a sample of adult psychiatric patients

  2020cites this paper
• Moxidectin Effects on Gut Microbiota of Wistar-Kyoto Rats: Relevance to Depressive-Like Behavior.

  2019cites this paper
• The Common Causes of Irritable Bowel Syndrome (IBS) in Northern Saudi Arabia

  2019cites this paper
• Impact of the Gut Microbiome on Behavior and Emotions

  2019cites this paper
• Association of human microbiome with health and disease states

  2019cites this paper
• Does Irritable Bowel Syndrome Exist? Identifiable and Treatable Causes of Associated Symptoms Suggest It May Not

  2019cites this paper
• The Role of the Gut Brain Axis and Microbiome in Colorectal Cancer, Alzheimer's Disease, and Crohn's Disease

  2019cites this paper
• The feeling of anger: from brain networks to linguistic expressions.

  2019cites this paper
• Anger Mediates the Relationship between Pain and Depression in Irritable Bowel Syndrome.

  2019cites this paper
• PSYCHIATRIC ASPECTS OF IRRITABLE BOWEL SYNDROME

  2019cites this paper
• Risk of psychiatric disorders in irritable bowel syndrome—A nationwide, population‐based, cohort study

  2018cites this paper
• Brain-Gut Miscommunication: Biopsychosocial Predictors of Quality of Life in Irritable Bowel Syndrome

  2018cites this paper
• Irritable Bowel Syndrome and Depression: A Shared Pathogenesis

  2018cites this paper
• Conditions Associated with Essential Tremor in Veterans: A Potential Role for Chronic Stress

  2018cites this paper
• Negative Emotions in Irritable Bowel Sindrome: which differences among IBS Subtypes?

  2018cites this paper
• Intra- i interindividualna povezanost stresa, raspoloženja i težine simptoma kod oboljelih od sindroma iritabilnog crijeva

  2018cites this paper
• The effects of probiotics on mood and emotion

  2018cites this paper
• Does depression increase the risk of stroke in patients with rheumatoid arthritis? A population-based cohort study

  2017cites this paper
• Stress and Other Factors Involved in the Pathophysiology of Irritable Bowel Syndrome. Review

  2017cites this paper
• Functional urological disorders: a sensitized defence response in the bladder–gut–brain axis

  2017cites this paper
• El Rol de la incongruencia en la evaluación de pacientes hospitalizados con trastornos gastrointestinales

  2017cites this paper
• Gut microbiota’s effect on mental health: The gut-brain axis

  2017cites this paper
• Effects of Patients' Affect on Adverse Procedural Events during Image-Guided Interventions.

  2017cites this paper
• Role of stem cell growth factor/c-Kit in the pathogenesis of irritable bowel syndrome

  2017cites this paper
• Exploring beliefs about emotions, emotional expression and support-seeking in persistent physical symptoms

  2017influential citation
• Personality traits and emotional patterns in irritable bowel syndrome.

  2016cites this paper
• Effects of electroacupuncture on corticotropin-releasing hormone in rats with chronic visceral hypersensitivity.

  2015cites this paper
• Anxiety and Quality of Life in patients with Irritable Bowel Syndrome

  2015cites this paper
• Anger, anger expression, cardiovascular risk factors, and gastrointestinal symptoms by hwa-byung symptoms in Korean adult women.

  2015cites this paper
• The Gut–Brain Axis

  2015cites this paper
• Ehealth: low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome.

  2014cites this paper