Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Genes, Chromosomes and Cancer

• Publication date

  2002-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/gcc.10026PMID 11807989
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000influential reference
• BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1.

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• Patched Target Igf2 Is Indispensable for the Formation of Medulloblastoma and Rhabdomyosarcoma*

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• Application of comparative genomic hybridization, spectral karyotyping, and microarray analysis in the identification of subtype-specific patterns of genomic changes in rhabdomyosarcoma.

  1999influential reference
• Embryonal rhabdomyosarcoma with only numerical chromosome changes. Case report and review of the literature.

  1999cited by this paper
• Diminished G1 Checkpoint after γ-Irradiation and Altered Cell Cycle Regulation by Insulin-like Growth Factor II Overexpression*

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  1998cited by this paper
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  1998cited by this paper
• Gene alterations and apoptosis in rhabdomyosarcoma.

  1997cited by this paper
• Molecular Genetics and Pathogenesis of Rhabdomyosarcoma

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  1996influential reference
• Cytogenetics of Bone and Soft Tissue Tumors

  1995cited by this paper
• Gains and losses of DNA sequences in osteosarcomas by comparative genomic hybridization.

  1995cited by this paper
• Comparative genomic hybridization analysis of human sarcomas: II. Identification of novel amplicons at 6p and 17p in osteosarcomas

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• Childhood Rhabdomyosarocoma with Anaplastic (Pleomorphic) Features: A Report of the Intergroup Rhabdomyosarcoma Study

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• Bcl-2 initiates a new category of oncogenes: regulators of cell death.

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• Amplification of the gli gene in childhood sarcomas.

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